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<title>GreenMedInfo</title>
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<language>en</language>
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<title>Ancient African Herb Bests Antibiotics (Amoxicillin) for Sinus Infections in Clinical Trial</title>
<link>https://greenmedinfo.com/content/ancient-african-herb-bests-antibiotics-amoxicillin-sinus-infections-clinical-t</link>
<description><div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2024<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/Ancient_African_Herb_Bests_Antibiotics_for_Sinus_Infections_in_Clinical_Trial-GreenMedInfo.jpg" /></p>
<p><span style="font-size:18px;"><em><strong><span style="letter-spacing: 0px;">For centuries, traditional healers in South Africa have relied on the Pelargonium sidoides plant to treat respiratory infections. Now modern research proves this ancient remedy works better than antibiotics for acute sinusitis</span></strong></em></span></p><p><a href="https://greenmedinfo.com/content/ancient-african-herb-bests-antibiotics-amoxicillin-sinus-infections-clinical-t" target="_blank">read more</a></p></description>
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<category domain="https://greenmedinfo.com/category/disease/nasal-congestion">Nasal Congestion</category>
<category domain="https://greenmedinfo.com/category/substance/pelargonium-sidoides-umka">Pelargonium sidoides</category>
<category domain="https://greenmedinfo.com/category/disease/sinusitis">Sinusitis</category>
<category domain="https://greenmedinfo.com/category/toxic-ingredients/antibiotics">Antibiotics</category>
<category domain="https://greenmedinfo.com/category/keywords/congestion">congestion</category>
<category domain="https://greenmedinfo.com/category/keywords/herbal%20remedy">herbal remedy</category>
<category domain="https://greenmedinfo.com/category/keywords/sinusitis">sinusitis</category>
<pubDate>Fri, 29 Mar 2024 11:00:00 +0000</pubDate>
<dc:creator>GMI Research Group</dc:creator>
<guid isPermaLink="false">293121 at https://greenmedinfo.com</guid>
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<title>New Study Shows Promise for Natural Support of Autism Symptoms</title>
<link>https://greenmedinfo.com/content/new-study-shows-promise-natural-support-autism-symptoms</link>
<description><div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2024<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/New_Study_Shows_Promise_for_Natural_Support_of_Autism_Symptoms-GreenMedInfo.jpg" style="width: 600px; height: 315px;" /></p>
<p><span style="font-size:18px;"><em><strong>A new double-blind, placebo-controlled study published in Psychiatry and Clinical Neurosciences shows exciting potential for sulforaphane, a compound found in broccoli sprouts, to help ease symptoms of irritability and hyperactivity in children with autism spectrum disorder (ASD).<sup>1</sup></strong></em></span></p><p><a href="https://greenmedinfo.com/content/new-study-shows-promise-natural-support-autism-symptoms" target="_blank">read more</a></p></description>
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<category domain="https://greenmedinfo.com/category/disease/alzheimers-disease">Alzheimer's Disease</category>
<category domain="https://greenmedinfo.com/category/disease/asthma">Asthma</category>
<category domain="https://greenmedinfo.com/category/disease/autism-spectrum-disorders">Autism Spectrum Disorders</category>
<category domain="https://greenmedinfo.com/category/substance/broccoli">Broccoli</category>
<category domain="https://greenmedinfo.com/category/disease/Cardiovascular%20Disease">Cardiovascular Disease</category>
<category domain="https://greenmedinfo.com/category/disease/inflammation">Inflammation</category>
<category domain="https://greenmedinfo.com/category/disease/oxidative-stress">Oxidative Stress</category>
<category domain="https://greenmedinfo.com/category/disease/parkinsons-disease">Parkinson's Disease</category>
<category domain="https://greenmedinfo.com/category/disease/schizophrenia">Schizophrenia</category>
<category domain="https://greenmedinfo.com/category/substance/sulforaphane">Sulforaphane</category>
<category domain="https://greenmedinfo.com/category/disease/Vaccination%3A%20All">Vaccination: All</category>
<category domain="https://greenmedinfo.com/category/keywords/autism%20spectrum%20disorders">autism spectrum disorders</category>
<category domain="https://greenmedinfo.com/category/keywords/healing%20foods">healing foods</category>
<category domain="https://greenmedinfo.com/category/keywords/natural%20health">natural health</category>
<pubDate>Fri, 29 Mar 2024 11:00:00 +0000</pubDate>
<dc:creator>GMI Research Group</dc:creator>
<guid isPermaLink="false">293083 at https://greenmedinfo.com</guid>
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<title>Cocoa and Pomegranates: The New Heroes Against Andropause (Man-O-Pause)</title>
<link>https://greenmedinfo.com/content/cocoa-and-pomegranates-new-heroes-against-andropause-man-o-pause</link>
<description><div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2024<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/Cocoa_and_Pomegranates-The_New_Heroes_Against_Andropause_Man-O-Pause-GreenMedInfo.jpg" /></p>
<p><span style="font-size:18px;"><em><strong>For aging men watching their vitality slowly drain away each year, a proprietary botanical blend represents newfound hope of restoring lost vigor and masculinity</strong></em></span></p><p><a href="https://greenmedinfo.com/content/cocoa-and-pomegranates-new-heroes-against-andropause-man-o-pause" target="_blank">read more</a></p></description>
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<category domain="https://greenmedinfo.com/category/disease/andropause-syndrome">Andropause Syndrome</category>
<category domain="https://greenmedinfo.com/category/substance/cocoa">Cocoa</category>
<category domain="https://greenmedinfo.com/category/disease/fatigue">Fatigue</category>
<category domain="https://greenmedinfo.com/category/disease/low-testosterone">Low Testosterone</category>
<category domain="https://greenmedinfo.com/category/disease/mood-disorders">Mood Disorders</category>
<category domain="https://greenmedinfo.com/category/substance/pomegranate">Pomegranate</category>
<category domain="https://greenmedinfo.com/category/disease/stress-and-anxiety">Stress and Anxiety</category>
<category domain="https://greenmedinfo.com/category/keywords/cocoa">Cocoa</category>
<category domain="https://greenmedinfo.com/category/keywords/men%27s%20health">men's health</category>
<category domain="https://greenmedinfo.com/category/keywords/pomegranate">pomegranate</category>
<pubDate>Fri, 29 Mar 2024 11:00:00 +0000</pubDate>
<dc:creator>GMI Research Group</dc:creator>
<guid isPermaLink="false">293086 at https://greenmedinfo.com</guid>
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<item>
<title>Cardioprotective effect of hydrogen-rich saline on isoproterenol-induced myocardial infarction.</title>
<link>https://greenmedinfo.com/article/cardioprotective-effect-hydrogen-rich-saline-isoproterenol-induced-myocardial-</link>
<description>
PMID:
Heart Lung Circ. 2015 Jun ;24(6):602-10. Epub 2014 Dec 4. PMID: 25533677
Abstract Title:
Cardioprotective Effect of Hydrogen-rich Saline on Isoproterenol-induced Myocardial Infarction in Rats.
Abstract:
BACKGROUND: Infusion with hydrogen gas-saturated saline has recently been reported to exert antioxidant and anti-inflammatory activity that may protect against organ damage induced by oxidative stress. Therefore because oxidative stress plays a significant role in the pathophysiology of myocardial infarction (MI), the aim of our study was to investigate whether hydrogen-rich saline has cardioprotective effects against isoproterenol-induced MI in rats.METHODS: An acute MI model was induced in male Wistar rats by subcutaneous injection of isoproterenol. Different doses of hydrogen-rich saline (5, 7.5, and 10 mL/kg body weight i.p.) or Vitamin C (250 mg/kg body weight i.g.) were administered to the rats. Oxidative stress indices including levels of myocardial marker enzymes, inflammatory cytokines, membrane-bound myocardial enzymes and histopathological changes were measured.RESULTS: Compared with those in isoproterenol-MI group, hydrogen-rich saline decreased malondialdehyde and 8-hydroxy-desoxyguanosine concentrations, enhanced superoxide dismutase and Na(+)-K(+)-ATPase activity, lowered Ca(2+)-ATPase activity and decreased interleukin-6 and tumour necrosis factor-αlevels in the serum and/or cardiac tissue of rats. Hydrogen-rich saline pretreatment also diminished infarct size, improved left heart function, and ameliorated pathological changes of the left heart.CONCLUSION: From these results, hydrogen-rich saline exerts cardiovascular protective effects against isoproterenol-induced MI at least in part via interactions which evoke antioxidant and anti-inflammatory activities.
<p><a href="https://greenmedinfo.com/article/cardioprotective-effect-hydrogen-rich-saline-isoproterenol-induced-myocardial-" target="_blank">read more</a></p></description>
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<category domain="https://greenmedinfo.com/category/substance/Hydrogen%20Water">Hydrogen Water</category>
<category domain="https://greenmedinfo.com/category/disease/myocardial-infarction">Myocardial Infarction</category>
<category domain="https://greenmedinfo.com/category/disease/oxidative-stress">Oxidative Stress</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/anti-inflammatory-agents">Anti-Inflammatory Agents</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/interleukin-6-downregulation">Interleukin-6 Downregulation</category>
<category domain="https://greenmedinfo.com/category/toxic-ingredients/Isoproterenol">Isoproterenol</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/tumor-necrosis-factor-tnf-alpha-inhibitor">Tumor Necrosis Factor (TNF) Alpha Inhibitor</category>
<category domain="https://greenmedinfo.com/category/study-types/animal-study">Animal Study</category>
<pubDate>Fri, 29 Mar 2024 06:58:15 +0000</pubDate>
<dc:creator>greenmedinfo</dc:creator>
<guid isPermaLink="false">293148 at https://greenmedinfo.com</guid>
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<item>
<title>Molecular hydrogen stabilizes atherosclerotic plaque in low-density lipoprotein receptor-knockout mice.</title>
<link>https://greenmedinfo.com/article/molecular-hydrogen-stabilizes-atherosclerotic-plaque-low-density-lipoprotein-r</link>
<description>
PMID:
Free Radic Biol Med. 2015 Oct ;87:58-68. Epub 2015 Jun 25. PMID: 26117323
Abstract Title:
Molecular hydrogen stabilizes atherosclerotic plaque in low-density lipoprotein receptor-knockout mice.
