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<?xml version="1.0"?><feed xmlns="http://www.w3.org/2005/Atom" xml:lang="en"> <id>https://humanlove.stream/api.php?hidebots=1&urlversion=1&days=7&limit=50&action=feedrecentchanges&feedformat=atom</id> <title>Human's Love - Recent changes [en]</title> <link rel="self" type="application/atom+xml" href="https://humanlove.stream/api.php?hidebots=1&urlversion=1&days=7&limit=50&action=feedrecentchanges&feedformat=atom"/> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/Special:RecentChanges"/> <updated>2025-07-02T20:51:41Z</updated> <subtitle>Track the most recent changes to the wiki in this feed.</subtitle> <generator>MediaWiki 1.30.0</generator> <entry> <id>https://humanlove.stream/index.php?title=Richtergold3590&diff=3615815&oldid=0</id> <title>Richtergold3590</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Richtergold3590&diff=3615815&oldid=0"/> <updated>2025-07-02T20:51:32Z</updated> <summary type="html"><p>Created page with &quot;Terahertz (THz) technology offers novel opportunities in the intraoperative neurodiagnosis. Recently, the significant progress was achieved in the study of brain gliomas and i...&quot;</p><p><b>New page</b></p><div>Terahertz (THz) technology offers novel opportunities in the intraoperative neurodiagnosis. Recently, the significant progress was achieved in the study of brain gliomas and intact tissues, highlighting a potential for THz technology in the intraoperative delineation of tumor margins. However, a lack of physical models describing the THz dielectric permittivity of healthy and pathological brain tissues restrains the further progress in this field. In the present work, the ex vivo THz dielectric response of human brain tissues was analyzed using relaxation models of complex dielectric permittivity. Dielectric response of tissues was parametrized by a pair of the Debye relaxators and a pair of the overdamped-oscillators - namely, the double-Debye (DD) and double-overdamped-oscillator (DO) models. Both models accurately reproduce the experimental curves for the intact tissues and the WHO Grades I-IV gliomas. While the DD model is more common for THz biophotonics, the DO model is more physically rigorous, since it satisfies the sum rule. In this way, the DO model and the sum rule were, then, applied to estimate the content of water in intact tissues and gliomas ex vivo. The observed results agreed well with the earlier-reported data, justifying water as a main endogenous label of brain tumors in the THz range. The developed models can be used to describe completely the THz-wave - human brain tissues interactions in the frameworks of classical electrodynamics, being quite important for further research and developments in THz neurodiagnosis of tumors.Among the multitude of optical polarization contrasts that can be observed in complex biological specimens, linear diattenuation (LD) imaging has received little attention. It is indeed challenging to image LD with basic polarizing microscopes because it is often relatively small in comparison with linear retardance (LR). In addition, interpretation of LD images is not straightforward when experiments are conducted in the visible range because LD can be produced by both dichroism and anisotropic scattering. Mueller polarimetry is a powerful implementation of polarization sensing able to differentiate and measure the anisotropies of specimens. In this article, near infrared transmission Mueller scanning microscopy is used to image LD in thin biological specimen sections made of various proteins with unprecedented resolution and sensitivity. The near infrared spectral range makes it possible to lower the contribution of dichroism to the total linear diattenuation in order to highlight anisotropic scattering. [https://www.selleckchem.com/products/t26.html this website] Pixel-by-pixel comparison of LD images with LR and multiphoton images demonstrates that LD is produced by under-resolved structures that are not revealed by other means, notably within the sarcomere of skeletal muscles. LD microscopy appears as a powerful tool to provide new insights into the macro-molecular organization of biological specimens at the sub-microscopic scale without labelling.We introduce a compact array fluorescence sensor principle that takes advantage of the long luminescence lifetimes of upconversion nanoparticles (UCNPs) to deploy a filter-free, optics-less contact geometry, advantageous for modern biochemical assays of biomolecules, pollutants or cells. Based on technologically mature CMOS chips for ∼10 kHz technical/scientific imaging, we propose a contact geometry between assayed molecules or cells and a CMOS chip that makes use of only a faceplate or direct contact, employing time-window management to reject the 975 nm excitation light of highly efficient UCNPs. The chip surface is intended to implement, in future devices, a resonant waveguide grating (RWG) to enhance excitation efficiency, aiming at the improvement of upconversion luminescence emission intensity of UCNP deposited atop of such an RWG structure. Based on mock-up experiments that assess the actual chip rejection performance, we bracket the photometric figures of merit of such a promising chip principle and predict a limit of detection around 10-100 nanoparticles.&lt;br /&gt;&lt;br /&gt; The main goal of this functional MRI (fMRI) study was to examine whether cognitive deficits in glioma patients prior to treatment are associated with abnormal brain activity in either the central executive network (CEN) or default mode network (DMN).&lt;br /&gt;&lt;br /&gt; Forty-six glioma patients, and 23 group-matched healthy controls (HCs) participated in this fMRI experiment, performing an N-back task. Additionally, cognitive profiles of patients were evaluated outside the scanner. A region of interest-based analysis was used to compare brain activity in CEN and DMN between groups. Post hoc analyses were performed to evaluate differences between low-grade glioma (LGG) and high-grade glioma (HGG) patients.&lt;br /&gt;&lt;br /&gt; In-scanner performance was lower in glioma patients compared to HCs. Neuropsychological testing indicated cognitive impairment in LGG as well as HGG patients. fMRI results revealed normal CEN activation in glioma patients, whereas patients showed reduced DMN deactivation compared to HCs. Brain activity levels did not diftioning of executive brain regions. Solely focusing on increases in brain activity may well be insufficient if we want to understand the underlying brain mechanism of cognitive impairments in patients, as our results indicate the importance of assessing deactivation.&lt;br /&gt;&lt;br /&gt; Heat stroke treatment focuses on rapid cooling because symptom severity correlates with the duration of hyperthermia (i.e., time during which the core body temperature is sustained above the critical threshold). Several reports have revealed that cold-water immersion is a safe and appropriate therapy for exertional heat stroke in young, otherwise healthy patients. However, few reports have assessed cold-water immersion in older patients. We document three cases of cold-water immersion in older heat stroke patients and evaluate its safety and efficacy.&lt;br /&gt;&lt;br /&gt; Three older patients with severe heat stroke were treated with cold-water immersion. Core body temperatures decreased rapidly, and no complications occurred during the treatment.&lt;br /&gt;&lt;br /&gt; Cold-water immersion can achieve rapid cooling and is effective in treating heat stroke. With special precautions, it can be performed safely for older patients. Further investigation is warranted to establish appropriate cooling methods in older adults.&lt;br /&gt;&lt;br /&gt;Cold-water immersion can achieve rapid cooling and is effective in treating heat stroke.</div></summary> <author><name>Richtergold3590</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Whitneysantiago6954</id> <title>User:Whitneysantiago6954</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Whitneysantiago6954"/> <updated>2025-07-02T20:51:29Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Whitneysantiago6954&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Whitneysantiago6954 (page does not exist)"><bdi>Whitneysantiago6954</bdi></a> was created</p></summary> <author><name>Whitneysantiago6954</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Lodbergmccormick5896</id> <title>User:Lodbergmccormick5896</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Lodbergmccormick5896"/> <updated>2025-07-02T20:51:22Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Lodbergmccormick5896&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Lodbergmccormick5896 (page does not exist)"><bdi>Lodbergmccormick5896</bdi></a> was created</p></summary> <author><name>Lodbergmccormick5896</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Riisfinch0267</id> <title>User:Riisfinch0267</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Riisfinch0267"/> <updated>2025-07-02T20:51:22Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Riisfinch0267&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Riisfinch0267 (page does not exist)"><bdi>Riisfinch0267</bdi></a> was created</p></summary> <author><name>Riisfinch0267</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Martensroed1485</id> <title>User:Martensroed1485</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Martensroed1485"/> <updated>2025-07-02T20:51:19Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Martensroed1485&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Martensroed1485 (page does not exist)"><bdi>Martensroed1485</bdi></a> was created</p></summary> <author><name>Martensroed1485</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Demantbeach9870&diff=3615814&oldid=0</id> <title>Demantbeach9870</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Demantbeach9870&diff=3615814&oldid=0"/> <updated>2025-07-02T20:51:18Z</updated> <summary type="html"><p>Created page with &quot;The vagus nerve plays a pivotal role in communication between the brain and peripheral organs involved in the sensory detection and the autonomic control of visceral activity....&quot;</p><p><b>New page</b></p><div>The vagus nerve plays a pivotal role in communication between the brain and peripheral organs involved in the sensory detection and the autonomic control of visceral activity. While the lack of appropriate experimental techniques to manipulate the physiological activity of the vagus nerve has been a long-standing problem, recent advancements in optogenetic tools, including viral vectors and photostimulation devices, during the late 2010s have begun to overcome this technical hurdle. Furthermore, identifying promoters for expressing transgenes in a cell-type-specific subpopulation of vagal neurons enables the selective photoactivation of afferent/efferent vagal neurons and specific visceral organ-innervating vagal neurons. In this chapter, we describe recent optogenetic approaches to study vagus nerve physiology and describe how these approaches have provided novel findings on the roles of vagus nerve signals in the cardiac, respiratory, and gastrointestinal systems. Compared with studies of the central nervous system, there are still few insights into vagus nerve physiology. Further studies with optogenetic tools will be useful for understanding the fundamental characteristics of vagus nerve signals transferred throughout the body.Using an optogenetic approach, we analyzed a local neuron network of the respiratory center in the medulla of a brainstem-spinal cord preparation isolated from neonatal rat. We developed a transgenic (Tg) rat line in which Phox2b-positive cells expressed archaerhodopsin-3 (Arch) or one of the step-function channelrhodopsin variants (ChRFR) under the control of Phox2b promoter-enhancer regions. Then, in en bloc preparations from 0- to 2-day-old Tg neonatal rats, we analyzed membrane potential changes of medullary respiratory-related neurons in response to photostimulation of the rostral ventral medulla. The photostimulation-induced inhibition or facilitation of the respiratory rhythm in Arch-expressing or ChRFR-expressing Tg rat preparations, respectively. [https://www.selleckchem.com/products/Cyclopamine.html Cyclopamine Hedgehog antagonist] Selective photoactivation of Phox2b-positive neurons expressing ChRFR in the rostral ventrolateral medulla of a neonatal rat en bloc preparation induced membrane potential changes of respiratory-related neurons that were dependent on heterogeneous properties of synaptic connections in the respiratory center. We concluded that the optogenetic approach is a powerful method of verifying a hypothetical model of local networks among respiratory-related neurons in the rostral ventrolateral medulla of neonatal rat.The formation and maintenance of episodic memories are important for our daily life. Accumulating evidence from extensive studies with pharmacological, electrophysiological, and molecular biological approaches has shown that both entorhinal cortex (EC) and hippocampus (HPC) are crucial for the formation and recall of episodic memory. However, to further understand the neural mechanisms of episodic memory processes in the EC-HPC network, cell-type-specific manipulation of neural activity with high temporal resolution during memory process has become necessary. Recently, the technological innovation of optogenetics combined with pharmacological, molecular biological, and electrophysiological approaches has significantly advanced our understanding of the circuit mechanisms for learning and memory. Optogenetic techniques with transgenic mice and/or viral vectors enable us to manipulate the neural activity of specific cell populations as well as specific neural projections with millisecond-scale temporal control during animal behavior. Integrating optogenetics with drug-regulatable activity-dependent gene expression systems has identified memory engram cells, which are a subpopulation of cells that encode a specific episode. Finally, millisecond pulse stimulation of neural activity by optogenetics has further achieved (a) identification of synaptic connectivity between targeted pairs of neural populations, (b) cell-type-specific single-unit electrophysiological recordings, and (c) artificial induction and modification of synaptic plasticity in targeted synapses. In this chapter, we summarize technological and conceptual advancements in the field of neurobiology of learning and memory as revealed by optogenetic approaches in the rodent EC-HPC network for episodic memories.Neural circuit function is determined not only by anatomical connections but also by the strength and nature of the connections, that is functional or physiological connectivity. To elucidate functional connectivity, selective stimulation of presynaptic terminals of an identified neuronal population is crucial. However, in the central nervous system, intermingled input fibers make selective electrical stimulation impossible. With optogenetics, this becomes possible, and enables the comprehensive study of functional synaptic connections between an identified population of neurons and defined postsynaptic targets to determine the functional connectome. By stimulating convergent synaptic inputs impinging on individual postsynaptic neurons, low frequency and small amplitude synaptic connections can be detected. Further, the optogenetic approach enables the measurement of cotransmission and its relative strength. Recently, optogenetic methods have been more widely used to study synaptic connectivity and revealed novel synaptic connections and revised connectivity of known projections. In this chapter, I focus on functional synaptic connectivity in the striatum, the main input structure of the basal ganglia, involved in the motivated behavior, cognition, and motor control, and its disruption in a range of neuropsychiatric disorders.Optogenetics, which relies on the use of photons to manipulate cellular and subcellular processes, has emerged as an important tool that has transformed several fields including neuroscience. Improvement of optogenetic topographies, together with integration with complementary tools such as electrophysiology, imaging, anatomical and behavioral analysis, facilitated this transformation. However, an inherent challenge associated with optogenetic manipulation of neurons in living organisms, such as rodents, is the requirement for implanting light-delivering optical fibers. This is partly because the current repertoires of light-sensitive opsins are activated only by visible light, which cannot effectively penetrate biological tissues. Insertion of optical fibers and subsequent photo-stimulation inherently damages brain tissue, and fiber tethering can constrain animal behavior. To overcome these technical limitations, we and other research groups recently developed minimally invasive &quot;fiberless optogenetics,&quot; which uses particles that can emit visible light through up-conversion luminescence in response to irradiation with tissue-penetrating near-infrared light.