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<updated>2025-05-10T00:53:24Z</updated>
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<updated>2025-05-10T00:56:07Z</updated>
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<entry>
<id>https://humanlove.stream/index.php?title=Purchase_Followers_Likes_Subscribers_Extra&diff=3065488&oldid=0</id>
<title>Purchase Followers Likes Subscribers Extra</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Purchase_Followers_Likes_Subscribers_Extra&diff=3065488&oldid=0"/>
<updated>2025-05-10T00:55:58Z</updated>
<summary type="html"><p>Created page with &quot;Collab posts permit two accounts to share the same publish, showing on both feeds with mixed likes, comments, and shares. The algorithm favors constant, high-quality posts, so...&quot;</p>
<p><b>New page</b></p><div>Collab posts permit two accounts to share the same publish, showing on both feeds with mixed likes, comments, and shares. The algorithm favors constant, high-quality posts, so maintaining an everyday schedule helps your account keep visible. Set up a content material calendar to have a clear picture of what to submit and when. Having more instagram followers sounds even higher now, right? Let’s have a look at how to improve your Instagram following by scheduling Instagram posts upfront and focusing on content that connects.&lt;br /&gt;&lt;br /&gt;An synthetic improve in followers may provide a short-term advantage, however a scarcity of engagement and authenticity will damage your popularity in the long term. Instead, focus on creating quality content and constructing real relationships with your viewers through engagement and networking. Growth may be gradual but the rewards within the form of a loyal and engaged following might be price it.&lt;br /&gt;&lt;br /&gt; [https://smmcpan.com/ شراء متابعين تيك توك] It is an easy and secure platform that lets you buy followers, likes, and feedback in a matter of minutes. With Socialfollow, you ought to purchase followers, likes, and comments from real, active users to assist enhance your engagement and visibility. In today’s social media panorama, constructing a considerable Instagram following can dramatically increase your visibility and affect. With over 1 billion monthly energetic users, Instagram is one of today’s most powerful advertising tools.&lt;br /&gt;&lt;br /&gt;This is a superb focused approach since the people you’ll attain have already proven interest in what you need to share. We strive to offer high-quality and relevant content for our viewers. It’s time to discover the chances of buying actual Instagram followers from trusted sources.&lt;br /&gt;&lt;br /&gt;We empower smart entrepreneurs, start-ups, SMBs and local businesses with detailed, actionable methods. Greedier Social Media provides an inexpensive resolution with a reliable supply time. You don’t have to interrupt the financial institution to purchase followers on Instagram with this supplier. They promise to supply only actual Instagram followers, so you don’t have to worry about shadow banning or fake accounts.&lt;br /&gt;&lt;br /&gt;A prime instance of this is Nuseir Yassin (Nas Daily), who has gained global recognition via his constant and fascinating posts. Real followers are followers who truly choose to follow you as a result of they like what you stand for, what you’re saying, or what you’re promoting. These are followers who are genuinely interested in you and your model.&lt;br /&gt;&lt;br /&gt;Buying social media followers is the act of buying a lot of fake or real followers on social media platforms like Instagram, Twitter or Facebook. These followers are normally bought from websites that provide numerous companies including followers, likes and views. The purpose of shopping for followers is to extend the variety of followers on a social media account, which is seen as a approach to increase the recognition and affect of the account. However, shopping for followers isn't beneficial as it can result in negative consequences, such as decreased engagement and decreased credibility. Buying social media followers could additionally be tempting, however it’s not a sustainable or moral way to grow your online presence.</div></summary>
<author><name>Facecougar1</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=Buy_Followers_Likes_Comments&diff=3065487&oldid=2859640</id>
<title>Buy Followers Likes Comments</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Buy_Followers_Likes_Comments&diff=3065487&oldid=2859640"/>
<updated>2025-05-10T00:55:50Z</updated>
<summary type="html"><p></p>
<table class="diff diff-contentalign-left" data-mw="interface">
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<td colspan="2" style="background-color: white; color:black; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: white; color:black; text-align: center;">Revision as of 00:55, 10 May 2025</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1" >Line 1:</td>
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<tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">Browse our vary of SMM services</del>, <del class="diffchange diffchange-inline">including choices for increased </del>likes, <del class="diffchange diffchange-inline">expanded follower base, or heightened view counts</del>. <del class="diffchange diffchange-inline">For large-scale requests, do not hesitate </del>to <del class="diffchange diffchange-inline">reach out </del>to <del class="diffchange diffchange-inline">our group directly. 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To guarantee you're making a wise move, it’s essential to buy real Instagram followers from reputable sites that share real followers</del>.&lt;br /&gt;&lt;br /&gt;<del class="diffchange diffchange-inline">Identifying your targets helps </del>you <del class="diffchange diffchange-inline">solidify your brand and guarantee your messages resonate with </del>the <del class="diffchange diffchange-inline">best individuals. Creating a compelling private model involves </del>a <del class="diffchange diffchange-inline">deep understanding of your ultimate targets. Our goal is </del>to <del class="diffchange diffchange-inline">supply an intensive information to effectively enhance your Instagram reach, equipping you with insights for knowledgeable decision-making. 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He is a Web publisher</del>, <del class="diffchange diffchange-inline">Web property investor, blogger and Web property builder</del>.&lt;br /&gt;&lt;br /&gt;<del class="diffchange diffchange-inline">Kicksta does not have </del>a <del class="diffchange diffchange-inline">minimal dedication interval, and </del>you<del class="diffchange diffchange-inline">'re free to cancel </del>your <del class="diffchange diffchange-inline">subscription at any time by visiting your settings</del>. <del class="diffchange diffchange-inline">We goal to </del>offer <del class="diffchange diffchange-inline">maximum flexibility to our clients</del>, <del class="diffchange diffchange-inline">allowing them </del>to <del class="diffchange diffchange-inline">regulate their subscriptions based on their wants</del>. <del class="diffchange diffchange-inline">“With nonstop 24/7 progress Kicksta has enabled us to create </del>a <del class="diffchange diffchange-inline">global community </del>of <del class="diffchange diffchange-inline">like-minded folks in the trend </del>and <del class="diffchange diffchange-inline">adjoining industries”. Kicksta combines machine learning and artificial intelligence to get more meaningful engagements. Raindrop Agency saves hours with Kicksta, just like 1000's of Kicksta customers</del>.&lt;br /&gt;&lt;br /&gt;<del class="diffchange diffchange-inline">However</del>, <del class="diffchange diffchange-inline">growing </del>your followers <del class="diffchange diffchange-inline">organically can be a slow and challenging course of</del>. <del class="diffchange diffchange-inline">However</del>, <del class="diffchange diffchange-inline">by </del>boosting <del class="diffchange diffchange-inline">your followers through a reputable SMM supplier</del>, <del class="diffchange diffchange-inline">you improve your probabilities of being thought of for brand offers. The second reason is that constructing a following organically can take plenty of time </del>and <del class="diffchange diffchange-inline">effort. Even </del>with <del class="diffchange diffchange-inline">constant engagement, it could take weeks or even months to succeed in your desired stage of recognition</del>. 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A bigger follower base can pique the interest </del>of <del class="diffchange diffchange-inline">different Instagram customers, leading to extra natural followers</del>.&lt;br /&gt;&lt;br /&gt;<del class="diffchange diffchange-inline">Social media exchange websites </del>are <del class="diffchange diffchange-inline">online platforms </del>that <del class="diffchange diffchange-inline">enable users </del>to <del class="diffchange diffchange-inline">extend their </del>social media <del class="diffchange diffchange-inline">presence by shopping for </del>followers, <del class="diffchange diffchange-inline">likes</del>, and <del class="diffchange diffchange-inline">views</del>. <del class="diffchange diffchange-inline">These </del>sites <del class="diffchange diffchange-inline">offer customers </del>the <del class="diffchange diffchange-inline">chance </del>to buy followers, <del class="diffchange diffchange-inline">likes, views</del>, and <del class="diffchange diffchange-inline">different social media engagement for their accounts. This permits users to rapidly and simply enhance the visibility of their model or product on social media</del>.</div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">Enjoy immediate supply and round-the-clock customer help. 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With <ins class="diffchange diffchange-inline">Analytics</ins>, <ins class="diffchange diffchange-inline">adjusting </ins>your <ins class="diffchange diffchange-inline">strategy for higher outcomes is now not a guessing game</ins>. <ins class="diffchange diffchange-inline">Aesthetics are every thing on </ins>Instagram, <ins class="diffchange diffchange-inline">and </ins>so <ins class="diffchange diffchange-inline">they go beyond every particular person post. 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So in case you are juggling with followers on </ins>a <ins class="diffchange diffchange-inline">number </ins>of <ins class="diffchange diffchange-inline">social accounts</ins>, <ins class="diffchange diffchange-inline">iDigic has your again</ins>.&lt;br /&gt;&lt;br /&gt;<ins class="diffchange diffchange-inline">It additionally offers </ins>a <ins class="diffchange diffchange-inline">variety of extra services that can help </ins>you <ins class="diffchange diffchange-inline">get the most out of </ins>your <ins class="diffchange diffchange-inline">social media accounts</ins>. <ins class="diffchange diffchange-inline">They </ins>offer <ins class="diffchange diffchange-inline">account management providers, analytics</ins>, <ins class="diffchange diffchange-inline">and customized campaigns </ins>to <ins class="diffchange diffchange-inline">assist you target the best viewers and maximize your attain</ins>. <ins class="diffchange diffchange-inline">SocialGreg offers </ins>a <ins class="diffchange diffchange-inline">broad range </ins>of <ins class="diffchange diffchange-inline">companies </ins>and <ins class="diffchange diffchange-inline">followers from different nations</ins>.&lt;br /&gt;&lt;br /&gt;<ins class="diffchange diffchange-inline">Fitness challenges</ins>, <ins class="diffchange diffchange-inline">especially when tied to </ins>your <ins class="diffchange diffchange-inline">brand’s identification, turn passive </ins>followers <ins class="diffchange diffchange-inline">into lively members</ins>. <ins class="diffchange diffchange-inline">Find out how top tech brands are turning features into storytelling</ins>, boosting <ins class="diffchange diffchange-inline">visibility</ins>, and <ins class="diffchange diffchange-inline">sparking engagement </ins>with <ins class="diffchange diffchange-inline">next-level content strategies</ins>. By <ins class="diffchange diffchange-inline">giving them extra than simply free products—exclusive content</ins>, <ins class="diffchange diffchange-inline">experiences</ins>, and <ins class="diffchange diffchange-inline">behind-the-scenes access—they turned these influencers into lifelong </ins>model <ins class="diffchange diffchange-inline">advocates</ins>.&lt;br /&gt;&lt;br /&gt;<ins class="diffchange diffchange-inline">Purchased Instagram followers from credible sources might help preserve engagement in your account, contributing to higher visibility </ins>and <ins class="diffchange diffchange-inline">ranking. Regular updates not solely maintain your lively </ins>followers <ins class="diffchange diffchange-inline">engaged but also enhance your discoverability</ins>, probably increasing <ins class="diffchange diffchange-inline">your viewers base. [https://smmcpan</ins>.<ins class="diffchange diffchange-inline">com/ زيادة متابعين انستقرام] It signifies your dedication to your brand</ins>, <ins class="diffchange diffchange-inline">painting </ins>a <ins class="diffchange diffchange-inline">picture </ins>of <ins class="diffchange diffchange-inline">reliability and trustworthiness</ins>.&lt;br /&gt;&lt;br /&gt;<ins class="diffchange diffchange-inline">In many cases, these super low cost suppliers </ins>are <ins class="diffchange diffchange-inline">providing low-quality or pretend followers </ins>that <ins class="diffchange diffchange-inline">won’t do your account any favors in the lengthy run. Stormlikes goes beyond Instagram </ins>to <ins class="diffchange diffchange-inline">cowl a number of </ins>social media <ins class="diffchange diffchange-inline">platforms, giving your campaigns a broader reach. 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</table></summary>
<author><name>Meatbonsai55</name></author> </entry>
<entry>
<id>https://humanlove.stream/wiki/User:Kudskcherry3100</id>
<title>User:Kudskcherry3100</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Kudskcherry3100"/>
<updated>2025-05-10T00:55:49Z</updated>
<summary type="html"><p>User account <a href="/index.php?title=User:Kudskcherry3100&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Kudskcherry3100 (page does not exist)"><bdi>Kudskcherry3100</bdi></a> was created</p>
</summary>
<author><name>Kudskcherry3100</name></author> </entry>
<entry>
<id>https://humanlove.stream/wiki/User:Randombeech67</id>
<title>User:Randombeech67</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Randombeech67"/>
<updated>2025-05-10T00:55:45Z</updated>
<summary type="html"><p>User account <a href="/index.php?title=User:Randombeech67&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Randombeech67 (page does not exist)"><bdi>Randombeech67</bdi></a> was created</p>
</summary>
<author><name>Randombeech67</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=10_Misconceptions_Your_Boss_Has_Concerning_Realistic_Doll_Sex&diff=3065486&oldid=0</id>
<title>10 Misconceptions Your Boss Has Concerning Realistic Doll Sex</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=10_Misconceptions_Your_Boss_Has_Concerning_Realistic_Doll_Sex&diff=3065486&oldid=0"/>
<updated>2025-05-10T00:55:40Z</updated>
<summary type="html"><p>Created page with &quot;&lt;p&gt;Title: The Realistic Doll Sex Industry: A Comprehensive Overview&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;The world of realistic doll sex has been a subject of fascination, interest, and controve...&quot;</p>
<p><b>New page</b></p><div>&lt;p&gt;Title: The Realistic Doll Sex Industry: A Comprehensive Overview&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;The world of realistic doll sex has been a subject of fascination, interest, and controversy for lots of. These adult dolls, likewise understood as love dolls or sex dolls, have actually been created to imitate the appearance and physical experiences of human partners, supplying a special and intimate experience for users. This short article aims to delve into the world of realistic doll sex, exploring its origins, advancement, and the often asked concerns surrounding it.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Origins of Realistic Doll Sex&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;The principle of utilizing inanimate items for sexual gratification can be traced back to ancient civilizations, such as the Greeks and Romans. Nevertheless, [https://omnismediagroup.com/members/lyreferry0/activity/145915/ real sex doll] -day realistic doll sex industry got traction in the late 20th century, with the development of sophisticated products and making techniques.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Early sex dolls were primarily made of silicone, but developments in products and innovation have led to the development of dolls crafted from thermoplastic elastomers (TPE), a material that boasts a more human-like feel and look.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;The Realistic Doll Sex Experience&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Realistic dolls are thoroughly created to duplicate the human form, total with lifelike skin, facial features, and even body hair. Some models even integrate artificial intelligence (AI) innovation, enabling the dolls to mimic human-like responses and interactions.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;The primary appeal of these dolls lies in their ability to offer users a sense of companionship, intimacy, and control that might be lacking in their real-life relationships. Additionally, [https://elevateducation.com/members/formatvelvet7/activity/1428022/ real sex doll] offered in the market enable users to tailor their dolls to their specific preferences, even more enhancing the overall experience.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Industry Growth and Development&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;The global realistic doll sex market has actually experienced substantial growth in the last few years, driven by factors such as increased approval of sex toys, the increase of online sales platforms, and the advancement of more advanced and realistic items.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;According to a report by Transparency Market Research, the worldwide sex doll market is predicted to reach a value of GBP 621.8 million by 2026, growing at a CAGR of 7.0% throughout the projection period from 2018 to 2026.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Regularly Asked Questions&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;ol&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;Are realistic dolls legal?&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt;&lt;/ol&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;The legality of realistic dolls differs depending on the region. In some nations, such as the United States and Canada, there are no laws explicitly banning the sale or possession of sex dolls. Nevertheless, [https://rentry.co/nfiwh2a9 real sex doll] , like the United Kingdom, have imposed age constraints and regulations on the sale and importation of these products.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;ol start=&quot;2&quot;&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;How much do realistic dolls cost?&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt;&lt;/ol&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;The price of realistic dolls can vary from a couple of hundred to several thousand dollars, depending on the quality of products, customization options, and additional functions, such as AI innovation.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;ol start=&quot;3&quot;&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;Can realistic dolls be cleaned up and preserved?&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt;&lt;/ol&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Yes, realistic dolls can be cleaned up and kept using customized cleansing options and care instructions provided by the manufacturer. Correct maintenance can assist guarantee the longevity and hygiene of the item.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;ol start=&quot;4&quot;&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;Do realistic dolls have any health advantages?&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt;&lt;/ol&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;While there is no conclusive clinical evidence, some users report that realistic dolls can help reduce feelings of loneliness, stress and anxiety, and tension. Nevertheless, it is vital to keep a healthy balance and not rely solely on these items for emotional or social fulfillment.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;ol start=&quot;5&quot;&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;Can realistic dolls be utilized for restorative purposes?&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt;&lt;/ol&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Some psychological health experts have actually begun checking out the prospective benefits of utilizing realistic dolls as a type of treatment for people with social anxiety, autism spectrum disorder, or other conditions that make human interaction challenging.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;In Conclusion&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;The realistic doll sex industry has actually evolved considerably recently, using users a vast array of personalization options, advanced features, and boosted user experiences. As the marketplace continues to grow and develop, it is vital for users and producers alike to approach the subject with maturity, respect, and an understanding of the possible ramifications and benefits.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;List of References&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;ol&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;Openness Market Research. (2019 ). Sex Doll Market (Material - Silicone, TPE, and Others; Price Range - Less than GBP 1,000, GBP 1,000 to GBP 5,000, and More than GBP 5,000; Distribution Channel - Online and Offline) - Global Industry Analysis, Size, Share, Growth, Trends, and Forecast, 2018 - 2026.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;BBC News. (2018 ). Sex dolls: 'I married my inflatable partner'.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;Vice. (2019 ). The Sex Dolls That Talk Back.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;MarketWatch. (2020 ). Sex dolls market to reach ₤ 621.8 million by 2026: Transparency Market Research.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;Psychology Today. (2018 ). Sex Dolls: The Future of Sex or a Sad Substitute?&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt;&lt;/ol&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;</div></summary>
<author><name>Quietwalk6</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=Reduced_Electrical_power_Cold_and_Atmospheric_Strain_PlasmaInduced_Polymerization_Semplice_Activity_as_well_as_Crystal_Regulation_of_Covalent_Organic_Frameworks&diff=3065485&oldid=0</id>
<title>Reduced Electrical power Cold and Atmospheric Strain PlasmaInduced Polymerization Semplice Activity as well as Crystal Regulation of Covalent Organic Frameworks</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Reduced_Electrical_power_Cold_and_Atmospheric_Strain_PlasmaInduced_Polymerization_Semplice_Activity_as_well_as_Crystal_Regulation_of_Covalent_Organic_Frameworks&diff=3065485&oldid=0"/>
<updated>2025-05-10T00:55:38Z</updated>
<summary type="html"><p>Created page with &quot;eceiving it. There are opportunities to improve longer-term LDL-C reduction and clinical outcomes through dosage optimisation and improved medication maintenance.AIM To invest...&quot;</p>
<p><b>New page</b></p><div>eceiving it. There are opportunities to improve longer-term LDL-C reduction and clinical outcomes through dosage optimisation and improved medication maintenance.AIM To investigate if adult cochlear implant (CI) recipients have received the recommended immunisations as compared to current guidelines and to report instances of meningitis within this population. METHODS Telephone interview of CI recipient's general practitioner (GP) surgeries for details regarding immunisations received. Subsequent reporting of immunisation rates of adult patients, under the care of the Northern Cochlear Implant Programme (NCIP) in New Zealand, when compared to the recommended guidelines from the Immunisation Advisory Centre (IMAC) and rates of meningitis of CI recipients are presented. RESULTS It is recommended to immunise against the most common organisms causing meningitis, Streptococcus pneumoniae and Haemophilus influenzae type b (HiB), as well as influenza. Data for 135 CI recipients over the last five years was complete. 14.8% of patients had received a full pneumococcal immunisation schedule. 11.9% had received a HiB immunisation and 62.2% an influenza vaccination. No patient had developed meningitis following CI insertion. CONCLUSION This paper highlights clear issues with the immunisation of adult CI recipients.An amendment to this paper has been published and can be accessed via a link at the top of the paper.Fetal growth restriction (FGR) is the major single cause of stillbirth1 and is also associated with neonatal morbidity and mortality2,3, impaired health and educational achievement in childhood4,5 and with a range of diseases in later life6. Effective screening and intervention for FGR is an unmet clinical need. Here, we performed ultrahigh performance liquid chromatography-tandem mass spectroscopy (UPLC-MS/MS) metabolomics on maternal serum at 12, 20 and 28 weeks of gestational age (wkGA) using 175 cases of term FGR and 299 controls from the Pregnancy Outcome Prediction (POP) study, conducted in Cambridge, UK, to identify predictive metabolites. Internal validation using 36 wkGA samples demonstrated that a ratio of the products of the relative concentrations of two positively associated metabolites (1-(1-enyl-stearoyl)-2-oleoyl-GPC (P-180/181) and 1,5-anhydroglucitol) to the product of the relative concentrations of two negatively associated metabolites (5α-androstan-3α,17α-diol disulfate and N1,N12-diacetylspermine) predicted FGR at term. [https://www.selleckchem.com/products/rvx-208.html Apabetalone] The ratio had approximately double the discrimination as compared to a previously developed angiogenic biomarker7, the soluble fms-like tyrosine kinase 1placental growth factor (sFLT1PlGF) ratio (AUC 0.78 versus 0.64, P = 0.0001). We validated the predictive performance of the metabolite ratio in two sub-samples of a demographically dissimilar cohort, Born in Bradford (BiB), conducted in Bradford, UK (P = 0.0002). Screening and intervention using this metabolite ratio in conjunction with ultrasonic imaging at around 36 wkGA could plausibly prevent adverse events through enhanced fetal monitoring and targeted induction of labor.Development of tau-based therapies for Alzheimer's disease requires an understanding of the timing of disease-related changes in tau. We quantified the phosphorylation state at multiple sites of the tau protein in cerebrospinal fluid markers across four decades of disease progression in dominantly inherited Alzheimer's disease. We identified a pattern of tau staging where site-specific phosphorylation changes occur at different periods of disease progression and follow distinct trajectories over time. These tau phosphorylation state changes are uniquely associated with structural, metabolic, neurodegenerative and clinical markers of disease, and some (p-tau217 and p-tau181) begin with the initial increases in aggregate amyloid-β as early as two decades before the development of aggregated tau pathology. Others (p-tau205 and t-tau) increase with atrophy and hypometabolism closer to symptom onset. These findings provide insights into the pathways linking tau, amyloid-β and neurodegeneration, and may facilitate clinical trials of tau-based treatments.Standard clinical care in neonatal and pediatric intensive-care units (NICUs and PICUs, respectively) involves continuous monitoring of vital signs with hard-wired devices that adhere to the skin and, in certain instances, can involve catheter-based pressure sensors inserted into the arteries. These systems entail risks of causing iatrogenic skin injuries, complicating clinical care and impeding skin-to-skin contact between parent and child. Here we present a wireless, non-invasive technology that not only offers measurement equivalency to existing clinical standards for heart rate, respiration rate, temperature and blood oxygenation, but also provides a range of important additional features, as supported by data from pilot clinical studies in both the NICU and PICU. These new modalities include tracking movements and body orientation, quantifying the physiological benefits of skin-to-skin care, capturing acoustic signatures of cardiac activity, recording vocal biomarkers associated with tonality and temporal characteristics of crying and monitoring a reliable surrogate for systolic blood pressure. These platforms have the potential to substantially enhance the quality of neonatal and pediatric critical care.The diagnosis of lymphomas and leukemias requires hematopathologists to integrate microscopically visible cellular morphology with antibody-identified cell surface molecule expression. To merge these into one high-throughput, highly multiplexed, single-cell assay, we quantify cell morphological features by their underlying, antibody-measurable molecular components, which empowers mass cytometers to 'see' like pathologists. When applied to 71 diverse clinical samples, single-cell morphometric profiling reveals robust and distinct patterns of 'morphometric' markers for each major cell type. Individually, lamin B1 highlights acute leukemias, lamin A/C helps distinguish normal from neoplastic mature T cells, and VAMP-7 recapitulates light-cytometric side scatter. Combined with machine learning, morphometric markers form intuitive visualizations of normal and neoplastic cellular distribution and differentiation. When recalibrated for myelomonocytic blast enumeration, this approach is superior to flow cytometry and comparable to expert microscopy, bypassing years of specialized training.</div></summary>