Abstract:
Hydrogen (H(2)) attenuates the development of atherosclerosis in mouse models. We aimed to examine the effects of H(2) on atherosclerotic plaque stability. Low-density lipoprotein receptor-knockout (LDLR(-/-)) mice fed an atherogenic diet were dosed daily with H(2) and/or simvastatin. In vitro studies were carried out in an oxidized-LDL (ox-LDL)-stimulated macrophage-derived foam cell model treated with or without H(2). H(2) or simvastatin significantly enhanced plaque stability by increasing levels of collagen, as well as reducing macrophage and lipid levels in plaques. The decreased numbers of dendritic cells and increased numbers of regulatory T cells in plaques further supported the stabilizing effect of H(2) or simvastatin. Moreover, H(2) treatment decreased serum ox-LDL level and apoptosis in plaques with concomitant inhibition of endoplasmic reticulum stress (ERS) and reduction of reactive oxygen species (ROS) accumulation in the aorta. In vitro, like the ERS inhibitor 4-phenylbutyric acid, H(2) inhibited ox-LDL- or tunicamycin (an ERS inducer)-induced ERS response and cell apoptosis. In addition, like the ROS scavenger N-acetylcysteine, H(2) inhibited ox-LDL- or Cu(2+) (an ROS inducer)-induced reduction in cell viability and increase in cellular ROS. Also, H(2) increased Nrf2 (NF-E2-related factor-2, an important factor in antioxidant signaling) activation and Nrf2 small interfering RNA abolished the protective effect of H(2) on ox-LDL-induced cellular ROS production. The inhibitory effects of H(2) on the apoptosis of macrophage-derived foam cells, which take effect by suppressing the activation of the ERS pathway and by activating the Nrf2 antioxidant pathway, might lead to an improvement in atherosclerotic plaque stability.
<p><a href="https://greenmedinfo.com/article/molecular-hydrogen-stabilizes-atherosclerotic-plaque-low-density-lipoprotein-r" target="_blank">read more</a></p></description>
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<category domain="https://greenmedinfo.com/category/disease/atherosclerosis">Atherosclerosis</category>
<category domain="https://greenmedinfo.com/category/substance/Hydrogen%3A%20Molecular">Hydrogen: Molecular</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/anti-apoptotic">Anti-Apoptotic</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/antioxidants">Antioxidants</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/nrf2-activation">Nrf2 activation</category>
<category domain="https://greenmedinfo.com/category/study-types/animal-study">Animal Study</category>
<pubDate>Fri, 29 Mar 2024 06:17:51 +0000</pubDate>
<dc:creator>greenmedinfo</dc:creator>
<guid isPermaLink="false">293146 at https://greenmedinfo.com</guid>
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<item>
<title>Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice.</title>
<link>https://greenmedinfo.com/article/treatment-hydrogen-molecule-attenuates-cardiac-dysfunction-streptozotocin-indu</link>
<description>
PMID:
Cardiovasc Pathol. 2015 ;24(5):294-303. Epub 2015 Apr 28. PMID: 25979689
Abstract Title:
Treatment with hydrogen molecule attenuates cardiac dysfunction in streptozotocin-induced diabetic mice.
Abstract:
INTRODUCTION: Diabetic cardiomyopathy, a disorder of the heart muscle in diabetic patients, is one of the major causes of heart failure. The aim of present study was to investigate the therapeutic effect of hydrogen molecule on streptozotocin-induced diabetic cardiomyopathy in mice.METHODS: Diabetes was induced in adult male mice by consecutive peritoneal injection of streptozotocin (50 mg/kg/day) for 5 days. Then, they were treated with hydrogen water (1.3±0.2 mg/l) for 8 weeks (four groups, n=83-88 in each group).RESULTS: Although treatment of diabetic mice with hydrogen water did not significantly affect blood glucose level, it significantly attenuated cardiac hypertrophy and reduced expression of atrial natriuretic factor andβ-myosin heavy chain; it alleviated cardiac fibrosis and reduced expression of collagen I and III, transforming growth factor beta, alpha-smooth muscle actin, and osteopontin; it reduced cardiac caspase-3 activity and ratio of bax/bcl-2. Importantly, hydrogen water treatment improved cardiac function in streptozotocin-diabetic mice. Furthermore, it was found that hydrogen water treatment abated oxidative stress, suppressed inflammation, and attenuated endoplasmic reticulum stress in the hearts of streptozotocin-diabetic mice. In addition, hydrogen water treatment suppressed activation of Jun NH2-terminal kinase and p38 mitogen activated protein kinase signaling and nuclear factorκB signaling in the hearts of streptozotocin-diabetic mice.CONCLUSION: Treatment with hydrogen molecule attenuated cardiac dysfunction in streptozotocin-induced diabetic mice, which was independent of glycemic control.SUMMARY: Treatment with hydrogen molecule attenuated cardiac dysfunction in streptozotocin-induced type 1 diabetic mice. Molecular hydrogen could thus be envisaged as a nutritional countermeasure for diabetic cardiomyopathy.
<p><a href="https://greenmedinfo.com/article/treatment-hydrogen-molecule-attenuates-cardiac-dysfunction-streptozotocin-indu" target="_blank">read more</a></p></description>
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<category domain="https://greenmedinfo.com/category/disease/cardiomyopathy">Cardiomyopathy</category>
<category domain="https://greenmedinfo.com/category/disease/diabetic-complications">Diabetic Complications</category>
<category domain="https://greenmedinfo.com/category/substance/Hydrogen%3A%20Molecular">Hydrogen: Molecular</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/antioxidants">Antioxidants</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/cardioprotective">Cardioprotective</category>
<category domain="https://greenmedinfo.com/category/study-types/animal-study">Animal Study</category>
<pubDate>Fri, 29 Mar 2024 05:55:55 +0000</pubDate>
<dc:creator>greenmedinfo</dc:creator>
<guid isPermaLink="false">293144 at https://greenmedinfo.com</guid>
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<item>
<title>Protective effects of hydrogen-rich medium on lipopolysaccharide-induced monocytic adhesion and vascular endothelial permeability.</title>
<link>https://greenmedinfo.com/article/protective-effects-hydrogen-rich-medium-lipopolysaccharide-induced-monocytic-a</link>
<description>
PMID:
Genet Mol Res. 2015 Jun 11 ;14(2):6202-12. Epub 2015 Jun 11. PMID: 26125821
Abstract Title:
Protective effects of hydrogen-rich medium on lipopolysaccharide-induced monocytic adhesion and vascular endothelial permeability through regulation of vascular endothelial cadherin.
Abstract:
We observed the effect of hydrogen-rich medium on lipopolysaccharide (LPS)-induced human umbilical vein endothelial cells (HUVECs), hyaline leukocyte conglutination, and permeability of the endothelium. Endotheliocytes were inoculated on 6-well plates and randomly divided into 4 groups: control, H2, LPS, LPS+H2, H2, and LPS+H2 in saturated hydrogen-rich medium. We applied Wright&#039;s stain-ing to observe conglutination of hyaline leukocytes and HUVECs, flow cytometry to determine the content of vascular cell adhesion protein 1 (VCAM-1) and intercellular adhesion molecule 1 (ICAM-1), enzyme-linked immunosorbent assay to measure the E-selectin concentration in the cell liquor, the transendothelial electrical resistance (TEER) to test the permeability of endothelial cells, and Western blot and immunofluorescence to test the expression and distribution of vascular endothelial (VE)-cadherin. Compared with control cells, there was an increase in endothelium-hyaline leukocyte conglutination, a reduction in VCAM-1, ICAM-1, and E-selectin, and the TEER value increased obviously. Compared with LPS, there was an obvious reduction in the conglutination of LPS+H2 cells, a reduction in VCAM-1, ICAM-1, and E-selectin levels, and a reduction in the TEER-resistance value, while the expression of VE-cadherin increased. Fluorescence results showed that, compared with control cells, the VE-cadherin in LPS cells was in-complete at the cell joints. Compared with LPS cells, the VE-cadherin in LPS+H2 cells was even and complete at the cell joints. Liquid rich in hydrogen could reduce LPS-induced production of adhesion molecules and endothelium-hyaline leukocyte conglutination, and influence the expression and distribution of VE-cadherin to regulate the permeability of the endothelium.
<p><a href="https://greenmedinfo.com/article/protective-effects-hydrogen-rich-medium-lipopolysaccharide-induced-monocytic-a" target="_blank">read more</a></p></description>
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<category domain="https://greenmedinfo.com/category/substance/Hydrogen%3A%20Molecular">Hydrogen: Molecular</category>
<category domain="https://greenmedinfo.com/category/disease/lipopolysaccharide-induced-toxicity">Lipopolysaccharide-Induced Toxicity</category>
<category domain="https://greenmedinfo.com/category/study-types/animal-study">Animal Study</category>
<pubDate>Fri, 29 Mar 2024 05:37:00 +0000</pubDate>
<dc:creator>greenmedinfo</dc:creator>
<guid isPermaLink="false">293142 at https://greenmedinfo.com</guid>
</item>
<item>
<title>Pharmacological postconditioning with lactic acid and hydrogen rich saline alleviates myocardial reperfusion injury in rats.</title>
<link>https://greenmedinfo.com/article/pharmacological-postconditioning-lactic-acid-and-hydrogen-rich-saline-alleviat</link>
<description>
PMID:
Sci Rep. 2015 Apr 30 ;5:9858. Epub 2015 Apr 30. PMID: 25928542
Abstract Title:
Pharmacological postconditioning with lactic acid and hydrogen rich saline alleviates myocardial reperfusion injury in rats.