</div></summary> <author><name>Demantbeach9870</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Bjerregaardgertsen8760&diff=3615813&oldid=0</id> <title>Bjerregaardgertsen8760</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Bjerregaardgertsen8760&diff=3615813&oldid=0"/> <updated>2025-07-02T20:51:03Z</updated> <summary type="html"><p>Created page with &quot;isolated lymph node lesion, and the third case had lymph node and cutaneous involvement following the resection of a previous cutaneous lesion. Imaging studies showed no syste...&quot;</p><p><b>New page</b></p><div>isolated lymph node lesion, and the third case had lymph node and cutaneous involvement following the resection of a previous cutaneous lesion. Imaging studies showed no systemic involvement. None of the lesions exhibited histopathologic features of malignancy. All neoplasms were well circumscribed, had cystic spaces, did not display atypia or necrosis, and had less than 4 mitoses per high power field. No recurrence has been observed at follow-up after resection in all cases. All published cases of CCH with lymph node involvement so far affected a single lymph node in the axillary or inguinal regions, lacked features of malignancy, and had excellent long-term prognosis. Some cases previously reported as hidradenocarcinoma probably fit into this category. Our series adds more evidence to this rare phenomenon of &quot;benign metastasis.&quot; Aggressive treatment should be avoided in these cases, and a long-term follow-up is warranted.&lt;br /&gt;&lt;br /&gt; Cutaneous Kaposi sarcoma (KS) covers a broad spectrum both clinically and pathologically. Some histological patterns of KS may be difficult to recognize and must be differentiated from other vascular neoplasms. We report on a 56-year-old Peruvian man who had been diagnosed with classical KS on the right foot 2 years before the present episode. He presented in our clinic with new lesions on the left foot. [https://www.selleckchem.com/products/vanzacaftor.html Vanzacaftor molecular weight] Histopathological findings included areas showing epithelioid cells with moderate pleomorphism, growing in solid sheets. Immunohistochemistry showed strong nuclear staining with a granular nuclear staining pattern for human herpesvirus 8 in the epithelioid cells. A diagnosis of epithelioid Kaposi sarcoma was made, which should be considered a new histological variant.&lt;br /&gt;&lt;br /&gt;Cutaneous Kaposi sarcoma (KS) covers a broad spectrum both clinically and pathologically. Some histological patterns of KS may be difficult to recognize and must be differentiated from other vascular neoplasms. We report on a 56-year-old Peruvian man who had been diagnosed with classical KS on the right foot 2 years before the present episode. He presented in our clinic with new lesions on the left foot. Histopathological findings included areas showing epithelioid cells with moderate pleomorphism, growing in solid sheets. Immunohistochemistry showed strong nuclear staining with a granular nuclear staining pattern for human herpesvirus 8 in the epithelioid cells. A diagnosis of epithelioid Kaposi sarcoma was made, which should be considered a new histological variant.&lt;br /&gt;&lt;br /&gt; Mesenchymal neoplasms with oncogenic kinase activity due to genomic alterations in receptor tyrosine kinase genes are a morphologically heterogeneous group with a variable biologic potential. A subset of these neoplasms are characterized by immunophenotypic property of dual S100 protein/CD34 expression, histopathological resemblance to lipofibromatosis or peripheral nerve sheath tumors, and often alterations in neurotrophic tropomyosin-related kinase genes. In this article, we present a case of an S100 protein/CD34-positive spindle cell neoplasm harboring a rare BRAF gene rearrangement (KIAA1549-BRAF fusion) and discuss the clinical, histopathological, and molecular variations associated with such neoplasms.&lt;br /&gt;&lt;br /&gt;Mesenchymal neoplasms with oncogenic kinase activity due to genomic alterations in receptor tyrosine kinase genes are a morphologically heterogeneous group with a variable biologic potential. A subset of these neoplasms are characterized by immunophenotypic property of dual S100 protein/CD34 expression, histopathological resemblance to lipofibromatosis or peripheral nerve sheath tumors, and often alterations in neurotrophic tropomyosin-related kinase genes. In this article, we present a case of an S100 protein/CD34-positive spindle cell neoplasm harboring a rare BRAF gene rearrangement (KIAA1549-BRAF fusion) and discuss the clinical, histopathological, and molecular variations associated with such neoplasms.&lt;br /&gt;&lt;br /&gt; Cutaneous reactive angiomatoses encompass a spectrum of conditions driven by underlying occlusive vasculopathy. We present 2 cases of reactive angioproliferation in the context of end-stage renal failure (ESRF) manifesting as painful cutaneous ulceration. The first case demonstrates histologic features of diffuse dermal angiomatosis. The second case illustrates a nonspecific pattern of vascular proliferation which does not conform to any of the classically described subtypes, therefore reinforcing the concept of a spectrum of histopathologic changes in reactive angioproliferations. Diffuse dermal angiomatosis has been described in ESRF alone and in association with calciphylaxis, a life-threatening condition. Recognizing the patterns of reactive angioproliferation in the context of ESRF therefore has clinical relevance. Earlier identification may facilitate mitigation of risk factors and improve prognosis.&lt;br /&gt;&lt;br /&gt;Cutaneous reactive angiomatoses encompass a spectrum of conditions driven by underlying occlusive vasculopathy. We present 2 cases of reactive angioproliferation in the context of end-stage renal failure (ESRF) manifesting as painful cutaneous ulceration. The first case demonstrates histologic features of diffuse dermal angiomatosis. The second case illustrates a nonspecific pattern of vascular proliferation which does not conform to any of the classically described subtypes, therefore reinforcing the concept of a spectrum of histopathologic changes in reactive angioproliferations. Diffuse dermal angiomatosis has been described in ESRF alone and in association with calciphylaxis, a life-threatening condition. Recognizing the patterns of reactive angioproliferation in the context of ESRF therefore has clinical relevance. Earlier identification may facilitate mitigation of risk factors and improve prognosis.&lt;br /&gt;&lt;br /&gt; Leiomyosarcoma is a common sarcoma of both organs and soft tissues; however, large intradermal tumors are extremely rare. Presented is a pleomorphic leiomyosarcoma in a 64-year-old man, initially considered to be a ruptured epidermal inclusion cyst. The patient had a mildly tender, enlarging soft-tissue mass with a central pore on his right upper back. Incomplete extirpation showed a 5 × 5 cm heterogeneous, predominantly pleomorphic sarcoma with areas of fascicular and storiform spindled cells infiltrating the subcutaneous soft tissue to the underlying fascia and extending upward into the middle and upper dermis with prominent extension into pilosebaceous units. There were small foci with myxoid stroma and large areas of necrosis. CD31 demonstrated thin-walled curvilinear vessels throughout the tumor. The first desmin immunohistochemical stain near areas with myxoid stroma was negative but smooth muscle actin positive. However, desmin positivity was strong and diffuse in the spindled and more pleomorphic areas on 2 additional tissue sections.</div></summary> <author><name>Bjerregaardgertsen8760</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Mclaughlinpratt6006</id> <title>User:Mclaughlinpratt6006</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Mclaughlinpratt6006"/> <updated>2025-07-02T20:51:01Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Mclaughlinpratt6006&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Mclaughlinpratt6006 (page does not exist)"><bdi>Mclaughlinpratt6006</bdi></a> was created</p></summary> <author><name>Mclaughlinpratt6006</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Slatteryaarup2003&diff=3615812&oldid=0</id> <title>Slatteryaarup2003</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Slatteryaarup2003&diff=3615812&oldid=0"/> <updated>2025-07-02T20:50:59Z</updated> <summary type="html"><p>Created page with &quot;Fragile X syndrome (FXS), a neurodevelopmental disorder with autistic features, is caused by the loss of the fragile X mental retardation protein. Sex-specific differences in...&quot;</p><p><b>New page</b></p><div>Fragile X syndrome (FXS), a neurodevelopmental disorder with autistic features, is caused by the loss of the fragile X mental retardation protein. Sex-specific differences in the clinical profile have been observed in FXS patients, but few studies have directly compared males and females in rodent models of FXS. To address this, we performed electroencephalography (EEG) recordings and a battery of autism-related behavioral tasks on juvenile and young adult Fmr1 knockout (KO) rats. EEG analysis demonstrated that compared to wild-type, male Fmr1 KO rats showed an increase in gamma frequency band power in the frontal cortex during the sleep-like immobile state, and both male and female KO rats failed to show an increase in delta frequency power in the sleep-like state, as observed in wild-type rats. Previous studies of EEG profiles in FXS subjects also reported abnormally increased gamma frequency band power, highlighting this parameter as a potential translatable biomarker. Both male and female Fmr1 KO rats displayed reduced exploratory behaviors in the center zone of the open field test, and increased distance travelled in an analysis of 24-h home cage activity, an effect that was more prominent during the nocturnal phase. Reduced wins against wild-type opponents in the tube test of social dominance was seen in both sexes. In contrast, increased repetitive behaviors in the wood chew test was observed in male but not female KO rats, while increased freezing in a fear conditioning test was observed only in the female KO rats. Our findings highlight sex differences between male and female Fmr1 KO rats, and indicate that the rat model of FXS could be a useful tool for the development of new therapeutics for treating this debilitating neurodevelopmental disorder.&lt;br /&gt;&lt;br /&gt; Hepatocellular carcinoma (HCC) is an aggressive malignancy with increasing mortality in China. Screening and identifying effective anticancer compounds from active traditional Chinese herbs for HCC are in demand. Akebia trifoliata (Thunb) Koidz, with pharmacological anti-HCC activities in clinical, has been shown in previous research. In the present research, we elucidated a potential anticancer effect of Akebia saponin E (ASE), which is isolated from the immature seeds of Akebia trifoliata (Thunb.) Koidz, and revealed that ASE could induce severe expanded vacuoles in HCC cells. But the potential mechanism of vacuole-formation and the anti-HCC effects by ASE remain uncover.&lt;br /&gt;&lt;br /&gt; To elucidate the potential mechanism of vacuole-formation and the proliferation inhibition effects by ASE in HCC cell lines.&lt;br /&gt;&lt;br /&gt; MTT assay, colony formation assay and flow cytometry were performed to detect cell viability. Immunofluorescence analysis was used to examine the biomarkers of endomembrane. Cells were infected with tandem mRFPternative candidate to treat human HCC.&lt;br /&gt;&lt;br /&gt;ASE can prospectively inhibit the kinase activity of PIKfyve to induce lysosome-associated cytoplasmic vacuolation, and may be utilized as an alternative candidate to treat human HCC.Peroxiredoxins are a group of thiol-specific antioxidant proteins that take six isoforms in vertebrates and allow the innate immune system to sense and detoxify reactive oxygen species. [https://www.selleckchem.com/products/vy-3-135.html VY-3-135 molecular weight] In this study, we identified and characterized the perxiredoxin-1 (SsPrdx1) cDNA sequence from the rockfish, Sebastes schlegelii. In silico analysis revealed that SsPrdx1 contained a 594 bp long open reading frame (ORF) encoding a protein of 198 amino acids, with a predicted molecular weight and theoretical isoelectric point of 21.97 kDa and 6.30, respectively. The SsPrdx1 gene comprised six exons linked by five introns, while peroxiredoxin signature motifs were found in the highly conserved third, fourth, and fifth exons. Phylogenetic analysis and sequence alignment suggested that SsPrdx1 is evolutionarily conserved and that its most closely related counterpart is Salarias fasciatus. Recombinant SsPrdx1 (rSsPrdx1) displayed supercoiled DNA protection and insulin disulfide reduction activities in a concentration-dependent manner, while cells transiently transfected with pcDNA3.1 (+)/SsPrdx1 exhibited significant cytoprotective effects under oxidative stress and wound healing activity. SsPrdx1 transcripts were constitutively expressed under normal physiological conditions, with the highest expression observed in the blood. Moreover, SsPrdx1 expression increased in the blood, spleen, and liver following immune provocation by LPS, poly IC, and Streptococcus iniae injection. Thus, this study provides insights into the role of SsPrdx1 in rockfish immune protection.In the present study, two C-type lectins (designated as VpClec-3 and VpClec-4) were identified and characterized from the manila clam Venerupis philippinarum. Multiple alignment and phylogenetic relationship analysis strongly suggested that VpClec-3 and VpClec-4 belong to the C-type lectin family. In nonstimulated clams, the VpClec-3 transcript was dominantly expressed in the hepatopancreas, while the VpClec-4 transcript was mainly expressed in gill tissues. Both VpClec-3 and VpClec-4 mRNA expression was significantly upregulated following Vibrio anguillarum challenge. Recombinant VpClec-4 (rVpClec-4) was shown to bind lipopolysaccharide (LPS) and glucan in vitro, whereas recombinant VpClec-3 (rVpClec-3) only bound to glucan. In addition, rVpClec-3 and rVpClec-4 displayed broad agglutination activities towards Vibrio harveyi, Vibrio splendidus and V. anguillarum, while no agglutination activities towards Enterobacter cloacae or Aeromonas hydrophila were observed in rVpClec-3. Moreover, hemocyte phagocytosis was significantly enhanced by rVpClec-3 and rVpClec-4. All the results showed that VpClecs function as pattern recognition receptors (PRRs) with distinct recognition spectra and are potentially involved in the innate immune responses of V. philippinarum.Pancreatic cancer is highly lethal, and the most effective treatment is curative resection followed by chemotherapy. Unfortunately, chemoresistance is an extremely common occurrence, and novel treatment modalities, such as immunotherapy and molecular targeted therapy, have shown limited success in clinical practice. Pancreatic cancer is characterized by an abundant stromal compartment. Cancer-associated fibroblasts (CAFs) and the extracellular matrix they deposit account for a large portion of the pancreatic tumor stroma. CAFs interact directly and indirectly with pancreatic cancer cells and can compromise the effects of, and even promote tumorigenic responses to, various treatment approaches. To eliminate these adverse effects, CAFs depletion strategies were developed. Instead of the anticipated antitumor effects of CAFs depletion, more aggressive tumor phenotypes were occasionally observed. The failure of universal stromal depletion led to the investigation of CAFs heterogeneity that forms the foundation for stromal remodeling and normalization.