<author><name>Shieldbagel0</name></author> </entry>
<entry>
<id>https://humanlove.stream/wiki/User:Foxhendrix6366</id>
<title>User:Foxhendrix6366</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Foxhendrix6366"/>
<updated>2025-05-10T00:55:30Z</updated>
<summary type="html"><p>User account <a href="/index.php?title=User:Foxhendrix6366&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Foxhendrix6366 (page does not exist)"><bdi>Foxhendrix6366</bdi></a> was created</p>
</summary>
<author><name>Foxhendrix6366</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=Vargasmackenzie3704&diff=3065484&oldid=0</id>
<title>Vargasmackenzie3704</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Vargasmackenzie3704&diff=3065484&oldid=0"/>
<updated>2025-05-10T00:55:28Z</updated>
<summary type="html"><p>Created page with &quot;This study examined the stress and coping patterns of middle school teachers. A final teacher sample of 102 and student sample of 1450 agreed to participate in the study. We c...&quot;</p>
<p><b>New page</b></p><div>This study examined the stress and coping patterns of middle school teachers. A final teacher sample of 102 and student sample of 1450 agreed to participate in the study. We conducted a latent profile analysis of the teachers' self-reported levels of stress and coping at the beginning of the school year and used the resulting profiles to predict teacher practices and student outcomes over time. Nearly all teachers were characterized by high stress and high coping (66%) or high stress and low coping (28%). Based on concurrent ratings and observations, the High Stress/Low Coping profile had higher burnout and lower self-efficacy, higher rates of observed reprimands, and higher student-reported depression in comparison to the other classes. The most adaptive profile, Low Stress/High Coping (6% of sample), had lower burnout, greater parent involvement and higher student prosocial skills in comparison to the other groups. Profiles also predicted the maintenance of most of these effects and the increase of some effects over the school year. Examining stress and coping in combination can inform efforts to improve teacher well-being and have a positive influence on student learning environments. Defending represents any prosocial behavior taken to assist an individual being victimized. Like other forms of prosocial behavior, defending may be best conceptualized as a multidimensional set of behaviors, including both direct and indirect forms of defending. The objective of the current research was to design and validate the Defending Behaviors Scale (DBS), a multidimensional self-report scale of defending behaviors. Data were collected from 572 early adolescents in Grades 6 to 8. Participants completed the DBS as well as established measures of bullying, victimization, empathy, aggression, social self-efficacy, social support, and prosocial behavior. Data were analyzed using an exploratory structural equation modeling framework. A four-factor model provided the best fit to the data. Direct defending included aggressive and solution-focused behaviors, whereas indirect defending included comforting and reporting to authority. Girls were more likely to defend others by offering comfort and reporting to authority, whereas aggressive defending was more common among boys. Each subscale demonstrated good internal consistency (α's 0.80-0.92) and was uniquely associated with empathy, aggression, and other types of prosocial behavior. The DBS is a new, psychometrically-valid measure that will aid in the assessment of heterogenous defending behaviors. We tested the role of teacher-child closeness in moderating the associations between early childhood adversity, measured as a cumulative risk index, and child outcomes during the kindergarten year. Using the ECLSK11, a national dataset of kindergarteners in the 2010-11 academic year, we examined three dimensions of executive function (cognitive flexibility, inhibitory control, working memory), as well as early reading and math scores, as key skills that facilitate the transition to school. Cumulative risk was negatively associated with all outcomes, and teacher-child closeness was positively associated with all outcomes. Teacher-child closeness moderated the relation between cumulative risk and working memory and cumulative risk and reading scores in a protective manner, but not cognitive flexibility, inhibitory control, or math scores. Implications for research in early childhood adversity and education are discussed. Teaching is one of the most challenging jobs, with a high turnover rate. Unfortunately, we know very little about how to retain teachers. This longitudinal field study (N&amp;nbsp;=&amp;nbsp;310) examined whether preschool teachers' stress mindset-that is, whether they believe stress is harmful or beneficial-predicted their job stress and turnover within a school year. The results suggested that teachers who believe in the potential benefits of stress experienced less job stress, and were therefore less likely to leave their jobs as quickly. These findings suggest that teachers' stress mindsets predict their psychological well-being and professional development. Using a stigma-based bullying framework, the current study investigated how (a) disability status was related to bullying-related behaviors when controlling for gender, grade level, and free or reduced lunch status; (b) gender, grade level, and free or reduced lunch status moderated the associations of disability status with bullying-related behaviors; and (c) classification in specific disability categories was associated with bullying-related behaviors with a sample of 10,483 students (47.8% female) in elementary, middle, and high school. School records data were collected on grade level, gender, free or reduced lunch price status, disability status, and disability category. Students completed the Bullying Participant Behaviors Questionnaire (BPBQ), rating five types of bully role behaviors (bullying behavior, assistant behavior, victimization, defending behavior, and outsider behavior). Findings indicated that having a disability was associated with increased victimization, assisting, and defending behaviong and outsider behaviors; and students with a learning disability reported more defending behavior. Exploratory analyses of the effects of school-level factors found that school size (enrollment) was positively related to prevalence of assisting and outsider behavior. [https://www.selleckchem.com/products/Cryptotanshinone.html check details] The percentage of low-income students in a school was positively associated with the extent of victimization and defending behaviors reported, but negatively associated with the extent of outsider behaviors reported. Published by Elsevier Ltd.Cyberbullying is a significant problem worldwide that affects adolescents' social relations, academic achievement, and mental health. As this form of bullying is typically viewed by a large audience it is important to understand the role of observers as they may hold a key for reducing bullying. The aim of this study was to investigate the role of the socio-cognitive factors of defending self-efficacy (i.e., belief in one's capability to defend) and moral disengagement (i.e., justifications for aggressive behavior) associated with general cyber defending behavior and cyber defending response types constructive and aggressive. Participants were 540 male and female students of diverse racial identity between the ages of 11 and 15&amp;nbsp;years who completed a questionnaire comprising multiple measures. Regression analyses revealed that at low levels of defending self-efficacy, moral disengagement was unrelated to general cyber defending behavior. However, at high levels of defending self-efficacy, moral disengagement was positively associated with general cyber defending.</div></summary>
<author><name>Vargasmackenzie3704</name></author> </entry>
<entry>
<id>https://humanlove.stream/wiki/User:Greyadvice76</id>
<title>User:Greyadvice76</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Greyadvice76"/>
<updated>2025-05-10T00:55:26Z</updated>
<summary type="html"><p>User account <a href="/index.php?title=User:Greyadvice76&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Greyadvice76 (page does not exist)"><bdi>Greyadvice76</bdi></a> was created</p>
</summary>
<author><name>Greyadvice76</name></author> </entry>
<entry>
<id>https://humanlove.stream/wiki/User:Bachstout8827</id>
<title>User:Bachstout8827</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Bachstout8827"/>
<updated>2025-05-10T00:55:22Z</updated>
<summary type="html"><p>User account <a href="/index.php?title=User:Bachstout8827&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Bachstout8827 (page does not exist)"><bdi>Bachstout8827</bdi></a> was created</p>
</summary>
<author><name>Bachstout8827</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=Wallermccleary5090&diff=3065483&oldid=0</id>
<title>Wallermccleary5090</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Wallermccleary5090&diff=3065483&oldid=0"/>
<updated>2025-05-10T00:55:08Z</updated>
<summary type="html"><p>Created page with &quot;87; 95% CI, 0.76-0.99), a higher probability of receiving allogeneic hematopoietic stem cell transplantation (RR 6.14; 95% CI, 4.03-9.35), fewer episodes of pneumonia (RR, 0.2...&quot;</p>
<p><b>New page</b></p><div>87; 95% CI, 0.76-0.99), a higher probability of receiving allogeneic hematopoietic stem cell transplantation (RR 6.14; 95% CI, 4.03-9.35), fewer episodes of pneumonia (RR, 0.25; 95% CI, 0.06-0.98), but a greater number of severe, treatment-emergent adverse events (RR, 1.34; 95% CI, 1.03-1.75), and a longer duration of intensive care unit hospitalization (MD, 6.84 days longer; 95% CI, 3.44 days longer to 10.24 days longer, very low certainty evidence). Low certainty evidence due to confounding in observational studies suggest superior overall survival without substantial treatment-emergent adverse effect of intensive antileukemic therapy over less-intensive therapy in older adults with AML who are candidates for intensive antileukemic therapy.In this paper, we investigate the outage probability and ergodic sum capacity of the downlink of the integrated satellite-terrestrial networks (ISTN) with a cooperative non-orthogonal multiple access (CNOMA) scheme, in which a user with better channel condition acts as a relay node and forwards information to the other users. In this paper, a pilot-based channel estimation method is considered which can verify the performance of this scheme with the imperfect channel state information. In this model, all these users are equipped with multi-antennas, and all of them are both in the coverage of a same beam of the satellite. Specifically, the exact analytical expression for the outage probability and ergodic sum capacity of the system is derived. The result shows that this coordinated non-orthogonal multiple access (CNOMA) scheme performs better than that of OMA (TDMA) in this model. Finally, the future research directions are given to further enhance the system capacity.Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting 1% of the world population. RA is associated with the presence of autoantibodies, of which anti-citrullinated protein antibodies (ACPA) are most prominent. ACPA are produced by citrullinated antigen-binding B cells that have presumably survived tolerance checkpoints. So far, it is unclear how and when such autoreactive B cells emerge. Light chain (LC) rearrangement and mutation rates can be informative with regard to selection steps during B-cell development. Therefore, we studied LC characteristics of ACPA-expressing B cells and secreted ACPA with the aim to better understand the development of this disease-specific, autoreactive B-cell response. Paired ACPA-IgG and ACPA-depleted IgG were isolated from serum (n = 87) and synovial fluid (SF, n = 21) of patients with established RA. We determined the LC composition for each fraction by ELISA using kappa(Igκ)- and lambda(Igλ) LC-specific antibodies. Cellular LC expression was determined using f a process of active selection.[This corrects the article DOI 10.1371/journal.pone.0245563.].Prey size selection in some bird species is determined by the size of the beak. However, we assumed for bird species swallowing whole prey that a cognitive process may be involved. As cognitive feature, brain mass was used. We hypothesized that the mass of the brain was more strongly positively correlated with prey size than morphological features such as beak volume, gizzard mass and body mass. We tested this hypothesis on eiders Somateria mollissima that swallow the prey whole, by using mean and maximum size of nine prey categories. Eiders were collected at the main wintering grounds in Denmark. As index of brain mass we used head volume, which is positively correlated with brain mass (r2 = 0.73). Head volume of eiders was significantly, positive correlated with mean and maximum size of blue mussels Mytilus edulis, razor clams Ensis directus and all prey sizes combined and the maximum size of draft whelk Hinia reticulata and conch Buccinum undatum. Gizzard mass was also significantly positively correlated with maximum size of draft whelk and conch. Beak volume and body mass was not significantly correlated with the size of any of the nine food items. Analyses of effect size for organs showed that head volume was positively related to prey size, whereas beak volume, gizzard mass and body mass did not show a significant positive relationship. These results indicate that cognitive processes connected to brain mass may be involved in prey size selection by eiders.[This corrects the article DOI 10.1371/journal.pone.0236347.].Few studies have investigated fathers' roles in child care in Madagascar. This study explored the perceptions, attitudes, and practices regarding fathers' involvement in child care using qualitative methods. Ten focus group discussions were conducted among parents of children aged 6-23 months; seven were among mothers, and three among fathers. In-depth semi-structured interviews (n = 8) were also conducted with key informants. Discussions and interviews were audio-recorded and the verbatim transcripts in Malagasy were translated into English. Data were analyzed using the thematic analysis approach. Provision of financial and material support as well as teaching and playing with the child were the main perceived roles of fathers. In practice, fathers spent their time alone with their children playing and holding them when the mother was unavailable. Busy schedules and separation due to work were major barriers to fathers' involvement. [https://www.selleckchem.com/products/ly2157299.html LY2157299 manufacturer] Traditional gender roles for child care in which the mother is seen as primarily responsible for the child were salient across the data. Consequently, men involved in child care activities and their wives were often criticized by the community. Nevertheless, there was self-reported interest from both mothers and fathers in involving men more in child care. Interventions aimed to increase fathers' involvement in child care may be more successful when they focus on shifting the community perceptions on the division of responsibilities between fathers and mothers.&lt;br /&gt;&lt;br /&gt; Existing literature on how employment loss affects depression has struggled to address potential endogeneity bias caused by reverse causality. The COVID-19 pandemic offers a unique natural experiment because the source of unemployment is very likely to be exogenous to the individual. This study assessed the effect of job loss and job furlough on the mental health of individuals in South Africa during the COVID-19 pandemic.&lt;br /&gt;&lt;br /&gt; The data for the study came from the first and second waves of the national survey, the National Income Dynamics-Coronavirus Rapid Mobile Survey (NIDS-CRAM), conducted during May-June and July-August 2020, respectively. The sample for NIDS-CRAM was drawn from an earlier national survey, conducted in 2017, which had collected data on mental health. Questions on depressive symptoms during the lockdown were asked in Wave 2 of NIDS-CRAM, using a 2-question version of the Patient Health Questionnaire (PHQ-2). The PHQ-2 responses (0-6 on the discrete scale) were regrouped into four categories making the ordered logit regression model the most suited for assessing the impact of employment status on depressive symptoms.</div></summary>
<author><name>Wallermccleary5090</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=Woodwarddueholm0848&diff=3065482&oldid=0</id>
<title>Woodwarddueholm0848</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Woodwarddueholm0848&diff=3065482&oldid=0"/>
<updated>2025-05-10T00:55:01Z</updated>
<summary type="html"><p>Created page with &quot;Purpose Lifestyle risk factors, such as alcohol use, smoking, high body mass index, poor sleep, and sedentary behavior, represent major public health issues for adolescents. T...&quot;</p>
<p><b>New page</b></p><div>Purpose Lifestyle risk factors, such as alcohol use, smoking, high body mass index, poor sleep, and sedentary behavior, represent major public health issues for adolescents. These factors have been associated with increased rates of major depressive disorder (MDD). The purpose of this paper is to investigate critical peaks in the prevalence of MDD at certain ages and to examine how these peaks might be amplified or attenuated by the presence of lifestyle risk factors. Methods A nationally representative sample of adolescents aged 11-17 years old (n = 2967) and time-varying effect models were used to investigate the associations between lifestyle risk factors and the prevalence of MDD by sex. Results The estimated prevalence of MDD significantly increased among adolescents from 4% (95% CI 3-6%) at 13 years of age to 19% (95% CI 15-24%) at 16 years of age. From the age of 13, males were significantly less likely to have a diagnosis of MDD than females with the maximum sex difference occurring at the age of 15 (OR 0.24, 95% CI 0.13-0.47). All lifestyle risk factors were at some point significantly associated with MDD, but these associations did not differ by sex, except for body mass index. Discussion These findings suggest that interventions designed to prevent the development of depression should be implemented in early adolescence, ideally before or at the age of 13 and particularly among young females given that the prevalence of MDD begins to rise and diverge from young males. Interventions should also simultaneously address lifestyle risk factors and symptoms of major depression.Purpose We aimed to assess intranasal (IN) epinephrine effects on cerebrospinal fluid (CSF) absorption, nasal mucosa quality, plasma epinephrine pharmacokinetics (PK), and cardiovascular changes in dogs. Methods CSF epinephrine concentration was measured and nasal mucosa quality was evaluated after IN epinephrine 4 mg and one or two 4 mg doses (21 min apart), respectively. Maximum plasma concentration [Cmax], time to Cmax [Tmax], area under the curve from 0 to 120 min [AUC0-120], and cardiovascular effects were evaluated after epinephrine IN (4 and 5 mg) and intramuscular (IM; 0.3 mg). Clinical observations were assessed. Results After epinephrine IN, there were no changes in CSF epinephrine or nasal mucosa. Cmax, Tmax, and AUC1-120 were similar following epinephrine IN and IM. Epinephrine IN versus IM increased plasma epinephrine at 1 min (mean ± SEM, 1.15 ± 0.48 for 4 mg IN and 1.7 ± 0.72 for 5 mg IN versus 0.47 ± 0.11 ng/mL for 0.3 mg IM). Epinephrine IN and IM produced similar heart rate and ECG results. Clinical observations included salivation and vomiting. Conclusions Epinephrine IN did not alter CSF epinephrine or nasal tissue and had similar cardiovascular effects as epinephrine IM. Epinephrine IN rapidly increased plasma epinephrine concentration versus epinephrine IM.The aim of this study was to assess the levels of awareness of oral cancer in healthcare staff at a district general hospital in the UK. [https://www.selleckchem.com/products/paeoniflorin.html check details] This excluded those staff involved in head and neck cancer management. The study identified the areas where there was a deficiency in knowledge and quantified any differences across the professions. Following a literature review utilising the National Institute for Health and Care Excellence (NICE) Healthcare Databases Advanced Research (HDAS) tool, a questionnaire was designed, which was piloted amongst healthcare professionals on one ward. The feedback from the respondents was used to test the suitability of the survey format and modified before implementation across the hospital. One hundred fifty-five completed surveys were collected. The respondents were divided into doctors, nursing staff, and healthcare assistants (HCAs). There were generally low to middle levels of subjective individual confidence in identifying oral cancer. There was confusion on the clinical signs of oral cancer, with 29% of respondents believing that toothache was a sign. Almost half of all the respondents believed that dental decay was a risk factor for oral cancer. Although the significance of an early diagnosis was recognised as being important, a number of respondents were not aware of the likely differences in morbidity and mortality based on the stage of disease on diagnosis. This study has demonstrated that the healthcare workforce has gaps in knowledge both in of the presentation of oral cancer and the morbidity and mortality associated with a delay in diagnosis. Further learning opportunities for all healthcare staff will help to reduce future disease burden.General practitioners (GPs) are among the main actors involved in early melanoma diagnosis. However, melanoma diagnostic accuracy and management are reported to be insufficient among GPs in Europe. The primary aim of this observational prospective study was to shed light on melanoma diagnostic practices among French-speaking Belgian GPs. The second aim was to specifically analyse these GPs' pigmented skin lesion diagnostic accuracy and management. GPs from the five French-speaking districts of Belgium were asked to complete a questionnaire, before taking part in a melanoma diagnostic training session. First, we assessed the GPs' current melanoma diagnostic practices. Then, their pigmented skin lesion diagnostic accuracy and management were evaluated, through basic theoretical questions and clinical images. These results were subsequently analysed, according to the GPs' sociodemographic characteristics and medical practice type. In total, 89 GPs completed the questionnaire. Almost half of the GPs (43%; CI = [33;54]) were confronted with a suspicious skin lesion as the main reason for consultation once every 3 months, while 33% (CI = [24;43]) were consulted for a suspicious lesion as a secondary reason once a month. Prior to training, one-third of the GPs exhibited suboptimal diagnostic accuracy in at least one of six &quot;life-threatening&quot; clinical cases among two sets of 10 clinical images of pigmented skin lesions, which can lead to inadequate patient management (i.e. incorrect treatment and/or inappropriate reinsurance). This study underlines the need to train GPs in melanoma diagnosis. GPs' pigmented skin lesion diagnostic accuracy and management should be improved to increase early melanoma detection.</div></summary>
<author><name>Woodwarddueholm0848</name></author> </entry>
<entry>
<id>https://humanlove.stream/wiki/User:Panchurch92</id>
<title>User:Panchurch92</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Panchurch92"/>
<updated>2025-05-10T00:54:58Z</updated>
<summary type="html"><p>User account <a href="/index.php?title=User:Panchurch92&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Panchurch92 (page does not exist)"><bdi>Panchurch92</bdi></a> was created</p>
</summary>
<author><name>Panchurch92</name></author> </entry>
<entry>
<id>https://humanlove.stream/wiki/User:Saillocust5</id>
<title>User:Saillocust5</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Saillocust5"/>
<updated>2025-05-10T00:54:49Z</updated>
<summary type="html"><p>User account <a href="/index.php?title=User:Saillocust5&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Saillocust5 (page does not exist)"><bdi>Saillocust5</bdi></a> was created</p>
</summary>
<author><name>Saillocust5</name></author> </entry>
<entry>
<id>https://humanlove.stream/wiki/User:Nedergaardford9265</id>
<title>User:Nedergaardford9265</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Nedergaardford9265"/>
<updated>2025-05-10T00:54:47Z</updated>
<summary type="html"><p>User account <a href="/index.php?title=User:Nedergaardford9265&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Nedergaardford9265 (page does not exist)"><bdi>Nedergaardford9265</bdi></a> was created</p>
</summary>
<author><name>Nedergaardford9265</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=10_Facts_About_Driving_Licence_Buy_That_Will_Instantly_Put_You_In_Good_Mood&diff=3065481&oldid=0</id>
<title>10 Facts About Driving Licence Buy That Will Instantly Put You In Good Mood</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=10_Facts_About_Driving_Licence_Buy_That_Will_Instantly_Put_You_In_Good_Mood&diff=3065481&oldid=0"/>
<updated>2025-05-10T00:54:43Z</updated>
<summary type="html"><p>Created page with &quot;&lt;h2&gt;The Risks and Consequences of Buying a Driving License: What You Need to Know&lt;/h2&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;In a world where faster ways often appear enticing, the temptation to buy...&quot;</p>