Abstract:
This study investigated whether pharmacological postconditioning with lactic acid and hydrogen rich saline can provide benefits similar to that of mechanical postconditioning. To our knowledge, this is the first therapeutic study to investigate the co-administration of lactic acid and hydrogen. SD rats were randomly divided into 6 groups: Sham, R/I, M-Post, Lac, Hyd, and Lac + Hyd. The left coronary artery was occluded for 45 min. Blood was withdrawn from the right atrium to measure pH. The rats were sacrificed at different time points to measure mitochondrial absorbance, infarct size, serum markers and apoptotic index. Rats in Lac + Hyd group had similar blood pH and ROS levels when compared to the M-Post group. Additionally, the infarct area was reduced to the same extent in Lac + Hyd and M-Post groups with a similar trends observed for serum markers of myocardial injury and apoptotic index. Although the level of P-ERK in Lac + Hyd group was lower, P-p38/JNK, TNFα, Caspase-8, mitochondrial absorbance and Cyt-c were all similar in Lac + Hyd and M-Post groups. The Lac and Hyd groups were able to partially mimic this protective role. These data suggested that pharmacological postconditioning with lactic acid and hydrogen rich saline nearly replicates the benefits of mechanical postconditioning.
<p><a href="https://greenmedinfo.com/article/pharmacological-postconditioning-lactic-acid-and-hydrogen-rich-saline-alleviat" target="_blank">read more</a></p></description>
<comments>https://greenmedinfo.com/article/pharmacological-postconditioning-lactic-acid-and-hydrogen-rich-saline-alleviat#comments</comments>
<category domain="https://greenmedinfo.com/category/disease/cardiovascular-diseases">Cardiovascular Diseases</category>
<category domain="https://greenmedinfo.com/category/substance/Hydrogen%20Water">Hydrogen Water</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/apoptotic">Apoptotic</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/tumor-necrosis-factor-tnf-alpha-inhibitor">Tumor Necrosis Factor (TNF) Alpha Inhibitor</category>
<category domain="https://greenmedinfo.com/category/study-types/animal-study">Animal Study</category>
<pubDate>Fri, 29 Mar 2024 03:56:18 +0000</pubDate>
<dc:creator>greenmedinfo</dc:creator>
<guid isPermaLink="false">293140 at https://greenmedinfo.com</guid>
</item>
<item>
<title>Hydrogen-rich saline attenuates cardiac and hepatic injury in a doxorubicin model.</title>
<link>https://greenmedinfo.com/article/hydrogen-rich-saline-attenuates-cardiac-and-hepatic-injury-doxorubicin-model</link>
<description>
PMID:
Mediators Inflamm. 2016 ;2016:1320365. Epub 2016 Dec 26. PMID: 28104928
Abstract Title:
Hydrogen-Rich Saline Attenuates Cardiac and Hepatic Injury in Doxorubicin Rat Model by Inhibiting Inflammation and Apoptosis.
Abstract:
Doxorubicin (DOX) remains the most effective anticancer agent which is widely used in several adult and pediatric cancers, but its application is limited for its cardiotoxicity and hepatotoxicity. Hydrogen, as a selective antioxidant, is a promising potential therapeutic option for many diseases. In this study, we found that intraperitoneal injection of hydrogen-rich saline (Hsaline) ameliorated the mortality, cardiac dysfunction, and histopathological changes caused by DOX in rats. Meanwhile, serum brain natriuretic peptide (BNP), aspartate transaminase (AST), alanine transaminase (ALT), albumin (ALB), tissue reactive oxygen species (ROS), and malondialdehyde (MDA) levels were also attenuated after Hsaline treatment. What is more, we further demonstrated that Hsaline treatment could inhibit cardiac and hepatic inflammation and apoptosis relative proteins expressions by western blotting test. In conclusion, our results revealed a protective effect of Hsaline on DOX-induced cardiotoxicity and hepatotoxicity in rats by inhibiting inflammation and apoptosis.
<p><a href="https://greenmedinfo.com/article/hydrogen-rich-saline-attenuates-cardiac-and-hepatic-injury-doxorubicin-model" target="_blank">read more</a></p></description>
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<category domain="https://greenmedinfo.com/category/disease/chemotherapy-induced-toxicity-doxorubicin">Chemotherapy-Induced Toxicity: Doxorubicin</category>
<category domain="https://greenmedinfo.com/category/substance/Hydrogen%20Water">Hydrogen Water</category>
<category domain="https://greenmedinfo.com/category/disease/inflammation">Inflammation</category>
<category domain="https://greenmedinfo.com/category/disease/oxidative-stress">Oxidative Stress</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/anti-apoptotic">Anti-Apoptotic</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/anti-inflammatory-agents">Anti-Inflammatory Agents</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/antioxidants">Antioxidants</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/malondialdehyde-down-regulation">Malondialdehyde Down-regulation</category>
<category domain="https://greenmedinfo.com/category/study-types/animal-study">Animal Study</category>
<category domain="https://greenmedinfo.com/category/study-types/vitro-study">In Vitro Study</category>
<pubDate>Fri, 29 Mar 2024 03:36:58 +0000</pubDate>
<dc:creator>greenmedinfo</dc:creator>
<guid isPermaLink="false">293138 at https://greenmedinfo.com</guid>
</item>
<item>
<title>Small amounts of inhaled hydrogen were superior to mild hypothermia in improving cardiac function and neurological outcome.</title>
<link>https://greenmedinfo.com/article/small-amounts-inhaled-hydrogen-were-superior-mild-hypothermia-improving-cardia</link>
<description>
PMID:
Shock. 2016 Sep ;46(3):312-8. PMID: 26849632
Abstract Title:
Hydrogen Inhalation is Superior to Mild Hypothermia in Improving Cardiac Function and Neurological Outcome in an Asphyxial Cardiac Arrest Model of Rats.
Abstract:
BACKGROUND: Non-shockable rhythms represent an increasing proportion of reported cases of out-of-hospital cardiac arrest but with an associated poor prognosis. In the present study, we investigated the effects of hydrogen inhalation on cardiac and neurological function after cardiopulmonary resuscitation and compared the therapeutic benefit with hypothermia in an asphyxial rat model of cardiac arrest.METHODS: Cardiopulmonary resuscitation was initiated after 5 min of untreated asphyxial cardiac arrest. Animals were randomly assigned to three experimental groups immediately after successful resuscitation: ventilation with 2% hydrogen/98% oxygen under normothermia (H2 inhalation), ventilation with 2% nitrogen/98% oxygen under normothermia (Control), and ventilation with 2% nitrogen/98% oxygen under hypothermia (TH). Mixed gas inhalation continued for 1 h while hypothermia continued for 2 h. Animals were observed up to 96 h for assessment of survival and neurologic recovery.RESULTS: No statistical differences in baseline measurements were observed among groups and all the animals were successfully resuscitated. Serum cardiac troponin T and S100B measured during earlier post-resuscitation period were markedly reduced in both H2 inhalation and hypothermic groups. However, significantly better left ventricular ejection fraction, cardiac work, and neurological deficit score were observed in the H2 inhalation group. Ninety-six hours survival rate was significantly higher in the H2 inhalation group (75.0%), either compared with TH (45.8%) or compared with Control (33.3%). But there was no statistical difference between TH and Control.CONCLUSIONS: Small amounts of inhaled hydrogen were superior to mild hypothermia in improving cardiac function and neurological outcome in this asphyxial rat model of cardiac arrest.
<p><a href="https://greenmedinfo.com/article/small-amounts-inhaled-hydrogen-were-superior-mild-hypothermia-improving-cardia" target="_blank">read more</a></p></description>
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<category domain="https://greenmedinfo.com/category/disease/cardiac-arrest">Cardiac Arrest</category>
<category domain="https://greenmedinfo.com/category/substance/Hydrogen%3A%20Molecular">Hydrogen: Molecular</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/cardioprotective">Cardioprotective</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/neuroprotective-agents">Neuroprotective Agents</category>
<category domain="https://greenmedinfo.com/category/study-types/animal-study">Animal Study</category>
<pubDate>Fri, 29 Mar 2024 02:06:24 +0000</pubDate>
<dc:creator>greenmedinfo</dc:creator>
<guid isPermaLink="false">293137 at https://greenmedinfo.com</guid>
</item>
<item>
<title>Hydrogen (H2) iInhibits isoproterenol-induced cardiac hypertrophy via antioxidative pathways.</title>
<link>https://greenmedinfo.com/article/hydrogen-h2-iinhibits-isoproterenol-induced-cardiac-hypertrophy-antioxidative-</link>
<description>
PMID:
Front Pharmacol. 2016 ;7:392. Epub 2016 Oct 27. PMID: 27833552
Abstract Title:
Hydrogen (H) Inhibits Isoproterenol-Induced Cardiac Hypertrophy via Antioxidative Pathways.