</div></summary> <author><name>Slatteryaarup2003</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Conradchappell6072&diff=3615811&oldid=0</id> <title>Conradchappell6072</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Conradchappell6072&diff=3615811&oldid=0"/> <updated>2025-07-02T20:50:56Z</updated> <summary type="html"><p>Created page with &quot;Taken together, AD-MSCs were effective in treating obesity-associated diabetes in an animal model as well as protective against cardiovascular diseases as shown by AIP, which...&quot;</p><p><b>New page</b></p><div>Taken together, AD-MSCs were effective in treating obesity-associated diabetes in an animal model as well as protective against cardiovascular diseases as shown by AIP, which might be partly due to the attenuation of inflammatory mediators. Thus, AD-MSCs may offer a promising therapeutic potential in counteracting obesity-related diseases in patients.Autoimmune diseases are driven largely by a pathogenic cytokine milieu produced by aberrantly activated lymphocytes. [https://www.selleckchem.com/products/diphenyleneiodonium-chloride-dpi.html Diphenyleneiodonium clinical trial] Many cytokines, including interferon gamma (IFN-γ), utilize the JAK/STAT pathway for signal propagation. Suppressor of Cytokine Signaling-1 (SOCS1) is an inducible, intracellular protein that regulates IFN-γ signaling by dampening JAK/STAT signaling. Using Fas deficient, MRL/MpJ-Faslpr/J (MRL/lpr) mice, which develop lupus-like disease spontaneously, we tested the hypothesis that a peptide mimic of the SOCS1 kinase inhibitory region (SOCS1-KIR) would inhibit lymphocyte activation and modulate lupus-associated pathologies. Consistent with in vitro studies, SOCS1-KIR intraperitoneal administration reduced the frequency, activation, and cytokine production of memory CD8+ and CD4+ T lymphocytes within the peripheral blood, spleen, and lymph nodes. In addition, SOCS1-KIR administration reduced lymphadenopathy, severity of skin lesions, autoantibody production, and modestly reduced kidney pathology. On a cellular level, peritoneal SOCS1-KIR administration enhanced Foxp3 expression in total splenic and follicular regulatory T cells, reduced the effector memory/naïve T lymphocyte ratio for both CD4+ and CD8+ cells, and reduced the frequency of GL7+ germinal center enriched B cells. Together, these data show that SOCS1-KIR treatment reduced auto-reactive lymphocyte effector functions and suggest that therapeutic targeting of the SOCS1 pathway through peptide administration may have efficacy in mitigating autoimmune pathologies.We aimed to investigate the endoscopic features and clinical course of CMV gastroenterocolitis in immunocompetent patients. We reviewed the medical records and endoscopic images of 86 immunocompetent patients with CMV gastroenterocolitis. Immunocompetent patients were defined as those without congenital or acquired immunodeficiency syndrome, use of anti-cancer chemotherapeutic and immunosuppressive agents, and inflammatory bowel diseases. The mean age was 65.5 ± 11.8 years and 53 (61.6%) were male. Sixty-eight (79.1%) patients had comorbidities. Upper gastrointestinal-dominant, small bowel-dominant, and colon-dominant types were observed in 19, 7, and 60 patients, respectively. Endoscopic features could be classified into discrete ulcerative type with/without exudate and diffuse erythematous type with/without exudate. Antiviral treatment with ganciclovir was initiated in 51 patients (59.3%), 40 of whom improved and 1 improved after changing ganciclovir to foscarnet. Thirty-three patients (38.4%) improved without antiviral treatment. Surgery was necessary in two patients because of colon perforation before antiviral treatment. Another two patients underwent surgery because of sigmoid stricture and cecal perforation during antiviral treatment. Endoscopic type was not associated with clinical outcomes, such as surgery and death. CMV gastroenterocolitis in immunocompetent patients mostly occur in older patients with comorbidities, and the endoscopic features vary with no association with clinical outcomes.In 2016, Venezuela faced a large diphtheria outbreak that extended until 2019. Nasopharyngeal or oropharyngeal samples were prospectively collected from 51 suspected cases and retrospective data from 348 clinical records was retrieved from 14 hospitals between November 2017 and November 2018. Confirmed pathogenic Corynebactrium isolates were biotyped. Multilocus Sequence Typing (MLST) was performed followed by next-generation-based core genome-MLST and minimum spanning trees were generated. Subjects between 10 and 19 years of age were mostly affected (n = 95; 27.3%). Case fatality rates (CFR) were higher in males (19.4%), as compared to females (15.8%). The highest CFR (31.1%) was observed among those under 5, followed by the 40 to 49 age-group (25.0%). Nine samples corresponded to C. diphtheriae and 1 to C. ulcerans. Two Sequencing Types (ST), ST174 and ST697 (the latter not previously described) were identified among the eight C. diphtheriae isolates from Carabobo state. Cg-MLST revealed only one cluster also from Carabobo. The Whole Genome Sequencing analysis revealed that the outbreak seemed to be caused by different strains with C. diphtheriae and C. ulcerans coexisting. The reemergence and length of this outbreak suggest vaccination coverage problems and an inadequate control strategy.Separation effects of sodium polyacrylate (PAAS) and gum Arabic (GA) on flotation of chalcopyrite and magnesium silicate minerals using potassium butyl xanthate (PBX) as collector were investigated by micro-flotation experiments, zeta potential, Infrared spectral (IR), SEM-EDS, XPS analysis and copper sulphide ore beneficiation test. The micro-flotation experiments and zeta potential measurements showed that combined depressant consisting of PAAS and GA could efficiently reduce the recoveries of mixed minerals of serpentine and talc more than 25%, while that of chalcopyrite remained above 70% at pH 9.2. Infrared spectral (IR), SEM-EDS and XPS analysis showed that PAAS chemically reacted with Mg on the surface of serpentine, while GA adsorbed on talc surface mainly via physical interaction and hydrogen bond may also play a role. Surface synergism between PAAS and GA was investigated by turbidity test and its depression mechanism was proposed. The technology feasibility of using PAAS and GA to improve the copper sulphide ore flotation performance was verified through artificial mixed ore flotation and laboratory closed-flotation operation.A hybrid system was designed and synthesized through reacting modified halloysite (Hal-Cl) with Schiff base (DAB-PC) and applied as catalytic support for anchoring Pd NPs to afford Pd@Hal-DAB-PC catalyst. The resultant material was well identified by various analyses including Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction patterns (XRD), thermogravimetric analysis (TGA), field-emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDS), transmission electron microscopy (TEM), and inductively coupled plasma-optical emission spectrometry (ICP-OES) and revealed outstanding catalytic activity in the Sonogashira reaction in aqueous media. Also, This nanocatalyst was simply collected and recycled up to six runs with a slight drop in efficiency, indicating the durability of Pd@Hal-DAB-PC.</div></summary> <author><name>Conradchappell6072</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Fengervaldez4992</id> <title>User:Fengervaldez4992</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Fengervaldez4992"/> <updated>2025-07-02T20:50:48Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Fengervaldez4992&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Fengervaldez4992 (page does not exist)"><bdi>Fengervaldez4992</bdi></a> was created</p></summary> <author><name>Fengervaldez4992</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Top_Fish_Shooting_Games_The_Ultimate_Guide_to_Slots&diff=3615810&oldid=380432</id> <title>Top Fish Shooting Games The Ultimate Guide to Slots</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Top_Fish_Shooting_Games_The_Ultimate_Guide_to_Slots&diff=3615810&oldid=380432"/> <updated>2025-07-02T20:50:42Z</updated> <summary type="html"><p></p><a href="https://humanlove.stream/index.php?title=Top_Fish_Shooting_Games_The_Ultimate_Guide_to_Slots&amp;diff=3615810&amp;oldid=380432">Show changes</a></summary> <author><name>Honeybone25</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Hooverdeleon1140&diff=3615809&oldid=0</id> <title>Hooverdeleon1140</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Hooverdeleon1140&diff=3615809&oldid=0"/> <updated>2025-07-02T20:50:34Z</updated> <summary type="html"><p>Created page with &quot;The aim of the study is to interpret the effects of air-impingement jet drying (AIJD) on drying kinetics, color, polyphenols, and antioxidation ability of Boletus aereus slice...&quot;</p><p><b>New page</b></p><div>The aim of the study is to interpret the effects of air-impingement jet drying (AIJD) on drying kinetics, color, polyphenols, and antioxidation ability of Boletus aereus slices. Page model was most suitable for expressing and predicting AIJD curves of B. aereus slices. The moisture-effective diffusion coefficient of AIJD ranged from 7.8876 × 10-10 to 2.1426 × 10-9 m2 /s, and AIJD also showed high efficiency due to its low activation energy (45.37 kJ/mol). AIJD is better for B. aereus slices than hot air drying (HAD) in accelerating the drying rate (DR) and shortening drying time, and maintaining color. p-hydroxybenzoic acid, protocatechuic acid, and rutin were identified in B. aereus slices by ultra high-performance liquid chromatography coupled with triple quadrupole mass spectrometry (UHPLC-QqQ-MS). Total polyphenols, flavanone, phenolic acids, and antioxidant activities were significantly lower in dried B. aereus slices than those in fresh B. aereus slices. In AIJD, drying temperature had the greatest effect on the quality of B. aereus slices, and AIJD at 50 °C is the optimum drying condition for B. aereus slices. PRACTICAL APPLICATION Boletus aereus occurs in many countries all over the world. In this paper, the effect of AIJD on color, polyphenols, and antioxidation ability in B. aereus slices and its drying kinetics were studied. [https://www.selleckchem.com/products/AR-42-HDAC-42.html AR-42 order] is an efficient drying method for B. aereus by decreasing its drying time, increasing DR, and protecting the color of B. aereus. These findings have provided important reference basis for people to have a better understanding of AIJD method, which was used to dry B. aereus. #link# This study also provides a new technique for drying B. aereus, which could improve dry efficiency and reduce drying cost.Divorce has received scant attention in Iran, despite the problems that arise for individuals and families and in social life. The present study aimed to find the divorce process of the Iranian couples among whom the woman was the divorce initiator. For this purpose, interviews were conducted, using the grounded theory method, with 34 Iranian divorcing men and women (women initiating a divorce and their spouses) to investigate their divorce experience. The results revealed that the psychological, communication, cultural, and social factors involved in the divorce phenomenon were observed in five stages (1) emergence of thinking about divorce, (2) hesitation on stay, (3) difficult decision-making, (4) separation, and (5) legal action. Despite more restrictive laws and more complicated social conditions for women initiating divorce than men, the number of women initiating the divorce is increasing in the changing cultural context of Iran. Therefore, we hope that our results on the divorce process help couples, families, and especially professionals plan preventive measures and develop clinical interventions targeting marriage and marital relationships.The Cardiff Acne Disability Index (CADI) is a questionnaire designed to measure the quality of life (QoL) of teenagers and young adults with acne. It has been used clinically and within therapeutic research globally. This review aims to appraise all published data regarding the clinical and research experience of CADI, its psychometric properties and validation, from its publication in 1992 until September 2020, into a single reference source. A literature search was conducted using Medline via Ovid, PubMed, EBSCOhost, Web of Science and Scopus. All full articles in the English language were included. Ninety-six clinical studies were identified and analysed. The CADI has been used in 44 different countries, including four multinational studies, and has validated translations in 25 languages. Twenty-nine therapeutic interventions have used CADI, demonstrating its responsiveness to change. Fourteen studies have assessed reliability through test-retest and internal consistency studies. Fifty-seven studies have demonstrated aspects of its validity through correlation to other measures and five studies have investigated the dimensionality of CADI. There is evidence of high internal consistency, test-retest reliability, responsiveness to change and significant correlation with other objective measures. The minimal clinically important difference and validated score meaning bands have not yet been reported. This information is needed to improve the interpretability of CADI scores for clinical use and in research. The authors of CADI have also rephrased question two of the measure to ensure inclusivity.Virgin coconut oil (VCO), an edible oil prepared from fresh coconut kernel by natural or mechanical means without undergoing chemical refining, has been in the limelight of research as functional food oil. The phenolic components in VCO have been accredited with these pharmacological benefits. The present study compared the phenolic constituents of freshly prepared fermentation processed (FVCO) and hot-pressed VCO (HVCO) and their anti-inflammatory efficacies. The biochemical analysis documented quantitative variation in the phenolic content, being higher in HVCO than FVCO (40.03 ± 5.8 µg and 25.55 ± 5.8 µg/mL of oil, respectively). In vitro studies observed nitric oxide radical scavenging efficacy (IC50 value of 14.84 ± 0.81 µg/mL) for HVCO polyphenols, which shows higher inhibition efficacy than FVCO (29.41 ± 1.7 µg/mL). In dextran and formalin mediated acute and chronic inflammation in mice, HVCO displayed more protective efficacy (40.5 and 46.4% inhibition) than FVCO (33.3 and 43.8% inhibition), which is similar to the standard diclofenac (55.6 and 59.8% inhibition). The study, thus, concludes that compared to FVCO, HVCO is a more active anti-inflammatory agent. PRACTICAL APPLICATION Virgin coconut oil, a widely used edible oil in South Asian countries, has been shown to have health benefits possibly exerted by the natural phenolics it contains. However, different modes of preparations of VCO determine the phenolic combinations and efficacy as well. Our study compared two different VCO preparations and suggests that the VCO prepared by the traditional way (HVCO) is pharmacologically potent than that prepared by simple fermentation process (FVCO) in reducing inflammation. The efficacy is attributed to the variations in phenolic profile revealed by LC-MS analysis. Hence, the current study suggests HVCO as a potential food supplement that can reduce the incidence of degenerative diseases.</div></summary> <author><name>Hooverdeleon1140</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Xukelleher5264&diff=3615808&oldid=0</id> <title>Xukelleher5264</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Xukelleher5264&diff=3615808&oldid=0"/> <updated>2025-07-02T20:50:34Z</updated> <summary type="html"><p>Created page with &quot;1 μg/kg food. [https://www.selleckchem.com/products/zotatifin.html selleck chemicals llc] Therefore, the Panel concluded that the recycled PET obtained from this process is n...