<p><b>New page</b></p><div>&lt;h2&gt;The Risks and Consequences of Buying a Driving License: What You Need to Know&lt;/h2&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;In a world where faster ways often appear enticing, the temptation to buy a driving license can look like a quick fix for those who are either unable or unwilling to go through the basic application process. Nevertheless, this apparently easy transaction carries substantial threats and repercussions. Before considering such an option, people need to understand the legal ramifications, safety issues, and ethical considerations related to the act of buying a driving license.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;h2&gt;Comprehending the Driving License&lt;/h2&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;A driving license serves as an official file that licenses a private to run an automobile. It is not merely a piece of plastic; it represents a person's competence in lorry operation and adherence to the rules of the road. Acquiring a driving license typically includes:&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;ol&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;&lt;strong&gt;Written Exam&lt;/strong&gt;: Understanding traffic laws and regulations.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;&lt;strong&gt;Vision Test&lt;/strong&gt;: Ensuring that the candidate can see properly.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;&lt;strong&gt;Practical Driving Test&lt;/strong&gt;: Demonstrating the capability to operate a car properly.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt;&lt;/ol&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;This comprehensive procedure is designed to ensure that just qualified individuals are permitted to drive, ultimately adding to public security.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;h2&gt;The Dark Side of Buying a Driving License&lt;/h2&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;While the attraction of a fast and simple option may lure some people, heading down the path of buying a driving license carries many downsides:&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;h3&gt;1. Legal Penalties&lt;/h3&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Buying a driving license is illegal in the majority of jurisdictions. The repercussions of being caught can be extreme, varying from hefty fines to jail time. Depending on regional laws, people may face:&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;ul&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;Criminal charges for scams or forgery.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;Suspension or revocation of any legitimate license they might later on get.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;Legal action versus sellers, which might cause increased examination on purchasers.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt;&lt;/ul&gt;&lt;br /&gt;&lt;br /&gt;&lt;h3&gt;2. Security Concerns&lt;/h3&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;People who buy a driving license frequently do not have the necessary training and knowledge needed to run a car safely. This can lead to dangerous scenarios on the road, which can threaten not just the purchaser however likewise other road users. Statistics indicate that inexperienced drivers are more prone to traffic accidents, which can lead to:&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;ul&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;Fatalities or severe injuries.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;Increased insurance coverage premiums for all drivers.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;Pressure on public resources like emergency situation services and hospitals.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt;&lt;/ul&gt;&lt;br /&gt;&lt;br /&gt;&lt;h3&gt;3. Ethical Considerations&lt;/h3&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Purchasing a driving license not only endangers individual security but likewise raises ethical concerns. It undermines the stability of the licensing system, which is developed to make sure that all drivers stick to the exact same requirements. Those who buy licenses basically cheat the system, impacting those dedicated to becoming safe, accountable drivers.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;h3&gt;4. Financial Risks&lt;/h3&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;While buying a driving license might appear more affordable than the expenses associated with genuine training and testing, it can have hidden expenses. These might consist of:&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;ul&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;Legal costs if captured.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;Increased insurance coverage rates if included in an accident as an unqualified driver.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;The possible requirement to go through the training and testing process anyway if the license is invalidated.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt;&lt;/ul&gt;&lt;br /&gt;&lt;br /&gt;&lt;h2&gt;How to Obtain a Legitimate Driving License&lt;/h2&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;For those who may think about buying a driving license due to impatience or perceived hassle, it's essential to understand that the main path is both available and useful in the long run. Here's a detailed guide to obtaining a genuine driving license:&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;ol&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;&lt;p&gt;&lt;strong&gt;Research Requirements&lt;/strong&gt;: Check the particular requirements for your jurisdiction, as these can differ extensively.&lt;/p&gt;&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;&lt;p&gt;&lt;strong&gt;Take a Driver's Education Course&lt;/strong&gt;: Many locations require or suggest taking a driver's education class, which can offer essential understanding and skills.&lt;/p&gt;&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;&lt;p&gt;&lt;strong&gt;Practice Driving&lt;/strong&gt;: Gain practical experience with a responsible and qualified driver directing you.&lt;/p&gt;&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;&lt;p&gt;&lt;strong&gt;Arrange a Written Test&lt;/strong&gt;: Prepare for the composed exam by studying your local traffic code and products offered by your licensing authority.&lt;/p&gt;&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;&lt;p&gt;&lt;strong&gt;Pass a Vision Test&lt;/strong&gt;: Ensure your eyesight meets required standards for driving.&lt;/p&gt;&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;&lt;p&gt;&lt;strong&gt;Complete the Driving Test&lt;/strong&gt;: After passing the composed test, book a practical driving test with a certified examiner.&lt;/p&gt;&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;&lt;p&gt;&lt;strong&gt;Receive your License&lt;/strong&gt;: Upon effective conclusion of all required examinations and training, you'll be provided a genuine driving license.&lt;/p&gt;&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt;&lt;/ol&gt;&lt;br /&gt;&lt;br /&gt;&lt;h2&gt;FAQs about Buying a Driving License&lt;/h2&gt;&lt;br /&gt;&lt;br /&gt;&lt;h3&gt;1. What are the risks of buying a driving license?&lt;/h3&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Buying a driving license postures legal, security, ethical, and monetary threats, consisting of potential jail time, accidents due to insufficient driving abilities, and increased insurance costs.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;h3&gt;2. Can I get a genuine driving license if I've currently purchased one?&lt;/h3&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;It's possible, however you might face legal consequences. It is a good idea to speak with a legal expert regarding your particular circumstance before proceeding to get a legitimate license.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;h3&gt;3. How can I report someone selling fake driving licenses?&lt;/h3&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;In many jurisdictions, you can report suspicious activity to local police or the Department of Motor Vehicles (DMV). Providing details such as names and areas can assist authorities resolve the issue.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;h3&gt;4. Are there any safe options to buying a license if I'm struggling?&lt;/h3&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Yes, consider enrolling in a driver's education program or looking for assistance from a coach or expert trainer to help you gain confidence and abilities behind the wheel.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;h3&gt;5. What should I do if I believe I've bought a fake driving license?&lt;/h3&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;If you think you've purchased a phony license, it's crucial to cease using it right away and notify the relevant authorities, such as the DMV, to avoid legal penalties against yourself.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;The temptation to buy a driving license is reasonable, specifically for those nervous to support the wheel. However, the consequences far outweigh any viewed advantages. By focusing on legitimate opportunities to obtain a driving license, individuals can ensure their own security and the safety of others on the road. Additionally, this investment of time and effort will result in a substantially more satisfying driving experience in the long run. Buying [https://click4r.com/posts/g/20852760/5-driving-license-online-myths-you-should-stay-clear-of related web site] is not practically obtaining a license; it's about ending up being a responsible, experienced driver.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;</div></summary>
<author><name>Radishparrot58</name></author> </entry>
<entry>
<id>https://humanlove.stream/wiki/User:Kidneyquill60</id>
<title>User:Kidneyquill60</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Kidneyquill60"/>
<updated>2025-05-10T00:54:35Z</updated>
<summary type="html"><p>User account <a href="/index.php?title=User:Kidneyquill60&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Kidneyquill60 (page does not exist)"><bdi>Kidneyquill60</bdi></a> was created</p>
</summary>
<author><name>Kidneyquill60</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=Blevinsblum9980&diff=3065480&oldid=0</id>
<title>Blevinsblum9980</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Blevinsblum9980&diff=3065480&oldid=0"/>
<updated>2025-05-10T00:54:34Z</updated>
<summary type="html"><p>Created page with &quot;As a conclusion, the BI tool enables greater organization and planning, facilitating the Family Health Clinic management, mainly for the monitoring of indicators and evaluatio...&quot;</p>
<p><b>New page</b></p><div>As a conclusion, the BI tool enables greater organization and planning, facilitating the Family Health Clinic management, mainly for the monitoring of indicators and evaluation processes.The National Primary Care Policy has provided a significant change in terms of health actions in the riverside territory, establishing health teams and equipment. The Riverside and Fluvial Family Health teams for the Legal Amazon and Pantanal areas have been innovative regarding the integral care of the forest populations. This study aims to analyze primary health care in the rural and riverside context in the Amazon territory, based on the production of individual and collective actions by health teams, as well as their performance through services offered in the municipalities. The study is cross-sectional, with a descriptive-analytical design and quantitative approach, and analyzes the coverage of primary health care actions of family health strategy teams in urban, rural and riverside areas of eight municipalities located in the state of Amazonas. The results showed that there was an increase in primary care coverage in almost all analyzed municipalities, indicating that techno-assistance models such as the riverside and fluvial teams resulted in the inclusion of a population that is scattered over large areas of the territory of municipalities. A health policy that promotes equity results in changes and alterations in the ways of life and health status of the Amazonian populations.Technological advances play an undeniable role in strengthening health systems. With regard to digital technologies, information systems and the analysis of health data are playing a growing role in health surveillance and preparing for and responding to disease outbreaks, the theme addressed by this article within the context of the Covid-19 pandemic in the State of Rio Grande do Norte. [https://www.selleckchem.com/products/shikonin.html Shikonin clinical trial] This study departs from the assumption that digital health interventions can increase Covid-19 response capacity. We developed a technology ecosystem that integrates different information systems to meet the needs outlined in international regulations governing the response to the pandemic. In addition to the main elements of the ecosystem, this article describes the application of this instrument by different institutional actors. The main decision making tool used in the state government's Covid-19 response, the ecosystem is a model for digital health interventions in Brazil's national health service. This experience in Rio Grande do Norte brings together elements that can contribute to studies investigating the resilience of health systems and analyzing health policies in emergency situations.Barriers faced by health services providing scheduled care result in high no-show rates. This article describes the main characteristics of an online appointment scheduling system incorporated into the citizens' electronic health record system (PEC e-SUS APS). Developed by the Bridge Laboratory, Federal University of Santa Catarina, which also developed the PEC e-SUS APS, the system allows patients to schedule appointments using the national patient communications hub, Conecte SUS Cidadão. The PEC e-SUS APS includes a professional's agenda module that allows patients to view available time slots and book and cancel appointments. Unfortunately, despite the benefits of online scheduling systems, their potential has been poorly exploited in Brazil. The main reasons for this include lack of information and training of health professionals on how to use the system and its potential benefits for Primary Health Care (PHC) services. Wider dissemination is needed to improve the adoption of the system and promote the routine use of this tool in health services in order to facilitate access to primary health care.This article aims to present the experience of 15 years of the Family Health Residency Program of the Sérgio Arouca National School of Public Health (ENSP/Fiocruz) in the city of Rio de Janeiro-RJ, and seeks to identify the challenges and potentialities of the training process of preceptors facing the development of resident training programs. Presents one of its effects that resulted in the contribution with the development of a multiprofessional residency program in partnership with the Municipal Health Department of Campo Grande-MS. Seeks to identify the challenges and potentialities of preceptors training process in the face of the development of training programs for residents. From a theoretical point of view, it presents as cross-cutting questions, multiprofessionality, interprofessionality and the relationship between field and nucleus in the formation of residences in the health professional area. Concludes by pointing out the challenges contained in the practice of the preceptorship of the ENSP program and how they can be implemented in the project of Campo Grande, as well as a new trend for cooperative education institutions for the current model of expansion of residences with the unit offeror to the municipal health departments.This article presents and problematizes innovation actions aimed at improving the quality of Primary Health Care (PHC), describing an experience that can be adapted to different contexts, considering diverse sociodemographic, economic, cultural and epidemiological realities. We conducted an exploratory study using documentary sources referring to the implementation of the Campo Grande Laboratory for Innovation in Primary Health Care (INOVAAPS). The project proposes the reorientation of the care model adopted in the municipality's public primary care services, redefining work processes and improving the quality of practice. We identified product, process and organizational innovations that have the potential to transform and tailor health care practices to the population's health needs. It is concluded that the proposals implemented by the project focus on the consolidation and expansion of access to primary care, recruitment and training of adequately qualified health professionals, adoption of resolutive technologies, regulatory improvement, and strengthening the mediating role of primary health care.</div></summary>
<author><name>Blevinsblum9980</name></author> </entry>
<entry>
<id>https://humanlove.stream/wiki/User:Dahlsloan5909</id>
<title>User:Dahlsloan5909</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Dahlsloan5909"/>
<updated>2025-05-10T00:54:33Z</updated>
<summary type="html"><p>User account <a href="/index.php?title=User:Dahlsloan5909&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Dahlsloan5909 (page does not exist)"><bdi>Dahlsloan5909</bdi></a> was created</p>
</summary>
<author><name>Dahlsloan5909</name></author> </entry>
<entry>
<id>https://humanlove.stream/wiki/User:Forsythkirkland0003</id>
<title>User:Forsythkirkland0003</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Forsythkirkland0003"/>
<updated>2025-05-10T00:54:19Z</updated>
<summary type="html"><p>User account <a href="/index.php?title=User:Forsythkirkland0003&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Forsythkirkland0003 (page does not exist)"><bdi>Forsythkirkland0003</bdi></a> was created</p>
</summary>
<author><name>Forsythkirkland0003</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=Langleysosa5855&diff=3065479&oldid=0</id>
<title>Langleysosa5855</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Langleysosa5855&diff=3065479&oldid=0"/>
<updated>2025-05-10T00:54:06Z</updated>
<summary type="html"><p>Created page with &quot;The field of landscape genetics has been rapidly evolving, adopting and adapting analytical frameworks to address research questions. Current studies are increasingly using re...&quot;</p>
<p><b>New page</b></p><div>The field of landscape genetics has been rapidly evolving, adopting and adapting analytical frameworks to address research questions. Current studies are increasingly using regression-based frameworks to infer the individual contributions of landscape and habitat variables on genetic differentiation. This paper outlines appropriate and inappropriate uses of multiple regression for these purposes, and demonstrates through simulation the limitations of different analytical frameworks for making correct inference. Of particular concern are recent studies seeking to explain genetic differences by fitting regression models with effective distance variables calculated independently on separate landscape resistance surfaces. When moving across the landscape, organisms cannot respond independently and uniquely to habitat and landscape features. Analyses seeking to understand how landscape features affect gene flow should model a single conductance or resistance surface as a parameterized function of relevant spatial covariates, and estimate the values of these parameters by linking a single set of resistance distances to observed genetic dissimilarity via a loss function. While this loss function may involve a regression-like step, the associated nuisance parameters are not interpretable in terms of organismal movement and should not be conflated with what is actually of interest the mapping between spatial covariates and conductance/resistance. The growth and evolution of landscape genetics as a field has been rapid and exciting. It is the goal of this paper to highlight past missteps and demonstrate limitations of current approaches to ensure that future use of regression models will appropriately consider the process being modeled, which will provide clarity to model interpretation.Autophagy is a self-degradative process that is crucial for maintaining cellular homeostasis by removing damaged cytoplasmic components and recycling nutrients. Such an evolutionary conserved proteolysis process is regulated by the autophagy-related (Atg) proteins. The incomplete understanding of plant autophagy proteome and the importance of a proteome-wide understanding of the autophagy pathway prompted us to predict Atg proteins and regulators in Arabidopsis. Here, we developed a systems-level algorithm to identify autophagy-related modules (ARMs) based on protein subcellular localization, protein-protein interactions, and known Atg proteins. This generates a detailed landscape of the autophagic modules in Arabidopsis. We found that the newly identified genes in each ARM tend to be upregulated and coexpressed during the senescence stage of Arabidopsis. We also demonstrated that the Golgi apparatus ARM, ARM13, functions in the autophagy process by module clustering and functional analysis. To verify the in silico analysis, the Atg candidates in ARM13 that are functionally similar to the core Atg proteins were selected for experimental validation. Interestingly, two of the previously uncharacterized proteins identified from the ARM analysis, AGD1 and Sec14, exhibited bona fide association with the autophagy protein complex in plant cells, which provides evidence for a cross-talk between intracellular pathways and autophagy. [https://www.selleckchem.com/products/salinosporamide-a-npi-0052-marizomib.html selleck products] Thus, the computational framework has facilitated the identification and characterization of plant-specific autophagy-related proteins and novel autophagy proteins/regulators in higher eukaryotes.Transvascular interventional radiology procedures have advanced in veterinary medicine, but basic knowledge about expected vascular size and vascular imaging requires further exploration. A prospective analytical study of 230 client-owned dogs was carried out to investigate correlations between ultrasound-measured femoral artery (FA) and femoral vein (FV) diameter and various morphometric and demographic dog variables, compare ultrasound-measured femoral vessel diameter to diameter predicted by body weight, compare right- and left-sided femoral vessel diameter, and assess measurement repeatability. Internal diameter of the FA and FV was measured with ultrasound bilaterally. Allometrically scaled body weight had the strongest correlation with FA and FV diameter (correlation coefficients 0.92 and 0.80, respectively), although thigh circumference (FA 0.89; FV0.78) and withers height (FA 0.84; FV 0.76) were also strongly correlated. Within the entire population, males had a smaller FA (P = .005), but not FV (P = .278), than females and age was negatively associated with FA (P = .031) and FV (P less then .001) diameter. Compared to ultrasound-derived measurements, body weight-predicted diameter overestimated by at least one French gauge in 32.6% and 35.2% of dogs for the FA and FV, respectively. Comparison of left and right FA and FV diameter revealed minimal mean differences, though limits of agreement could encompass multiple French gauge sizes (Mean difference [limits of agreement] FA = 0.00 mm [0.85-0.84 mm]; FV = 0.04 mm [1.92-1.99 mm]). Intra- and interoperator repeatability coefficients of variation were less then 9%. Femoral vessel diameter in dogs is influenced by multiple factors, with potential for clinically relevant differences between right- and left-sided vessels. Ultrasound measurement of femoral vessels could improve transvascular preprocedural planning.Periodontitis is an irreversible, chronic inflammatory disease where inflammophilic pathogenic microbial communities accumulate in the gingival crevice. Neutrophils are a major component of the innate host response against bacterial challenge, and under homeostatic conditions, their microbicidal functions typically protect the host against periodontitis. However, a number of periodontal pathogens developed survival strategies to evade neutrophil microbicidal functions while promoting inflammation, which provides a source of nutrients for bacterial growth. Research on periodontal pathogens has largely focused on a few established species Tannerella forsythia, Treponema denticola, Fusobacterium nucleatum, Aggregatibacter actinomycetemcomitans, and Porphyromonas gingivalis. However, advances in culture-independent techniques have facilitated the identification of new bacterial species in periodontal lesions, such as the two Gram-positive anaerobes, Filifactor alocis and Peptoanaerobacter stomatis, whose characterization of pathogenic potential has not been fully described.</div></summary>
<author><name>Langleysosa5855</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=Peelecarstens9534&diff=3065478&oldid=0</id>
<title>Peelecarstens9534</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Peelecarstens9534&diff=3065478&oldid=0"/>
<updated>2025-05-10T00:54:04Z</updated>
<summary type="html"><p>Created page with &quot;STUDY DESIGN Longitudinal Cohort Study OBJECTIVE. Determine if duration of postoperative opioids is associated with long term outcomes, and if initial postoperative opioid dos...&quot;</p>