Abstract:
Hydrogen (H) has been shown to have a strong antioxidant effect on preventing oxidative stress-related diseases. The goal of the present study is to determine the pharmacodynamics of Hin a model of isoproterenol (ISO)-induced cardiac hypertrophy.Mice (C57BL/6J; 8-10 weeks of age) were randomly assigned to four groups: Control group (= 10), ISO group (= 12), ISO plus Hgroup (= 12), and Hgroup (= 12). Mice received H(1 ml/100g/day, intraperitoneal injection) for 7 days before ISO (0.5 mg/100g/day, subcutaneous injection) infusion, and then received ISO with or without Hfor another 7 days. Then, cardiac function was evaluated by echocardiography. Cardiac hypertrophy was reflected by heart weight/body weight, gross morphology of hearts, and heart sections stained with hematoxylin and eosin, and relative atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) mRNA levels. Cardiac reactive oxygen species (ROS), 3-nitrotyrosine and p67 (phox) levels were analyzed by dihydroethidium staining, immunohistochemistry and Western blotting, respectively. Forstudy, H9c2 cardiomyocytes were pretreated with H-rich medium for 30 min, and then treated with ISO (10μM) for the indicated time. The medium and ISO were re-changed every 24 h. Cardiomyocyte surface areas, relative ANP and BNP mRNA levels, the expression of 3-nitrotyrosine, and the dissipation of mitochondrial membrane potential (MMP) were examined. Moreover, the expression of extracellular signal-regulated kinase1/2 (ERK1/2), p-ERK1/2, p38, p-p38, c-Jun NH2-terminal kinase (JNK), and p-JNK were measured by Western blotting bothand.Intraperitoneal injection of Hprevented cardiac hypertrophy and improved cardiac function in ISO-infused mice. H-rich medium blocked ISO-mediated cardiomyocytes hypertrophyHblocked the excessive expression of NADPH oxidase and the accumulation of ROS, attenuated the decrease of MMP, and inhibited ROS-sensitive ERK1/2, p38, and JNK signaling pathways.Hinhibits ISO-induced cardiac/cardiomyocytes hypertrophy bothand, and improves the impaired left ventricular function. Hexerts its protective effects partially through blocking ROS-sensitive ERK1/2, p38, and JNK signaling pathways.
<p><a href="https://greenmedinfo.com/article/hydrogen-h2-iinhibits-isoproterenol-induced-cardiac-hypertrophy-antioxidative-" target="_blank">read more</a></p></description>
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<category domain="https://greenmedinfo.com/category/disease/cardiac-hypertrophy">Cardiac Hypertrophy</category>
<category domain="https://greenmedinfo.com/category/substance/Hydrogen%3A%20Molecular">Hydrogen: Molecular</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/cardioprotective">Cardioprotective</category>
<category domain="https://greenmedinfo.com/category/toxic-ingredients/Isoproterenol">Isoproterenol</category>
<category domain="https://greenmedinfo.com/category/study-types/animal-study">Animal Study</category>
<category domain="https://greenmedinfo.com/category/study-types/vitro-study">In Vitro Study</category>
<pubDate>Fri, 29 Mar 2024 01:41:56 +0000</pubDate>
<dc:creator>greenmedinfo</dc:creator>
<guid isPermaLink="false">293136 at https://greenmedinfo.com</guid>
</item>
<item>
<title>High-concentration hydrogen protects mouse heart against ischemia/reperfusion injury.</title>
<link>https://greenmedinfo.com/article/high-concentration-hydrogen-protects-mouse-heart-against-ischemiareperfusion-i</link>
<description>
PMID:
Sci Rep. 2017 Nov 1 ;7(1):14871. Epub 2017 Nov 1. PMID: 29093541
Abstract Title:
High-concentration hydrogen protects mouse heart against ischemia/reperfusion injury through activation of thePI3K/Akt1 pathway.
Abstract:
The study investigated the role of Akt1 through the cardioprotection of high-concentration hydrogen (HCH). C57BL/6 mice were randomly divided into the following groups: sham, I/R, I/R + HCH, I/R + HCH + LY294002 (PI3K inhibitor), I/R + HCH + wortmannin (PI3K inhibitor), I/R + LY294002, and I/R + wortmannin. After 45 min of ischemia, HCH (67% Hand 33% O) was administered to mice during a 90-min reperfusion. To investigate the role of Akt1 in the protective effects of HCH, mice were divided into the following groups: I/R + A-674563 (Akt1 selective inhibitor), I/R + HCH + A-674563, I/R + CCT128930 (Akt2 selective inhibitor), and I/R + HCH + CCT128930. After a 4-h reperfusion, serum biochemistry, histological, western blotting, and immunohistochemical analyses were performed to evaluate the role of the PI3K-Akt1 pathway in the protection of HCH. In vitro, 75% hydrogen was administered to cardiomyocytes during 4 h of reoxygenation after 3-h hypoxia. Several analyses were performed to evaluate the role of the Akt1 in the protective effects of hydrogen. HCH resulted in the phosphorylation of Akt1 but not Akt2, and Akt1 inhibition markedly abolished HCH-induced cardioprotection. Our findings reveal that HCH may exert cardioprotective effects through a PI3K-Akt1-dependent mechanism.
<p><a href="https://greenmedinfo.com/article/high-concentration-hydrogen-protects-mouse-heart-against-ischemiareperfusion-i" target="_blank">read more</a></p></description>
<comments>https://greenmedinfo.com/article/high-concentration-hydrogen-protects-mouse-heart-against-ischemiareperfusion-i#comments</comments>
<category domain="https://greenmedinfo.com/category/substance/Hydrogen%3A%20Molecular">Hydrogen: Molecular</category>
<category domain="https://greenmedinfo.com/category/disease/myocardial-ischemia">Myocardial Ischemia</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/cardioprotective">Cardioprotective</category>
<category domain="https://greenmedinfo.com/category/study-types/animal-study">Animal Study</category>
<pubDate>Fri, 29 Mar 2024 01:07:02 +0000</pubDate>
<dc:creator>greenmedinfo</dc:creator>
<guid isPermaLink="false">293134 at https://greenmedinfo.com</guid>
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<item>
<title>Hydrogen-rich saline attenuates hippocampus endoplasmic reticulum stress after cardiac arrest.</title>
<link>https://greenmedinfo.com/article/hydrogen-rich-saline-attenuates-hippocampus-endoplasmic-reticulum-stress-after</link>
<description>
PMID:
Neurosci Lett. 2017 Feb 15 ;640:29-36. Epub 2017 Jan 10. PMID: 28087437
Abstract Title:
Hydrogen-rich saline attenuates hippocampus endoplasmic reticulum stress after cardiac arrest in rats.
Abstract:
BACKGROUND: Hydrogen-rich saline can selectively scavenge reactive oxygen species (ROS) and protect brain against ischemia reperfusion (I/R) injury. Endoplasmic reticulum stress (ERS) has been implicated in the pathological process of cerebral ischemia. However, very little is known about the role of hydrogen-rich saline in mediating pathophysiological reactions to ERS after I/R injury caused by cardiac arrest.METHODS: The rats were randomly divided into three groups, sham group (n=30), ischemia/reperfusion group (n=40) and hydrogen-rich saline group (n=40). The rats in experimental groups were subjected to 4min of cardiac arrest and followed by resuscitation. Then they were randomized to receive 5ml/kg of either hydrogen-rich saline or normal saline.RESULTS: Hydrogen-rich saline significantly improves survival rate and neurological function. The beneficial effects of hydrogen-rich saline were associated with decreased levels of oxidative products, as well as the increased levels of antioxidant enzymes. Furthermore, the protective effects of hydrogen-rich saline were accompanied by the increased activity of glucose-regulated protein 78 (GRP78), the decreased activity of cysteinyl aspartate specific proteinase-12 (caspase-12) and C/EBP homologous protein (CHOP).CONCLUSIONS: Hydrogen-rich saline attenuates brain I/R injury may through inhibiting hippocampus ERS after cardiac arrest in rats.
<p><a href="https://greenmedinfo.com/article/hydrogen-rich-saline-attenuates-hippocampus-endoplasmic-reticulum-stress-after" target="_blank">read more</a></p></description>
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<category domain="https://greenmedinfo.com/category/disease/cerebral-ischemia">Cerebral Ischemia</category>
<category domain="https://greenmedinfo.com/category/substance/Hydrogen%3A%20Molecular">Hydrogen: Molecular</category>
<category domain="https://greenmedinfo.com/category/disease/oxidative-stress">Oxidative Stress</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/antioxidants">Antioxidants</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/neuroprotective-agents">Neuroprotective Agents</category>
<category domain="https://greenmedinfo.com/category/study-types/animal-study">Animal Study</category>
<pubDate>Fri, 29 Mar 2024 00:17:25 +0000</pubDate>
<dc:creator>greenmedinfo</dc:creator>
<guid isPermaLink="false">293133 at https://greenmedinfo.com</guid>
</item>
<item>
<title>Hydrogen gas attenuates myocardial ischemia reperfusion injury.</title>
<link>https://greenmedinfo.com/article/hydrogen-gas-attenuates-myocardial-ischemia-reperfusion-injury</link>
<description>
PMID:
Cell Physiol Biochem. 2017 ;43(4):1503-1514. Epub 2017 Oct 16. PMID: 29035876
Abstract Title:
Hydrogen Gas Attenuates Myocardial Ischemia Reperfusion Injury Independent of Postconditioning in Rats by Attenuating Endoplasmic Reticulum Stress-Induced Autophagy.