&quot;</p><p><b>New page</b></p><div>1 μg/kg food. [https://www.selleckchem.com/products/zotatifin.html selleck chemicals llc] Therefore, the Panel concluded that the recycled PET obtained from this process is not considered to be of safety concern, when used at up to 100% for the manufacture of materials and articles for contact with all types of foodstuffs for long-term storage at room temperature, with or without hotfill. The final articles made of this recycled PET are not intended to be used in microwave and conventional ovens and such uses are not covered by this evaluation.The EFSA Panel on Food Contact Materials, Enzymes and Processing Aids (CEP) assessed the safety of the recycling process ONDUPET (EU register number RECYC182), which uses the EREMA Basic technology. The input material is hot caustic washed and dried poly(ethylene terephthalate) (PET) flakes originating from collected post-consumer PET containers, including no more than 5% PET from non-food consumer applications. The flakes are heated in a continuous reactor under vacuum before being extruded. Having examined the challenge test provided, the Panel concluded that the continuous reactor (step 2, for which a challenge test was provided) is critical in determining the decontamination efficiency of the process. The operating parameters to control the performance of this step are temperature, pressure and residence time. It was demonstrated that this recycling process is able to ensure a level of migration of potential unknown contaminants into food below the conservatively modelled migration of 0.15 μg/kg food, derived from the exposure scenario for toddlers when such recycled PET is used at up to 100%. Therefore, the Panel concluded that the recycled PET obtained from this process is not considered to be of safety concern when used at up to 100% for the manufacture of thermoformed trays and containers for contact with all types of foodstuffs, except drinking water, for long-term storage at room temperature. Trays made of this recycled PET are not intended to be used in microwave and conventional ovens and such uses are not covered by this evaluation.Methyltransferase-like 3 (METTL3) is a methyltransferase responsible for N6-methyladenosine mRNA modifications, which has been demonstrated to serve oncogenic roles in various types of cancer; however, the exact function of METTL3 in oesophageal squamous cell carcinoma (ESCC) has not been determined. The present study aimed to explore the regulatory role of METTL3 in ESCC. In the present study, reverse transcription-quantitative PCR and western blotting were used to examine mRNA and protein expression, CCK-8 assays and flow cytometry were used to determine cellular viability and apoptosis, and wound healing and Transwell assays were conducted to study cellular migration and invasion. The expression levels of METTL3 were significantly higher in ESCC tissues and cell lines compared with adjacent non-tumour tissues and the normal oesophageal epithelial cell line HET-1A, respectively. Increased METTL3 expression was associated with an advanced clinical stage of ESCC and poorer prognosis. Furthermore, the genetic knockdown of METTL3 using small interfering RNA significantly suppressed ESCC growth, invasion and migration in vitro, and induced cellular apoptosis, in addition to reducing the phosphorylation levels of PI3K and AKT. In conclusion, the present study demonstrated that the upregulation of METTL3 promoted ESCC progression, and that inhibition of METTL3 significantly suppressed the malignant phenotypes of ESCC cells, at least in part, by downregulating PI3K/AKT signalling activity. Thus, it is suggested that METTL3 may be a promising therapeutic target for ESCC.Atherosclerosis is a cardiovascular disease that is pathologically associated with the growth of atherosclerotic plaques and vascular vulnerability. Intravascular ultrasound (IVUS) has been used to evaluate and treat cardiovascular diseases. Accumulating evidence has demonstrated that Gd2O3-doped nanoparticles contrast can be applied for the diagnosis of human diseases. In the present study, eplerenone (EPL), a mineralocorticoid receptor antagonist, was first doped with Gd2O3 nanoparticles (Gd2O3-EPL), following which its diagnostic efficacy for use in IVUS measurements (Gd2O3-EPL-IVUS) was evaluated for patients suspected with atherosclerosis. Gd2O3-EPL-IVUS presented with higher accuracy and sensitivity compared with IVUS in diagnosing 188 patients with suspected atherosclerosis. Gd2O3-EPL-IVUS exhibited stronger signals associated with plaque morphology compared with aloe IVUS for patients with atherosclerosis. In addition, Gd2O3-EPL-IVUS application resulted in clearer arterial plaque images compared with IVUS by binding mineralocorticoid receptors. Atherosclerosis was subsequently confirmed in all patients using computerized tomography-coronary angiography. Gd2O3-EPL-IVUS showed more accuracy in measuring vessel size, plaque burden and minimal lumen area compared with IVUS analysis alone. In conclusion, these outcomes suggest that Gd2O3-EPL-IVUS is a reliable tool for the evaluation of coronary lesions in patients with atherosclerosis.A maternal high-fat diet (HFD) has been shown to exert deleterious effects on fetal programming by impairing embryo growth, and exerts a long-term effect on the health of offspring. The present study aimed to evaluate the effect of a maternal HFD on the ovaries of offspring from the perspective of oxidative stress. Female C57BL/6J mice were randomly assigned to four groups fed various HFDs during the preconception (4 weeks) and gestation-lactation periods. Offspring were fed a normal diet after weaning, and serum and ovaries were collected at 10 weeks of age. The developmental status of follicles was observed using hematoxylin and eosin staining. The serum oxidative stress levels and insulin resistance were detected using ELISA test kits. The expression of phosphorylated form of H2AX histone variant (γH2AX), forkhead box protein O3a (FOXO3a), Bcl-2-like protein 11 (Bim)and insulin-like growth factor (IGF)-1 in ovarian tissue was analyzed using reverse transcription-quantitative PCR and western blot analyses to further explore the pathogenic mechanism. Prenatal exposure to a maternal HFD resulted in a reduced number of primordial and preantral follicles in the ovaries of offspring. Exposure to an HFD in the preconception period exerted a greater effect on the offspring compared with exposure to an HFD in the gestation-lactation period. A reduction in fat intake during the preconception, gestation and lactation periods significantly reduced the associated adverse outcomes. The expression of genes (FOXO3a, IGF-1, γH2AX and Bim) involved in oxidative stress showed a decreasing trend (high-fat/high-fat&amp;gt;high-fat/control&amp;gt;control/high-fat &amp;gt;control/control) in the ovaries of offspring. Overall, HFD exposure during the preconception period exerted a greater effect on offspring compared with HFD exposure during the gestation-lactation period. The long-term effect on follicular growth and development may be associated with increased oxidative stress and the activation of the insulin/PI3K/Akt pathway.</div></summary> <author><name>Xukelleher5264</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Underwater_Adventure_Best_Fish_Shooting_Game_Slots_to_Play&diff=3615807&oldid=0</id> <title>Underwater Adventure Best Fish Shooting Game Slots to Play</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Underwater_Adventure_Best_Fish_Shooting_Game_Slots_to_Play&diff=3615807&oldid=0"/> <updated>2025-07-02T20:50:31Z</updated> <summary type="html"><p>Created page with &quot;Introduction to Seafood Shooting Game Video poker machines&lt;br /&gt;&lt;br /&gt;Fish shooting video game slots merge the particular excitement of conventional slot mechanics together wi...&quot;</p><p><b>New page</b></p><div>Introduction to Seafood Shooting Game Video poker machines&lt;br /&gt;&lt;br /&gt;Fish shooting video game slots merge the particular excitement of conventional slot mechanics together with the interactive thrill regarding fish shooting gameplay. This unique combination invites players in order to engage with dynamic graphics, where multi-colored aquatic environments and animated fish offer an immersive encounter alongside spinning fishing reels. Players can experience potential winning additional bonuses and multipliers as they actively ‘shoot’ targets, adding some skill to typically the excitement of luck.&lt;br /&gt;&lt;br /&gt;Currency and vitality systems play the crucial role within gameplay and monetization, mirroring popular species of fish shooting games. Players collect in-game foreign currency to enhance their weapons, while vitality limits can inspire ongoing engagement, driving in-game purchases and even rewards.&lt;br /&gt;&lt;br /&gt; [https://skitterphoto.com/photographers/770407/rosenberg-rodriquez 789 เกมสล็อต] are vital regarding sustaining interest within these games. VIP systems offer distinctive perks for faithful players, while beauty upgrades allow intended for personalization, enhancing the particular overall player expertise. By integrating these features, fish capturing game slots not just captivate players but additionally create lucrative monetization pathways, ensuring they come back for more engaging gameplay and even exciting rewards.&lt;br /&gt;&lt;br /&gt;Precisely what Are Fish Capturing Games?&lt;br /&gt;&lt;br /&gt;Fish capturing games can be a well-known genre of online video games that combine hunting aspects with vibrant marine graphics. In these kinds of interactive games, participants take on the role of the shooter who makes use of a virtual weapon to aim with a number of00 fish diving in expansive aquatic environments. The aim is to precisely shoot and get as many seafood as you possibly can within a given time or even using a limited number of shots, earning points and rewards along the way. Often mixed with bright shades and exciting sound effects, these games appeal to players due to be able to their simplicity, competing nature, plus the excitement of pursuing evasive aquatic creatures. They can be located on various gaming platforms and mobile devices, attracting everyday gamers as effectively as those in search of a more skill-based experience. As fish shooting games get popularity, they carry on and evolve, incorporating advanced graphics, thrilling game play elements, and several strategies to engage users in a good immersive underwater journey.&lt;br /&gt;&lt;br /&gt;Overview of the Genre&lt;br /&gt;&lt;br /&gt;The type of **musical theater** is characterized by simply its fusion associated with song, dance, and dialogue to express narratives, often checking out themes of love, discord, and social problems. Emerging back in the nineteenth century, historical growth saw the move from vaudeville and operetta towards the more cohesive structures regarding the Broadway audio by the mid-20th century, exemplified by iconic works like &quot;Oklahoma! &quot; plus &quot;West Side Account. &quot;&lt;br /&gt;&lt;br /&gt;Musical cinema holds significant cultural significance as this reflects societal modifications, often addressing politics and cultural issues, such as throughout &quot;Hamilton, &quot; which often reinterprets American historical past. Its influence extends beyond the period, impacting film, television, and even online video games, shaping soundtracks and storytelling techniques. The genre features evolved with scientific advancements and modern themes, branching in to various styles like rock musicals in addition to jukebox productions.&lt;br /&gt;&lt;br /&gt;This kind of ongoing evolution demonstrates the genre’s adaptability, making it some sort of powerful medium regarding reflection and enjoyment. Musical theater continues to captivate followers, illustrating its long lasting importance in the particular cultural landscape.&lt;br /&gt;&lt;br /&gt;Historic History&lt;br /&gt;&lt;br /&gt;The historic background of virtually any subject often displays a tapestry regarding significant events, milestones, and influential figures that shape its context. For illustration, the evolution of democracy may be traced back to historic Greece, where early on forms emerged around the 5th century BCE. Key milestones, such as the signing of typically the Magna Carta in 1215, laid the particular groundwork for modern governance by limiting the powers associated with the monarchy.&lt;br /&gt;&lt;br /&gt;The Enlightenment from the 17th and 18th decades further propelled democratic ideals, with philosophers like John Locke and Montesquieu suggesting for individual rights and the separating of powers. The American Revolution (1775-1783) plus the French Revolution (1789-1799) marked crucial events that influenced movements across typically the globe, influencing other nations to strive for similar freedoms.&lt;br /&gt;&lt;br /&gt;The particular 20th century witnessed monumental changes, including the expansion of suffrage and civil rights movements, which more entrenched democratic rules in societies throughout the world. These historical impacts underscore how the particular past continuously shapes contemporary contexts, illustrating the interplay between history and societal progress.&lt;br /&gt;&lt;br /&gt;Evolution of Doing some fishing Games&lt;br /&gt;&lt;br /&gt;The advancement of fishing game titles has been marked simply by significant technological developments and shifts within gaming platforms. Formerly popularized in the late 20th hundred years through physical arcade machines, these video games offered players the thrill of catching online fish in attractive underwater arenas. The simplicity and enjoyment of shooting game titles drew players straight into lively, interactive environments, laying the research for future innovations.&lt;br /&gt;&lt;br /&gt;With the advent of mobile phones and even PCs, fish taking pictures games experienced the surge in popularity. Titles like Coins 777 showcase a number of arenas that dip players in diverse aquatic settings, letting for diverse game play experiences. Similarly, Dragon Fish Shooting incorporates unique features this kind of as power-ups plus customizable weapons, enhancing the competitive aspect and keeping participants engaged.&lt;br /&gt;&lt;br /&gt;These technological advancements have built fish shooting games not only accessible but also more interesting, allowing gamers to indulge in their particular love for doing some fishing anytime, anywhere. The particular transition from games machines to cellular platforms illustrates typically the evolution of gambling, demonstrating how seafood shooting games include adapted to modern day tastes while retaining their core attractiveness.&lt;br /&gt;&lt;br /&gt;Key Features associated with Fish Shooting Online games&lt;br /&gt;&lt;br /&gt;Fish shooting video games have become a popular genre in both on-line and arcade video gaming due to their particular engaging gameplay and vibrant visuals. These kinds of games combine elements of skill in addition to luck, where gamers aim to blast various types of fish to be able to earn points in addition to rewards. With dynamic graphics and audio effects that mimic an underwater surroundings, fish shooting online games provide players along with an immersive knowledge. The appeal runs beyond simple technicians, incorporating exciting features that enhance opposition, strategy, and cultural interaction. As participants navigate through different levels and come across unique challenges, the game’s key capabilities greatly contribute to be able to its enjoyment and replayability, so that it is a new favorite choice intended for both casual gamers and those seeking a far more thrilling expertise. Within the following parts, we are going to explore the particular essential features of which define fish taking pictures games, highlighting what makes them so fascinating and enjoyable.&lt;br /&gt;&lt;br /&gt;Interesting Gameplay Mechanics&lt;br /&gt;&lt;br /&gt;Participating gameplay mechanics have reached the heart associated with enhancing player conversation and fostering effort in modern video gaming. Innovative systems like collaborative objectives permit players to group up, tackling problems that require various strategies and unique character abilities. 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Kế tiếp, bấm nút lưu để bắt đầu bắt đầu quá trình ghi lại video.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Một ưu điểm đặc sắc của StreamRecorder.io là tính năng cấu hình video chất lượng. Khi nhập URL video, bạn có thể chọn lựa chọn các các mức chất lượng khác nhau, từ low đến high, dựa vào băng thông của bạn và nhu cầu của bạn. Điều này sẽ giúp tải về video với chất lượng như bạn kỳ vọng mà không gặp phải tình trạng ngắt quãng hay lag trong quá trình ghi.