<p><b>New page</b></p><div>STUDY DESIGN Longitudinal Cohort Study OBJECTIVE. Determine if duration of postoperative opioids is associated with long term outcomes, and if initial postoperative opioid dosage is associated with opioid cessation after spine surgery. SUMMARY OF BACKGROUND DATA Preoperative opioid use is associated with poor outcomes, but little evidence exists regarding the implications of opioid dosage and duration after spine surgery. METHODS Data from our state's prescription drug database was linked to our prospective clinical spine registry to analyze opioid dispensing and outcomes in elective surgical spine patients between 2010 and 2017. Patients were stratified based on preoperative chronic opioid use and multivariable regression was used to assess associations between duration of postoperative opioids and outcomes at one year, including satisfaction, chronic opioid use, and meaningful improvements in pain, disability, and quality of life. In a secondary aim, a Cox proportional hazards model was used to determine iffaster opioid cessation. LEVEL OF EVIDENCE 2.STUDY DESIGN Prospective database analysis OBJECTIVE. To assess the effect of age on patient-reported outcomes (PROs) and complication rates after surgical treatment for spondylolisthesis SUMMARY OF BACKGROUND DATA. [https://www.selleckchem.com/products/o-propargyl-puromycin.html O-Propargyl-Puromycin] Degenerative lumbar spondylolisthesis affects 3-20% of the population and up to 30% of the elderly. There is not yet consensus on whether age is a contraindication for surgical treatment of elderly patients. METHODS The Quality Outcomes Database lumbar registry was used to evaluate patients from 12 U.S. academic and private centers who underwent surgical treatment for grade 1 lumbar spondylolisthesis between July 2014 and June 2016. RESULTS A total of 608 patients who fit the inclusion criteria were categorized by age into the following groups 80-year-old patients; p = 0.002). There were no baseline differences in PROs (Oswestry Disability Index, EQ-5D, Numeric Rating Scale for leg pain and back pain) among age categories. A significant improvement for all PROs was seen regardless of age (p less then 0.05), and most patients met minimal clinically important differences (MCIDs) for improvement in postoperative PROs. No differences in hospital readmissions or reoperations were seen among age groups (p less then 0.05). Multivariate analysis demonstrated that, after controlling other variables, a higher age did not decrease the odds of achieving MCID at 12 months for the PROs. CONCLUSION Our results indicate that well-selected elderly patients undergoing surgical treatment of grade 1 spondylolisthesis can achieve meaningful outcomes. This modern, multicenter U.S. study reflects the current use and limitations of spondylolisthesis treatment in the elderly, which may be informative to patients and providers. LEVEL OF EVIDENCE 4.STUDY DESIGN Retrospective cohort OBJECTIVE. To determine how type, location, and size of endplate lesions on magnetic resonance imaging (MRI) may be associated with symptomatology and clinical outcomes after ACDF. SUMMARY OF BACKGROUND DATA Structural endplate abnormalities are important phenomena that remain understudied in the cervical spine. Anterior cervical discectomy and fusion (ACDF) is a common surgical treatment for degenerative disc disease; however, adjacent segment degeneration/disease (ASD) may develop. METHODS We performed a retrospective study with prospectively-collected data of patients who underwent ACDF. Charts were reviewed for preoperative sagittal MRI of the cervical spine. Endplate abnormalities were identified and stratified by type (atypical, typical), location, relation to operative levels, presence at the adjacent level, and size. These strata were assessed for association with presenting symptoms, patient-reported, and postoperative outcomes. RESULTS Of 861 patients, 57.3% had eviwith atypical abnormalities experienced greater rates of ASD and reoperation. This highlights the relevance of a degenerative spine phenotypic assessment, and suggests endplate abnormalities may prognosticate clinical outcomes after surgery. LEVEL OF EVIDENCE 3.STUDY DESIGN Case-control study from a continuous series OBJECTIVES. To study the impact of perioperative sitting radiographs in adult spinal deformity (ASD) patients and determine whether proximal junctional kyphosis (PJK) can be prevented using preoperative sitting radiograph. SUMMARY OF BACKGROUND DATA Radiographic analysis of ASD comprises standing whole-spine radiography which cannot evaluate the relaxed posture without head-to-foot compensation. METHODS Preoperative and postoperative whole-spine standing and sitting radiographs and proximal mechanical complications in surgically treated spinal disorders with a minimum of 1-year follow-up were studued. Whole-spinal alignment was defined by cervical lordosis (CL), sagittal vertical axis (SVA), T1 slope (T1S), thoracic kyphosis (TK), lumbar lordosis (LL), pelvic incidence (PI), pelvic tilt (PT), sacral slope (SS), and level of kyphotic apex (KA). Proximal mechanical complication was described as a PJK (proximal junctional angle &amp;gt;20°) or reoperation due to V to the C2 plumb line in preoperative sitting radiographs. LEVEL OF EVIDENCE 3.STUDY DESIGN Cross-sectional survey. OBJECTIVE To determine the prevalence of back pain in American children and adolescents, with a focus on anatomic region, duration, severity, and treatment patterns, and to investigate for any predictive variables. SUMMARY OF BACKGROUND DATA No study has examined the prevalence of back pain in American children and adolescents in the last 15 years. Because the prevalence of back pain varies greatly by country and year of investigation, previous studies are not generalizable. METHODS A United States epidemiological cross-sectional survey-based investigation was performed in children and adolescents ages between 10 and 18 years, equally split by age and sex, and representing census-weighted distributions of state of residence, race/ethnicity, and health insurance status. Prevalence of back pain was evaluated and described. RESULTS In total, 1236 (33.7%) participants reported experiencing back pain within the last year and 325 (8.9%) reported severe back pain within the last year.</div></summary>
<author><name>Peelecarstens9534</name></author> </entry>
<entry>
<id>https://humanlove.stream/wiki/User:Michaelsenhoyle8719</id>
<title>User:Michaelsenhoyle8719</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Michaelsenhoyle8719"/>
<updated>2025-05-10T00:54:03Z</updated>
<summary type="html"><p>User account <a href="/index.php?title=User:Michaelsenhoyle8719&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Michaelsenhoyle8719 (page does not exist)"><bdi>Michaelsenhoyle8719</bdi></a> was created</p>
</summary>
<author><name>Michaelsenhoyle8719</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=Wilkinsonmadsen4563&diff=3065477&oldid=0</id>
<title>Wilkinsonmadsen4563</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Wilkinsonmadsen4563&diff=3065477&oldid=0"/>
<updated>2025-05-10T00:54:02Z</updated>
<summary type="html"><p>Created page with &quot;To identify the risk factors of strabismus surgery among Taiwanese children with severe cerebral palsy (CP) and strabismus.&lt;br /&gt;&lt;br /&gt; This retrospective nationwide populatio...&quot;</p>
<p><b>New page</b></p><div>To identify the risk factors of strabismus surgery among Taiwanese children with severe cerebral palsy (CP) and strabismus.&lt;br /&gt;&lt;br /&gt; This retrospective nationwide population-based cohort study examined a cohort of newly diagnosed pediatric CP patients (age ≤ 10 y) between 1997 and 2013 with strabismus. The primary endpoint was strabismus surgery. A stepwise logistic regression was applied to determine the demographic factors, ophthalmic conditions, and comorbidities associated with strabismus surgery.&lt;br /&gt;&lt;br /&gt; Out of 808 patients, 115 had received strabismus surgery. The significant factors correlated to strabismus surgery in pediatric patients with severe CP and strabismus were CP diagnosis age &amp;lt; 4 years, residency in a suburban/rural area, low birth weight, and strabismic amblyopia.&lt;br /&gt;&lt;br /&gt; In CP children with strabismus who have risk factors of younger CP diagnosis age (age &amp;lt; 4 y), residency in a suburban/rural area, a low birthweight, and the presence of strabismic amblyopia, strabismus surgery should be considered.&lt;br /&gt;&lt;br /&gt;In CP children with strabismus who have risk factors of younger CP diagnosis age (age less then 4 y), residency in a suburban/rural area, a low birthweight, and the presence of strabismic amblyopia, strabismus surgery should be considered.&lt;br /&gt;&lt;br /&gt; Lung cancer contributes to high cancer mortality worldwide with 80% of total cases diagnosed as non-small cell lung cancer (NSCLC). [https://www.selleckchem.com/products/10058-f4.html selleck chemical] Epidermal growth factor receptor (EGFR) tyrosine kinase (TK) domain serves as a druggable target in NSCLC patients with exon 19 deletion and L858R mutation. However, patients eventually succumbed to resistance to first- and second-generation EGFR-TK inhibitors through activation of T790M mutation. Third-generation EGFR-TKI, Osimertinib exhibits high efficacy in patients with exon 19 deletion/L858R/T790M mutation but they experienced acquired resistance thereafter. Available treatment options in NSCLC patients remains a challenge due to unknown molecular heterogeneity responsible for acquired resistance to EGFR-TKI. In this study, we aim to generate Osimertinib-resistant (OR) cells from H1975 carrying L858R/T790M double mutation which can be used as a model to elucidate mechanism of resistance.&lt;br /&gt;&lt;br /&gt; OR cells were established via stepwise-dose escalation and limiting single-cell dilstance cells may serve as in-vitro model facilitating discovery of molecular aberration present during acquired mechanism of resistance.&lt;br /&gt;&lt;br /&gt; Sialic acids (SIAs), for example, α2,6-SIAs, can link to conserved N-glycans of immunoglobulin G (IgG). In this study, we investigated the correlation between α2,6-SIA on IgG and IgM and the disease activity of arthritis and rheumatoid arthritis (RA) in mice.&lt;br /&gt;&lt;br /&gt; We measured α2,6-SIA levels in IgGs and IgMs in collagen-induced arthritis (CIA). Additionally, α2,6-SIA levels in rheumatoid factors (RFs) and anti-cyclic citrullinated peptide (anti-CCP) antibodies in RA patients were measured. Correlations between α2,6-SIA on Igs and CIA were analyzed and also in RA patients by utilizing the disease activity score 28 (DAS28). The ability to differentiate RA progression by Ig and autoantibody α2,6-SIA levels was examined.&lt;br /&gt;&lt;br /&gt; In CIA mice, plasma IgG-α2,6-SIA/IgG ratios decreased, whereas plasma IgM-α2,6-SIA/IgM ratios increased. Moreover, arthritis was not observed in collagen-injected mice with decreased IgG-α2,6-SIA/IgG ratios and without increased IgM-α2,6-SIA/IgM ratios. Isolated IgG-α2,6-SIA/IgG ratios displayedA ratios on IgM and IgG correlated with the occurrence of CIA and RA disease activity. Thus, α2,6-SIA ratios on IgG-anti-CCP antibodies and IgMRF are potential markers for evaluating RA disease activities.&lt;br /&gt;&lt;br /&gt; Gene therapy is the advanced therapeutics for supplying or replacing the genetic material in patients with inherited disorders. Recent clinical studies have made some progress in a wide range of applications, including monogenic disorders, neurodegenerative diseases, malignant tumors, and congenital diseases. Heart diseases, especially myocardial ischemia, remain one of the leading causes of mortality worldwide and usually result in irreparable cardiomyocyte damage and severe heart failure.&lt;br /&gt;&lt;br /&gt; Most advances in induced pluripotent stem cell (iPSC) technologies for promoting regenerative medicine and stem cell research. However, the driver molecules of myocardial-lineage differentiation and the functional reconstruction capacity of iPSC-derived cardiomyocytes are still an open question. Nanomedicine-based gene delivery provided a crucial platform to carry on the biogenomic materials for equipping functionalities and engineering the living organ environment. Nanodiamond (ND), a carbon-based nanomaterial, has been discovered and shown the high biocompatible and less toxicity for transporting protein, drug, and genomic plasmids.&lt;br /&gt;&lt;br /&gt; Here, we applied ND as a gene delivery vehicle to carry microRNA (miR-181a), and then transfected into iPS to promote cardiomyocyte-lineage differentiation. Notably, miR-181a plays a key role in iPS-derived cardiomyocyte differentiation which directly targets Hox-A11, leading to elevated MyoD expression and enhanced cardiomyocyte differentiation.&lt;br /&gt;&lt;br /&gt; Our study demonstrated that miR-181a promotes iPSC differentiation into functional cardiomyocytes. Delivery of NANO-DIAMOND-miR-181a may host clinical potential to enhance the differentiation and recovery of the cardiogenic function in injured cardiomyocytes.&lt;br /&gt;&lt;br /&gt;Our study demonstrated that miR-181a promotes iPSC differentiation into functional cardiomyocytes. Delivery of NANO-DIAMOND-miR-181a may host clinical potential to enhance the differentiation and recovery of the cardiogenic function in injured cardiomyocytes.&lt;br /&gt;&lt;br /&gt; Nonalcoholic steatohepatitis (NASH) is closely related to reactive oxygen species (ROS). Superoxide anion radicals, the main product of ROS, can be reduced by manganese superoxide dismutase (SOD2) to hydrogen peroxide, which is further reduced by catalase (CAT) and glutathione peroxidase (GPX) to water. We aimed to investigate the association between the most important genetic variants of SOD2, CAT, and GPX1 and susceptibility to NASH.&lt;br /&gt;&lt;br /&gt; A total of 126 adults with liver tissue-verified NASH, 56 patients with liver tissue-verified nonalcoholic fatty liver (NAFL), and 153 healthy controls were enrolled. Their DNA profiles were retrieved for genotype assessment of SOD2 47T&amp;gt;C (rs4880), CAT -262C&amp;gt;T (rs1001179), and GPX1 593C&amp;gt;T (rs1050450) variation.&lt;br /&gt;&lt;br /&gt; There were statistical differences between the SOD2 and CAT genotypes across the NASH, NAFL, and control groups, but not GPX1. The NASH group had a significantly higher frequency of subjects with SOD2 C allele (38.8%) compared with the NASL group (25.0%) and the controls (22.</div></summary>
<author><name>Wilkinsonmadsen4563</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=Mccannhutchison2846&diff=3065476&oldid=0</id>
<title>Mccannhutchison2846</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Mccannhutchison2846&diff=3065476&oldid=0"/>
<updated>2025-05-10T00:53:56Z</updated>
<summary type="html"><p>Created page with &quot;Hospital Information Systems assessment is important to ensure the quality of provided healthcare services. This research evaluates the success of the clinical information sys...&quot;</p>
<p><b>New page</b></p><div>Hospital Information Systems assessment is important to ensure the quality of provided healthcare services. This research evaluates the success of the clinical information system used in the General Hospital &quot;Asklepieio Voulas&quot;. A questionnaire was developed based on the DeLone &amp;amp; McLean information systems success model, and used on February 2020, to record the users' opinions regarding the information system. The reliability of the questionnaire was tested by applying Cronbach's alpha analysis, descriptive statistics was calculated for all variables of the questionnaire, and new variables was created to investigate the relationships between the model's factors. Correlation analysis between the factors and linear multiple regression analysis between some of the factors of the DeLone &amp;amp; McLean success model were conducted 218 users responded to the survey, 56.3% of them were medical doctors, 24.1% nurses, and 19.6% other staff of the hospital. [https://www.selleckchem.com/products/elexacaftor.html selleck products] Results highlight that the users of the system are satisfied with it. A77.3% of the participants believe that they perform their work more easily when using the system, while 89.3% of the participants believe that the system is useful in their work. According to the results of the model, system quality and information quality seems to be related with the system usage. Information quality plays the most important role in the use of the system while the system quality plays the most important role in user satisfaction. Based on the users' opinions, the &quot;Asklepieio Voulas&quot; Hospital Information System can be assumed as successful.&lt;br /&gt;&lt;br /&gt; This study aimed to evaluate the effectiveness of tele-expertise (tele-ECG) in primary health care in Cameroon for the management of patients with cardiovascular diseases or risk factors.&lt;br /&gt;&lt;br /&gt; It is a controlled multicenter study carried out in Cameroon's two health facilities where tele-ECG has been implemented (intervention centers) and two other where telemedicine has been not implemented (control centers). Patients having cardiovascular risk factors or diseases received usual primary health care in the control centers. In contrast, they received usual primary health care and could perform an ECG associated with cardiologists' remote expertise (tele-ECG) in the intervention centers. The primary outcome was to evaluate the rate of patients' access to an ECG test and to cardiologist' expertise.&lt;br /&gt;&lt;br /&gt; Telemedicine is effective for the management of patients with cardiovascular diseases in primary health care. It could improve healthcare providers' clinical processes, clinical outcomes of patients and their satisfaction.&lt;br /&gt;&lt;br /&gt;Telemedicine is effective for the management of patients with cardiovascular diseases in primary health care. It could improve healthcare providers' clinical processes, clinical outcomes of patients and their satisfaction.The CAPABLE project has been funded by the EU Horizon 2020 Programme over the years 2020-24 to support home care. A system is being designed and implemented supporting remote monitoring and virtual coaching for cancer patients. The system is based on a distributed modular architecture involving many components encapsulating various knowledge. The Case Manager has been designed as a separate component with the aim of coordinating the problem solving strategies. A first version of the Case Manager has been released and used by the components in a prototypical scenario shown at the first project review.Quality of care and patient satisfaction are important aspects of high standard care. If clinical staff is subject to an elevated workload there is a possible decrease of both. This justifies the development of tools to quantify the workload and to find organizational changes that will normalize it. We have previously developed a simulation system to quantify the workload of the staff working in a regional reference center for the treatment of bleeding and hemorrhagic disorders. The goal of this new work is to simulate, through an agent-based model, the impact of adding a physician to the staff. Ten sets of initial parameters were defined to simulate ten typical weeks. Results show that the introduction of the new physician together with a second ambulatory room can reduce the workload of all the staff to the expected 8-hour. In this situation, in which the staff workload does not exceed the daily capacity, we may suppose that an increase in the quality of care and patient satisfaction will be possible.To identify patients with similar clinical profiles and derive insights from the records and outcomes of similar patients can help fast and precise diagnosis and other clinical decisions for rare diseases. Similarity methods are required to take into account the semantic relations between medical concepts and also the different relevance of all medical concepts presented in patients' medical records. In this paper, we introduce the methods developed in the context of rare disease screening/diagnosis from clinical data warehouse using medical concept embedding and adjusted aggregations. Our methods provided better preliminary results than baseline methods, with a significant improvement of precision among the top ranked similar patients, which is encouraging for further fine-tuning and application on a large-scale dataset for new/candidate patient identification.Building on Rogers' Diffusion of Innovation Theory, Bass models describe the diffusion processes distinguishing between innovation (p) and imitation (q). This study aimed at modelling the uptake of RIS, PACS and EHR systems in Germany and Finland. The Bass models revealed a quick and almost identical uptake process across all three systems for Finland. In contrast, the Bass models mirrored a slower uptake in Germany. Consequently, the Finnish &quot;imitation&quot; coefficients were larger than the German ones. While in Germany almost free market forces were driving the adoption through imitation but without tail wind from policy, the adoption process in Finland was centrally governed. This suggests that the diffusion process in Finland reflected a well-managed roll-out of the systems rather than imitation behaviour. Thus, in order for Bass model coefficients to be understood properly, additional contextual information is required.</div></summary>
<author><name>Mccannhutchison2846</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=20_Resources_Thatll_Make_You_More_Efficient_At_Gas_Safety_Certificate_Landlord_Milton_Keynes&diff=3065475&oldid=0</id>
<title>20 Resources Thatll Make You More Efficient At Gas Safety Certificate Landlord Milton Keynes</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=20_Resources_Thatll_Make_You_More_Efficient_At_Gas_Safety_Certificate_Landlord_Milton_Keynes&diff=3065475&oldid=0"/>
<updated>2025-05-10T00:53:51Z</updated>
<summary type="html"><p>Created page with &quot;&lt;p&gt;Title: The Importance of a Gas Safety Certificate for Landlords in Milton Keynes&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;As a landlord, it is your legal obligation to guarantee the safety of you...&quot;</p>
<p><b>New page</b></p><div>&lt;p&gt;Title: The Importance of a Gas Safety Certificate for Landlords in Milton Keynes&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;As a landlord, it is your legal obligation to guarantee the safety of your occupants. One vital aspect of this responsibility is getting a gas safety certificate for your property in Milton Keynes. This certificate is evidence that all gas devices, fittings, and flues in the property are safe to use. In this article, we will go over the importance of a gas safety certificate for proprietors in Milton Keynes and address some frequently asked concerns.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Gas safety certificates are required by law for all rental properties in the UK. They need to be gotten annually by a Gas Safe registered engineer who will check all gas home appliances, fittings, and flues in the property to ensure they are safe to use. The engineer will check for gas leaks, carbon monoxide poisoning, and other prospective dangers.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;There are numerous reasons that a gas safety certificate is important for proprietors in Milton Keynes. To start with, it is a legal requirement. Failure to acquire a gas safety certificate can lead to fines, imprisonment, and even a restriction on renting out properties. Second of all, it makes sure the safety of your tenants. Gas home appliances that are not appropriately kept can lead to carbon monoxide poisoning, fires, and explosions. Thirdly, it can supply you with comfort, knowing that your property is safe and compliant with guidelines.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Frequently asked questions:&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Q: Who can issue a gas safety certificate? [https://copeland-vest-4.mdwrite.net/20-fun-details-about-gas-safety-certificate-landlord-milton-keynes boiler engineer milton keynes] : A Gas Safe registered engineer should release a gas safety certificate.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Q: How often do I need to get a gas safety certificate?A: A gas safety certificate must be obtained annually.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Q: What occurs if I don't have a gas safety certificate?A: Failure to get a gas safety certificate can lead to fines, jail time, and even a restriction on leasing out homes.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Q: How long does a gas safety certificate last?A: A gas safety certificate is valid for 12 months from the date of inspection.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Q: Can I carry out the gas safety check myself?A: No, only a Gas Safe registered engineer can carry out the gas safety check.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Here are some actions that landlords in Milton Keynes can require to guarantee they comply with gas safety policies:&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;ol&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;Only use a Gas Safe registered engineer to perform gas work.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;Keep records of all gas safety evaluations and share them with your occupants.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;Provide your occupants with a copy of the gas safety certificate before they move in.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;Perform routine gas safety checks.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;Guarantee that all gas home appliances are frequently serviced and preserved.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt;&lt;/ol&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;In conclusion, a gas safety certificate is an essential file for property owners in Milton Keynes. It ensures the safety of your tenants, supplies assurance, and is a legal requirement. By utilizing a Gas Safe registered engineer and performing routine gas safety checks, you can ensure that your home is compliant with guidelines and safe to lease.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;List of Gas Safe Registered Engineers in Milton Keynes:&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;ol&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;A &amp;amp; &amp;amp; J Gas Services - 01908 631112&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;CPS Gas Services - 01908 648648&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;D &amp;amp; &amp;amp; J Plumbing and Heating - 01908 374566&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;GAS Heating Services - 01908 631631&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;MK Gas Solutions - 01908 376060&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt;&lt;/ol&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;By following these actions and working with a Gas Safe registered engineer, you can make sure that your residential or commercial property is safe, compliant with regulations, and that your tenants are protected.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;</div></summary>
<author><name>Brakeglider69</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=Watkinsnikolajsen4776&diff=3065474&oldid=0</id>
<title>Watkinsnikolajsen4776</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Watkinsnikolajsen4776&diff=3065474&oldid=0"/>
<updated>2025-05-10T00:53:48Z</updated>
<summary type="html"><p>Created page with &quot;Overexpression associated with miR-1298 attenuates myocardial ischemia-reperfusion damage by simply focusing on PP2A.&lt;br /&gt;&lt;br /&gt;The aim of this study is to find out the pract...&quot;</p>