Abstract:
BACKGROUND/AIMS: To study the effect of inhaling hydrogen gas on myocardial ischemic/reperfusion(I/R) injury in rats.METHODS: Seventy male Wistar albino rats were divided into five groups at random as the sham group (Sham). The I/R group (I/R), The ischemic postconditioning group (IPo), The I/R plus hydrogen group (IH2) and the ischemic postconditioning plus hydrogen group (IPoH2). The Sham group was without coronary occlusion. In I/R group, Ischemic/reperfusion injury was induced by coronary occlusion for 1 hour. Followed by 2 hours of reperfusion. In the IPo and IPoH2 group, four cycles of 1 min reperfusion/1 min ischemia was given at the end of 1 hour coronary occlusion. While 2% hydrogen was administered by inhalation 5 min before reperfusion till 2 hours after reperfusion in both the IPoH2 and IH2 group. The heart and blood samples were harvested at the end of the surgical protocol. Then the myocardium cell endoplasmic reticulum(ER) stress and autophagy was observed by electron microscope. In addition, the cardiac ER stress and autophagy related proteins expression were detected by Western blotting analysis.RESULTS: Both inhaling 2% hydrogen and ischemic postconditioning treatment reduced the ischemic size and serum troponin I level in rats with I/R injury, and inhaling hydrogen showed a more curative effect compared with ischemic postconditioning treatment. Meanwhile inhaling hydrogen showed a better protective effect in attenuating tissue reactive oxygen species. Malondialdehyde levels and immunoreactivities against 8-hydroxy-2&#039;-deoxyguanosine and inhibiting cardiac endoplasmic reticulum stress and down-regulating autophagy as compared with ischemic postconditioning treatment.CONCLUSION: These results revealed a better protective effect of hydrogen on myocardial ischemic/reperfusion injury in rats by attenuating endoplasmic reticulum stress and down-regulating autophagy compared with ischemic postconditioning treatment.
<p><a href="https://greenmedinfo.com/article/hydrogen-gas-attenuates-myocardial-ischemia-reperfusion-injury" target="_blank">read more</a></p></description>
<comments>https://greenmedinfo.com/article/hydrogen-gas-attenuates-myocardial-ischemia-reperfusion-injury#comments</comments>
<category domain="https://greenmedinfo.com/category/substance/Hydrogen%3A%20Molecular">Hydrogen: Molecular</category>
<category domain="https://greenmedinfo.com/category/disease/myocardial-ischemia">Myocardial Ischemia</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/cardioprotective">Cardioprotective</category>
<category domain="https://greenmedinfo.com/category/study-types/animal-study">Animal Study</category>
<pubDate>Thu, 28 Mar 2024 23:18:24 +0000</pubDate>
<dc:creator>greenmedinfo</dc:creator>
<guid isPermaLink="false">293132 at https://greenmedinfo.com</guid>
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<item>
<title>The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After percutaneous coronary intervention for ST-elevated myocardial infarction</title>
<link>https://greenmedinfo.com/article/effects-hydrogen-gas-inhalation-adverse-left-ventricular-remodeling-after-perc</link>
<description>
PMID:
Circ J. 2017 Jun 23 ;81(7):940-947. Epub 2017 Mar 17. PMID: 28321000
Abstract Title:
The Effects of Hydrogen Gas Inhalation on Adverse Left Ventricular Remodeling After Percutaneous Coronary Intervention for ST-Elevated Myocardial Infarction - First Pilot Study in Humans.
Abstract:
BACKGROUND: Hydrogen gas inhalation (HI) reduced infarct size and mitigated adverse left ventricular (LV) remodeling in a rat model of acute myocardial infarction (AMI). We designed a prospective, open-label, rater-blinded clinical pilot study in patients experiencing ST-elevated MI (STEMI).Methods and Results:The 20 patients with an initial diagnosis of STEMI were assigned to either an HI group (1.3% Hwith 26% oxygen) or a control group (26% oxygen). There were no HI-related severe adverse events. In the full analysis set, the cardiac salvage index as evaluated using cardiac magnetic resonance imaging at 7 days after primary percutaneous coronary intervention (PCI), showed no significant between-group difference (HI: 50.0±24.3%; control: 60.1±20.1%; P=0.43). However, the improvement from day 7 in the HI group was numerically greater than that in the control group in some of the surrogate outcomes at 6-month follow-up, including the LV stroke volume index (HI: 9.2±7.1 mL/m; control: -1.4±7.2 mL/m; P=0.03) and the LV ejection fraction (HI: 11.0%±9.3%; control: 1.7%±8.3%; P=0.11).CONCLUSIONS: The first clinical study has shown that HI during PCI is feasible and safe and may also promote LV reverse remodeling at 6 months after STEMI. The study was not powered to test efficacy and a further large-scale trial is warranted. (Clinical trials registration: UMIN00006825).
<p><a href="https://greenmedinfo.com/article/effects-hydrogen-gas-inhalation-adverse-left-ventricular-remodeling-after-perc" target="_blank">read more</a></p></description>
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<category domain="https://greenmedinfo.com/category/substance/Hydrogen%3A%20Molecular">Hydrogen: Molecular</category>
<category domain="https://greenmedinfo.com/category/disease/myocardial-infarction">Myocardial Infarction</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/cardioprotective">Cardioprotective</category>
<category domain="https://greenmedinfo.com/category/study-types/human-study">Human Study</category>
<pubDate>Thu, 28 Mar 2024 23:10:25 +0000</pubDate>
<dc:creator>greenmedinfo</dc:creator>
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<title>The Science Behind Beta Glucan: A Game-Changer in Natural Healing</title>
<link>https://greenmedinfo.com/slide/science-behind-beta-glucan-game-changer-natural-healing</link>
<description>Unlock the secret to optimal health with beta glucan, the natural powerhouse that's taking the wellness world by storm. </description>
<pubDate>Thu, 28 Mar 2024 21:15:49 +0000</pubDate>
<dc:creator>GMI Research Group</dc:creator>
<guid isPermaLink="false">293128 at https://greenmedinfo.com</guid>
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<title>The Science Behind Beta Glucan: A Game-Changer in Natural Healing</title>
<link>https://greenmedinfo.com/content/science-behind-beta-glucan-game-changer-natural-healing</link>
<description><div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2024<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/The_Science_Behind_Beta_Glucan-A_Game_Changer_in_Natural_Healing-GreenMedInfo.jpg" style="width: 600px; height: 315px;" /></p>
<p><span style="font-size:18px;"><em><strong><span style="letter-spacing: 0px;">Unlock the secret to optimal health with beta glucan, the natural powerhouse that's taking the wellness world by storm. From heart health to immune support, this extraordinary dietary fiber is revolutionizing the way we approach well-being</span></strong></em></span></p><p><a href="https://greenmedinfo.com/content/science-behind-beta-glucan-game-changer-natural-healing" target="_blank">read more</a></p></description>
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<pubDate>Thu, 28 Mar 2024 21:12:39 +0000</pubDate>
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<title>Ancient African Herb Bests Antibiotics (Amoxicillin) for Sinus Infections in Clinical Trial</title>
<link>https://greenmedinfo.com/slide/ancient-african-herb-bests-antibiotics-amoxicillin-sinus-infections-clinical-tri</link>
<description><p>Modern research proves an ancient African herbal remedy works better than antibiotics for acute sinusitis</p>
</description>
<pubDate>Thu, 28 Mar 2024 18:11:12 +0000</pubDate>
<dc:creator>GMI Research Group</dc:creator>
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<title>Sesame Waste Product Beats Alzheimer's Drugs in Clinical Trial</title>
<link>https://greenmedinfo.com/content/sesame-waste-product-beats-alzheimers-drugs-clinical-trial</link>
<description><div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2024<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/Sesame_Waste_Product_Beats_Alzheimers_Drugs_in_Clinical_Trial-GreenMedInfo.jpg" style="width: 600px; height: 315px;" /></p>
<p><span style="font-size:18px;"><em><strong><span style="letter-spacing: 0px;">For over 20 years and billions of dollars, pharmaceutical companies have fruitlessly tried to develop an Alzheimer's drug. Meanwhile, a solution was lying in waste piles all along</span></strong></em></span></p>
<p><span style="letter-spacing: 0px;"><strong><a href="/disease/alzheimers-disease" rel="dofollow" target="_blank">Alzheimer's disease</a></strong> continues to confound doctors and researchers alike, with no truly effective treatments discovered yet. However, a new study shows promise for a shockingly simple approach - an extract from <strong><a href="/substance/sesame-seed-oil" rel="dofollow" target="_blank">sesame oil</a></strong> manufacturing waste.</span></p><p><a href="https://greenmedinfo.com/content/sesame-waste-product-beats-alzheimers-drugs-clinical-trial" target="_blank">read more</a></p></description>
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<category domain="https://greenmedinfo.com/category/disease/alzheimers-disease">Alzheimer's Disease</category>
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<pubDate>Thu, 28 Mar 2024 11:00:00 +0000</pubDate>
<dc:creator>GMI Research Group</dc:creator>
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<title>Nanoplastics in Our Bloodstream: A Silent Contributor to Heart Disease</title>
<link>https://greenmedinfo.com/content/nanoplastics-our-bloodstream-silent-contributor-heart-disease</link>
<description><div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2024<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/Nanoplastics_in_Our_Blood-A_Silent_Contributor_to_Heart_Disease-GreenMedInfo.jpg" style="width: 600px; height: 315px;" /></p>
<p><span style="font-size:18px;"><strong><em>They're smaller than a grain of sand, but they might be causing a storm in your arteries. Dive into the world of nanoplastics, the invisible threat that might be contributing to heart disease</em></strong></span></p><p><a href="https://greenmedinfo.com/content/nanoplastics-our-bloodstream-silent-contributor-heart-disease" target="_blank">read more</a></p></description>
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<pubDate>Thu, 28 Mar 2024 11:00:00 +0000</pubDate>
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<title>Men: Looking to Conceive? Eating Nuts Are Good For Your Nuts (Sperm and Fertility)</title>
<link>https://greenmedinfo.com/content/men-looking-conceive-eating-nuts-are-good-your-nuts-sperm-and-fertility</link>
<description><div class="copyright">This article is copyrighted by GreenMedInfo LLC, 2024<br/><strong><a href="/greenmedinfocom-re-post-guidelines">Visit our Re-post guidelines</a></strong></div><p class="rtecenter"><img alt="" src="//cdn.greenmedinfo.com/sites/default/files/ckeditor/blank.justin/images/Men-Looking_to_Conceive-Eating_Nuts_Are_Good_For_Your_Nuts-Sperm_and_Fetility-GreenMedInfo.jpg" /></p>
<p><em style="font-size: 18px; letter-spacing: 0px;"><strong>With sperm quality and fertility rates on the decline globally, researchers are looking at simple diet interventions that could help reverse this worrying trend</strong></em></p><p><a href="https://greenmedinfo.com/content/men-looking-conceive-eating-nuts-are-good-your-nuts-sperm-and-fertility" target="_blank">read more</a></p></description>
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<category domain="https://greenmedinfo.com/category/substance/almond">Almond</category>
<category domain="https://greenmedinfo.com/category/substance/hazelnut">Hazelnut </category>
<category domain="https://greenmedinfo.com/category/disease/infertility">Infertility</category>
<category domain="https://greenmedinfo.com/category/substance/Nuts%3A%20All">Nuts: All</category>
<category domain="https://greenmedinfo.com/category/substance/omega-3-fatty-acids">Omega-3 Fatty Acids</category>
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<category domain="https://greenmedinfo.com/category/substance/walnut">Walnut</category>
<category domain="https://greenmedinfo.com/category/keywords/healing%20foods">healing foods</category>
<category domain="https://greenmedinfo.com/category/keywords/male-fertility">male fertility</category>
<category domain="https://greenmedinfo.com/category/keywords/nuts">nuts</category>
<pubDate>Thu, 28 Mar 2024 11:00:00 +0000</pubDate>
<dc:creator>GMI Research Group</dc:creator>
<guid isPermaLink="false">293080 at https://greenmedinfo.com</guid>
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<item>
<title>Hydrogen-containing saline alleviates pressure overload-induced interstitial fibrosis and cardiac dysfunction.</title>
<link>https://greenmedinfo.com/article/hydrogen-containing-saline-alleviates-pressure-overload-induced-interstitial-f</link>
<description>
PMID:
Mol Med Rep. 2017 Aug ;16(2):1771-1778. Epub 2017 Jun 23. PMID: 28656216
Abstract Title:
Hydrogen-containing saline alleviates pressure overload-induced interstitial fibrosis and cardiac dysfunction in rats.