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Cuối cùng, hãy chú ý vào những tùy chọn lưu trữ và xuất file một khi quá trình tải xuống hoàn tất. StreamRecorder.io cho phép bạn quyết định định dạng video mà bạn đang cần, còn mang đến các phương án lưu trữ an toàn trên điện toán đám mây hoặc trên thiết bị cá nhân của bạn. Điều này giúp ích cho bạn quản lý một cách dễ dàng và khám phá video thời điểm cần thiết.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;</div></summary> <author><name>Gumbotany00</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Hodgeboone4159&diff=3615804&oldid=0</id> <title>Hodgeboone4159</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Hodgeboone4159&diff=3615804&oldid=0"/> <updated>2025-07-02T20:50:08Z</updated> <summary type="html"><p>Created page with &quot;Brand perception is a key element in achieving business success how a brand is perceived by current and potential users determines what they think and their disposition toward...&quot;</p><p><b>New page</b></p><div>Brand perception is a key element in achieving business success how a brand is perceived by current and potential users determines what they think and their disposition towards the brand. The users' perception also determines whether they will perceive the sports service as offering a greater quality or value than other services, whether they will be more loyal, or whether they will recommend the service. This paper analyses the brand perception of users of a public sports service, creating a model of structural equations that analyses how credibility and trust influence a user's congruence with the brand and the generation of positive attitudes towards the brand and how these variables influence loyalty levels and recommendations. The results indicate that the proposed model can explain the variables of trust, congruence, attitudes, loyalty and word of mouth by more than 60%. The study finds that credibility influences trust but that credibility in itself does not cause a congruence with the brand, whereas trust does. Similarly, trust does not generate attitudes towards the brand but credibility and congruence do. Congruence generates loyalty but attitudes do not, and congruence, attitudes and loyalty influence recommendation to a similar extent, with congruence having the highest influence.Workers of different generations often complain about one another as their opinions, values, attitudes, and approaches to work differ. This might lead to a reduction in labor productivity that can negatively impact the economic growth of any nation. In this paper, we used generation mix indices to analyze whether generation gap has any impact on economic growth. Using Thailand's data between 1961 to 2019, we found that when generations were intensely mixed, economic growth did suffer.Based on a qualitative semi-structured interview, this paper argues that pedagogical positions can be negotiated and adjusted once a policy is introduced and a safe space for negotiation is created. It is a case study where we cite evidence from a Saudi university that shows the change in teachers' assumptions and, consequently, the negotiation process they had gone through within their institution due to a sudden policy shift. The paper highlights the importance of policies and the surrounding circumstances when it comes to negotiating pedagogical beliefs. This paper challenges the long-established assumption that age and much experience make it difficult for teachers to adapt their face-to-face educational activities to online platforms. We argue that institutional policies play a crucial role in shaping and reshaping teachers' assumptions and practices when the following conditions are met sound IT infrastructure, technological support, and continuous training.Crop productivity in most smallholder farming systems in Sub-Saharan Africa experience low use of soil amendment resources, low and erratic rainfall, frequent dry spells, and droughts. [https://www.selleckchem.com/products/poly-vinyl-alcohol.html selleck products] Rain-fed agriculture has a high crop yield potential if rainfall and soil nutrient input resources are utilized effectively. Thus, in 2011, we set up an on-farm experiment in Meru South (sub-humid) and Mbeere South (marginal sub-humid) sub-counties in upper Eastern Kenya to assess conservation-effective management (CEM) practices effects on maize (Zea Mays L.) yields response and soil nutrients. The CEM practices were; tied ridging (TR), mulching (MC), and minimum tillage (MT), with conventional tillage (CT) as a control. There were frequent dry spells and droughts during the experimental period. The experiment ran for four seasons, from the long rains season of 2011 (LR11), short rains seasons of 2011 (SR11), long rains season of 2012 (LR12), short rains 2012 (SR12), and long rains season of 2013 (LR13). In Meru South, TR and CEM effects on soil nutrients.The current dominating production and consumption model is based on the linear economy (LE) model, within which raw materials are extracted-processed-consumed-discarded. A circular economy (CE) constitutes a regenerative systemic approach to economic development which views waste as a valuable resource to be reprocessed back into the economy. In order to understand the circular strategy for a systemic change from an LE to a CE as a means of resolving the issue of plastic waste, this research aims to map current circular strategy trends across the system perspective contained in the literature relating to plastic CE literature. The novelty of the research lies in the mapping and review of the distribution of comprehensive circular strategies within the 9R framework across the entire system perspective (e.g. micro-meso-macro) down to its sub-levels in the literature on a plastic CE. The bibliographic mapping and systematic literature review iindicateed that the majority of the research focused on recycle (R8), on to fossil-based plastics.Genome-wide association studies (GWAS) have become beneficial in identifying genetic variants underlying susceptibility to various complex diseases and conditions, including obesity. Utilizing the Drosophila Genetic Reference Panel (DGRP), we performed a GWAS of lifespan of 193 genetically distinct lines on a high sugar diet (HSD). The DGRP analysis pipeline determined the most significant lifespan associated polymorphisms were within loci of genes involved in neural processes, behavior, development, and apoptosis, among other functions. Next, based on the relevance to obesity pathology, and the availability of transgenic RNAi lines targeting the genes we identified, whole-body in vivo knockdown of several candidate genes was performed. We utilized the GAL4-UAS binary expression system to independently validate the impacts of these loci on Drosophila lifespan during HSD. These loci were largely confirmed to affect lifespan in that HSD setting, as well as a normal diet setting. However, we also detected unexpected dietary effects of the HSD, including inconsistent diet effects on lifespan relative to a normal diet and a strong downregulation of feeding quantity.Toxoplasma gondii (T. gondii) is one of the most pervasive neurotropic pathogens causing different lesions in a wide variety of mammals as intermediate hosts, including humans. It is estimated that one-third of the world population is infected with T. gondii; however, for a long time, there has been much interest in the examination of the possible role of this parasite in the development of mental disorders, such as Alzheimer's disease (AD). T. gondii may play a role in the progression of AD using mechanisms, such as the induction of the host's immune responses, inflammation of the central nervous system (CNS), alteration in the levels of neurotransmitters, and activation of indoleamine-2,3-dyoxigenase. This paper presents an appraisal of the literature, reports, and studies that seek to the possible role of T. gondii in the development of AD. For achieving the purpose of the current study, a search of six English databases (PubMed, ScienceDirect, Web of Science, Scopus, ProQuest, and Google Scholar) was performed.</div></summary> <author><name>Hodgeboone4159</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Smallmccurdy6437</id> <title>User:Smallmccurdy6437</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Smallmccurdy6437"/> <updated>2025-07-02T20:50:04Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Smallmccurdy6437&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Smallmccurdy6437 (page does not exist)"><bdi>Smallmccurdy6437</bdi></a> was created</p></summary> <author><name>Smallmccurdy6437</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Stantonhopper0987</id> <title>User:Stantonhopper0987</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Stantonhopper0987"/> <updated>2025-07-02T20:50:03Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Stantonhopper0987&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Stantonhopper0987 (page does not exist)"><bdi>Stantonhopper0987</bdi></a> was created</p></summary> <author><name>Stantonhopper0987</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Nicholsondesai1638</id> <title>User:Nicholsondesai1638</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Nicholsondesai1638"/> <updated>2025-07-02T20:49:54Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Nicholsondesai1638&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Nicholsondesai1638 (page does not exist)"><bdi>Nicholsondesai1638</bdi></a> was created</p></summary> <author><name>Nicholsondesai1638</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Fish_Hunting_in_Slots_The_Exciting_World_of_Fish_Shooting_Games&diff=3615803&oldid=0</id> <title>Fish Hunting in Slots The Exciting World of Fish Shooting Games</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Fish_Hunting_in_Slots_The_Exciting_World_of_Fish_Shooting_Games&diff=3615803&oldid=0"/> <updated>2025-07-02T20:49:44Z</updated> <summary type="html"><p>Created page with &quot;Introduction to Fish Shooting Game Slot machines&lt;br /&gt;&lt;br /&gt;Fish shooting sport slots merge the excitement of traditional slot mechanics with the interactive thrill associated...&quot;</p><p><b>New page</b></p><div>Introduction to Fish Shooting Game Slot machines&lt;br /&gt;&lt;br /&gt;Fish shooting sport slots merge the excitement of traditional slot mechanics with the interactive thrill associated with fish shooting game play. 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In this specific collaborative and ideal environment, every player's contribution is valued, making for some sort of more immersive and connected gaming knowledge.&lt;br /&gt;&lt;br /&gt;Visual and Music Elements&lt;br /&gt;&lt;br /&gt;Visual in addition to audio elements enjoy a crucial function in enhancing engagement and conveying communications effectively in media presentations. By incorporating visuals such while images, infographics, in addition to videos, creators could capture attention in addition to break the monotony of text, assisting better understanding. If viewers encounter impressive visuals, their mental connection to the information deepens, making data more memorable.&lt;br /&gt;&lt;br /&gt;In addition, audio components, which includes soundtracks and voiceovers, bring a dynamic layer to the particular storytelling experience. Sound can evoke emotions, set the develop, and reinforce typically the message, guiding viewers perception. For illustration, a well-chosen soundtrack can amplify exhilaration, while a calming voiceover can provide quality and focus.&lt;br /&gt;&lt;br /&gt;Collectively, these multimedia pieces create a unified interplay that harmonizes with articles, enhances engagement, and shapes viewers perception. By participating multiple senses, designers can foster a new more immersive encounter, encouraging viewers to connect with the particular material on a deeper level. Ultimately, integrating visuals and even audio effectively transforms the way information is delivered and even absorbed, ensuring a lasting impact.&lt;br /&gt;&lt;br /&gt;Bonus Models and Rewards&lt;br /&gt;&lt;br /&gt;Reward rounds and returns play a important role in boosting player engagement plus excitement within typically the gaming environment. By simply offering these components, games create a new dynamic experience that captivates players and even keeps them approaching back for even more. Bonus rounds serve as special video game features that offer gamers with unique options to amplify their very own winnings or check out different gameplay mechanics.&lt;br /&gt;&lt;br /&gt;These rounds are made to break the boredom of regular game play, injecting an additional layer of joy and anticipation. During bonus rounds, gamers can unlock unique prizes, providing the exhilarating sense of achievement. Rewards, such while in-game currency, uncommon items, or multipliers, further elevate typically the enjoyment level, motivating players to make an effort for these enticing goals.&lt;br /&gt;&lt;br /&gt;As players engage with these kinds of exciting elements, they can be more likely to be able to develop a stronger attachment to the particular game, resulting throughout improved retention rates. By successfully developing bonus rounds and even rewards, games enhance an immersive surroundings where excitement gows best, ultimately enhancing the particular overall gaming knowledge.&lt;br /&gt;&lt;br /&gt;How to Participate in Fish Shooting Video game Slot machines&lt;br /&gt;&lt;br /&gt;Fish firing game slots incorporate the excitement regarding traditional casino video poker machines together with the interactive components of arcade-style firing games, building a exclusive and engaging gaming experience. In this specific innovative format, participants immerse themselves in a vibrant underwater world where they aim and blast at various seafood while simultaneously spinning reels. The aim is definitely not only to catch fish intended for prizes but also in order to activate special characteristics and bonus times through strategic game play. 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Knowing these elements is crucial for efficient navigation and diamond in the video game.&lt;br /&gt;&lt;br /&gt;By way of example, rules may possibly govern scoring, player versus player connections, or time limits, establishing a platform that promotes competitors and strategy. Handles, often mapped in order to buttons or touchscreen display gestures, direct personality movement, actions, or even special abilities, making players feel energized and involved within the game planet.&lt;br /&gt;&lt;br /&gt;Together, rules in addition to controls enhance participant engagement by cultivating a rewarding, challenging atmosphere. Mastering these ingredients enables participants to learn strategies, collaborate with others, and conform to varying game situations. Ultimately, a practical set of guidelines and intuitive handles not simply supports fair play but furthermore enhances the excitement and enjoyment associated with the gameplay experience. By embracing these foundational aspects, players can fully immerse themselves and flourish in the video game environment.</div></summary> <author><name>Waterdoubt99</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Meadowsarnold0055&diff=3615802&oldid=0</id> <title>Meadowsarnold0055</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Meadowsarnold0055&diff=3615802&oldid=0"/> <updated>2025-07-02T20:49:42Z</updated> <summary type="html"><p>Created page with &quot;Given reach and usability, an adapted SDT male-tailored app was found to be acceptable and could encourage positive health-seeking behavioural change among men.This paper focu...