<p><b>New page</b></p><div>Overexpression associated with miR-1298 attenuates myocardial ischemia-reperfusion damage by simply focusing on PP2A.&lt;br /&gt;&lt;br /&gt;The aim of this study is to find out the practice patterns, awareness, and knowledge about psychodermatology in Albanian dermatologists. A survey questionnaire was sent to Albanian dermatologists by mail and distributed during a regional dermatology conference. The dermatologists were requested to provide information on demographic variables, level of training, referral patterns, degree of comfort in managing psychocutaneous disorders, awareness of community resources, and interest in continuing medical educational activities. A total of 75 surveys were mailed in and 41 were returned for analysis. Only 13.2% of dermatologists reported clear understanding of psychodermatology and 41.5% reported being somewhat comfortable in diagnosing and treating psychocutaneous disorders, however requiring further help. Psoriasis, prurigo, and acne were the most common diagnoses associated with psychiatric involvement. The most common diagnoses referred by dermatologists to psychiatrists were psoriasis, prurigo, acne, and trichotillomania. Almost all 98% of dermatologists were not aware of any community resources. [https://www.selleckchem.com/products/mrtx1133.html MRTX1133] About 70% of dermatologists expressed interest in attending continuing medical educational activities. Albanian dermatologist have significant gap in the knowledge, training, awareness, and in treating psychocutaneous disease. © 2020 Wiley Periodicals, Inc.Colletotrichum graminicola is a hemibiotrophic fungus that causes anthracnose leaf blight (ALB) and anthracnose&amp;nbsp;stalk rot (ASR) in maize. Despite substantial economic losses caused by these diseases, the defence mechanisms against this pathogen remain poorly understood. Several hormones are suggested to aid in defence against C.&amp;nbsp;graminicola, such as jasmonic acid (JA) and salicylic acid (SA), but supporting genetic evidence was not reported. Green leaf volatiles (GLVs) are a group of well-characterized volatiles that induce JA biosynthesis in maize and are known to function in defence against necrotrophic pathogens. Information regarding the role of GLVs and JA in interactions with (hemi)biotrophic pathogens remains limited. To functionally elucidate GLVs and JA in defence against a hemibiotrophic pathogen, we tested GLV- and JA-deficient mutants, lox10 and opr7 opr8, respectively, for resistance to ASR and ALB and profiled jasmonates and SA in their stalks and leaves throughout infection. Both mutants were resistant and generally displayed elevated levels of SA and low amounts of jasmonates, especially at early stages of infection. Pretreatment with GLVs restored susceptibility of lox10 mutants, but not opr7 opr8 mutants, which coincided with complete rescue of JA levels. Exogenous methyl jasmonate restored susceptibility in both mutants when applied before inoculation, whereas methyl salicylate did not induce further resistance in either of the mutants, but did induce mutant-like resistance in&amp;nbsp;the wild type. Collectively, this study reveals that GLVs and JA contribute to maize susceptibility to C.&amp;nbsp;graminicola due to suppression of SA-related defences. © 2020 The Authors. Molecular Plant Pathology published by British Society for Plant Pathology and John Wiley &amp;amp; Sons Ltd.Urea amidolyase (UA), a bifunctional enzyme that is widely distributed in bacteria, fungi, algae, and plants, plays a pivotal role in the recycling of nitrogen in the biosphere. Its substrate urea is ultimately converted to ammonium, via successive catalysis at the C-terminal urea carboxylase (UC) domain and followed by the N-terminal allophanate hydrolyse (AH) domain. Although our previous studies have shown that Kluyveromyces lactis UA (KlUA) functions efficiently as a homodimer, the architecture of the full-length enzyme remains unresolved. Thus how the biotin carboxyl carrier protein (BCCP) domain is transferred within the UC domain remains unclear. Here we report the structures of full-length KlUA in its homodimer form in three different functional states by negatively-stained single-particle electron microscopy. We report here that the ADP-bound structure with or without urea shows two possible locations of BCCP with preferred asymmetry, and that when BCCP is attached to the carboxyl transferase domain of one monomer, it is attached to the biotin carboxylase domain in the second domain. Based on this observation, we propose a BCCP-swinging model for biotin-dependent carboxylation mechanism of this enzyme. © 2020 The Protein Society.AIMS Chronic kidney disease (CKD) is associated with an increased risk of cardiovascular disease (CVD). We examined the characteristics, management and outcomes of patients with CKD in the All New Zealand Acute Coronary Syndrome Quality Improvement (ANZACS-QI) national registry. METHODS The cohort comprised New Zealand (NZ) patients with an acute coronary syndrome undergoing coronary angiography between January 2013 and December 2016. Patients were categorized according to their stage of CKD. [https://www.selleckchem.com/products/mrtx1133.html MRTX1133] Outcomes included all-cause and cause-specific mortality and hospitalization with myocardial infarction (MI), stroke and major bleeding. RESULTS Of the 20 604 patients, 20.3% had normal renal function, with 53.3%, 23.3%, 1.7% and 1.4% having CKD stages 2, 3, 4 and 5 CKD, respectively. Patients with severe CKD were more likely to be Māori or Pacific and live in an area with greater socioeconomic deprivation. Death, recurrent MI or stroke, and major bleeding all increased incrementally with each worsening stage of CKD severity. Compared with those with normal renal function, patients with stage 5 CKD had a much higher all-cause (hazard ratio [HR] 16.41, 95% CI 13.06-20.61), cardiovascular (HR 16.38, 95% CI 12.17-22.04) and non-cardiovascular mortality (HR 13.66 9, 95% CI.56-19.51). In addition, patients with stage 5 CKD were at a higher risk of recurrent MI or stroke (HR 4.73, 95% CI 3.86-5.80) and bleeding (HR 5.84, 95% CI 4.39-7.76). CONCLUSION CKD was associated with increased mortality and a high incidence of morbidity in patients undergoing coronary angiography in New Zealand. Initiatives to understand and improve outcomes in this group of patients are urgently needed. © 2020 Asian Pacific Society of Nephrology.</div></summary>
<author><name>Watkinsnikolajsen4776</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=Troelsenthomasen4370&diff=3065473&oldid=0</id>
<title>Troelsenthomasen4370</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Troelsenthomasen4370&diff=3065473&oldid=0"/>
<updated>2025-05-10T00:53:41Z</updated>
<summary type="html"><p>Created page with &quot;org/) competition.Tripartite α-pore-forming toxins are constructed of three proteins (A, B and C) and are found in many bacterial pathogens. While structures of the B and C c...&quot;</p>
<p><b>New page</b></p><div>org/) competition.Tripartite α-pore-forming toxins are constructed of three proteins (A, B and C) and are found in many bacterial pathogens. While structures of the B and C components from Gram-negative bacteria have been described, the structure of the A component of a Gram-negative α-pore-forming toxin has so far proved elusive. SmhA, the A component from the opportunistic human pathogen Serratia marcescens, has been cloned, overexpressed and purified. Crystals were grown of selenomethionine-derivatized protein and anomalous data were collected. Phases were calculated and an initial electron-density map was produced.The current study was designed to seek the role of the glycogen synthase kinase-3β (GSK-β)-regulated NF-E2-related factor 2 (Nrf2) pathway in the antioxidant effect induced by Apigenin-7-O-β-D-(-6&quot;-p-coumaroyl)-glucopyranoside (APG). [https://www.selleckchem.com/products/PF-2341066.html Crizotinib cell line] Rat primary cultured cortical neurons were challenged by oxygen and glucose deprivation/reoxygenation (OGD/R) and then treated with APG. Cell viability, phosphorylation of GSK-β at Ser9 and nuclear expression of Nrf2 were measured. Male Sprague Dawley rats challenged by 2-h middle cerebral artery occlusion were treated with 50 mg/kg APG, and the neurological score, infarct volume, phosphorylation of GSK-3β and nuclear expression of Nrf2 were analyzed. The neuroprotective effect of APG and the expression levels of antioxidant enzymes and oxidative products were also examined in the presence and absence of Nrf2-siRNA and PI3K inhibitors. APG reduced the apoptotic proportion, attenuated LDH release and increased cell viability, and in vivo, APG improved neurological scores and reduced infarct volume. APG increased GSK-3β phosphorylation and Nrf2 nuclear translocation, while these effects were prevented by PI3K inhibitors or Nrf2-siRNA treatment in both OGD/R cell cultures and ischemic/reperfusion rats. These findings reveal that GSK-3β phosphorylation-mediated Nrf2 activation is involved in the neuroprotective effect of APG.Androgens play a fundamental role in the morbidity and mortality of COVID-19, inducing both the ACE-2 receptor to which SARS-CoV-2 binds to gain entry into the cell, and TMPRS22, the transmembrane protease that primes the viral spike protein for efficient infection. The United States stands alone among developed nations in permitting one androgen, oral DHEA, to be freely available OTC and online as a 'dietary supplement'. DHEA is widely used by males in the US to offset the age-related decline in circulating androgens. This fact may contribute to the disparate statistics of COVID-19 morbidity and mortality in this country. In regulatory antithesis, every other developed nation regulates DHEA as a controlled substance. DHEA is an extremely potent inhibitor of glucose-6-phosphate dehydrogenase (G6PD), with uniquely unstable uncompetitive inhibition kinetics. This has particular relevance to COVID-19 because G6PD-deficient human cells have been demonstrated to be exceptionally sensitive to infection by human coronavirus. Because DHEA is lipophilic and freely passes into cells, oral DHEA bypasses the normal controls regulating androgen biology and uncompetitive G6PD inhibition. DHEA's status as a 'dietary supplement' means that no clinical trials demonstrating safety have been performed, and, in the absence of physician supervision, no data on adverse events have been collected. During the current pandemic, the unrestricted availability of oral DHEA as a 'dietary supplement' cannot be considered safe without proof from placebo-controlled clinical trials that it is not contributing to the severity of COVID-19. US physicians may therefore wish to query their patients' use of DHEA.Oxidative stress is proposed to be involved in nonalcoholic fatty liver disease (NAFLD). However, antioxidant therapy results in controversial outcomes. Therefore, we generated a new antioxidant/NAFLD mouse model, LiasHigh/HighLeprdb/db mice, by crossbreeding Leprdb/db mice, an obesity mouse model, with LiasHigh/High mice, generated by overexpression of lipoic acid synthase gene (Lias) and having increased endogenous antioxidant capacity, to investigate whether the new model could block the development of NAFLD. We have systemically characterized the novel model based on the main features of human NAFLD, determined the impact of enhanced endogenous antioxidant capacity on the retardation of NAFLD and elucidated the underlying mechanisms using various biological and pathological methods. We found that LiasHigh/HighLeprdb/db mice ameliorated many pathological changes of NAFLD compared with the control. In particular, LiasHigh/HighLeprdb/db mice displayed the improved liver mitochondrial function, reflecting the decline of mitochondrial microvesicular steatosis, and reduced oxidative stress, which mainly contributes to the alleviation of pathologic alterations of the NAFLD progression. Our new model shows that mitochondrial dysfunction is a major pathogenesis for liver steatosis. Overexpression of Lias gene effectively reduces oxidative stress and protects mitochondria, and consequently attenuates NAFLD/NASH.Hyperthyroidism contributes to many other disease conditions, including neurodegenerative diseases. Parkinson's disease (PD) is one of the most common neurodegenerative diseases. The purpose of this study was to investigate the risk of PD in patients with hyperthyroidism. A total of 8788 patients with hyperthyroidism and 8788 controls (without hyperthyroidism) matched by age, gender, index year, and Charlson Comorbidity Index (CCI) score were enrolled between 2000 and 2012. Patients were then followed until the end of 2013 using Taiwan's National Health Insurance Research Database, at which time participants who developed PD were identified. Cox regression analysis was used to calculate the hazard ratio (HR) with a 95% CI of PD incidence rate between patients with hyperthyroidism and unaffected controls. Patients with hyperthyroidism had a significantly increased risk of PD compared with unaffected controls (1.21 vs 0.45 per 1000 person-years, HR 2.69, 95% CI 1.08-6.66) after adjusting for age, gender, CCI score, comorbidities, and antithyroid therapy.</div></summary>
<author><name>Troelsenthomasen4370</name></author> </entry>
<entry>
<id>https://humanlove.stream/wiki/User:Prattmorton3913</id>
<title>User:Prattmorton3913</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Prattmorton3913"/>
<updated>2025-05-10T00:53:38Z</updated>
<summary type="html"><p>User account <a href="/index.php?title=User:Prattmorton3913&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Prattmorton3913 (page does not exist)"><bdi>Prattmorton3913</bdi></a> was created</p>
</summary>
<author><name>Prattmorton3913</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=Hardinmarquez5454&diff=3065472&oldid=0</id>
<title>Hardinmarquez5454</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Hardinmarquez5454&diff=3065472&oldid=0"/>
<updated>2025-05-10T00:53:35Z</updated>
<summary type="html"><p>Created page with &quot;Childhood obesity is a public health emergency that has reached a pandemic level and imposed a massive economic burden on healthcare systems. Our objective was to provide an u...&quot;</p>
<p><b>New page</b></p><div>Childhood obesity is a public health emergency that has reached a pandemic level and imposed a massive economic burden on healthcare systems. Our objective was to provide an update on (1) challenges of obesity definition and classification in the perioperative setting, (2) challenges of perioperative patient positioning and vascular access, (3) perioperative implications of childhood obesity, (3) anesthetic medication dosing and opioid-sparing techniques in obese children, and (4) research gaps in perioperative childhood obesity research including a call to action.&lt;br /&gt;&lt;br /&gt; Despite the near axiomatic observation that obesity is a pervasive clinical problem with considerable impact on perioperative health, there have only been a handful of research into the many ramifications of childhood obesity in the perioperative setting. A nuanced understanding of the surgical and anesthetic risks associated with obesity is essential to inform patients' perioperative consultation and their parents' counseling, improve preoperative risk mitigation, and improve patients' rescue process when complications occur.&lt;br /&gt;&lt;br /&gt; Anesthesiologists and surgeons will continue to be confronted with an unprecedented number of obese or overweight children with a high risk of perioperative complications.&lt;br /&gt;&lt;br /&gt;Anesthesiologists and surgeons will continue to be confronted with an unprecedented number of obese or overweight children with a high risk of perioperative complications.&lt;br /&gt;&lt;br /&gt; Commercial availability of virtual reality headsets and software has exponentially grown over the last decade as it has become more sophisticated, less expensive, and portable. Although primarily used by the general public for entertainment, virtual reality has been adopted by periprocedural clinicians to improve patient experiences and treatments. The purpose of this review is to explore recently reported evidence for virtual reality effectiveness for pediatric periprocedural care and discuss considerations for clinical implementation.&lt;br /&gt;&lt;br /&gt; In the preprocedure setting, practitioners use virtual reality to introduce children to periprocedural environments, distract attention from preprocedural vascular access, and increase cooperation with anesthesia induction. Intraprocedure, virtual reality decreases sedation requirements, and in some instances, eliminates anesthesia for minor procedures. Virtual reality also augments pain reduction therapies in the acute and extended rehabilitation periods, resulting in faster recovery and improved outcomes. Virtual reality seems to be well treated for pediatric use, given close clinical care and carefully curated content.&lt;br /&gt;&lt;br /&gt; Given the multiple clinical applications of virtual reality to supplement pediatric periprocedural care, practitioners should consider developing clinical programs that reliably provide access to virtual reality. [https://www.selleckchem.com/products/pki587.html PKI587] Future research should focus on identification of patient characteristics and types of software that yield optimal patient outcomes.&lt;br /&gt;&lt;br /&gt;Given the multiple clinical applications of virtual reality to supplement pediatric periprocedural care, practitioners should consider developing clinical programs that reliably provide access to virtual reality. Future research should focus on identification of patient characteristics and types of software that yield optimal patient outcomes.&lt;br /&gt;&lt;br /&gt; Children are at risk of severe hypoxemia in the perioperative period owing to their unique anatomy and physiology. Safe and effective airway management strategies are therefore key to the practice of pediatric anesthesia. The goal of this review is to highlight recent publications (2019-2021) aimed to advance pediatric airway safety and to highlight a proposed simple, pediatric-specific, universal framework to guide clinical practice.&lt;br /&gt;&lt;br /&gt; Recent investigations demonstrate that infants with normal and difficult airways experience high incidences of multiple laryngoscopy attempts and resulting hypoxemia. Video laryngoscopy may improve tracheal intubation first attempt success rate in infants with normal airways. In infants with difficult airways, standard blade video laryngoscopy is associated with higher first attempt success rates over non-standard blade video laryngoscopy. Recent studies in children with Pierre Robin sequence and mucopolysaccharidoses help guide airway equipment and technique selection. Department airway leads and hospital difficult airway services are necessary to disseminate knowledge, lead quality improvement initiatives, and promote evidence-based practice guidelines.&lt;br /&gt;&lt;br /&gt; Pediatric airway management morbidity is a common problem in pediatric anesthesia. Improvements in individual practitioner preparation and management strategies as well as systems-based policies are required. A simple, pediatric-specific, universal airway management framework can be adopted for safe pediatric anesthesia practice.&lt;br /&gt;&lt;br /&gt;Pediatric airway management morbidity is a common problem in pediatric anesthesia. Improvements in individual practitioner preparation and management strategies as well as systems-based policies are required. A simple, pediatric-specific, universal airway management framework can be adopted for safe pediatric anesthesia practice.&lt;br /&gt;&lt;br /&gt; Despite real advances in paediatric anaesthesia management, such as a growing awareness of the relevance of anaesthesia conduct as well as of the lack of evidence for neurotoxicity of anaesthetic agents, it must be said that there are still important questions in our specialty that remain unanswered. Standardization and harmonization of airway management, analgesia techniques and outcome measures are the important issues we are facing at the beginning of this decade.&lt;br /&gt;&lt;br /&gt; Major improvements in airway management of neonates and infants resulted from the introduction of videolaryngoscopes and the systematic use of nasal oxygenation during endotracheal intubation. Similarly, the increasing popularity of dexmedetomidine has led to the generalization of its use, which, considering that it may produce undesirable effects, poses a challenge for the future. Moreover, recent systematic reviews have confirmed a lack of evidence for the efficacy of many techniques used in clinical practice.&lt;br /&gt;&lt;br /&gt; The shift in research from the neurotoxicity of anaesthetic agents to factors related to anaesthetic conduct are discussed.</div></summary>
<author><name>Hardinmarquez5454</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=Estradaennis5209&diff=3065471&oldid=0</id>
<title>Estradaennis5209</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Estradaennis5209&diff=3065471&oldid=0"/>
<updated>2025-05-10T00:53:31Z</updated>
<summary type="html"><p>Created page with &quot;No other changes were seen in oximetry, cardiac frequency and diastolic arterial pressure. In our group of normal subjects, cTBS applied to the left DLPFC was able to reduce o...&quot;</p>
<p><b>New page</b></p><div>No other changes were seen in oximetry, cardiac frequency and diastolic arterial pressure. In our group of normal subjects, cTBS applied to the left DLPFC was able to reduce oxygenation in the left cortex. Right hemisphere inhibition was associated with a significant reduction in systolic pressure.This study replicated and extended previous research (Bloom &amp;amp; Friedman, 2013) indicating that humans can correctly identify emotional expressions in photographs of dog faces when tested with one breed (i.e., a Malinois). It examined the effect of dog facial morphology on accuracy of emotion identification by using images of a Malinois, as well as two-different breeds (Doberman and Rhodesian Ridgeback) expressing six-discrete emotions (happiness, sadness, anger, fear, disgust, surprise). Using a sample of 105-undergraduate students, participants were shown slides presenting four different expressive images of the same breed and asked to identify the image that best depicted one of the six emotions. Analyses indicated that participants were able to correctly identify all emotions across all dog breeds significantly better than chance, replicating the previous study for the Malinois, and extending its findings to additional breeds. Accuracy of emotion identification was predicted to be lower for the Doberman due to its darker coloration, possibly interfering with recognition of subtle emotional cues, but was found to be highest for the Malinois, followed by the Doberman, and then the Rhodesian Ridgeback.Human glioblastoma (GBM) is one of the most feared primary malignant brain tumors. We investigated the effect of hyperbaric oxygen (HBO) on GBM patient-derived cells and on microglia cell biology (CHME-5). HBO administered to GBM cells inhibited cell proliferation, downregulated hypoxia-inducible factor 1 α (HIF-1α) expression, and induced glucose metabolism reprogramming (glucose rewiring). It also affected the ability of a cell to perpetuate its lineage, give rise to differentiated cells and interact with its environment to maintain a balance between quiescence, proliferation and regeneration (stemness features). Such an effect may be ascribable to an increase in intracellular ROS levels and to the triggering of inflammasome signaling by HBO itself through caspase1 activation. Moreover, the results obtained from the combination of HBO and radiotherapy (RT) clearly showed a radiosensitising effect of HBO on GBM cells grown in both 2D and 3D, and a radioprotective effect of HBO in CHME-5. In addition, the exposure of M0 microglia cells to exhausted medium or extracellular vesicles (EVs) of HBO-treated GBM cells upregulated the expression of pro-inflammatory cytokines IL1β, IL6 and STAT1, whilst also downregulating the anti-inflammatory cytokine PPARγ. Collectively, these data provide a scientific rationale for the use of HBO in combination with RT for the treatment of patients with GBM.The AP-1 member Fra-1 is overexpressed in TNBC and plays crucial roles in tumor progression and treatment resistance. [https://www.selleckchem.com/products/fluzoparib.html check details] In a previous large-scale screen, we identified PARP1 to be among 118 proteins that interact with endogenous chromatin-bound Fra-1 in TNBC cells. PARP1 inhibitor (olaparib) is currently in clinical use for treatment of BRCA-mutated TNBC breast cancer. Here, we demonstrate that the Fra-1-PARP1 interaction impacts the efficacy of olaparib treatment. We show that PARP1 interacts with and downregulates Fra-1, thereby reducing AP-1 transcriptional activity. Olaparib treatment, or silencing of PARP1, consequently, increases Fra-1 levels and enhances its transcriptional activity. Increased Fra-1 can have adverse effect, including treatment resistance. We also found that a large fraction of PARP1-regulated genes was dependent on Fra-1. We show that by inhibiting Fra-1/AP-1, non-BRCA-mutated TNBC cells can become sensitized to olaparib treatment. We identify that high PARP1 expression is indicative of a poor clinical outcome in breast cancer patients overall (P = 0.01), but not for HER-2 positive patients. In conclusion, by exploring the functionality of the Fra-1 and PARP1 interaction, we propose that targeting Fra-1 could serve as a combinatory therapeutic approach to improve olaparib treatment outcome for TNBC patients.Treatment of aggressive meningiomas remains challenging due to a high rate of recurrence in higher-grade meningiomas, frequent subtotal resections, and the lack of effective systemic treatments. Substantial overexpression associated with a poor prognosis has been demonstrated for kinesin family member 11 (KIF11) in high-grade meningiomas. Due to anti-tumor activity for KIF11 inhibitors (KIF11i) filanesib and ispinesib in other cancer types, we sought to investigate their mode of action and efficacy for the treatment of aggressive meningiomas. Dose curve analysis of both KIF11i revealed IC50 values of less than 1 nM in anaplastic and benign meningioma cell lines. Both compounds induced G2/M arrest and subsequent subG1 increase in all cell lines. Profound induction of apoptosis was detected in the anaplastic cell lines determined by annexin V staining. KIF11i significantly inhibited meningioma growth in xenotransplanted mice by up to 83%. Furthermore, both drugs induced minor hematological side effects, which were less pronounced for filanesib. We identified substantial in vitro and in vivo anti-tumor effects of the KIF11 inhibitors filanesib and ispinesib, with filanesib demonstrating better tolerability, suggesting future use of filanesib for the treatment of aggressive meningioma.&lt;br /&gt;&lt;br /&gt; There is a shortage of data concerning the natural history of patients with moderate aortic stenosis (AS). The aim of this study was to assess the effect of moderate AS on mortality in the general population and in the subgroups of patients with moderate AS and reduced ejection fractions (EF) and patients with moderate AS and low aortic valve gradients. The study was not designed to address the applicability of treatment in this population.&lt;br /&gt;&lt;br /&gt; Outcomes were compared between patients with moderate AS and a propensity-matched cohort (13 ratio) without AS. The primary outcome was survival until end of follow-up.&lt;br /&gt;&lt;br /&gt; Among approximately 40,000 patients who underwent echocardiographic evaluations between 2011 and 2016, 952 had moderate AS. Median follow-up duration was 181weeks (interquartile range, 179-182weeks) for the entire cohort and 174weeks (interquartile range, 169-179weeks) for the propensity-matched groups. Propensity matching successfully balanced most preexisting clinical differences. Increased mortality was observed in the group of patients with moderate AS before propensity matching and persisted following propensity matching (median survival 4.</div></summary>
<author><name>Estradaennis5209</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=Casino_Games_5_Best_VegasStyle_Apps_For_Ipad_And_Iphone&diff=3065470&oldid=2948650</id>
<title>Casino Games 5 Best VegasStyle Apps For Ipad And Iphone</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Casino_Games_5_Best_VegasStyle_Apps_For_Ipad_And_Iphone&diff=3065470&oldid=2948650"/>
<updated>2025-05-10T00:53:24Z</updated>
<summary type="html"><p></p>
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<td colspan="2" style="background-color: white; color:black; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: white; color:black; text-align: center;">Revision as of 00:53, 10 May 2025</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1" >Line 1:</td>
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</table></summary>
<author><name>Lightorange47</name></author> </entry>
<entry>
<id>https://humanlove.stream/wiki/User:Knudsenmahoney5216</id>
<title>User:Knudsenmahoney5216</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Knudsenmahoney5216"/>
<updated>2025-05-10T00:53:24Z</updated>
<summary type="html"><p>User account <a href="/index.php?title=User:Knudsenmahoney5216&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Knudsenmahoney5216 (page does not exist)"><bdi>Knudsenmahoney5216</bdi></a> was created</p>
</summary>
<author><name>Knudsenmahoney5216</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=Hybridization_Outcomes_Have_Solid_Genomic_as_well_as_Ecological_Contingencies&diff=3065469&oldid=0</id>
<title>Hybridization Outcomes Have Solid Genomic as well as Ecological Contingencies</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Hybridization_Outcomes_Have_Solid_Genomic_as_well_as_Ecological_Contingencies&diff=3065469&oldid=0"/>
<updated>2025-05-10T00:53:24Z</updated>
<summary type="html"><p>Created page with &quot;0% and -3.4% for a small CTV.&lt;br /&gt;&lt;br /&gt; To assess the relevance of virtual reality distraction (VR) during uterovaginal brachytherapy applicators&#039; removal, as an alternative...&quot;</p>