Abstract:
Cardiac fibrosis induced by sustained pressure overload contributes to heart failure. Oxidative stress serves an important role in cardiac remodeling and heart failure independent of etiological factors. The application of hydrogen as an antioxidant is a novel concept in disease treatment, however no studies as present have investigated the effects of hydrogen on cardiac fibrosis. In the present study, the effects of hydrogen on pressure overload‑induced cardiac fibrosis and heart failure were investigated in abdominal aortic‑constricted rats. Masson&#039;s trichrome staining and echocardiography were used to evaluate the fibrotic area and cardiac function, respectively. Reactive oxygen species (ROS) content was detected by immunofluorescence. Malondialdehyde (MDA) concentration, the activity of superoxide dismutase (SOD) and hydroxyproline content were measured by spectrophotometry. Western blot analysis was used to detect the protein levels of transforming growth factor (TGF)‑β1, connective tissue growth factor (CTGF), NADPH oxidases (NOX)2, NOX4, p38 mitogen‑activated protein kinase (MAPK) and Smad2/3. Reverse transcription‑quantitative polymerase chain reaction was performed to detect the mRNA expression of collagen I (Col I) and fibronectin 1 (FN1). Hydrogen-containing saline (HCS) treatment was observed to improve interstitial fibrosis and cardiac function and to decrease the level of ROS, the oxidative‑stress marker MDA and expression of NOXs, while increasing the activity of the anti‑oxidant enzyme SOD. HCS treatment also decreased the phosphorylation of p38 MAPK and Smad2/3, and the expression of TGF‑β1 and CTGF, which were accompanied by reduced hydroxyproline content, Col I and FN1 mRNA levels. These results indicate that HCS treatment can improve cardiac function by reducing interstitial fibrosis in pressure‑overloaded rats through its anti‑oxidative properties and via suppression of TGF-β1 signaling.
<p><a href="https://greenmedinfo.com/article/hydrogen-containing-saline-alleviates-pressure-overload-induced-interstitial-f" target="_blank">read more</a></p></description>
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<category domain="https://greenmedinfo.com/category/disease/heart-failure">Heart Failure</category>
<category domain="https://greenmedinfo.com/category/substance/Hydrogen%20Water">Hydrogen Water</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/cardioprotective">Cardioprotective</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/malondialdehyde-down-regulation">Malondialdehyde Down-regulation</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/superoxide-dismutase-regulation">Superoxide Dismutase Up-regulation</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/transforming-growth-factor-beta-tgf-%CE%B2-inhibitor">Transforming growth factor beta (TGF-β) inhibitor</category>
<category domain="https://greenmedinfo.com/category/study-types/animal-study">Animal Study</category>
<pubDate>Thu, 28 Mar 2024 08:30:02 +0000</pubDate>
<dc:creator>greenmedinfo</dc:creator>
<guid isPermaLink="false">293116 at https://greenmedinfo.com</guid>
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<title>Molecular hydrogen potentiates beneficial anti-infarct effect of hypoxic postconditioning in isolated rat hearts.</title>
<link>https://greenmedinfo.com/article/molecular-hydrogen-potentiates-beneficial-anti-infarct-effect-hypoxic-postcond</link>
<description>
PMID:
Can J Physiol Pharmacol. 2017 Aug ;95(8):888-893. Epub 2017 Mar 28. PMID: 28350967
Abstract Title:
Molecular hydrogen potentiates beneficial anti-infarct effect of hypoxic postconditioning in isolated rat hearts: a novel cardioprotective intervention.
Abstract:
Generation of free radicals through incomplete reduction of oxygen during ischemia-reperfusion (I/R) is well described. On the other hand, molecular hydrogen (H) reduces oxidative stress due to its ability to react with strong oxidants and easily penetrate cells by diffusion, without disturbing metabolic redox reactions. This study was designed to explore cardioprotective potential of hypoxic postconditioning (HpostC) against I/R (30 min global I - 120 min R) in isolated rat hearts using oxygen-free Krebs-Henseleit buffer (KHB). Furthermore, the possibility to potentiate the effect of HpostC by Husing oxygen-free KHB saturated with H(H+ HpostC) was tested. HPostC was induced by 4 cycles of 1-minute perfusion with oxygen-free KHB intercepted by 1-minute perfusion with normal KHB, at the onset of reperfusion. H+ HPostC was applied in a similar manner using H-enriched oxygen-free KHB. Cardioprotective effects were evaluated on the basis of infarct size (IS, in % of area at risk, AR) reduction, post-I/R recovery of heart function, and occurrence of reperfusion arrhythmias. HPostC significantly reduced IS/AR compared with non-conditioned controls. Hpresent in KHB during HPostC further decreased IS/AR compared with the effect of HPostC, attenuated severe arrhythmias, and significantly restored heart function (vs. controls). Cardioprotection by HpostC can be augmented by molecular hydrogen infusion.
<p><a href="https://greenmedinfo.com/article/molecular-hydrogen-potentiates-beneficial-anti-infarct-effect-hypoxic-postcond" target="_blank">read more</a></p></description>
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<category domain="https://greenmedinfo.com/category/substance/Hydrogen%20Water">Hydrogen Water</category>
<category domain="https://greenmedinfo.com/category/disease/myocardial-infarction">Myocardial Infarction</category>
<category domain="https://greenmedinfo.com/category/disease/oxidative-stress">Oxidative Stress</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/antioxidants">Antioxidants</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/cardioprotective">Cardioprotective</category>
<category domain="https://greenmedinfo.com/category/study-types/animal-study">Animal Study</category>
<pubDate>Thu, 28 Mar 2024 08:11:34 +0000</pubDate>
<dc:creator>greenmedinfo</dc:creator>
<guid isPermaLink="false">293115 at https://greenmedinfo.com</guid>
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<item>
<title>Inhalation of hydrogen attenuates progression of chronic heart failure.</title>
<link>https://greenmedinfo.com/article/inhalation-hydrogen-attenuates-progression-chronic-heart-failure</link>
<description>
PMID:
Front Physiol. 2018 ;9:1026. Epub 2018 Jul 31. PMID: 30108516
Abstract Title:
Inhalation of Hydrogen Attenuates Progression of Chronic Heart Failure via Suppression of Oxidative Stress and P53 Related to Apoptosis Pathway in Rats.