&quot;</p><p><b>New page</b></p><div>Given reach and usability, an adapted SDT male-tailored app was found to be acceptable and could encourage positive health-seeking behavioural change among men.This paper focuses on the ways in which gender, conceived as the product of an ongoing social and cultural construction in and through communication processes, is accomplished during medical encounters and through the narratives produced within these interactions. The main objective is to examine (1) when and by what devices gender becomes interactionally relevant; (2) the participants' narratives on 'gender issues'; (3) the interplay between the narratives produced and the forms of communication created, also considering which form may be more effective in challenging gender stereotypes and bias. Data are drawn from a corpus of self-administered audio-recorded interactions between a female gynecologist/midwife and pregnant patients. The consultations (half of them mediated, half not) took place in a city of North Italy; the patients (sometimes accompanied by the husband) are migrant women from North and West Africa. The main results show that (1) at each stage of the examinations, an orientation to gender emerges, mainly through questions that display categorizations, category-bound activities, and cultural assumptions about gender when referred to the patient, these devices often reproduce the traditional cultural model of femininity and, connected to this, the 'normal' (heterosexual and stable) intimate relationship as socially expected; (2) medical dialogue as patient-centered approach is the most recurrent form of interaction and often leads to a co-construction of narratives in which personal uniqueness is more relevant than gender roles, expectations, and stereotyped representations; when husbands are involved, however, the interactions seem to shift toward doctor-centered forms of communication, and this usually leads to asymmetrical and directive constructions of narratives about differentiated and traditional gender roles.The Patient Reported Outcome Measurement Information System (PROMIS) is a NIH-funded measure that has item banks assessing a variety of physical, social, and mental health domains. Short forms from the emotional distress item bank (which includes measures of Depression, Anxiety, and Anger) were included in the Diagnostic and Statistical Manual for Mental Disorders-Fifth edition as emerging measures to be administered at intake to aid diagnosis and throughout treatment to track progress. The purpose of the current study was to further investigate the PROMIS distress item bank's construct validity using the Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF). The sample included 344 college students (119 males, 225 females) who were administered the MMPI-2-RF and the PROMIS Anxiety, Anger, and Depression short forms. Zero-order correlations between the PROMIS scales and the Restructured Clinical Scales and Internalizing Specific Problems Scales were examined. Overall, these results suggest that scores from the PROMIS Anxiety, Anger, and Depression scales evidence convergent validity but have problematic construct validity (particularly for Depression). Future revision of the scales should be considered and sufficient external validation evidence should be available for review before psychological assessments are recommended and distributed for widespread clinical use.Purpose Previous data suggest that tronco-conical cuffs should be used for accurate blood pressure (BP) measurement in the obese. However, not only arm size but also its shape may affect the accuracy of BP measurement when a cylindrical cuff is used.Methods In 197 subjects with arm circumference &amp;gt;32 cm, and 157 subjects with arm circumference ≤ 32 cm, the upper-arm was considered as formed from two truncated cones and the frustum slant angles of the proximal (upper angle) and distal (middle angle) truncated cones were measured. Five cylindrical and five tronco-conical cuffs of appropriate size in relation to arm circumference were used.Results In the group with large arm, the upper slant angle was greater than the middle angle (86.5 ± 1.7° versus 84.7 ± 2.3°), whereas in the group with normal arm the two angles were similar. In the former group, the cylindrical cuff overestimated BP by 2.5 ± 5.4/1.7 ± 4.7 mmHg, whereas in the latter negligible between-cuff BP discrepancies were found. In the whole sample, BP discrepancies between the cylindrical and the tronco-conical cuffs correlated with both arm size and shape, considered as the difference between the upper and middle slant angles (all p less then 0.0001). [https://www.selleckchem.com/products/catechin-hydrate.html Catechin hydrate] Among the participants with large arm, the between-cuff BP discrepancies increased progressively with increasing upper-middle angle difference (3.75 ± 0.38/2.78 ± 0.32 mmHg for the top tertile, p less then 0.001/ less then 0.001).Conclusions These data indicate that in people with large upper arms, the tronco-conical shape of the arm is more pronounced on the lower than the upper half, a feature that amplifies the BP measurement error when cylindrical cuffs are used.This paper aimed to assess the impact of maternal common mental disorders (CMD) among caregivers living with HIV on the cognitive functioning of their child. Data were collected at baseline and 12 months follow-up from mother-child dyads recruited as part of an ongoing trial in Zimbabwe. Symptoms of CMD were assessed using the Shona Symptom Questionnaire. Mixed-effects linear regression was used to assess child cognitive scores at follow-up (using the Mullen Scales of Early Learning) in relation to caregiver CMD prevalence over 12 months. At baseline, caregivers reporting CMD (n = 230; 40.1%) were less likely to have completed higher education (46.9% vs. 56.9%; p = 0.02), more likely to be unmarried (27.8% vs. 16.0%; p less then 0.01), and experience food insecurity (50.0% vs. 29.4%; p less then 0.01) compared to the group without CMD (n = 344). There were 4 CMD patterns over time (i) Emerging CMD (n = 101; 19.7% of caregivers) defined as those who were below the cut-off at baseline, and above it at 12 months; (ii) Improving CMD (n = 76; 14.</div></summary> <author><name>Meadowsarnold0055</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Blame_Manga_Online_English_Highquality_Scans&diff=3615801&oldid=3615761</id> <title>Blame Manga Online English Highquality Scans</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Blame_Manga_Online_English_Highquality_Scans&diff=3615801&oldid=3615761"/> <updated>2025-07-02T20:49:39Z</updated> <summary type="html"><p></p><table class="diff diff-contentalign-left" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr style="vertical-align: top;" lang="en"> <td colspan="2" style="background-color: white; color:black; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: white; color:black; text-align: center;">Revision as of 20:49, 2 July 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1" >Line 1:</td><td colspan="2" class="diff-lineno">Line 1:</td></tr><tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">Though </del>most modifications are <del class="diffchange diffchange-inline">prone </del>to be minor, Manga Zone Studio <del class="diffchange diffchange-inline">might </del>change its Privateness <del class="diffchange diffchange-inline">Coverage from time to time</del>, and in Manga Zone Studio's sole discretion. Manga Zone Studio encourages guests to <del class="diffchange diffchange-inline">frequently verify </del>this page for any modifications to its Privacy Coverage. Your continued use of this <del class="diffchange diffchange-inline">web </del>site after any change <del class="diffchange diffchange-inline">in </del>this Privacy <del class="diffchange diffchange-inline">Coverage </del>will constitute your acceptance of such change. Manga Zone Studio <del class="diffchange diffchange-inline">might </del>collect statistics concerning the <del class="diffchange diffchange-inline">behavior </del>of <del class="diffchange diffchange-inline">visitors </del>to its websites. Manga Zone Studio could display this info publicly or <del class="diffchange diffchange-inline">provide </del>it to others.&lt;br /&gt;&lt;br /&gt;<del class="diffchange diffchange-inline">It additionally provides accomplished collection such as Naruto and Dragon Ball. To ensure an authentic studying experience</del>, <del class="diffchange diffchange-inline">hoopla has up </del>to <del class="diffchange diffchange-inline">date its ActionView feature, permitting customers to comply </del>with the <del class="diffchange diffchange-inline">story panel-</del>by-<del class="diffchange diffchange-inline">panel </del>in the <del class="diffchange diffchange-inline">conventional right-</del>to<del class="diffchange diffchange-inline">-left format</del>. <del class="diffchange diffchange-inline">You </del>can <del class="diffchange diffchange-inline">even purchase coins </del>to <del class="diffchange diffchange-inline">redeem </del>for <del class="diffchange diffchange-inline">chapters or volumes of </del>manga <del class="diffchange diffchange-inline">collection that are obtainable for buy</del>. <del class="diffchange diffchange-inline">Most manga collection have free chapters</del>, and <del class="diffchange diffchange-inline">many series in the Plus catalog include Every Day Free Chapters, the place you'll find </del>a <del class="diffchange diffchange-inline">way to learn one chapter per day</del>. <del class="diffchange diffchange-inline">One Other great characteristic of ComicRack </del>is <del class="diffchange diffchange-inline">its capacity </del>to <del class="diffchange diffchange-inline">arrange your comedian assortment</del>.&lt;br /&gt;&lt;br /&gt;By 2019 the manga had over 50 million copies in circulation, making it one of <del class="diffchange diffchange-inline">the </del>best-selling manga <del class="diffchange diffchange-inline">series </del>of all time. Manga Plus is <del class="diffchange diffchange-inline">another great </del>manga subscription app – the official service of Shueisha (publisher of Shonen Jump). <del class="diffchange diffchange-inline">Right </del>Here, you<del class="diffchange diffchange-inline">'ll </del>find <del class="diffchange diffchange-inline">well-liked </del>titles like <del class="diffchange diffchange-inline">these </del>in Shonen <del class="diffchange diffchange-inline">Leap</del>, with early <del class="diffchange diffchange-inline">access </del>to <del class="diffchange diffchange-inline">sequence </del>from different Shueisha magazines. Mangamo is <del class="diffchange diffchange-inline">among </del>the finest manga <del class="diffchange diffchange-inline">studying </del>apps, with a large library of over 1,000 titles and 20,000 chapters. They offer officially licensed manga curated by a <del class="diffchange diffchange-inline">devoted </del>editorial <del class="diffchange diffchange-inline">group </del>and professionally translated into English<del class="diffchange diffchange-inline">.&lt;br /&gt;&lt;br /&gt;These points can then be used to get reductions on future purchases or leases. This function is a good way to economize for avid manga readers who frequently use the app. Throughout the appraisal process of Crunchyroll, I evaluated its capabilities as an anime streaming web site and a separate manga platform. [https://novamanga.com/ manga scans] This free manga website is developed to reinforce the watching and reading experience. I found that it supplies an essential service for manga readers.&lt;br /&gt;&lt;br /&gt;You can read up to a hundred chapters free of charge every single day, however if you want to read more than that, you’ll must pay a small fee. You might use the in-browser reader or obtain and read it via the Manga Canine app on Playstore and Apple App Retailer. The search operate is quite intuitive and suggests titles as you sort.&lt;br /&gt;&lt;br /&gt;Throughout my assessment of Viz, I discovered it to be a web-based manga platform with quite a lot of must-read manga. This manga on-line web site is great for checking the most recent information and updates on manga comics. Nana (stylized as NANA) is a Japanese manga series written and illustrated by Ai Yazawa. First printed as a two-part prologue in Shueisha’s month-to-month shōjo&amp;nbsp;manga magazine&amp;nbsp;Cookie in 1999, Nana was later serialized in the same journal from Might 2000 to Might 2009, earlier than going on indefinite hiatus</del>.</div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">It also offers completed series such as Naruto and Dragon Ball. To guarantee an genuine reading experience, hoopla has up to date its ActionView characteristic, permitting customers to observe the story panel-by-panel in the traditional right-to-left format. You also can buy coins to redeem for chapters or volumes of manga sequence which may be obtainable for purchase. 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Mangamo is <ins class="diffchange diffchange-inline">amongst </ins>the finest manga <ins class="diffchange diffchange-inline">reading </ins>apps, with a large library of over 1,000 titles and 20,000 chapters. They offer officially licensed manga curated by a <ins class="diffchange diffchange-inline">dedicated </ins>editorial <ins class="diffchange diffchange-inline">staff </ins>and professionally translated into English.</div></td></tr></table></summary> <author><name>Chancepeen76</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Making_a_Splash_The_Best_Fish_Shooting_Game_Slots_for_Thrilling_Wins&diff=3615800&oldid=0</id> <title>Making a Splash The Best Fish Shooting Game Slots for Thrilling Wins</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Making_a_Splash_The_Best_Fish_Shooting_Game_Slots_for_Thrilling_Wins&diff=3615800&oldid=0"/> <updated>2025-07-02T20:49:37Z</updated> <summary type="html"><p>Created page with &quot;Introduction to Seafood Shooting Game Slots&lt;br /&gt;&lt;br /&gt;Fish shooting sport slots merge typically the excitement of traditional slot mechanics with all the interactive thrill i...&quot;</p><p><b>New page</b></p><div>Introduction to Seafood Shooting Game Slots&lt;br /&gt;&lt;br /&gt;Fish shooting sport slots merge typically the excitement of traditional slot mechanics with all the interactive thrill involving fish shooting game play. 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By integrating these features, fish firing game slots not merely captivate players but additionally create lucrative monetization pathways, ensuring offered back for even more engaging gameplay in addition to exciting rewards.&lt;br /&gt;&lt;br /&gt;Exactly what Are Fish Shooting Games?&lt;br /&gt;&lt;br /&gt;Fish firing games can be a popular genre of on-line video games that will combine hunting technicians with vibrant marine graphics. In these interactive games, players personify the role of a shooter who makes use of a virtual tool to aim with a number of00 fish floating around in expansive aquatic environments. The target is to effectively shoot and get as many species of fish as possible within the given time or even using a constrained number of photographs, earning points in addition to rewards along the particular way. 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Musical theater proceeds to captivate audiences, illustrating its everlasting importance in typically the cultural landscape.&lt;br /&gt;&lt;br /&gt;Famous Backdrop&lt;br /&gt;&lt;br /&gt;The traditional background of virtually any subject often reflects a tapestry associated with significant events, breakthrough, and influential figures that shape their context. For example, the evolution associated with democracy could be followed back to historic Greece, where earlier forms emerged around the 5th century BCE. 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By embracing these kinds of foundational aspects, participants can fully dip themselves and thrive in the online game environment.</div></summary> <author><name>Waterdoubt99</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Villarrealdowney5711</id> <title>User:Villarrealdowney5711</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Villarrealdowney5711"/> <updated>2025-07-02T20:48:58Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Villarrealdowney5711&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Villarrealdowney5711 (page does not exist)"><bdi>Villarrealdowney5711</bdi></a> was created</p></summary> <author><name>Villarrealdowney5711</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Marriage_Ceremony_Reward_Kitchen_Towels&diff=3615796&oldid=0</id> <title>Marriage Ceremony Reward Kitchen Towels</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Marriage_Ceremony_Reward_Kitchen_Towels&diff=3615796&oldid=0"/> <updated>2025-07-02T20:48:55Z</updated> <summary type="html"><p>Created page with &quot;Read on Viva Wedding Photography‘s picks for the best bathtub towels for wedding registry in 2023. From monogrammed tub towel units to beach essentials that scream &#039;vacay vi...