<p><b>New page</b></p><div>0% and -3.4% for a small CTV.&lt;br /&gt;&lt;br /&gt; To assess the relevance of virtual reality distraction (VR) during uterovaginal brachytherapy applicators' removal, as an alternative to nitrous oxide (N&lt;br /&gt;&lt;br /&gt; O) conscious sedation, to decrease anxiety and pain perception.&lt;br /&gt;&lt;br /&gt; We prospectively evaluated 35 patients treated with cervical brachytherapy for locally or locally advanced cervical cancer. Brachytherapy applicators were removed in the patient's room at the end of the treatment. Patients were assigned to N&lt;br /&gt;&lt;br /&gt; O conscious sedation (reference group) or VR (experimental group). Anxiety and pain were evaluated with the STAI-E score and with Visual Analogical Scales (VAS).&lt;br /&gt;&lt;br /&gt; Fourteen patients were treated with VR and 21 with N&lt;br /&gt;&lt;br /&gt; O. STAI-E baselines scores were 35 in the VR group and 38 in the reference group and declined to 30 and 28, respectively after procedure. The mean VAS-anxiety was 2.9 before and 2.7 at the peak in the VR group versus 4.1 and 1.6, respectively in the reference group. The mean VAS-pain was 1.0 before, 3.1 at the peak and 0.4 after the procedure in the experimental group, versus 1.8, 2.0, and 0.6 respectively in the N&lt;br /&gt;&lt;br /&gt; O group. Four patients in the VR group experienced mild nausea/vomiting or dizziness during the procedure. The preparation duration was higher in the VR group, with a similar duration for the removal itself.&lt;br /&gt;&lt;br /&gt; Replacing a medical gas by a virtual reality device was feasible and led to acceptable levels of pain and anxiety. Prospective randomized trials are needed to confirm efficacy and to determine which patients could benefit the most from this approach.&lt;br /&gt;&lt;br /&gt;Replacing a medical gas by a virtual reality device was feasible and led to acceptable levels of pain and anxiety. Prospective randomized trials are needed to confirm efficacy and to determine which patients could benefit the most from this approach.&lt;br /&gt;&lt;br /&gt; Besides HIV, people who inject drugs (PWID) experience other biomedical adversities, including injection-related injuries and infections. Yet, they are often inadequately addressed due to the prioritisation of HIV-related issues. This article explored the risk environment and socio-structural adversities of PWID living with injection-related injuries and infections, as well as existing management and treatment challenges of these conditions in harm reduction interventions.&lt;br /&gt;&lt;br /&gt; We undertook an ethnographic study from April 2018 to December 2019 in selected areas of Dhaka, Bangladesh. This component of the study involved 2500 hours of observations and informal conversations, 35 in-depth interviews and five focus group discussions with PWID experiencing injection-related injuries and infections. We also performed seven key-informant interviews with service providers and clinical experts. We applied thematic analysis and used various theoretical social scientific conceptualisations to analyse the relationship betd infections nestled PWID within various prongs of biomedical and socio-structural adversity, without viable and targeted treatment modalities. Thus, it is integral to nurture a multifaceted harm reduction intervention tailored to their biomedical and socio-structural needs.&lt;br /&gt;&lt;br /&gt;Injection-related injuries and infections nestled PWID within various prongs of biomedical and socio-structural adversity, without viable and targeted treatment modalities. Thus, it is integral to nurture a multifaceted harm reduction intervention tailored to their biomedical and socio-structural needs.Human tuberculosis is still a major world health concern. In Uruguay, contrary to the world trend, an increase in cases has been observed since 2006. Although the incidence of MDR-resistant strains is low and no cases of XDR-TB were registered, an increase in the number of patients with severe tuberculosis requiring critical care admission was observed. As a first aim, we performed the analysis of the genetic structure of strains isolated from patients with severe tuberculosis admitted to an intensive care unit. We compared these results with those corresponding to the general population observing a statistically significant increase in the Haarlem genotypes among ICU patients (53.3% vs 34.7%; p less then 0.05). In addition, we investigated the association of clinical outcomes with the genotype observing a major incidence of hepatic dysfunctions among patients infected with the Haarlem strain (p less then 0.05). The cohort presented is one of the largest studied series of critically ill patients with tuberculosis.&lt;br /&gt;&lt;br /&gt; Osseous shortening of the forearm is performed during forearm replantation; however, no large clinical reviews have discussed its effects on patient outcomes. A recent cadaver study demonstrated the progressive loss of forearm pronation/supination ranges of motion with increased shortening lengths using external fixation. Our study aimed to quantify the effects of shortening on passive forearm motion using internal fixation after 2, 4, and 6 cm of mid-forearm shortening.&lt;br /&gt;&lt;br /&gt; A volar Henry approach and direct approach to the ulna were used on 8 cadaveric specimens. The forearms were sequentially shortened by 2, 4, and 6 cm. Fixation was performed on the volar surfaces of the radius and ulna. Pronation and supination of the forearms were tested by applying 1 Nm of torque at baseline and after the fixation of both the radius and ulna using osteotomy. Radiographs and measurements were obtained at each phase to determine the maximum radial bow and radioulnar gap. Data were analyzed using a linear mixed-effects modty.&lt;br /&gt;&lt;br /&gt; Finger avulsion injuries account for 5% of upper extremity injuries requiring evaluation in an emergency room. They are devastating injuries that require microvascular reconstruction or amputation. As public awareness rises, there is a growing market for silicone rings, with limited data on their ability to prevent ring avulsion injuries.&lt;br /&gt;&lt;br /&gt; Five cadaver forearms were attached to a custom fixture, allowing for ring avulsion simulations. [https://www.selleckchem.com/products/Streptozotocin.html buy Streptozotocin] Specifically designed silicone or metal rings of varying sizes (#4-#11) were assigned to one of five fingers on each forearm, based on fit. The contralateral corresponding finger was tested using a ring of the same size in the other material. A preload of 2 N was applied to each ring, and ultimate failure force was determined by applying an upward force at a loading rate of 500 mm/sec until failure. Additionally, a fifth cadaver forearm was used to determine the ultimate failure force of silicone rings in a clenched fist position.&lt;br /&gt;&lt;br /&gt; The average ultimate failure force for silicone rings of all sizes was 53.</div></summary>
<author><name>Burmaclam19</name></author> </entry>
<entry>
<id>https://humanlove.stream/wiki/User:Icicleyoke9</id>
<title>User:Icicleyoke9</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Icicleyoke9"/>
<updated>2025-05-10T00:53:21Z</updated>
<summary type="html"><p>User account <a href="/index.php?title=User:Icicleyoke9&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Icicleyoke9 (page does not exist)"><bdi>Icicleyoke9</bdi></a> was created</p>
</summary>
<author><name>Icicleyoke9</name></author> </entry>
<entry>
<id>https://humanlove.stream/wiki/User:Holecase2</id>
<title>User:Holecase2</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Holecase2"/>
<updated>2025-05-10T00:53:18Z</updated>
<summary type="html"><p>User account <a href="/index.php?title=User:Holecase2&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Holecase2 (page does not exist)"><bdi>Holecase2</bdi></a> was created</p>
</summary>
<author><name>Holecase2</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=Tatemcnulty2795&diff=3065468&oldid=0</id>
<title>Tatemcnulty2795</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Tatemcnulty2795&diff=3065468&oldid=0"/>
<updated>2025-05-10T00:53:15Z</updated>
<summary type="html"><p>Created page with &quot;This article provides an overview of the current knowledge on hypophosphatasia-a rare genetic disease of very variable presentation and severity-with a special focus on adoles...&quot;</p>
<p><b>New page</b></p><div>This article provides an overview of the current knowledge on hypophosphatasia-a rare genetic disease of very variable presentation and severity-with a special focus on adolescents and adults. It summarizes the available information on the many known mutations of tissue-nonspecific alkaline phosphatase (TNSALP), the epidemiology and clinical presentation of the disease in adolescents and adults, and the essential diagnostic clues. The last section reviews the therapeutic approaches, including recent reports on enzyme replacement therapy (EnzRT).An integrated electrochemical immunoassay is described for the determination of circulating tumor cells (CTCs). For the first time, Ketjen black (KB), which is a superconductive carbon&amp;nbsp;material, was incorporated with Au nanoparticles (AuNPs) and used to modify the surface of gold electrodes. A cocktail of anti-epithelial cell adhesion molecules (EpCAM) and anti-vimentin antibodies was chosen to capture the CTCs. Palladium-iridium-boron-phosphorus alloy-modified mesoporous nanospheres (PdIrBPMNS) served as a catalytic tag to amplify the current signal. Glycine-HCl (Gly-HCl) was used as an antibody eluent to release and collect the captured CTCs from the electrodes for further clinical research without compromising cell viability. The response of the method increased linearly from 10 to 1 × 106 cells mL-1 CTCs, while the detection limit was calculated to be as low as 2 cells mL-1. This method was successfully used to determine CTCs in spiked blood samples and demonstrated good recovery. Graphical abstractKetjen black/AuNPs was incorporated in the electrochemical platform to enhance the electron transfer ability of the electrode surface. PdIrBP mesoporous nanospheres were used to amplify DPV signal in this assay. The introduction of Gly-HCl realized nondestructive recovery of circulating tumor cells.BACKGROUND This review focuses on exosomes derived from various cancer cells. The review discusses the possibility of differentiating macrophages in alternatively activated anti-inflammatory pro-tumorigenic M2 macrophage phenotypes and classically activated pro-inflammatory, anti-tumorigenic M1 macrophage phenotypes in the tumor microenvironment (TME). The review is divided into two main parts, as follows (1) role of exosomes in alternatively activating M2-like macrophages-breast cancer-derived exosomes, hepatocellular carcinoma (HCC) cell-derived exosomes, lung cancer-derived exosomes, prostate cancer-derived exosomes, Oral squamous cell carcinoma (OSCC)-derived exosomes, epithelial ovarian cancer (EOC)-derived exosomes, Glioblastoma (GBM) cell-derived exosomes, and colorectal cancer-derived exosomes, (2) role of exosomes in classically activating M1-like macrophages, oral squamous cell carcinoma-derived exosomes, breast cancer-derived exosomes, Pancreatic-cancer derived modified exosomes, and colorectal canon the vesicular cargo, the molecular constituents, the exosomes have the potential to change the fate of macrophage phenotypes, either M1, classically activated macrophages, or M2, alternatively activated macrophages. In this review, we discuss and describe the ability of tumor-derived exosomes in the mechanism of macrophage activation and polarization.BACKGROUND MicroRNAs (miRNAs) are considered as promising cancer biomarkers. The aim of the present study is to investigate the prognostic significance of miR-200c in patients with oral squamous cell carcinoma (OSCC). MATERIALS AND METHODS Quantitative real-time PCR (qRT-PCR) was used to determine the expression levels of miR-200c in 204 pairs of OSCC and adjacent noncancerous. Correlations between miR-200c expression levels and clinicopathological characteristics were investigated. Survival analysis was performed using the Kaplan-Meier method and log-rank test. Multivariate analysis of the prognostic factors was performed with a Cox proportional hazards regression model. RESULTS The expression of miR-200c was significantly down-regulated in OSCC tissues compared with adjacent non-tumor tissues (p less then 0.0001). [https://www.selleckchem.com/products/srpin340.html SRPIN340 mouse] Low expression of miR-200c in tumor tissues was significantly correlated with the positive N classification (p = 0.013), advanced TNM stage (p = 0.007) and poor differentiation grade (p = 0.026). Lower miR-200c expression in patients was significantly associated with poor recurrence-free survival (RFS, p = 0.0003) and overall survival (OS, p = 0.0026). Multivariate analysis confirmed that low miR-200c expression was an independent predictor for poor RFS (hazard ratio (HR) 1.705, 95% CI 1.136-2.56, p = 0.01) and OS (HR 1.669, 95% CI 1.03-2.703, p = 0.037) in patients with OSCC. CONCLUSION Our results suggest that the miR-200c might be a potential prognostic biomarker for OSCC.Recurrent stroke is a frequent event and clinical trials that addressed the best secondary prevention are sparse. If patients take a&amp;nbsp;thrombocyte aggregation inhibitor (TAI) before the recurrent stroke, clopidogrel can be chosen instead of aspirin or vice versa but evidence is lacking. A&amp;nbsp;3-week period of dual antiplatelet treatment might be a&amp;nbsp;good alternative after acute reinfarction. The results of the recently published RESTART trial support resuming TAI treatment after a&amp;nbsp;hemorrhagic stroke and showed that the intracerebral hemorrhage (ICH) rate is not elevated in comparison with a&amp;nbsp;study group without TAI. Patients with ICH associated with oral anticoagulation (OAC) and atrial fibrillation should be restarted on novel OACs, if there are no relevant contraindications and the risk of ischemia is high. The anticoagulation treatment of patients with cerebral amyloid angiopathy is still a clinical dilemma as there is a&amp;nbsp;high risk of recurrent ICH. These patients might be candidates for left appendage closure.Sharp force trauma is routinely encountered in forensic practice. Often the question is posed, how much pressure or energy would have been necessary to inflict a cut with a specific knife, in order to further characterize the perpetrator or determine his intent to cause harm. This paper investigates two knife blades and its individual pressures needed to cut through the epidermis and dermis. In order to examine the necessary force for cutting through the skin, we performed experiments on a piglet skin-on-gelatin phantom. Two similarly small knives-a paring knife with a serrated blade and a Swiss Army pocket knife with a smooth blade-were moved over the phantom surface using a mobile cutting apparatus with varying weight on the load arm with the knife. The depth of the cut was to be determined according to a scale from zero to three grade 0 = no cut; grade 1 = cut into epidermis only; grade 2 = cut into dermis; grade 3 = complete transection of the entire skin. Each cut inflicted at a specific pressure force was assessed closely in order to ascertain depth, calculate the velocity, and ultimately determine the point at which a cut would inflict grade 3 damage.</div></summary>
<author><name>Tatemcnulty2795</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=Odomleonard4701&diff=3065467&oldid=0</id>
<title>Odomleonard4701</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Odomleonard4701&diff=3065467&oldid=0"/>
<updated>2025-05-10T00:53:11Z</updated>
<summary type="html"><p>Created page with &quot;Introduction Brain metastases (BM) are a frequent complication of metastatic cancer. Due to the wider availability and application of screening procedures, an increasing fract...&quot;</p>
<p><b>New page</b></p><div>Introduction Brain metastases (BM) are a frequent complication of metastatic cancer. Due to the wider availability and application of screening procedures, an increasing fraction of patients are diagnosed at the asymptomatic stage. The introduction of immune checkpoint inhibitors and targeted therapies has revolutionized treatment in several frequently BM-causing entities like metastatic lung cancer, melanoma and breast cancer. However, registered trials of new targeted and immunotherapy mostly excluded patients with BM resulting in limited knowledge of the intracranial efficacy of new systemic agents.Areas covered The present review highlights recent advances in systemic therapies for the treatment and prophylaxis of the three leading BM causing tumors NSCLC, melanoma and breast cancer.Expert opinion High intracranial efficacy was observed for several next-generation tyrosine kinase inhibitors as well as immune checkpoint inhibitors, especially in patients with asymptomatic disease. Ongoing discussions addressed the need for local therapies in patients with asymptomatic BM and the availability of systemic therapy with high intracranial efficacy. Further BM-specific studies as well as BM-specific endpoints in registered trials are needed to define the role of systemic monotherapies in patients with BM.&lt;br /&gt;&lt;br /&gt; Global warming directly influencing ozone layer depletion, which eventually is increasing ultraviolet radiation penetration having far-reaching impacts on living biota. This particularly influences the primary producer microalgae which are the basic unit of food webs in the aquatic habitats. Therefore, it is necessary to concentrate the research at this micro-level to understand the harmful impact of increased UV-B radiation ever before. Consequently, the present attempt aimed to focus on the influence of UV-B on growth criteria, photosynthetic pigments, some metabolites, and ultrastructure of the freshwater cyanobacteria, &lt;br /&gt;&lt;br /&gt; (Microcoleaceae), &lt;br /&gt;&lt;br /&gt; (Nostocaceae), &lt;br /&gt;&lt;br /&gt; (Microcystaceae), the Chlorophyte &lt;br /&gt;&lt;br /&gt; (Scenedesmaceae), and the marine Cyanobacterium &lt;br /&gt;&lt;br /&gt; (Microcystaceae).&lt;br /&gt;&lt;br /&gt; The cultures of investigated algae were subjected directly to different duration periods (1, 3, 5, and 7 h) of artificial UV-B in addition to unirradiated control culture and allowed to grow for 10 days, after which the algal samples were anh, pigments, and metabolic activity, as well as the cellular ultrastructure of some cyanobacteria and chlorophytes.High-throughput analysis of compound dissolved in DMSO and arrayed in multiwell plates for quality control (QC) purposes has widespread utility in drug discovery, ranging from the QC of assay-ready plates dispatched by compound management, to compound integrity check in the screening collection, to reaction monitoring of chemical syntheses in microtiter plates. [https://www.selleckchem.com/products/a-d-glucose-anhydrous.html buy α-D-Glucose anhydrous] Due to the large number of samples (thousands per batch) involved, these workflows can put a significant burden on the liquid chromatography-mass spectrometry (LC-MS) platform typically used. To achieve the required speed of seconds per sample, several chromatography-free MS approaches have previously been used with mixed results. In this study, we demonstrated the feasibility of acoustic ejection-mass spectrometry (AE-MS) in full-scan mode for high-throughput compound QC in miniaturized formats, featuring direct, contactless liquid sampling, minimal sample consumption, and ultrafast analytical speed. The sample consumption and analysis time by AE-MS represent, respectively, a 1000-fold and 30-fold reduction compared with LC-MS. In qualitative QC, AE-MS generated comparable results to conventional LC-MS in identifying the presence and absence of expected compounds. AE-MS also demonstrated its utility in relative quantifications of the same compound in serial dilution plates, or substrate in chemical synthesis. To facilitate the processing of a large amount of data generated by AE-MS, we have developed a data processing platform using commercially available tools. The platform demonstrated fast and straightforward data extraction, reviewing, and reporting, thus eliminating the need for the development of custom data processing tools. The overall AE-MS workflow has effectively eliminated the analytical bottleneck in the high-throughput compound QC work stream.Objectives To assess the association between team sport participation and behavioral, psychological, and social health outcomes in young athletes. Methods A systematic review and meta-analysis were undertaken to identify studies published between 01/01/1950-05/01/2020 investigating the association between team sport participation and health outcomes in young athletes (50. Prospective and retrospective studies were included; non-primary literature was excluded. Health outcomes were categorized as 1) behavioral, 2) psychological, or 3) social. Data were extracted to form 2 × 2 tables for each study to calculate odds ratios (OR) and 95% confidence intervals (CI). Results Of 371 queried articles, 34 studies from 10 countries across 4 continents were included, with 9 reporting homogenous outcomes for meta-analysis. Behavioral Fifteen studies evaluated behavioral health outcomes of alcohol and/or drug use, fitness, and diet. Quantitatively, team sport participation was found to decrease rates of cigarette/tobacco uThough few studies mentioned potential negative effects of team sport participation, the majority reported improved behavioral, psychological, and social health outcomes in youth athletes worldwide.Refugees are a highly vulnerable marginalized population with unique medical and psychosocial needs. Unfortunately, the Interim Federal Health Program (IFHP) in Canada partially covers the medical needs of refugee claimants but does not include hospice or home-based palliative care. This report describes the case of a refugee claimant cancer patient who was admitted to an inpatient tertiary cancer center medical oncology ward in Ontario, Canada, for ∼11 months due to insufficient community-based palliative care resources available for patients covered by the IFHP. This case report highlights the differences in palliative care coverage between the provincial health care coverage, Ontario Health Insurance Plan, and federal health care coverage for refugees, IFHP, from a practical point of view, how this can affect the palliative care available for patients and their families, and the impact on the Canadian health care system.</div></summary>
<author><name>Odomleonard4701</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=Vangsgaardmaxwell4831&diff=3065466&oldid=0</id>
<title>Vangsgaardmaxwell4831</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Vangsgaardmaxwell4831&diff=3065466&oldid=0"/>
<updated>2025-05-10T00:53:06Z</updated>
<summary type="html"><p>Created page with &quot;Since I believed i was now spending some of my summers in Reno I decided that the smart money move was to patronize the so-called local casinos that cater towards the local po...&quot;</p>
<p><b>New page</b></p><div>Since I believed i was now spending some of my summers in Reno I decided that the smart money move was to patronize the so-called local casinos that cater towards the local population rather when compared with the tourist casinos on the strip. Concept here being that the shrewd locals were receiving superior reward cards and a better across deal stupid tourists who patronized the strip.&lt;br /&gt;&lt;br /&gt;Of course if you are a rank beginner on the internet gambling after that you should benefits of the play for free games are generally offered on any good casino net page. If the site you are created in does not offer any free play then go to another site that is equipped with this to be had. And then play a number of the these games to get aquainted with any game is played. It allows you to envision out what games are on the market on and also. It also allows which check out the odds in the process. It might benefit you to study some among the rules within the game before begin to play so are able to learn when you actually play one from the games.&lt;br /&gt;&lt;br /&gt;#4 Nice Rack - Look in the casino dealers rack of chips around them. If it is empty along with the chips might be Casion Online front among the smiling faced crowded casino customers, you want to seize a seat and plant some roots. This is also a great way to see generally if the table is hot, if the casino dealer has learned to start coloring up and dropping his tips this might another strong indicator. Empty racks are a smart sign of some hot kitchen table!&lt;br /&gt;&lt;br /&gt;Slots - Arguably essentially the most popular games you may play in any casino due to their simplicity (and people happen to like the sights and sounds). Spin the mechanical reels by pushing a button and check if the symbols come up aligned. They will do - you Casino Live will be a winner!&lt;br /&gt;&lt;br /&gt;For this, you may have to read all the about sport that already been provided anyone start taking pleasure in. You can also try some practice games before putting your own in objective ones. Some not only help you in knowing the games we can also practice and plan your strategies.&lt;br /&gt;&lt;br /&gt; [https://www.youtube.com/@iwinshona iwin] to take a glance at two important factors with this no deposit feature. Purchasers involves how some Casino s will you shouldn't no deposit members get a specific associated with games in the casino. For example, a gambler might be able to play slots or blackjack games at an online Casino with the free money.&lt;br /&gt;&lt;br /&gt;Next is checking the casino for technical ailments. Since the game rrs determined by a complicated interaction of one's physical wheel with virtual players betting online, a technical glitch can result in a lot of frustration. A common problem is often a small delay in the audio/video feed that is caused by slow Online connections. So try stop high traffic times having a better playing live through.</div></summary>
<author><name>Vangsgaardmaxwell4831</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=Nine_Even_Better_Ways_To_Stamped_Concrete_Without_Questioning_Yourself&diff=3065465&oldid=0</id>
<title>Nine Even Better Ways To Stamped Concrete Without Questioning Yourself</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Nine_Even_Better_Ways_To_Stamped_Concrete_Without_Questioning_Yourself&diff=3065465&oldid=0"/>
<updated>2025-05-10T00:53:05Z</updated>
<summary type="html"><p>Created page with &quot;Curing and Sealing After stamping, the concrete must cure properly. This drying process actually strengthens the concrete, making it less permeable and more durable. Once cure...&quot;</p>