Abstract:
Continuous damage from oxidative stress and apoptosis are the important mechanisms that facilitate chronic heart failure (CHF). Molecular hydrogen (H) has potentiality in the aspects of anti-oxidation. The objectives of this study were to investigate the possible mechanism of Hinhalation in delaying the progress of CHF.A total of 60 Sprague-Dawley (SD) rats were randomly divided into four groups: Sham, Sham treated with H, CHF and CHF treated with H. Rats from CHF and CHF treated with Hgroups were injected isoprenaline subcutaneously to establish the rat CHF model. One month later, the rat with CHF was identified by the echocardiography. After inhalation of H, cardiac function was improved vs. CHF (<p><a href="https://greenmedinfo.com/article/inhalation-hydrogen-attenuates-progression-chronic-heart-failure" target="_blank">read more</a></p></description>
<comments>https://greenmedinfo.com/article/inhalation-hydrogen-attenuates-progression-chronic-heart-failure#comments</comments>
<category domain="https://greenmedinfo.com/category/disease/heart-failure">Heart Failure</category>
<category domain="https://greenmedinfo.com/category/substance/Hydrogen%3A%20Molecular">Hydrogen: Molecular</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/anti-apoptotic">Anti-Apoptotic</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/antioxidants">Antioxidants</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/cardioprotective">Cardioprotective</category>
<category domain="https://greenmedinfo.com/category/study-types/animal-study">Animal Study</category>
<pubDate>Thu, 28 Mar 2024 07:56:18 +0000</pubDate>
<dc:creator>greenmedinfo</dc:creator>
<guid isPermaLink="false">293114 at https://greenmedinfo.com</guid>
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<item>
<title>Early aerobic exercise combined with hydrogen-rich saline as preconditioning protects myocardial injury.</title>
<link>https://greenmedinfo.com/article/early-aerobic-exercise-combined-hydrogen-rich-saline-preconditioning-protects-</link>
<description>
PMID:
Appl Biochem Biotechnol. 2019 Mar ;187(3):663-676. Epub 2018 Jul 23. PMID: 30033489
Abstract Title:
Early Aerobic Exercise Combined with Hydrogen-Rich Saline as Preconditioning Protects Myocardial Injury Induced by Acute Myocardial Infarction in Rats.
Abstract:
It has been reported that hydrogen-rich saline (HRS) water reduces oxidative stress, and early aerobic exercise (eAE) acts an efficient exercise preconditioning (EP) against cardiac I/R injury. However, whether early aerobic exercise combined with hydrogen-rich saline (eAE-HRS) water can more effectively protect myocardial damage induced by acute myocardial infarction (MI) is still unknown. This study was aimed to evaluate the effect of eAE-HRS in preventing MI-induced myocardial damage and explore the possible underlying mechanisms. After Sprague-Dawley (SD) rats were given a intragastric administration of HRS (1.6 ppm) at a dosage of 10 mL/kg weight daily for 3 weeks and/or the SD rats were performed a eAE program with 3 weeks running training, the left anterior descending coronary artery was ligated to induce MI. We assessed the effects of eAE-HRS on myocardial injury and oxidative damage in the MI model of rats and detected the effects of eAE-HRS on the expressions of cardiac OGG1 and Tom40, Tom20, and Tim23. The eAE-HRS increased significantly left ventricular systolic pressure, reduced left ventricular end-diastolic pressure, and potentiated + dp/dt, -dp/dt, heart coefficient and pH after MI injury. The eAE-HRS reduced MI-induced CK-MB level, c-Tnl level, h-FABP level, infarct size. The eAE-HRS enhanced MI-induced levels of the superoxide dismutase and total antioxidant capacity, attenuated MI-induced levels of malondialdehyde and catalase. The eAE-HRS increased expressions of OGG1, Tom20 and Tim23 proteins after MI injury, but not Tom40. The eAE-HRS has the potential to be a novel precautionary measure to protect myocardial injury after MI via partially regulating expressions of antioxidant-related proteins and mitochondrial-associated proteins.
<p><a href="https://greenmedinfo.com/article/early-aerobic-exercise-combined-hydrogen-rich-saline-preconditioning-protects-" target="_blank">read more</a></p></description>
<comments>https://greenmedinfo.com/article/early-aerobic-exercise-combined-hydrogen-rich-saline-preconditioning-protects-#comments</comments>
<category domain="https://greenmedinfo.com/category/substance/Hydrogen%20Water">Hydrogen Water</category>
<category domain="https://greenmedinfo.com/category/disease/myocardial-infarction">Myocardial Infarction</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/antioxidants">Antioxidants</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/cardioprotective">Cardioprotective</category>
<category domain="https://greenmedinfo.com/category/therapeutic-actions/exercise-aerobic">Exercise: Aerobic</category>
<category domain="https://greenmedinfo.com/category/study-types/animal-study">Animal Study</category>
<pubDate>Thu, 28 Mar 2024 07:52:46 +0000</pubDate>
<dc:creator>greenmedinfo</dc:creator>
<guid isPermaLink="false">293112 at https://greenmedinfo.com</guid>
</item>
<item>
<title>Hydrogen gas improves left ventricular hypertrophy in Dahl rat of salt-sensitive hypertension.</title>
<link>https://greenmedinfo.com/article/hydrogen-gas-improves-left-ventricular-hypertrophy-dahl-rat-salt-sensitive-hyp</link>
<description>
PMID:
Clin Exp Hypertens. 2019 ;41(4):307-311. Epub 2018 Jun 14. PMID: 29902079
Abstract Title:
Hydrogen gas improves left ventricular hypertrophy in Dahl rat of salt-sensitive hypertension.
Abstract:
PURPOSE: Hypertension is an important risk factor for death resulting from stroke, myocardial infarction, and end-stage renal failure. Hydrogen (H) gas protects against many diseases, including ischemia-reperfusion injury and stroke. The effects of Hon hypertension and its related left ventricular (LV) function have not been fully elucidated. The purpose of this study was to investigate the effects of Hgas on hypertension and LV hypertrophy using echocardiography.METHODS: Dahl salt-sensitive (DS) rats were randomly divided into three groups: those fed an 8% NaCl diet until 12 weeks of age (8% NaCl group), those additionally treated with 2% Hgas (8% NaCl + 2% Hgroup), and control rats maintained on a diet containing 0.3% NaCl until 12 weeks of age (0.3% NaCl group). Hgas was supplied through a gas flowmeter and delivered by room air (2% hydrogenated room air, flow rate of 10 L/min) into a cage surrounded by an acrylic chamber. We evaluated interventricular septal wall thickness (IVST), LV posterior wall thickness (LVPWT), and LV mass using echocardiography.RESULTS: IVST, LVPWT, and LV mass were significantly higher in the 8% NaCl group than the 0.3% NaCl group at 12 weeks of age, whereas they were significantly lower in the 8% NaCl + 2% Hgroup than the 8% NaCl group. There was no significant difference in systolic blood pressure between the two groups.CONCLUSION: Our findings suggest that chronic Hgas inhalation may help prevent LV hypertrophy in hypertensive DS rats.
<p><a href="https://greenmedinfo.com/article/hydrogen-gas-improves-left-ventricular-hypertrophy-dahl-rat-salt-sensitive-hyp" target="_blank">read more</a></p></description>
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<category domain="https://greenmedinfo.com/category/disease/hypertension">Hypertension</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/antihypertensive-agents">Antihypertensive Agents</category>
<category domain="https://greenmedinfo.com/category/study-types/animal-study">Animal Study</category>
<pubDate>Thu, 28 Mar 2024 07:49:30 +0000</pubDate>
<dc:creator>greenmedinfo</dc:creator>
<guid isPermaLink="false">293111 at https://greenmedinfo.com</guid>
</item>
<item>
<title>Hydrogen‑rich solution against myocardial injury and aquaporin expression.</title>
<link>https://greenmedinfo.com/article/hydrogen-rich-solution-against-myocardial-injury-and-aquaporin-expression</link>
<description>
PMID:
Mol Med Rep. 2018 Aug ;18(2):1925-1938. Epub 2018 Jun 20. PMID: 29956781
Abstract Title:
Hydrogen‑rich solution against myocardial injury and aquaporin expression via the PI3K/Akt signaling pathway during cardiopulmonary bypass in rats.
Abstract:
Myocardial ischemia, hypoxia and reperfusion injury are induced by aortic occlusion, cardiac arrest and resuscitation during cardiopulmonary bypass (CPB), which can severely affect cardiac function. The aim of the present study was to investigate the effects of hydrogen‑rich solution (HRS) and aquaporin (AQP) on cardiopulmonary bypass (CPB)‑induced myocardial injury, and determine the mechanism of the phosphatidylinositol 3‑kinase (PI3K)/protein kinase B (Akt) signaling pathway. Sprague Dawley rats were divided into a sham operation group, a CPB surgery group and a HRS group. A CPB model was established, and the hemodynamic parameters were determined at the termination of CPB. The myocardial tissues were observed by hematoxylin and eosin, and Masson staining. The levels of myocardial injury markers [adult cardiac troponin I (cTnI), lactate dehydrogenase (LDH), creatine kinase MB (CK‑MB) and brain natriuretic peptide (BNP)], inflammatory factors [interleukin (IL)‑1β, IL‑6 and tumor necrosis factor‑α(TNF‑α)] and oxidative stress indicators [superoxide dismutase (SOD), malondialdehyde (MDA) and myeloperoxidase (MPO)] were determined by ELISA. Furthermore, H9C2 cells were treated with HRS following hypoxia/reoxygenation. Cell viability and cell apoptosis were investigated. The expression of apoptosis regulator Bcl‑2 (Bcl‑2), apoptosis regulator Bax (Bax), caspase 3, AQP‑1, AQP‑4, phosphorylated (p)‑Akt, heme oxygenase 1 (HO‑1) and nuclear factor erythroid 2‑related factor 2 (Nrf2) were investigated using western blotting and quantitative‑polymerase chain reaction of tissues and cells. Following CPB, myocardial cell arrangement was disordered, myocardial injury markers (cTnI, LDH, CK‑MB and BNP), inflammatory cytokines (IL‑1β, IL‑6 and TNF‑α) and MDA levels were significantly increased compared with the sham group; whereas the SOD levels were significantly downregulated following CPB compared with the sham group. HRS attenuated myocardial injury, reduced the expression levels of cTnI, LDH, CK‑MB, BNP, IL‑1β, IL‑6, TNF‑α, MDA and MPO, and increased SOD release. Levels of Bcl‑2, AQP‑1, AQP‑4, p‑Akt, HO‑1 and Nrf2 were significantly increased following HRS; whereas Bax and caspase‑3 expression levels were significantly reduced following CPB. HRS treatment significantly increased the viability of myocardial cells, reduced the rate of myocardial cell apoptosis and the release of MDA and LDH compared with the CPB group. A PI3K inhibitor (LY294002) was revealed to reverse the protective effect of HRS treatment. HRS was demonstrated to attenuate CPB‑induced myocardial injury, suppress AQP‑1 and AQP‑4 expression following CPB treatment and protect myocardial cells via the PI3K/Akt signaling pathway.