&quot;</p><p><b>New page</b></p><div>Read on Viva Wedding Photography‘s picks for the best bathtub towels for wedding registry in 2023. From monogrammed tub towel units to beach essentials that scream 'vacay vibes', our well-liked choices are the go-to picks that our customers adore. Whether you're looking for a treat-yourself kind of towel or a fun reward for a good friend, these prime picks will surely add a contact of customized luxury to your life. Selecting the&amp;nbsp;best towels for wedding registry&amp;nbsp;involves balancing luxury, practicality, and private style. Whether you prioritize plush Turkish cotton, quick-drying comfort, or eco-friendly materials, fastidiously think about your needs to create a registry that displays your values.&lt;br /&gt;&lt;br /&gt;There are some gadgets which might be nearly by no means a good idea if you want to choose a particular gift for the newlyweds. You ought to avoid giving these 18 awful wedding ceremony gifts until the couple has specifically requested something else. Most of our girls's garments are out there in sizes extra-small via extra-large in common, petite, and tall. Even higher, we've plenty of options obtainable in plus sizes 1X, 2X, and 3X as properly. These finest towels for registry have a dark gray geometric print on one facet and a light teal dobby border, which makes them stand out.&lt;br /&gt;&lt;br /&gt;As a result, now can be the best time to share some straightforward methods for displaying them. Giving towels as a gift can improve the lavatory of current graduates, first-time homebuyers, or newlyweds transferring on to their subsequent phase of life. Help your family members design a relaxing and comfy bathing experience. Giving someone soft towels will improve their daily routine by offering them with a sturdy, essential item. Yes, eco-friendly towels are an excellent choice for a sustainable wedding registry.&lt;br /&gt;&lt;br /&gt;Let your creativeness run wild with our extensive selection of options to make every towel a stylish reflection of you. Creating the&amp;nbsp;greatest towels for marriage ceremony registry&amp;nbsp;ensures comfort and elegance in your new house. Discover our top picks for the&amp;nbsp;greatest towels for wedding ceremony registry, guaranteeing your married life starts with the proper mix of practicality and pampering.&lt;br /&gt;&lt;br /&gt;&lt;ul&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;In addition, low-linting fibers make certain that your favorite towel remains intact even after being washed.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;If you’re compiling a list of&amp;nbsp;best towels for wedding registry, this set supplies great value.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;li&gt;Since 2015, we have reduced the burden of outbound packaging per shipment by 41% on common, that’s over 2 million tons of packaging materials.&lt;/li&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt;&lt;/ul&gt;&lt;br /&gt;&lt;br /&gt;Thanks to the 2-ply combed ringspun cotton jacquard structure, they're very plush and absorbent. These SIMPLI-MAGIC Spa Bath Towels are good for individuals who prefer the coziness of a thick towel without the lengthy drying time. In Ukraine, embroidered towels are broadly used and have an extended historical past of serving as a major factor of celebrations, day by day life, home décor, and wedding ceremony ceremonies. Even although things change with time, for many individuals, the marriage will at all times be remembered as the happiest day of their lives.&lt;br /&gt;&lt;br /&gt;The cotton fibers in these towels are longer and stronger because they're looped inside the towel’s basis rather than twisted outward. [https://www.etsy.com/shop/ToweLify wedding favors] are between 400 and 600 GSM, however these are high-end 700GSM. They even have a five-inch dobby border the place you can add a monogram, a majorly grown-up improve.&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;Our monogrammed bath towels make excellent items for bridesmaids, wedding presents, or just to deal with yourself. Whether you’re gifting a monogrammed towel wrap or a custom embroidered towel, our towels make every special occasion more unforgettable. Made from 100 percent OEKO-TEX® certified cotton, these 54”x30” towels balance absorbency and fast drying, ideal for small loos. Perfect for couples seeking&amp;nbsp;greatest towels for marriage ceremony registry&amp;nbsp;with an eco-friendly twist, these towels are lightweight and feature banded edges for visible enchantment. They are also quick-dry wedding towels, making them good for humid climates or frequent travelers. If sustainability is a precedence, these are among the many&amp;nbsp;finest towels for marriage ceremony registry&amp;nbsp;you can find.&lt;br /&gt;&lt;br /&gt;&lt;h2&gt;On-line Outfitters, Online Shopping&lt;/h2&gt;&lt;br /&gt;&lt;br /&gt;Clothing websites and clothes shop are enjoyable to explore, and right here at Lands' End, we go the extra mile to be positive to have a nice time browsing. Our site is a breeze to navigate, and we offer a range of ladies's clothing choices so you can shortly find what you're looking for. Be positive to make use of the towels and sheets that are listed on the registry.&lt;br /&gt;&lt;br /&gt;&lt;h3&gt;Skl Home By Saturday Knight Ltd Rhapsody Bath Towel&lt;/h3&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;Customers find the dish towel to be well-made and exquisite, with the monogram looking nice and matching the net footage. Furthermore, it is certified by GOTS (Global Organic Textile Standard), the world’s leading standard for textile processing of organic fibers. Therefore, you can be assured about your family’s health in addition to the environment when using these towels. Our greatest sellers are all about bringing type and comfort to your daily routines. Next, pick up the entire object, flip it over, and then fold both sides. Now, these towels are curved on this course, but it doesn’t matter as a result of we’re about to cut off that portion of the towel.&lt;br /&gt;&lt;br /&gt;They are suitable for practically any occasion and make pretty presents for bridal showers. The most problematic facet of giving towels as presents is wrapping them. Towels may be bulky and huge, and they hardly ever come in a box of their own, which makes them tough to package deal.&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;Aim for a mixture of sizes, supplies, and purposes to ensure your registry is well-rounded. Indulge your self in spa-like luxury with these best bath towels for wedding registry. The set is made from 500 GSM one hundred pc cotton, recognized for its softness, absorbency, and durability. That means final comfort and quick results when drying your hands and face after washing up or drying off after stepping out of a scorching bathe.&lt;br /&gt;&lt;br /&gt;&lt;div style=&quot;text-align:center&quot;&gt;&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt;&lt;/div&gt;&lt;br /&gt;&lt;br /&gt;&lt;h2&gt;Review This Product&lt;/h2&gt;&lt;br /&gt;&lt;br /&gt;Customers discover the dish towel to be an ideal gift, significantly noting it makes a cute wedding ceremony present. The weight of a towel is usually measured in grams per sq. meter (GSM). For a thick, velvety, and delicate towel, look for towels with a GSM ranking greater than 600. However, the upper the GSM, the longer it'll take in your towel to dry.&lt;br /&gt;&lt;br /&gt;As an added bonus, we make it easy to personalize a lot of the objects we provide. All we'd like from you is your initials, and we'll take care of the remainder. Our classic monograms add a touch of favor to virtually any article of clothes. There is no such factor as a towel that can final forever, but a nice bath towel will final for many years.&lt;br /&gt;&lt;br /&gt;Towels are incessantly manufactured from cotton or a cotton-polyester blend because of its glorious absorbency and fluffy texture. That said, mildew scents can develop shortly in cotton if you use them in humid climates, so switching to a linen towel may be better. These ultra-thin towels, which are sometimes known as Hammam or Fouta towels, might look like a seashore wrap, but they’re really quite durable. Despite their thinness, Turkish towels are equally as absorbent as their bulkier counterparts, and they dry twice as shortly. Wedding towels as icons A wedding towel is a symbol of the newlyweds’ future household life, love, and shared life path.&lt;br /&gt;&lt;br /&gt;They’re among the many&amp;nbsp;greatest towels for wedding registry&amp;nbsp;if you’re in search of something ornamental and practical for the kitchen. These customized towels are excellent for including a private touch to your kitchen decor, making them an excellent addition to any wedding ceremony registry. Experience the luxury of 100% Turkish cotton with these customizable towels, good for creating a spa-like atmosphere in your toilet.</div></summary> <author><name>Hallrod29</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Cottonjordan0156</id> <title>User:Cottonjordan0156</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Cottonjordan0156"/> <updated>2025-07-02T20:48:50Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Cottonjordan0156&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Cottonjordan0156 (page does not exist)"><bdi>Cottonjordan0156</bdi></a> was created</p></summary> <author><name>Cottonjordan0156</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Read_The_Kaguyasama_Manga_Sequence_Guya_Moe&diff=3615795&oldid=0</id> <title>Read The Kaguyasama Manga Sequence Guya Moe</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Read_The_Kaguyasama_Manga_Sequence_Guya_Moe&diff=3615795&oldid=0"/> <updated>2025-07-02T20:48:43Z</updated> <summary type="html"><p>Created page with &quot;In each case, Manga Zone Studio collects such information only insofar as is critical or appropriate to satisfy the aim of the customer&#039;s interplay with Manga Zone Studio. Man...&quot;</p><p><b>New page</b></p><div>In each case, Manga Zone Studio collects such information only insofar as is critical or appropriate to satisfy the aim of the customer's interplay with Manga Zone Studio. Manga Zone Studio does not disclose personally-identifying info aside from as described below. And visitors can at all times refuse to supply personally-identifying information, with the caveat that it might stop them from partaking in sure website-related actions. A subscription service known as &quot;Manga Plus MAX&quot; was added to the app in October 2023. You could change the theme shade, and the default light blue-suited me nice.&lt;br /&gt;&lt;br /&gt;VIZ Media publishes manga and distributes and licenses Japanese anime, films, and television sequence. As a manga fan, you’ve probably experienced the frustration of getting your go-to sites abruptly blocked, bombarded with annoying adverts, or just not carrying the collection you’re dying to learn. Movie Star voices include Snoop Dogg, Mr. Beast, and Gwyneth Paltrow. For creators and businesses, Speechify Studio offers superior tools, including AI Voice Generator, AI Voice Cloning, AI Dubbing, and its AI Voice Changer.&lt;br /&gt;&lt;br /&gt;This collection is primarily in English and is beneficial for readers studying English as a second language. INKR Comics offers a subscription-based mannequin called &quot;INKR Additional&quot; that costs $4.ninety nine per thirty days. The company has expanded beyond digital choices – since 2018, they've revealed physical editions of well-liked collection. They actively encourage interplay between readers, management, translators, and editors by way of boards, social media, and Discord.&lt;br /&gt;&lt;br /&gt;E-book Walker is one of the best manga reader apps out there, with an unlimited library of each Japanese and English manga titles. One of the unique options of this app is the option to obtain chapters for offline reading, which is useful for many who do not have an web connection or who wish to save on information usage. Moreover, it offers digital versions of light novels and different e-books, making it a one-stop-shop for all your studying wants.&lt;br /&gt;&lt;br /&gt;Like I mentioned earlier, this is a great app and I love the low subscription value, but I would love it should you could think about my suggestions. [https://novamanga.com/ manga scans] Manga is a term used to define the vary of comic books or graphic novels originating in Japan. Whether comedy, romance, motion, or horror, you can see manga sequence in several genres. Like Anime, Manga has enjoyed much recognition prior to now few years. These comics are extremely popular amongst totally different communities globally. Some websites allow you to download manga for offline reading, but availability is dependent upon the site’s options.</div></summary> <author><name>Parcelsmash7</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Reel_in_the_Big_Fish_Strategies_for_Winning_Fish_Shooting_Game_Slots&diff=3615794&oldid=380552</id> <title>Reel in the Big Fish Strategies for Winning Fish Shooting Game Slots</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Reel_in_the_Big_Fish_Strategies_for_Winning_Fish_Shooting_Game_Slots&diff=3615794&oldid=380552"/> <updated>2025-07-02T20:48:39Z</updated> <summary type="html"><p></p><a href="https://humanlove.stream/index.php?title=Reel_in_the_Big_Fish_Strategies_for_Winning_Fish_Shooting_Game_Slots&amp;diff=3615794&amp;oldid=380552">Show changes</a></summary> <author><name>Captalk73</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Rouseklavsen4758&diff=3615793&oldid=0</id> <title>Rouseklavsen4758</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Rouseklavsen4758&diff=3615793&oldid=0"/> <updated>2025-07-02T20:48:32Z</updated> <summary type="html"><p>Created page with &quot;The OTML panel demonstrated robustness and reproducibility for TMB evaluation. Results also suggest the possibility of using the panel for mutational signatures and variant de...