<p><b>New page</b></p><div>Curing and Sealing After stamping, the concrete must cure properly. This drying process actually strengthens the concrete, making it less permeable and more durable. Once cured, a sealer is applied to protect the surface and enhance the colors.&lt;br&gt;&lt;br&gt;Low Maintenance Stamped concrete is relatively easy to maintain compared to other materials. Regular sweeping and occasional washing with soap and water will keep it looking fresh. Unlike pavers, there are no joints where weeds can grow.&lt;br&gt;&lt;br&gt;Cost-Effective Stamped concrete offers the look of premium materials at a significantly lower price point. On average, stamped concrete costs $8 to $12 per square foot installed, which is up to 50% less than natural stone or limestone. The installation costs are also lower compared to individual pavers or stones that must be laid piece by piece.&lt;br&gt;&lt;br&gt;As with any significant home improvement, consulting with experienced concrete contractors who specialize in decorative concrete will help ensure your project's success. Their expertise in proper site preparation, concrete mixing, and stamping techniques is crucial for a beautiful, long-lasting result.&lt;br&gt;&lt;br&gt;Limitations to Consider Potential for Cracking Like all concrete, stamped concrete is susceptible to cracking due to ground shifting, settling, or extreme temperature changes. While control joints can help manage cracking, they cannot eliminate it entirely.&lt;br&gt;&lt;br&gt;Resealing Requirements To maintain its appearance and protection, stamped concrete should be resealed every 2-3 years. This maintenance requirement adds to the long-term cost, with resealing averaging about $1.50 per square foot (not including labor).&lt;br&gt;&lt;br&gt;Stamping Process The stamping phase is time-sensitive and requires careful coordination. The stamps are sprayed with a release agent to prevent concrete from sticking to them and then pressed into the wet concrete. Contractors may step on the stamps or use tamping tools to create the impression. Colored release agents can be used to accent cracks and grout lines, enhancing the realistic appearance of the pattern.&lt;br&gt;&lt;br&gt;More Complex Repairs When damage does occur, repairs to stamped concrete can be more involved than replacing individual pavers or bricks. Matching the color and pattern of an existing stamped concrete installation can be challenging.&lt;br&gt;&lt;br&gt;What Is Stamped Concrete? Stamped concrete is a decorative concrete technique where freshly poured concrete is imprinted with patterns and textures using polyurethane stamps. These stamps, typically 2-by-2-foot squares about an inch thick, are pressed into wet concrete to create designs that mimic more expensive materials. The result is a surface that can resemble natural stone, brick, tile, [http://classicalmusicmp3freedownload.com/ja/index.php?title=%E5%88%A9%E7%94%A8%E8%80%85:JanellTarpley stamped concrete] wood planks, or even more creative patterns.&lt;br&gt;&lt;br&gt;Advantages of Stamped Concrete Design Versatility The sky's the limit with stamped concrete designs. You can choose textures that mimic limestone, granite, slate, brick, wood, and more. Colors can be customized to match your home's exterior or landscape design.&lt;br&gt;&lt;br&gt;Slipperiness Some stamped concrete surfaces can become [https://www.thetimes.co.uk/search?source=nav-desktop&amp;q=slippery slippery] when wet, particularly those with smoother textures. However, this can be mitigated by choosing textured patterns and anti-slip sealers for areas like pool decks.&lt;br&gt;&lt;br&gt;Efficient Installation Unlike brick or stone installation which can take weeks, stamped concrete projects can typically be completed in just two to three days. This means less disruption to your property and faster enjoyment of your new space.&lt;br&gt;&lt;br&gt;[https://search.google.com/local/reviews?placeid=ChIJRUxPZqlT4okRxuKnyg-pRXU Stamped concrete] has revolutionized outdoor and indoor spaces by offering the aesthetic appeal of premium materials at a fraction of the cost. With its versatility and relatively simple installation process, it's no wonder that stamped concrete has become increasingly popular for homeowners and businesses alike. This comprehensive guide explores everything you need to know about this decorative concrete option.&lt;br&gt;&lt;br&gt;Durability and Longevity When properly installed and maintained, stamped concrete can last approximately 25 years or more. Its one-piece construction provides a solid, stable surface that won't shift or settle like individual pavers might.&lt;br&gt;&lt;br&gt;Feature Stamped Concrete Pavers Strength 3,000-4,000 PSI 8,000+ PSI Cost $6-$12 per sq ft $8-$25+ per sq ft Installation Time 2-3 days 1-2 weeks Lifespan ~25 years 50+ years Repair Ease More difficult Individual pieces replaceable Maintenance Easier to clean, requires resealing More difficult to clean, no sealing needed While pavers offer superior strength and easier repairs, stamped concrete provides a more affordable option with a seamless appearance and simpler maintenance routine.</div></summary>
<author><name>JeannineHagenaue</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=Buurklavsen5083&diff=3065464&oldid=0</id>
<title>Buurklavsen5083</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Buurklavsen5083&diff=3065464&oldid=0"/>
<updated>2025-05-10T00:52:58Z</updated>
<summary type="html"><p>Created page with &quot;Malignant hyperthermia-associated rhabdomyolysis is a condition that lies on the spectrum of malignant hyperthermia (MH). Unlike MH, malignant-hyperthermia-associated rhabdomy...&quot;</p>
<p><b>New page</b></p><div>Malignant hyperthermia-associated rhabdomyolysis is a condition that lies on the spectrum of malignant hyperthermia (MH). Unlike MH, malignant-hyperthermia-associated rhabdomyolysis is a condition which most commonly is recognized in the postoperative period by the development of discolored brown urine with notably absent rigidity, tachypnea, tachycardia, and hyperthermia. The presented case describes the subtle onset of malignant hyperthermia-associated rhabdomyolysis, along with a review of relevant literature.Uterine arteriovenous malformation (AVM) is a rare condition that is potentially life-threatening. There are limited published reports on this condition. This is a case report of a 25-year-old woman who presented with a symptomatic AVM. We review the differential diagnoses, evaluation, and treatment options. Conservative treatment with interventional radiology can be considered in select women who desire fertility preservation.Between 2015 and 2019, the total number of births in South Dakota declined by 7 percent. As infant mortality rates are calculated per 1,000 live births, slight increases or decreases in total deaths and deaths due to specific causes manifest in notable shifts in yearly infant mortality rates (IMR). In 2019, 10 more infants died than in 2018 (80 vs. 70). With the decline in the state's births, the IMR increased from 5.9 to 6.7, which is significantly higher than the U.S. rate of 5.7 for 2018. South Dakota's 2019 increase in births of very low birth weight infants and deaths due to congenital anomalies contributed to this increase in mortality. In South Dakota, between 2015-19, 62 percent of all infant deaths occurred during the first 27 days of life. Though the rate of death for the state's minority infants remains significantly higher than that of its white infants, a decline in the ratio of the minority to white IMR is noted. Further, the rate of death due to sudden unexpected infant death (SUID) remained stable between 2018-19 but there is evidence that increasingly these deaths are caused by accidental suffocation or strangulation in bed which is typically preventable with safe sleeping environments for infants. The interactions between birth weight, incidence, cause, and timing of death are explored in this annual review of infant mortality.We present the case of a 65-year-old patient who developed a large posterobasal ventricular septal defect resulting from an extensive acute myocardial infarction involving the inferior and basal septum and wall. We repaired the interventricular lesion by verticalizing the cardiac apex to perform a left posterobasal ventriculotomy. We removed a great part of the residual infarcted tissue, leaving the residual scar in place. Our technique first involved creating a double-layer patch comprising heterologous pericardium and a non-collagen-impregnated Sauvage Dacron patch, fixed with single pledgeted U-stitches from the right side of the anterior septum; then we applied a third layer of heterologous pericardium on the left side of the septum in order to have only a pericardial surface in contact with blood on both ventricular sides. [https://www.selleckchem.com/products/cytidine-5-triphosphate-disodium-salt.html see more] A running suture was used to complete the procedure from the middle to the posterior rim of the ventricular septal defect. The final triple-layer patch allowed us to obtain a complete and durable closure of the defect. The subsequent closure of the left ventriculotomy was performed with a similar bilayer pericardium-Dacron patch (always leaving pericardium on the internal surface). This technique proved effective, guaranteeing resistance to suture stress, less risk of leakage, and reduced thrombogenicity.We present a patient with an acute type A aortic dissection that involves the aortic root. The high mortality of patients with this condition is often associated with operations performed by surgeons with minimal experience dealing with aortic diseases. Therefore, less-experienced surgeons often opt for less complicated techniques like supracoronary ascending aortic replacement. However, according to the latest guidelines for the management of aortic diseases, the aortic root should be replaced when it is compromised by the dissection. The Bentall-de Bono technique treats the aortic root and demands less experience than valve-sparing aortic surgery.Mitral valve surgery can be especially difficult in patients with mitral annular calcification. Not only is it associated with higher morbidity and mortality, but there is no consensus strategy for the treatment of mitral annular calcification, which may render some patients inoperable. We describe a case of severe mitral annular calcification successfully treated with the cavitron ultrasonic surgical aspirator. We demonstrate the proper technique for and the efficacy of using this instrument for decalcification of the mitral annulus. The video tutorial includes the patient presentation, preoperative and postoperative imaging, and the proper surgical technique for cavitron ultrasonic surgical aspirator-assisted mitral annular decalcification. With the proper technique, the cavitron ultrasonic surgical aspirator may mitigate the risk of surgical complications associated with severe calcification of the mitral annulus.Reoperations for a dysfunctional mechanical aortic valve prosthesis are usually performed with a repeat sternotomy. Reopening the chest may be associated with a heart structure tear, bleeding, excessive transfusion, and a possible unfavorable outcome. Experience performing a redo aortic valve replacement with a minimally invasive approach and avoiding lysis of the pericardial adhesions is growing. We describe a redo aortic valve replacement procedure performed because of subvalvular pannus formation in a patient with a mechanical prosthesis. A partial J-shaped hemisternotomy at the 3rd intercostal space was performed; the ascending aorta was exposed and the valve was replaced with a sutureless bioprosthesis. The video tutorial shows the surgical approach, cardiopulmonary bypass solutions, and sutureless valve deployment.Aortic resection with an extended end-to-end anastomosis is the surgical gold standard treatment for infant aortic coarctation and has excellent early and long-term outcomes. Subclavian flap aortoplasty is an alternative surgical technique that offers some advantages because there is no need to do extensive dissection and mobilization of the aortic arch and descending aorta as required in an extended end-to-end anastomosis. This video tutorial illustrates the technical aspects of subclavian flap aortoplasty in an infant.</div></summary>
<author><name>Buurklavsen5083</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=0543747022&diff=3065463&oldid=3065421</id>
<title>0543747022</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=0543747022&diff=3065463&oldid=3065421"/>
<updated>2025-05-10T00:52:48Z</updated>
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<td colspan="2" style="background-color: white; color:black; text-align: center;">Revision as of 00:52, 10 May 2025</td>
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<tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>ما هي خدمات شركة فيكس لتصليح الثلاجات في أبوظبي؟&lt;br /&gt;&lt;br /&gt;تعد شركة فيكس واحدة من الشركات الرائدة في تقديم خدمات تصليح الثلاجات في أبوظبي. تقدم الشركة مجموعة متنوعة من الخدمات تضمن لك الحفاظ على أدائها الأمثل، ومن بين <del class="diffchange diffchange-inline">إليكم </del>الخدمات:&lt;br /&gt;&lt;br /&gt; • إصلاح الأعطال الشائعة: اعطال مثل عدم تبريد الثلاجة أو وجود تسرب للمياه.&lt;br /&gt;&lt;br /&gt; • الصيانة الدورية: للحفاظ على الأجهزة في حالة تشغيل جيدة ومنع حدوث الأعطال المفاجئة.&lt;br /&gt;&lt;br /&gt; • الاستبدال: قطع الغيار الأصلية عند الحاجة لضمان الأداء العالي.&lt;br /&gt;&lt;br /&gt;أهمية الحفاظ على ثلاجتك بحالة جيدة&lt;br /&gt;&lt;br /&gt;<del class="diffchange diffchange-inline">يعتبر الخبراء </del>الثلاجة من الأجهزة الحيوية في المنازل، فهي تحفظ الطعام وتضمن سلامته. <del class="diffchange diffchange-inline">[https://adlistr.com/user/profile تصليح ثلاجات في أبوظبي] ، </del>من المهم جداً الحفاظ عليها في حالة جيدة. فالمحافظة على ثلاجتك يمكن أن:&lt;br /&gt;&lt;br /&gt; • تخفض فواتير الكهرباء: الثلاجات ذات الأداء الجيد تستهلك طاقة أقل.&lt;br /&gt;&lt;br /&gt; • تمتد عمر الثلاجة: العناية المناسبة قد تضيف سنوات لعملها.&lt;br /&gt;&lt;br /&gt; • تحافظ على سلامة الأطعمة: تجنب أي تلوث أو فساد.&lt;br /&gt;&lt;br /&gt;لذا، فإن العناية بالثلاجة ليست مجرد خيار، بل ضرورة لضمان راحتك وسلامتك.&lt;br /&gt;&lt;br /&gt;خدمات تصليح الثلاجات&lt;br /&gt;&lt;br /&gt;إصلاح العطل الشائعة في الثلاجات&lt;br /&gt;&lt;br /&gt;تواجه الثلاجات أحيانًا مجموعة من الأعطال التي تحتاج إلى تصليح سريع للحفاظ على وظيفتها. من بين الأعطال الأكثر شيوعًا التي يمكن أن تواجهها:&lt;br /&gt;&lt;br /&gt; • عدم التبريد: قد يحدث ذلك بسبب انسداد في الثلاجة أو نقص في الغاز.&lt;br /&gt;&lt;br /&gt; • صوت مزعج: قد يكون نتيجة لعطل في المروحة أو الموتور.&lt;br /&gt;&lt;br /&gt; • تسرب المياه: في <del class="diffchange diffchange-inline">بعض </del>الأحيان، يمكن أن يكون هناك تسرب للمياه بسبب انسداد في التصريف.&lt;br /&gt;&lt;br /&gt;مع شركة فيكس، يمكن لمتخصصينا التعامل مع جميع هذه المشكلات بفاعلية، مما يمنحك العودة إلى استخدام ثلاجتك بأسرع وقت ممكن.&lt;br /&gt;&lt;br /&gt;صيانة منتظمة لضمان أداء مثالي&lt;br /&gt;&lt;br /&gt;الصيانة الدورية هي المفتاح لضمان أداء الثلاجة بأفضل حالاتها. إليك بعض النصائح التي تساعدك في ذلك:&lt;br /&gt;&lt;br /&gt; • تنظيف الثلاجة من الداخل والخارج: يساعد ذلك على منع تراكم الجراثيم والروائح الكريهة.&lt;br /&gt;&lt;br /&gt; • فحص الأجزاء الداخلية: مثل الأرفف والمروحة.&lt;br /&gt;&lt;br /&gt; • ضبط درجة الحرارة: تأكد من ضبطها عند النسبة المثلى للحفاظ على الطعام.&lt;br /&gt;&lt;br /&gt;تذكر، الصيانة الدورية لا تمنع الأعطال فحسب، بل تزيد من كفاءة الثلاجة وتطيل من عمرها.&lt;br /&gt;&lt;br /&gt;أسعار وعروض الشركة&lt;br /&gt;&lt;br /&gt;تكلفة تصليح الثلاجات في أبوظبي&lt;br /&gt;&lt;br /&gt;عندما يتعلق الأمر بتصليح الثلاجات في أبوظبي، تقدم شركة فيكس أسعارًا تنافسية تشمل <del class="diffchange diffchange-inline">كل </del>خدماتها. تتراوح تكلفة التصليح حسب نوع العطل ومدى تعقيده، ولكن بشكل عام، يمكن أن تتوقع ما يلي:&lt;br /&gt;&lt;br /&gt; • إصلاح الأعطال البسيطة: <del class="diffchange diffchange-inline">يبدأ </del>من 150 درهم.&lt;br /&gt;&lt;br /&gt; • استبدال القطع الداخلية: قد تكلف من 300 إلى six hundred درهم حسب نوع القطعة.&lt;br /&gt;&lt;br /&gt; • خدمات الصيانة الدورية: تبدأ من 100 درهم لكل زيارة.&lt;br /&gt;&lt;br /&gt;عروض وخصومات خاصة&lt;br /&gt;&lt;br /&gt;لتخفيف العبء المالي على العملاء، تقدم شركة فيكس عروض وخصومات مميزة على خدماتها. <del class="diffchange diffchange-inline">إليكم </del>تشمل:&lt;br /&gt;&lt;br /&gt; • خصم 15% على أول زيارة: للعملاء الجدد لتجربة خدمتنا.&lt;br /&gt;&lt;br /&gt; <del class="diffchange diffchange-inline">• </del>عروض <del class="diffchange diffchange-inline">تحديدا </del>في المناسبات: مثل حلول شهر رمضان أو الأعياد.&lt;br /&gt;&lt;br /&gt; • عقد صيانة سنوي: يقدم تخفيضات كبيرة على الفواتير الشهرية.&lt;br /&gt;&lt;br /&gt;إذا كنت تبحث عن أفضل أسعار وخدمات تصليح الثلاجات في أبوظبي، فلا تتردد في الاتصال بشركة فيكس للاستفادة من هذه العروض المميزة.&lt;br /&gt;&lt;br /&gt;كيفية التواصل مع شركة فيكس&lt;br /&gt;&lt;br /&gt;الاتصال بالخدمة العملاء&lt;br /&gt;&lt;br /&gt;إذا كنت تواجه أي مشكلة مع ثلاجتك أو تحتاج إلى استفسارات حول خدمات شركة فيكس، فإن الاتصال بفريق خدمة العملاء هو الخطوة الأولى. يمكنك الاتصال على الرقم:&lt;br /&gt;&lt;br /&gt; • 0543747022&lt;br /&gt;&lt;br /&gt;يتواجد فريق خدمة العملاء على مدار الساعة لتقديم الدعم اللازم والإجابة على استفساراتك. كما يمكنك التواصل عبر البريد الإلكتروني أو من خلال صفحات الشركة على وسائل التواصل الاجتماعي لمزيد من المعلومات.&lt;br /&gt;&lt;br /&gt;حجز موعد لزيارة فني التصليح&lt;br /&gt;&lt;br /&gt;لجعل تجربتك أكثر سهولة، قامت شركة فيكس بتبسيط عملية حجز المواعيد لفني التصليح. يمكنك حجز موعد عبر:&lt;br /&gt;&lt;br /&gt; • الاتصال الهاتفي: تحدث مع أحد ممثلي خدمة العملاء لتحديد موعد ملائم.&lt;br /&gt;&lt;br /&gt; • التطبيقات الذكية: بعض العملاء يفضلون استخدام التطبيقات لحجز المواعيد بسرعة وجاهزية.&lt;br /&gt;&lt;br /&gt; • الموقع الإلكتروني: يمكنك ملء نموذج حجز لتحديد الوقت الذي يناسبك.&lt;br /&gt;&lt;br /&gt;بمجرد تحديد الموعد، سيتواجد الفني في الوقت المحدد لضمان تقديم الخدمة بكفاءة عالية. بالتواصل المناسب، ستحصل على الدعم الذي تحتاجه وخدمة تصليح ممتازة.&lt;br /&gt;&lt;br /&gt;الضمانات وسياسة الشركة&lt;br /&gt;&lt;br /&gt;ضمان الخدمة المقدمة&lt;br /&gt;&lt;br /&gt;تؤمن شركة فيكس بأن جودة الخدمة هي الأساس في بناء الثقة مع العملاء. لذلك، تقدم الشركة ضمانًا يمتد حتى ستة أشهر على جميع خدمات تصليح الثلاجات. هذا يعني أنك ستكون مشمولًا بالضمان في حال تكرار أي مشكلة تم إصلاحها خلال فترة الضمان، مما يعكس التزام الشركة بتقديم خدمات ذات جودة فائقة.&lt;br /&gt;&lt;br /&gt; • صيغة الضمان: تأتي مع كل خدمة، مما يمنحك راحة البال.&lt;br /&gt;&lt;br /&gt; • تغطية شاملة: تشمل معظم الأعطال الشائعة مع استثناءات بسيطة.&lt;br /&gt;&lt;br /&gt;سياسة الاستبدال والاسترجاع&lt;br /&gt;&lt;br /&gt;تؤمن شركة فيكس بحق العملاء في استرداد أموالهم أو استبدال القطع. في حال وقوع أي مشكلة مع القطع الجديدة المستخدمة، يمكن للعملاء الاستفادة من سياسة الاستبدال بما يلي:&lt;br /&gt;&lt;br /&gt; • استبدال القطع المعطوبة: خلال فترة الضمان.&lt;br /&gt;&lt;br /&gt; • استرداد الأموال: في حالة عدم الرضا عن الخدمة المقدمة.&lt;br /&gt;&lt;br /&gt;من خلال هذه السياسات، تسعى شركة فيكس إلى ضمان رضا العملاء التام وبناء علاقة طويلة الأمد معهم، مما يجعل تجربتك معها مريحة ومضمونة.</div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>ما هي خدمات شركة فيكس لتصليح الثلاجات في أبوظبي؟&lt;br /&gt;&lt;br /&gt;تعد شركة فيكس واحدة من الشركات الرائدة في تقديم خدمات تصليح الثلاجات في أبوظبي. تقدم الشركة مجموعة متنوعة من الخدمات تضمن لك الحفاظ على أدائها الأمثل، ومن بين <ins class="diffchange diffchange-inline">هذه </ins>الخدمات:&lt;br /&gt;&lt;br /&gt; • إصلاح الأعطال الشائعة: اعطال مثل عدم تبريد الثلاجة أو وجود تسرب للمياه.&lt;br /&gt;&lt;br /&gt; • الصيانة الدورية: للحفاظ على الأجهزة في حالة تشغيل جيدة ومنع حدوث الأعطال المفاجئة.&lt;br /&gt;&lt;br /&gt; • الاستبدال: قطع الغيار الأصلية عند الحاجة لضمان الأداء العالي.&lt;br /&gt;&lt;br /&gt;أهمية الحفاظ على ثلاجتك بحالة جيدة&lt;br /&gt;&lt;br /&gt;<ins class="diffchange diffchange-inline">تعتبر </ins>الثلاجة من الأجهزة الحيوية في المنازل، فهي تحفظ الطعام وتضمن سلامته. <ins class="diffchange diffchange-inline">لذا، </ins>من المهم جداً الحفاظ عليها في حالة جيدة. فالمحافظة على ثلاجتك يمكن أن:&lt;br /&gt;&lt;br /&gt; • تخفض فواتير الكهرباء: الثلاجات ذات الأداء الجيد تستهلك طاقة أقل.&lt;br /&gt;&lt;br /&gt; • تمتد عمر الثلاجة: العناية المناسبة قد تضيف سنوات لعملها.&lt;br /&gt;&lt;br /&gt; • تحافظ على سلامة الأطعمة: تجنب أي تلوث أو فساد.&lt;br /&gt;&lt;br /&gt;لذا، فإن العناية بالثلاجة ليست مجرد خيار، بل ضرورة لضمان راحتك وسلامتك.&lt;br /&gt;&lt;br /&gt;خدمات تصليح الثلاجات&lt;br /&gt;&lt;br /&gt;إصلاح العطل الشائعة في الثلاجات&lt;br /&gt;&lt;br /&gt;تواجه الثلاجات أحيانًا مجموعة من الأعطال التي تحتاج إلى تصليح سريع للحفاظ على وظيفتها. من بين الأعطال الأكثر شيوعًا التي يمكن أن تواجهها:&lt;br /&gt;&lt;br /&gt; • عدم التبريد: قد يحدث ذلك بسبب انسداد في الثلاجة أو نقص في الغاز.&lt;br /&gt;&lt;br /&gt; • صوت مزعج: قد يكون نتيجة لعطل في المروحة أو الموتور.&lt;br /&gt;&lt;br /&gt; • تسرب المياه: في <ins class="diffchange diffchange-inline">العديد </ins>الأحيان، يمكن أن يكون هناك تسرب للمياه بسبب انسداد في التصريف.&lt;br /&gt;&lt;br /&gt;مع شركة فيكس، يمكن لمتخصصينا التعامل مع جميع هذه المشكلات بفاعلية، مما يمنحك العودة إلى استخدام ثلاجتك بأسرع وقت ممكن.&lt;br /&gt;&lt;br /&gt;صيانة منتظمة لضمان أداء مثالي&lt;br /&gt;&lt;br /&gt;الصيانة الدورية هي المفتاح لضمان أداء الثلاجة بأفضل حالاتها. إليك بعض النصائح التي تساعدك في ذلك:&lt;br /&gt;&lt;br /&gt; • تنظيف الثلاجة من الداخل والخارج: يساعد ذلك على منع تراكم الجراثيم والروائح الكريهة.&lt;br /&gt;&lt;br /&gt; • فحص الأجزاء الداخلية: مثل الأرفف والمروحة.&lt;br /&gt;&lt;br /&gt; • ضبط درجة الحرارة: تأكد من ضبطها عند النسبة المثلى للحفاظ على الطعام.&lt;br /&gt;&lt;br /&gt;تذكر، الصيانة الدورية لا تمنع الأعطال فحسب، بل تزيد من كفاءة الثلاجة وتطيل من عمرها.&lt;br /&gt;&lt;br /&gt;أسعار وعروض الشركة&lt;br /&gt;&lt;br /&gt;تكلفة تصليح الثلاجات في أبوظبي&lt;br /&gt;&lt;br /&gt;عندما يتعلق الأمر بتصليح الثلاجات في أبوظبي، تقدم شركة فيكس أسعارًا تنافسية تشمل <ins class="diffchange diffchange-inline">جميع </ins>خدماتها. تتراوح تكلفة التصليح حسب نوع العطل ومدى تعقيده، ولكن بشكل عام، يمكن أن تتوقع ما يلي:&lt;br /&gt;&lt;br /&gt; • إصلاح الأعطال البسيطة: <ins class="diffchange diffchange-inline">بتم بدء </ins>من 150 درهم.&lt;br /&gt;&lt;br /&gt; • استبدال القطع الداخلية: قد تكلف من 300 إلى six<ins class="diffchange diffchange-inline">-</ins>hundred درهم حسب نوع القطعة.&lt;br /&gt;&lt;br /&gt; • خدمات الصيانة الدورية: تبدأ من 100 درهم لكل زيارة.&lt;br /&gt;&lt;br /&gt;عروض وخصومات خاصة&lt;br /&gt;&lt;br /&gt;لتخفيف العبء المالي على العملاء، تقدم شركة فيكس عروض وخصومات مميزة على خدماتها. <ins class="diffchange diffchange-inline">هذه </ins>تشمل:&lt;br /&gt;&lt;br /&gt; • خصم 15% على أول زيارة: للعملاء الجدد لتجربة خدمتنا.&lt;br /&gt;&lt;br /&gt; <ins class="diffchange diffchange-inline">[https://createyourdestiny.us/members/cafediving8/activity/116292/ تصليح ثلاجات في أبوظبي] </ins>عروض <ins class="diffchange diffchange-inline">خاصة </ins>في المناسبات: مثل حلول شهر رمضان أو الأعياد.&lt;br /&gt;&lt;br /&gt; • عقد صيانة سنوي: يقدم تخفيضات كبيرة على الفواتير الشهرية.&lt;br /&gt;&lt;br /&gt;إذا كنت تبحث عن أفضل أسعار وخدمات تصليح الثلاجات في أبوظبي، فلا تتردد في الاتصال بشركة فيكس للاستفادة من هذه العروض المميزة.&lt;br /&gt;&lt;br /&gt;كيفية التواصل مع شركة فيكس&lt;br /&gt;&lt;br /&gt;الاتصال بالخدمة العملاء&lt;br /&gt;&lt;br /&gt;إذا كنت تواجه أي مشكلة مع ثلاجتك أو تحتاج إلى استفسارات حول خدمات شركة فيكس، فإن الاتصال بفريق خدمة العملاء هو الخطوة الأولى. يمكنك الاتصال على الرقم:&lt;br /&gt;&lt;br /&gt; • 0543747022&lt;br /&gt;&lt;br /&gt;يتواجد فريق خدمة العملاء على مدار الساعة لتقديم الدعم اللازم والإجابة على استفساراتك. كما يمكنك التواصل عبر البريد الإلكتروني أو من خلال صفحات الشركة على وسائل التواصل الاجتماعي لمزيد من المعلومات.&lt;br /&gt;&lt;br /&gt;حجز موعد لزيارة فني التصليح&lt;br /&gt;&lt;br /&gt;لجعل تجربتك أكثر سهولة، قامت شركة فيكس بتبسيط عملية حجز المواعيد لفني التصليح. يمكنك حجز موعد عبر:&lt;br /&gt;&lt;br /&gt; • الاتصال الهاتفي: تحدث مع أحد ممثلي خدمة العملاء لتحديد موعد ملائم.&lt;br /&gt;&lt;br /&gt; • التطبيقات الذكية: بعض العملاء يفضلون استخدام التطبيقات لحجز المواعيد بسرعة وجاهزية.&lt;br /&gt;&lt;br /&gt; • الموقع الإلكتروني: يمكنك ملء نموذج حجز لتحديد الوقت الذي يناسبك.&lt;br /&gt;&lt;br /&gt;بمجرد تحديد الموعد، سيتواجد الفني في الوقت المحدد لضمان تقديم الخدمة بكفاءة عالية. بالتواصل المناسب، ستحصل على الدعم الذي تحتاجه وخدمة تصليح ممتازة.&lt;br /&gt;&lt;br /&gt;الضمانات وسياسة الشركة&lt;br /&gt;&lt;br /&gt;ضمان الخدمة المقدمة&lt;br /&gt;&lt;br /&gt;تؤمن شركة فيكس بأن جودة الخدمة هي الأساس في بناء الثقة مع العملاء. لذلك، تقدم الشركة ضمانًا يمتد حتى ستة أشهر على جميع خدمات تصليح الثلاجات. هذا يعني أنك ستكون مشمولًا بالضمان في حال تكرار أي مشكلة تم إصلاحها خلال فترة الضمان، مما يعكس التزام الشركة بتقديم خدمات ذات جودة فائقة.&lt;br /&gt;&lt;br /&gt; • صيغة الضمان: تأتي مع كل خدمة، مما يمنحك راحة البال.&lt;br /&gt;&lt;br /&gt; • تغطية شاملة: تشمل معظم الأعطال الشائعة مع استثناءات بسيطة.&lt;br /&gt;&lt;br /&gt;سياسة الاستبدال والاسترجاع&lt;br /&gt;&lt;br /&gt;تؤمن شركة فيكس بحق العملاء في استرداد أموالهم أو استبدال القطع. في حال وقوع أي مشكلة مع القطع الجديدة المستخدمة، يمكن للعملاء الاستفادة من سياسة الاستبدال بما يلي:&lt;br /&gt;&lt;br /&gt; • استبدال القطع المعطوبة: خلال فترة الضمان.&lt;br /&gt;&lt;br /&gt; • استرداد الأموال: في حالة عدم الرضا عن الخدمة المقدمة.&lt;br /&gt;&lt;br /&gt;من خلال هذه السياسات، تسعى شركة فيكس إلى ضمان رضا العملاء التام وبناء علاقة طويلة الأمد معهم، مما يجعل تجربتك معها مريحة ومضمونة.</div></td></tr>
</table></summary>
<author><name>Kenyaneed66</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=The_Explanation_Each_Webbased_Business_Demands_a_Reliable_Fulfillment_Partner&diff=3065462&oldid=0</id>
<title>The Explanation Each Webbased Business Demands a Reliable Fulfillment Partner</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=The_Explanation_Each_Webbased_Business_Demands_a_Reliable_Fulfillment_Partner&diff=3065462&oldid=0"/>
<updated>2025-05-10T00:52:38Z</updated>
<summary type="html"><p>Created page with &quot;&lt;p&gt;Amidst the rapidly evolving world of online business, the performance of your fulfillment operations can determine your success. As e-commerce continues to expand, customer...&quot;</p>
<p><b>New page</b></p><div>&lt;p&gt;Amidst the rapidly evolving world of online business, the performance of your fulfillment operations can determine your success. As e-commerce continues to expand, customers have come to demand rapid delivery times and hassle-free shopping interactions. This is how a trustworthy fulfillment hub comes into action. By assigning your order fulfillment to a trusted partner, you can concentrate on what you do best—growing your enterprise and supporting your patrons.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Selecting the right fulfilment provider is essential for ensuring high client contentment and optimizing operations. These facilities are experts in managing stock, preparing, and dispatching shipments, allowing you to scale your enterprise without the burden of operation difficulties. Regardless of whether you are a nascent company or an mature business, a trustworthy fulfilment provider can boost your operational effectiveness and help you meet customer expectations regularly.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;h3 id=&quot;keyprimaryimportant-benefitsadvantagesgains-of-usingutilizingemploying-a-fulfilmentfulfillmentorder-processing-centre&quot;&gt;Primary Gains of Using a Fulfillment Centre&lt;/h3&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Utilizing a fulfillment centre can remarkably enhance logistical effectiveness for digital businesses. By outsourcing shipping and goods management to a dedicated team, businesses can focus more on essential activities such as advertising and consumer engagement. This enables for asset allocation that is more strategic, ultimately driving growth and creativity in a competitive market.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Furthermore important advantage of a fulfillment centre is flexibility. As an e-commerce business increases, the demands for order processing and dispatch can change significantly. A fulfilment partner can quickly adjust to elevated order volumes during busy seasons without the need for businesses to spend in additional infrastructure or workforce. This flexibility ensures that companies can maintain a excellent level of service without the corresponding overhead costs of managing operations in-house.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Additionally, partnering with a fulfillment centre enhances consumer contentment through improved delivery times and order correctness. Order processing centres often have established relationships with delivery carriers and utilize advanced technology to simplify tracking and processing. This not only ensures timely deliveries but also develops trust with customers, which is crucial for repeat business and developing a faithful customer base.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;h3 id=&quot;choosingselectingdeciding-on-the-rightidealperfect-fulfilmentfulfillment-partnerprovider&quot;&gt;Deciding on the Perfect Fulfilment Provider&lt;/h3&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Choosing the perfect fulfillment provider is crucial for the success of your online business. Begin by evaluating their background and standing in the market. Look for partners with a demonstrated track record of providing excellent service. Analyzing reviews and recommendations from other businesses can yield valuable insights. Make sure they have the resources to handle your specific product types and volumes, as this will greatly affect your business efficiency.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;A important factor to consider is the systems and systems employed by the fulfilment center. A trustworthy partner should employ state-of-the-art inventory control systems and order processing software that connect effectively with your online store. This will not only enhance operations but also boost precision in order fulfillment. Inquire about their shipping options and delivery times, as these can greatly impact customer contentment and retention.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;In conclusion, consider the scalability of the fulfilment center. As your enterprise expands, your fulfillment needs will evolve. Choose a partner that can adjust to your evolving needs, whether that includes increasing order amounts, growing to new territories, or introducing additional offerings. A adaptable fulfilment partner can assist your company's growth path and help you take advantage of new opportunities while maintaining high service quality.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;h3 id=&quot;optimizingenhancingimproving-your-business-with-fulfilmentfulfillmentlogistics-solutionsservices&quot;&gt;Improving Your Business with Logistics Solutions&lt;/h3&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;A reliable fulfilment center can dramatically enhance your business operations by optimizing the order management system. By delegating your fulfilment needs, you can concentrate on key areas such as promotion and product innovation. With state-of-the-art technology and efficient inventory management, fulfilment centres can ensure prompt delivery and precise order fulfillment, minimizing the likelihood of errors that can lead to unhappy customers.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Additionally, partnering with a fulfilment service allows for growth potential. As your business scales, your fulfilment needs will change, and a specialized centre can adapt accordingly. This means you do not be burdened during peak seasons, as they have the capabilities and expertise to manage increased demand. Agile solutions offered by fulfilment centres can support you ensure a smooth customer experience, which is important for maintaining loyal clients.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Finally, utilizing fulfilment services can lead to cost savings. By taking advantage of the resources and cost efficiencies that [https://cochran-warming-2.thoughtlanes.net/fulfilment-centre-solutions-a-thorough-overview fulfilment centre] s provide, you can reduce shipping and handling costs. This not only improves your margins but also allows you to offer appealing pricing or free shipping options to your customers. Aligning in a fulfilment partner is a smart move that can position your online business for long-term success and sustainability.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;</div></summary>