<p><a href="https://greenmedinfo.com/article/hydrogen-rich-solution-against-myocardial-injury-and-aquaporin-expression" target="_blank">read more</a></p></description>
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<category domain="https://greenmedinfo.com/category/substance/Hydrogen%20Water">Hydrogen Water</category>
<category domain="https://greenmedinfo.com/category/disease/myocardial-ischemia">Myocardial Ischemia</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/anti-inflammatory-agents">Anti-Inflammatory Agents</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/antioxidants">Antioxidants</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/cardioprotective">Cardioprotective</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/Heme%20oxygenase-1%20up-regulation">Heme oxygenase-1 up-regulation</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/interleukin-1-beta-downregulation">Interleukin-1 beta downregulation</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/interleukin-6-downregulation">Interleukin-6 Downregulation</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/nrf2-activation">Nrf2 activation</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/tumor-necrosis-factor-tnf-alpha-inhibitor">Tumor Necrosis Factor (TNF) Alpha Inhibitor</category>
<category domain="https://greenmedinfo.com/category/study-types/animal-study">Animal Study</category>
<pubDate>Thu, 28 Mar 2024 07:42:32 +0000</pubDate>
<dc:creator>greenmedinfo</dc:creator>
<guid isPermaLink="false">293110 at https://greenmedinfo.com</guid>
</item>
<item>
<title>Pilot study of molecular hydrogen therapy in Parkinson's disease.</title>
<link>https://greenmedinfo.com/article/pilot-study-molecular-hydrogen-therapy-parkinsons-disease</link>
<description>
PMID:
Mov Disord. 2013 Jun ;28(6):836-9. Epub 2013 Feb 11. PMID: 23400965
Abstract Title:
Pilot study of H₂therapy in Parkinson&#039;s disease: a randomized double-blind placebo-controlled trial.
Abstract:
BACKGROUND: Oxidative stress is involved in the progression of Parkinson&#039;s disease (PD). Recent studies have confirmed that molecular hydrogen (H₂) functions as a highly effective antioxidant in cultured cells and animal models. Drinking H₂-dissolved water (H₂-water) reduced oxidative stress and improved Parkinson&#039;s features in model animals.METHODS: In this a placebo-controlled, randomized, double-blind, parallel-group clinical pilot study, the authors assessed the efficacy of H₂-water in Japanese patients with levodopa-medicated PD. Participants drank 1,000 mL/day of H₂-water or pseudo water for 48 weeks.RESULTS: Total Unified Parkinson&#039;s Disease Rating Scale (UPDRS) scores in the H₂-water group (n=9) improved (median, -1.0; mean±standard deviation, -5.7±8.4), whereas UPDRS scores in the placebo group (n=8) worsened (median, 4.5; mean±standard deviation, 4.1±9.2). Despite the minimal number of patients and the short duration of the trial, the difference was significant (P<p><a href="https://greenmedinfo.com/article/pilot-study-molecular-hydrogen-therapy-parkinsons-disease" target="_blank">read more</a></p></description>
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<category domain="https://greenmedinfo.com/category/substance/Hydrogen%3A%20Molecular">Hydrogen: Molecular</category>
<category domain="https://greenmedinfo.com/category/disease/parkinsons-disease">Parkinson's Disease</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/neuroprotective-agents">Neuroprotective Agents</category>
<category domain="https://greenmedinfo.com/category/study-types/human-study">Human Study</category>
<pubDate>Thu, 28 Mar 2024 06:59:49 +0000</pubDate>
<dc:creator>greenmedinfo</dc:creator>
<guid isPermaLink="false">293108 at https://greenmedinfo.com</guid>
</item>
<item>
<title>Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis.</title>
<link>https://greenmedinfo.com/article/therapeutic-efficacy-infused-molecular-hydrogen-saline-rheumatoid-arthritis</link>
<description>
PMID:
Int Immunopharmacol. 2014 Aug ;21(2):468-73. Epub 2014 Jun 11. PMID: 24929023
Abstract Title:
Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study.
Abstract:
The aim of this study was to demonstrate the safety and efficacy of H2-saline infusion for treatment of rheumatoid arthritis (RA). We conducted a randomized, double-blind, placebo-controlled investigation of the infusion of 1 ppm H2-dissolved saline (H2-saline) in 24 RA patients. Patients were randomized 1:1 to receive 500 ml of either H2-saline or placebo-saline, which was drop infused intravenously (DIV) daily for 5 days. The disease activity score in 28 joints (DAS28) was measured at baseline, immediately post infusion, and after 4 weeks. Therapeutic effects of H2-saline on joint inflammation were estimated by measuring serum biomarkers for RA, tumor necrosis factor-α(TNFα), interleukin-6 (IL-6), matrix metalloproteinase-3 (MMP-3), and urinary 8-hydroxydeoxyguanosine (8-OHdG). In the H2-infused group, average DAS28 decreased from 5.18±1.16 to 4.02±1.25 immediately post infusion and reached 3.74±1.22 after 4 weeks. No significant decrease in DAS28 was observed in the placebo group throughout the study. IL-6 levels in the H2 group significantly decreased in 4 weeks by 37.3±62.0% compared to baseline, whereas it increased by 33.6±34.4% in the placebo group. TNFαlevels did not change remarkably in the H2 or placebo groups in 4 weeks post-infusion compared to baseline. The relative ratio of 8-OHdG in the H2 group also significantly decreased by 4.7%. After 4 weeks, MMP3 was significantly reduced by 19.2%±24.6% in the H2 group, and increased by 16.9%±50.2% in the placebo group. Drop infusion of H2 safely and effectively reduced RA disease activity.
<p><a href="https://greenmedinfo.com/article/therapeutic-efficacy-infused-molecular-hydrogen-saline-rheumatoid-arthritis" target="_blank">read more</a></p></description>
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<category domain="https://greenmedinfo.com/category/substance/Hydrogen%3A%20Molecular">Hydrogen: Molecular</category>
<category domain="https://greenmedinfo.com/category/disease/inflammation">Inflammation</category>
<category domain="https://greenmedinfo.com/category/disease/rheumatoid-arthritis">Rheumatoid Arthritis</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/anti-inflammatory-agents">Anti-Inflammatory Agents</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/interleukin-6-downregulation">Interleukin-6 Downregulation</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/tumor-necrosis-factor-tnf-alpha-inhibitor">Tumor Necrosis Factor (TNF) Alpha Inhibitor</category>
<category domain="https://greenmedinfo.com/category/study-types/human-study">Human Study</category>
<pubDate>Thu, 28 Mar 2024 06:57:36 +0000</pubDate>
<dc:creator>greenmedinfo</dc:creator>
<guid isPermaLink="false">293107 at https://greenmedinfo.com</guid>
</item>
<item>
<title>Novel haemodialysis (HD) treatment employing molecular hydrogen (H2)-enriched dialysis solution improves prognosis of chronic dialysis patients.</title>
<link>https://greenmedinfo.com/article/novel-haemodialysis-hd-treatment-employing-molecular-hydrogen-h2-enriched-dial</link>
<description>
PMID:
Sci Rep. 2018 Jan 10 ;8(1):254. Epub 2018 Jan 10. PMID: 29321509
Abstract Title:
Novel haemodialysis (HD) treatment employing molecular hydrogen (H)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observational study.
Abstract:
Recent studies have revealed unique biological characteristics of molecular hydrogen (H) as an anti-inflammatory agent. We developed a novel haemodialysis (E-HD) system delivering an H(30-80 ppb)-enriched dialysis solution by water electrolysis, and conducted a non-randomized, non-blinded, prospective observational study exploring its clinical impact. Prevalent chronic HD patients were allocated to either the E-HD (n = 161) group or the conventional HD (C-HD: n = 148) group, and received the respective HD treatments during the study. The primary endpoint was a composite of all-cause mortality and development of non-lethal cardio-cerebrovascular events (cardiac disease, apoplexy, and leg amputation due to peripheral artery disease). During the 3.28-year mean observation period, there were no differences in dialysis parameters between the two groups; however, post-dialysis hypertension was ameliorated with significant reductions in antihypertensive agents in the E-HD patients. There were 91 events (50 in the C-HD group and 41 in the E-HD group). Multivariate analysis of the Cox proportional hazards model revealed E-HD as an independent significant factor for the primary endpoint (hazard ratio 0.59; [95% confidence interval: 0.38-0.92]) after adjusting for confounding factors (age, cardiovascular disease history, serum albumin, and C-reactive protein). HD applying an H-dissolved HD solution could improve the prognosis of chronic HD patients.
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<category domain="https://greenmedinfo.com/category/disease/hemodialysis">Hemodialysis</category>
<category domain="https://greenmedinfo.com/category/substance/Hydrogen%3A%20Molecular">Hydrogen: Molecular</category>
<category domain="https://greenmedinfo.com/category/pharmacological-actions/renoprotective">Renoprotective</category>
<category domain="https://greenmedinfo.com/category/study-types/human-study">Human Study</category>
<pubDate>Thu, 28 Mar 2024 06:50:35 +0000</pubDate>
<dc:creator>greenmedinfo</dc:creator>
<guid isPermaLink="false">293106 at https://greenmedinfo.com</guid>
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