<author><name>Lyricaugust21</name></author> </entry>
<entry>
<id>https://humanlove.stream/wiki/User:Lyhnekaya6686</id>
<title>User:Lyhnekaya6686</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Lyhnekaya6686"/>
<updated>2025-05-10T00:52:33Z</updated>
<summary type="html"><p>User account <a href="/index.php?title=User:Lyhnekaya6686&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Lyhnekaya6686 (page does not exist)"><bdi>Lyhnekaya6686</bdi></a> was created</p>
</summary>
<author><name>Lyhnekaya6686</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=Kicksta_Get_Instagram_Followers_100_Percent_Real_Followers&diff=3065461&oldid=0</id>
<title>Kicksta Get Instagram Followers 100 Percent Real Followers</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Kicksta_Get_Instagram_Followers_100_Percent_Real_Followers&diff=3065461&oldid=0"/>
<updated>2025-05-10T00:52:32Z</updated>
<summary type="html"><p>Created page with &quot;Make sure you choose a supplier that can ship within a timeframe that suits your wants and expectations. They provide high-quality followers at honest prices, and the best hal...&quot;</p>
<p><b>New page</b></p><div>Make sure you choose a supplier that can ship within a timeframe that suits your wants and expectations. They provide high-quality followers at honest prices, and the best half is, their companies won’t elevate any red flags with the Instagram algorithm. Plus, they have got your again with ensures in case anything goes incorrect.&lt;br /&gt;&lt;br /&gt;By boosting your followers, your engagement charges can improve extra shortly, and produce you nearer to changing into a well-known model or influencer. However, it's necessary to note that not all followers are created equal. [https://smmcpan.com/ زيادة متابعين انستقرام] To build a group that actually helps and engages along with your content, you need focused engagement. This means attracting people who are genuinely thinking about your niche and usually have a tendency to interact with your content material. With subtle and focused engagement, your content can reach the proper individuals at the right time, leading to organic growth and a loyal following.&lt;br /&gt;&lt;br /&gt;Rather than immediately delivering followers, they gradually add smaller amounts over weeks and months. With consistent posting, you can successfully grow 1k to 5k engaged followers over a 6 month timeframe. You can belief the staff at Media Mister to offer you the honest and objective recommendation you have to choose the proper products on your promotional marketing campaign. We're at all times on hand to reply any questions you would possibly have and explain intimately how our companies work. Media Mister transforms your social presence on Instagram, TikTok, YouTube, and more. Elevate your authority with premium followers, likes, and engagement to achieve the popularity and affect you deserve throughout every platform.&lt;br /&gt;&lt;br /&gt;Videos with plenty of views gain far more reach and develop profiles organically. Posts which have little to no likes by no means have explosive exposure. Fast, real likes present the indicators your posts deserve to achieve massive audiences.&lt;br /&gt;&lt;br /&gt;From influencer collabs to UGC that sells, uncover how footwear brands are lacing up daring strategies and strolling everywhere in the competitors. Explore methods that shine bright—discover how prime manufacturers are leveraging storytelling, influencer magic, and irresistible visuals to seize consideration (and wallets). Uncover the glow-up secrets behind viral strategies, authentic influencer partnerships, and content that converts. With planning and collaboration now extra efficient than ever, you have loads of time to brainstorm new and thrilling content material ideas that will develop your Instagram account. With the Instagram grid view, you'll find a way to gauge the visible attraction of your content at first glance.</div></summary>
<author><name>Restlisa7</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=Dudleydohn6198&diff=3065460&oldid=0</id>
<title>Dudleydohn6198</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Dudleydohn6198&diff=3065460&oldid=0"/>
<updated>2025-05-10T00:52:21Z</updated>
<summary type="html"><p>Created page with &quot;The coronavirus disease 2019 restrictions on in-person simulation activities necessitated modifying the traditional boot camp skills curriculum for matriculating PGY1 general...&quot;</p>
<p><b>New page</b></p><div>The coronavirus disease 2019 restrictions on in-person simulation activities necessitated modifying the traditional boot camp skills curriculum for matriculating PGY1 general surgery residents to a virtual format. This study investigated the relative effectiveness of in-person versus virtual instruction on the development of suturing and knot-tying skills.&lt;br /&gt;&lt;br /&gt; In all, 55 residents participated in a validated, proficiency-based, preinternship skills curriculum, 26 in 2019 and 29 in 2020. Both groups received an introduction to the curriculum, were given time for practice and offered one-on-one tutoring by faculty by request, and completed a filmed posttest. The 2019 class received in-person instruction during a boot camp at the end of June, while the 2020 class was provided with suture kits and received instruction via Zoom throughout June. The 2 groups were compared by post-test performance, date of task proficiency, and additional coaching required.&lt;br /&gt;&lt;br /&gt; In 2019, 5.7% of the posttest tasks were graded as proficient versus 87% in 2020. The 2020 class outperformed the 2019 class on every metric in every task (P &amp;lt; .001). In 2019, faculty spent 55.5 hours with residents in one-on-one remediation, resulting in proficiency in 64% of the tasks by November. In 2020, 18 hours of one-on-one remediation resulted in proficiency in 92% of the tasks by September.&lt;br /&gt;&lt;br /&gt; Learners who received virtual instruction with access to materials at home gained proficiency in suturing and knot-tying skills earlier and with less coaching. These data demonstrate that the virtual curriculum is effective and an improvement on the previous in-person curriculum.&lt;br /&gt;&lt;br /&gt;Learners who received virtual instruction with access to materials at home gained proficiency in suturing and knot-tying skills earlier and with less coaching. These data demonstrate that the virtual curriculum is effective and an improvement on the previous in-person curriculum.&lt;br /&gt;&lt;br /&gt; Postoperative surgical site infection is a major source of morbidity after pancreatic head resections, and data suggest bacterobilia as a leading cause. Some centers use intraoperative bile duct cultures to guide postoperative antimicrobial prophylaxis. This prospective study evaluates culture differences between traditional bile duct swab versus bile duct aspiration intraoperative samples.&lt;br /&gt;&lt;br /&gt; Prospective patients undergoing pancreatic head resection with both bile duct swab and bile duct aspiration were included. [https://www.selleckchem.com/products/OSI-906.html Linsitinib] Cultures were reviewed for organism characteristics. Any growth of organisms was considered a positive culture. Bile duct swab yield and characteristics were compared with bile duct aspiration. Postoperative surgical site infection complications were compared to bile duct culture results.&lt;br /&gt;&lt;br /&gt; Fifty patients were included. Bile duct aspiration resulted in a significantly higher median number of organisms compared to bile duct swab (6 vs 3; P &amp;lt; .001). There were no differences in the number of patients (37 vs 33) having positive bile duct aspiration and bile duct swab cultures (P= .385). Anaerobic cultures (not possible with bile duct swab) were positive in 21 patients with bile duct aspiration. A total of 37 (74%) patients had preoperative biliary stenting, which highly associated (P &amp;lt; .001) with positive cultures. Bile duct culture organisms correlated with postoperative surgical site infection in 12/17 (71%) patients.&lt;br /&gt;&lt;br /&gt; Use of bile duct aspiration improves intraoperative bile duct culture organism yield over bile duct swab and may improve tailoring of antibiotics in patients undergoing pancreatic head resection.&lt;br /&gt;&lt;br /&gt;Use of bile duct aspiration improves intraoperative bile duct culture organism yield over bile duct swab and may improve tailoring of antibiotics in patients undergoing pancreatic head resection.This paper presents an effective sliding mode control defined on the basis of super twisting algorithm (ST-SMC) for three-phase grid-tied three-level neutral point clamped (NPC) inverters. Unlike the existing SMC techniques devoted for grid-tied NPC inverters, the proposed ST-SMC method suppresses chattering and achieves good tracking performance while maintaining the prominent features of the sliding mode control such as robustness and simple implementation. Furthermore, the proposed ST-SMC method has the ability to operate with imbalanced and deteriorated grid voltages. The steady-state and transient performances of ST-SMC with ideal, imbalanced and deteriorated grid voltages are investigated experimentally. The experimental results expose that the presented control approach offers fast transient response and achieves the grid current control with small total harmonic distortion.The efficacy of early administration of dual antiplatelet therapy (DAPT) for secondary prevention after acute ischemic stroke or transient ischemic attack (TIA) is uncertain. This systematic review and meta-analysis compares the safety and efficacy of early administration ( less then 24 hours) of DAPT (using either clopidogrel or ticagrelor with aspirin) versus single antiplatelet therapy (SAPT; aspirin alone) in acute non-cardioembolic ischemic stroke or TIA, incorporating data from large randomized controlled trials. Published trials fulfilling our criteria were identified from an electronic search of MEDLINE, with key words including &quot;clopidogrel or ticagrelor&quot;, &quot;aspirin&quot;, &quot;ischemic stroke&quot;, &quot;transient ischemic attack&quot;, and &quot;randomized controlled trial&quot;. Included were 3 randomized controlled trials of 21,067 patients assessing early administration ( less then 24 hours from symptom onset) of DAPT versus SAPT in non-cardioembolic acute ischemic stroke or TIA. Our efficacy outcomes were ischemic stroke and all-cause mortality. Our safety outcome was severe bleeding. We performed a meta-analysis to pool results with a hierarchical Bayesian random-effects model. Dual antiplatelet therapy significantly reduced the risk of ischemic stroke (hazard ratio [HR], 0.73; 95% credible interval [CrI] 0.54, 0.97), while increasing the risk of severe bleeding (HR, 2.48; 95% CrI 1.07, 5.26). There was a non-significant numerical trend toward increased mortality with DAPT (HR, 1.29; 95% CrI 0.73, 2.23). These observations were robust under the sensitivity analysis. In the present systematic review and meta-analysis of randomized controlled trials, DAPT reduced the risk of ischemic stroke at the cost of an increase in severe bleeding. Additional trials examining the ideal timing of DAPT administration are needed to thoroughly investigate the role, if any, of routine DAPT in patients with non-cardioembolic ischemic stroke or high-risk TIA.</div></summary>
<author><name>Dudleydohn6198</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=Fisherneal9260&diff=3065459&oldid=0</id>
<title>Fisherneal9260</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Fisherneal9260&diff=3065459&oldid=0"/>
<updated>2025-05-10T00:52:20Z</updated>
<summary type="html"><p>Created page with &quot;BACKGROUND Vector-borne diseases are a major public health concern and cause significant morbidity and mortality. Zika virus (ZIKV) is the etiologic agent of a massive outbrea...&quot;</p>
<p><b>New page</b></p><div>BACKGROUND Vector-borne diseases are a major public health concern and cause significant morbidity and mortality. Zika virus (ZIKV) is the etiologic agent of a massive outbreak in the Americas that originated in Brazil in 2015 and shows a strong association with congenital ZIKV syndrome in newborns. Cache Valley virus (CVV) is a bunyavirus that causes mild to severe illness in humans and ruminants. In this study, we investigated the vector competence of Virginia mosquitoes for ZIKV and CVV to explore their abilities to contribute to potential outbreaks. METHODS To determine vector competence, mosquitoes were fed a blood meal comprised of defibrinated sheep blood and virus. The presence of midgut or salivary gland barriers to ZIKV infection were determined by intrathoracic inoculation vs oral infection. After 14-days post-exposure, individual mosquitoes were separated into bodies, legs and wings, and saliva expectorant. Virus presence was detected by plaque assay to determine midgut infection, dissemination, aratory transmission study provided further understanding of potential ZIKV and CVV transmission cycles with Aedes mosquitoes from Virginia. The ability for these mosquitoes to transmit ZIKV and CVV make them a public health concern and suggest targeted control programs by mosquito and vector abatement districts.BACKGROUND Cystic echinococcosis, caused by the cestode Echinococcus granulosus, is a neglected tropical disease with remarkable morbidity in humans and a problem of worldwide economic importance in livestock industry. Understanding the molecular basis of the parasite growth and development is essential for the disease diagnosis, management and control. The tetraspanin (TSP) family of proteins are transmembrane proteins with a role in many physiological processes of eukaryotic organisms. TSPs present in the tegumental surface of platyhelminths play pivotal roles in host-parasite interaction. However, little is known about the role of TSPs in growth and development in the Platyhelminthes. To understand the role of TSP1 in the growth and development of E. granulosus we investigated the effect of EgTSP1-specific long dsRNA in different in vitro stages of the parasite. METHODS Different stages of E. granulosus, protoscoleces and strobilated worms, were cultivated In vitro in di-phasic media. Using long dsRNA and ccines and RNAi-based drugs.OBJECTIVE Despite scaling-up testing and antiretroviral treatment in Latin America, advanced HIV remains a significant public health problem. The objective of the present study was look for historical risk factors for death in French Guiana's HIV cohort taking into account the immunological status, the main opportunistic infections, and their treatment. A retrospective cohort study was conducted on data collected between 1992 and 2008 to identify factors associated with death in a cohort 2323 patients. RESULTS There were 370 deaths for a total 9608 patient-years. Being on tuberculosis treatment was associated with a greater hazard of death. The diagnosis of confirmed tuberculosis, of histoplasmosis, of toxoplasmosis, and pneumocystosis were independently associated with death. Interactions terms between cotrimoxazole treatment and pneumocystosis, or between confirmed tuberculosis and tuberculosis treatment showed a protective treatment-effect. All patients having received anti-tuberculosis treatment (n = 347) did not have a final diagnosis of tuberculosis (n = 93). For histoplasmosis, 199 patients received antifungal treatment while 141 were diagnosed as having histoplasmosis. The number of patients on anti-tuberculosis drugs was far greater that the number of patients with confirmed tuberculosis, and these patients on treatment without confirmed tuberculosis had a twofold greater risk of dying.BACKGROUND Hung Vuong Hospital (HVH) is a 900-bed maternity hospital in Ho-Chi-Minh-City, Vietnam. Due to low compliance, a quasi-experimental, observational study was&amp;nbsp;conducted with the aim to improve hand hygiene. [https://www.selleckchem.com/products/cvn293.html find more] METHODS A multimodal promotion strategy was established in 2010 and further developed towards ongoing, repetitive and inventive campaigns including&amp;nbsp;patient participation. Hand hygiene compliance was monitored by direct observation and healthcare-associated infections (HAIs) by applying standard definitions. RESULTS Between 2010 and 2018, a total of 43,711 hand hygiene opportunities were observed. Compliance improved from 21.5% (95%CI 20.2-22.8%) in 2010 to 75.1% (73.9-76.2%) in 2018 (incidence rate ratio, IRR , 1.10; 95%CI, 1.10-1.11). This was achieved through increasing recourse to alcohol-based hand rubbing. A total of 554,720 women were admitted to HVH during the study period for 353,919 deliveries (198,679 vaginal; 155,240 by C-section) and 257,127 surgical procedures. The HAI-incidence decreased significantly from 1.10 episodes per 1000 patient-days in 2010 to 0.45 per 1000 patient-days in 2018 (IRR 0.85;&amp;nbsp;95%CI, 0.79-0.90). Significant improvement was observed also for surgical site infections after gynaecological surgery (IRR 0.95; 95%CI, 0.92-0.99) and endometritis after abortion (IRR 0.80; 95%CI, 0.68-0.93). CONCLUSIONS A multimodal strategy aiming at behaviour change significantly improved and sustained hand hygiene, which contributed to the reduction of healthcare-associated infections.BACKGROUND Rapamycin, an inhibitor of the serine/threonine protein kinase mTOR, is an immunosuppressant used to treat renal transplant recipients, but it can cause endothelial and mitochondrial dysfunction. Metformin is used for the treatment of type 2 diabetes and was reported to exert therapeutic effects against rheumatoid arthritis and obesity by improving mitochondrial dysfunction via the activation of fibroblast growth factor 21. We investigated the therapeutic effects of rapamycin-metformin combination therapy in obese mice with collagen-induced arthritis (CIA). METHODS Mouse embryonic fibroblasts were treated with rapamycin, metformin, or rapamycin-metformin, and their respiratory level and mitochondrial gene expression were assayed. Mice were fed a high-fat diet, immunized with type II collagen, and subsequently treated with rapamycin-metformin daily for 10 weeks. RESULTS Rapamycin-treated cells exhibited dysfunction of mitochondrial respiration and decreased mitochondrial gene expression compared with rapamycin-metformin-treated cells.</div></summary>
<author><name>Fisherneal9260</name></author> </entry>
<entry>
<id>https://humanlove.stream/wiki/User:Bernsteinbech4865</id>
<title>User:Bernsteinbech4865</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Bernsteinbech4865"/>
<updated>2025-05-10T00:52:12Z</updated>
<summary type="html"><p>User account <a href="/index.php?title=User:Bernsteinbech4865&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Bernsteinbech4865 (page does not exist)"><bdi>Bernsteinbech4865</bdi></a> was created</p>
</summary>
<author><name>Bernsteinbech4865</name></author> </entry>
<entry>
<id>https://humanlove.stream/index.php?title=15_Reasons_You_Must_Love_Gas_Safety_Certificate_Landlord_Milton_Keynes&diff=3065458&oldid=0</id>
<title>15 Reasons You Must Love Gas Safety Certificate Landlord Milton Keynes</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=15_Reasons_You_Must_Love_Gas_Safety_Certificate_Landlord_Milton_Keynes&diff=3065458&oldid=0"/>
<updated>2025-05-10T00:52:11Z</updated>
<summary type="html"><p>Created page with &quot;&lt;p&gt;Title: The Importance of a Gas Safety Certificate for Landlords in Milton Keynes&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;As a landlord, it is your legal obligation to guarantee the safety of you...&quot;</p>
<p><b>New page</b></p><div>&lt;p&gt;Title: The Importance of a Gas Safety Certificate for Landlords in Milton Keynes&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;As a landlord, it is your legal obligation to guarantee the safety of your occupants. One vital aspect of this responsibility is getting a gas safety certificate for your property in Milton Keynes. This certificate is evidence that all gas devices, fittings, and flues in the property are safe to use. In this article, we will go over the importance of a gas safety certificate for proprietors in Milton Keynes and address some frequently asked concerns.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Gas safety certificates are required by law for all rental properties in the UK. They need to be gotten annually by a Gas Safe registered engineer who will check all gas home appliances, fittings, and flues in the property to ensure they are safe to use. The engineer will check for gas leaks, carbon monoxide poisoning, and other prospective dangers.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;There are numerous reasons that a gas safety certificate is important for proprietors in Milton Keynes. To start with, it is a legal requirement. Failure to acquire a gas safety certificate can lead to fines, imprisonment, and even a restriction on renting out properties. Second of all, it makes sure the safety of your tenants. Gas home appliances that are not appropriately kept can lead to carbon monoxide poisoning, fires, and explosions. Thirdly, it can supply you with comfort, knowing that your property is safe and compliant with guidelines.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Frequently asked questions:&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Q: Who can issue a gas safety certificate? [https://copeland-vest-4.mdwrite.net/20-fun-details-about-gas-safety-certificate-landlord-milton-keynes boiler engineer milton keynes] : A Gas Safe registered engineer should release a gas safety certificate.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Q: How often do I need to get a gas safety certificate?A: A gas safety certificate must be obtained annually.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Q: What occurs if I don't have a gas safety certificate?A: Failure to get a gas safety certificate can lead to fines, jail time, and even a restriction on leasing out homes.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Q: How long does a gas safety certificate last?A: A gas safety certificate is valid for 12 months from the date of inspection.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Q: Can I carry out the gas safety check myself?A: No, only a Gas Safe registered engineer can carry out the gas safety check.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Here are some actions that landlords in Milton Keynes can require to guarantee they comply with gas safety policies:&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;ol&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;Only use a Gas Safe registered engineer to perform gas work.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;Keep records of all gas safety evaluations and share them with your occupants.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;Provide your occupants with a copy of the gas safety certificate before they move in.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;Perform routine gas safety checks.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;Guarantee that all gas home appliances are frequently serviced and preserved.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt;&lt;/ol&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;In conclusion, a gas safety certificate is an essential file for property owners in Milton Keynes. It ensures the safety of your tenants, supplies assurance, and is a legal requirement. By utilizing a Gas Safe registered engineer and performing routine gas safety checks, you can ensure that your home is compliant with guidelines and safe to lease.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;List of Gas Safe Registered Engineers in Milton Keynes:&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;ol&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;A &amp;amp; &amp;amp; J Gas Services - 01908 631112&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;CPS Gas Services - 01908 648648&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;D &amp;amp; &amp;amp; J Plumbing and Heating - 01908 374566&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;GAS Heating Services - 01908 631631&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;MK Gas Solutions - 01908 376060&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt;&lt;/ol&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;By following these actions and working with a Gas Safe registered engineer, you can make sure that your residential or commercial property is safe, compliant with regulations, and that your tenants are protected.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;</div></summary>
<author><name>Brakeglider69</name></author> </entry>
<entry>
<id>https://humanlove.stream/wiki/User:Futtrupgoode4457</id>
<title>User:Futtrupgoode4457</title>
<link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Futtrupgoode4457"/>
<updated>2025-05-10T00:52:10Z</updated>
<summary type="html"><p>User account <a href="/index.php?title=User:Futtrupgoode4457&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Futtrupgoode4457 (page does not exist)"><bdi>Futtrupgoode4457</bdi></a> was created</p>
</summary>
<author><name>Futtrupgoode4457</name></author> </entry>
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