&quot;</p><p><b>New page</b></p><div>The OTML panel demonstrated robustness and reproducibility for TMB evaluation. Results also suggest the possibility of using the panel for mutational signatures and variant detection. Collaborative efforts between academia and companies are crucial to accelerate the translation of new biomarkers into clinical research.A series of 2-amino-5-arylmethyl- or 5-heteroarylmethyl-1,3-thiazole derivatives were synthesized and evaluated for BK channel-opening activities in cell-based fluorescence assay and electrophysiological recording. The assay results indicated that the activities of the investigated compounds were influenced by the physicochemical properties of the substituent at benzene ring.Novel cyclic peptide derivatives based on ogipeptins A, B, C, and D were synthesized. Starting with a mixture of ogipeptins A-D, a practical four-step synthetic procedure was followed to prepare novel derivatives with various kinds of acyl side chains. Among the 45 new synthetic derivatives identified, the antibacterial activities of compounds 8-3 and 8-38 were comparable with those of ogipeptin A. In in vitro nephrotoxicity screening using LLC-PK1 cells, compounds 8-3 and 8-38 showed significantly lower cytotoxicity (LD20 &amp;gt; 480 μM) than colistin (LD20 = 44.2 μM).Candida albicans, in specific conditions, is responsible of severe invasive systemic candidiasis that are related to its ability to produce biofilm on biological and artificial surfaces. Many studies reported the role of iron in fungal growth and virulence and the ability of metal chelating agents to interfere with C. albicans metabolism, virulence and biofilm formation. Here we report the activity of 3-hydroxy-1,2-dimethyl-4(1H)-pyridinone (deferiprone) derivatives against C. albicans planktonic cells and biofilm. Some of the studied compounds (2b and 3b) were able to chelate Fe(III) and Cu(II), and showed an interesting activity on planktonic cells (MIC50 of 32 μg/mL and 16 μg/mL respectively) and on biofilm formation (BMIC50 of 32 μg/mL and 16 μg/mL respectively) in cultured ATCC 10,231C. [https://www.selleckchem.com/products/u18666a.html U18666A price] albicans; this activity was reduced, in a concentration dependent way, by the addition of Fe(III) and Cu(II) to the culture media. Furthermore, the most active compound 3b showed a low toxicity on Galleria mellonella larvae.Root parasitic plant germination is induced by the host-derived chemical, strigolactone (SL). We found that a major microbial culture broth component, tryptone, inhibits the SL-inducible germination of a root parasitic plant, Orobanche minor. l-tryptophan (l-Trp) was isolated as the active compound from tryptone. We further found that l-Trp related compounds (1b-11), such as a major plant hormone auxin (8, indole-3-acetic acid; IAA), also inhibit the germination and post-radicle growth of O. minor. We designed a hybrid chemical (13), in which IAA is attached to a part of SL, and found that this synthetic analog induced the germination of O. minor, and also inhibited post-radicle growth. Moreover, contrary to our expectations, we found that N-acetyl Trp (9) showed germination stimulating activity, and introduction of a substitution at C-5 position increased its activity (12a-12f). Our data, in particular, the discovery of a structurally hybrid compound that has two activities that induce spontaneous germination and inhibit subsequent radical growth, would provide new types of germination regulators for root parasitic plants.Necroptosis is a form of programmed cell death that contributes to the pathophysiology of multiple diseases. Development of small-molecule anti-necroptosis agents has great promising clinical therapeutic relevance. The benzothiazole compounds were discovered by our group from an in-house fluorine-containing compound library as potent necroptosis inhibitors. Herein, a chiral dimethylcyclopropyl benzothiazole necroptosis inhibitor was developed and the enantiomeric profiling resulted that the (S) form was generally more potent than the (R) counterpart in 2 ~ 4-fold toward cell necroptosis, receptor-interacting protein (RIP) kinases 1 and 3. The chiral compounds could significantly inhibit the expression of the phosphorylation of RIPK1, RIPK3 and MLKL in necroptotic cells. The molecular modelling studies predicted the binding modes of the enantiomers with RIP and explained their activity differences, guiding further rational design of the chiral necroptosis inhibitors.A series of novel derivatives based on mogrol were designed and synthesized in attempt to improve anti-lung cancer activity. The cytotoxicity against human lung cancer cells including A549 and NCI-H460 were performed by Cell Counting Kit-8 (CCK8) assay in vitro. The screening result showed that compound 8f exhibited the strongest activity with an IC50 value of 4.47 μM against A549 cell, and could induce the cell apoptosis in a dose-dependent manner and arrest cell cycle at G0/G1 phase. Besides, compound 8f displayed anti-proliferation effect on A549 cell through inhibiting phosphorylation of signal transducer and activator of transcription 3 (STAT3). Furthermore, compared with morgol, compound 10a significantly improved the cytotoxicity against NCI-H460 with the IC50 value of 17.13 μM. The research stimulated the development of potential therapeutic agent for lung cancer from the natural mogrol.In our continuing efforts to develop novel neuroprotectants for Alzheimer's disease (AD), a series of analogs based on a lead compound that was recently shown to target the mitochondrial complex I were designed, synthesized and biologically characterized to understand the structure features that are important for neuroprotective activities. The results from a cellular AD model highlighted the important roles of the 4-OH on the phenyl ring and the 5-OCH3 on the indole ring of the lead compound. The results also demonstrated that the β-keto moiety can be modified to retain or improve the neuroprotective activity. Docking studies of selected analogs to the FMN site of mitochondrial complex I also supported the observed neuroprotective activities. Collectively, the results provide further information to guide optimization and development of analogs based on this chemical scaffold as neuroprotectants with a novel mechanism of action for AD.</div></summary> <author><name>Rouseklavsen4758</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Stoutgustavsen0276&diff=3615792&oldid=0</id> <title>Stoutgustavsen0276</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Stoutgustavsen0276&diff=3615792&oldid=0"/> <updated>2025-07-02T20:48:32Z</updated> <summary type="html"><p>Created page with &quot;However, high level of emotional support from the spouse increased the health practice score. Conclusions The findings highlighted the factors effective on health practices in...&quot;</p><p><b>New page</b></p><div>However, high level of emotional support from the spouse increased the health practice score. Conclusions The findings highlighted the factors effective on health practices including involvement in pre-pregnancy counseling, early prenatal care and emotional support for the adolescent pregnant woman.Objectives It is widely accepted that sexual and reproductive health in adolescents are among the health priorities in the world that affects health aspects and the formation of beliefs and socioeconomic development in the community. However, achieving goals related to sexual and reproductive health is not possible without awareness and participation of the adolescents. On the other hand, proper knowledge about such issues can prevent many problems in this regard. Methods This qualitative study was carried out for one month in schools of Alborz University of Medical Sciences using content analysis. Data were collected from semi-structured, individual and in-depth interviews with female students. In addition, data analysis was performed using guided qualitative content analysis (theory-based). Results Analysis of the data led to the extraction of 11 primary codes classified in six categories of protection motivation constructs (perceived sensitivity, perceived severity, response efficiency, response cost, self-efficacy, and internal rewards) and two additional categories (communications and social contexts). Conclusion All interviewees found themselves exposed to sexually transmitted diseases and emphasized sexual self-care even though the majority of these individuals had inadequate self-efficacy.Objectives To determine the prevalence of muscle-enhancing behaviors in adolescents and young adults using a nationally representative sample in the USA and to examine differences by sex, race/ethnicity, age, socioeconomic status, body mass index, and participation in team sports. Methods Prospective cohort data from the National Longitudinal Study of Adolescent to Adult Health, Waves I through III (1994-2002) were analyzed. Engagement in muscle-enhancing behaviors including dietary changes, exercise and weightlifting, supplement use, performance-enhancing substances, and anabolic androgenic steroids were recorded. Multiple logistic regression models using generalized estimating equations, incorporating robust standard errors with clustering by school and within persons, and using national sample weighting, were used to determine associations with muscle-enhancing behaviors across three data collection waves. Results Of the 18,924 adolescents at baseline, 29.2% of males and 7.0% of females reported weight gain attempts, while 25.2% of males and 3.8% of females reported any muscle-enhancing behavior. All muscle-enhancing behaviors were more common in males compared to females (p less then 0.001). Among young men 18-26 years old, 15.6% reported using legal performance enhancing substances and 2.7% reported using androgenic anabolic steroids. Factors that were associated with muscle-enhancing behaviors in males across three data collection waves included Black or Hispanic/Latino race/ethnicity, age over 14 years, higher parental education, lower body mass index, and participation in team sports. Conclusions Muscle-enhancing behaviors ranging from dietary changes to supplement and androgenic anabolic steroid use are common among adolescent and young adult males. Clinicians should consider screening for muscle-enhancing behaviors in these populations.Background Evidence of the relationship between tobacco use and multiple health risk behaviours is limited. Objectives The study aimed to investigate the relationship between tobacco use and health risk behaviours in university students across different cultures. Methods In a cross-sectional study the sample included 23,396 university students from 27 countries in Africa, Asia and the Americas. Results Indicate that 5.8 and 5.5% were daily and not daily tobacco users, respectively. In adjusted logistic regression analysis, less than daily and/or daily tobacco use was associated with nutrition and dietary risk behaviour (overweight or obesity, high sodium consumption, rarely or never having breakfast and not avoiding fat and cholesterol), addictive behaviour (binge drinking, drug use, and gambling), sleep risk behaviours (long sleep, poor sleep quality and restless sleep) and other health risk behaviour (having been in a physical fight, inadequate tooth brushing, and multiple sexual partners in the past year). Conclusions Compared to non-tobacco users, less than daily and/or daily tobacco users had significantly higher overweight or obesity, dietary risk behaviour, addictive behaviour, sleep risk behaviours and other health risk behaviour. These associations may be taken into account in health promotion strategies targeting multiple health compromising behaviours.Objectives The present pilot study examined the associations between attachment relationships, psychological problems, and negative automatic thoughts among late adolescents in Rawalpindi, Pakistan. Subjects A total of 98 participants (male = 49, female = 49) were recruited from government colleges in Rawalpindi, Pakistan. [https://www.selleckchem.com/MEK.html this website] Methods The measures used to assess the research variables of this cross sectional study were the Inventory of Parent-Peer Attachment (IPPA-Urdu), Depression, Anxiety, and Stress Scale (DASS-Urdu), and the Automatic Thought Questionnaire (ATQ-Urdu). Results All of these measures had good reliabilities. Findings of the correlation analyses demonstrated that maternal, paternal and peer attachment relationships were negatively related to symptoms of depression and anxiety as well as to negative automatic thoughts. On the other hand, depressive and anxiety symptoms were positively associated with negative automatic thoughts. Additionally, findings suggested that future studies must investigate adolescents from two-parent households and exclude those with only one living parent. Conclusion The results underscored the need for further investigations of the linkages between attachment relationships, negative automatic thoughts and psychological problems on larger samples.</div></summary> <author><name>Stoutgustavsen0276</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Entendiendo_el_seguro_de_negocios_Una_gua_para_emprendedores&diff=3615791&oldid=0</id> <title>Entendiendo el seguro de negocios Una gua para emprendedores</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Entendiendo_el_seguro_de_negocios_Una_gua_para_emprendedores&diff=3615791&oldid=0"/> <updated>2025-07-02T20:48:31Z</updated> <summary type="html"><p>Created page with &quot;&lt;p&gt;Iniciar un negocio es una de las decisiones más emocionantes y desafiantes que puede tomar un emprendedor. [https://notes.io/wUD4P El mejor seguro comercial en San Marcos...&quot;</p><p><b>New page</b></p><div>&lt;p&gt;Iniciar un negocio es una de las decisiones más emocionantes y desafiantes que puede tomar un emprendedor. [https://notes.io/wUD4P El mejor seguro comercial en San Marcos TX] , también conlleva una serie de riesgos que pueden amenazar la estabilidad y el éxito de la empresa. Es aquí donde entra en juego el seguro de negocios. Este tipo de seguro es esencial para proteger tus inversiones y garantizar que tu sueño empresarial no se vea afectado por imprevistos. Desde daños físicos hasta demandas legales, tener una póliza adecuada puede ser la diferencia entre la continuidad y el cierre de tu negocio.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;En San Marcos, TX, contar con un seguro de negocios fiable es vital. Existen diferentes opciones disponibles, y elegir el mejor seguro comercial en San Marcos puede parecer una tarea abrumadora. No obstante, es posible encontrar un seguro asequible que ofrezca la cobertura necesaria para proteger tus bienes y a tu personal. En este artículo, [https://watson-mohammad.hubstack.net/seguro-de-negocios-protegiendo-tu-inversion Seguro De Negocios San Marcos TX] el significado del seguro de negocios y qué considerar al seleccionar la póliza adecuada para tus necesidades empresariales en esta vibrante comunidad.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;h3 id=&quot;tipos-de-seguros-de-negocios&quot;&gt;Tipos de seguros de negocios&lt;/h3&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;El seguro de negocios es fundamental para proteger a los emprendedores de diversos riesgos que pueden afectar su operación. Existen varios tipos de seguros que se pueden elegir según las necesidades específicas del negocio. Uno de los más comunes es el seguro de responsabilidad civil, que cubre daños a terceros y protege al empresario ante posibles demandas. Este tipo de seguro es vital para cualquier negocio, ya que asegura la continuidad de las actividades ante incidentes imprevistos.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Otro tipo importante es el seguro de propiedad comercial, el cual protege los activos físicos del negocio, como el local, el equipo y el inventario. Este seguro es especialmente relevante para negocios que dependen de instalaciones físicas y bienes tangibles. En San Marcos TX, existen opciones de seguro de negocios asequibles que permiten a los emprendedores proteger sus inversiones y minimizar pérdidas en caso de robos, incendios u otros desastres.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Por último, el seguro de interrupción de negocio es crucial para aquellos emprendedores que desean enfrentar periodos en los que su operación se ve afectada debido a un siniestro. Este seguro puede cubrir los ingresos perdidos y los gastos operativos mientras la empresa se recupera. En San Marcos TX, contar con un confiable seguro de negocios que incluya estas coberturas es esencial para garantizar la estabilidad y el crecimiento de cualquier emprendimiento.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;h3 id=&quot;beneficios-del-seguro-comercial&quot;&gt;Beneficios del seguro comercial&lt;/h3&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;El seguro comercial ofrece una protección esencial para los emprendedores, asegurando que su inversión esté resguardada frente a diversos riesgos. Desde daños físicos en las instalaciones hasta la pérdida de inventario, este tipo de seguro permite a los dueños de negocios en San Marcos TX manejar mejor las incertidumbres del entorno empresarial. Contar con una póliza puede proporcionar la tranquilidad necesaria para enfocarse en el crecimiento y desarrollo del negocio.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Además, tener un seguro de negocios confiable en San Marcos TX puede ser un factor determinante al momento de establecer relaciones comerciales. Los clientes y socios potenciales suelen preferir trabajar con empresas que demuestran responsabilidad y respaldo ante imprevistos. Así, un buen seguro no solo protege los activos, sino que también puede mejorar la reputación y la credibilidad de la empresa en el mercado local.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Finalmente, el acceso a ofertas de seguro comercial asequibles en San Marcos TX permite a emprendedores de diferentes tamaños y sectores aprovechar estos beneficios sin afectar en gran medida su presupuesto. Al comparar opciones, es posible encontrar el mejor seguro comercial que se adapte a las necesidades específicas del negocio, garantizando así una protección adecuada sin comprometer la viabilidad financiera.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;h3 id=&quot;consejos-para-seleccionar-el-mejor-seguro&quot;&gt;Consejos para seleccionar el mejor seguro&lt;/h3&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Seleccionar el mejor seguro de negocios es fundamental para proteger tu inversión y asegurar la continuidad de tus operaciones. Primero, es importante evaluar las necesidades específicas de tu negocio. Considera factores como el tipo de industria, la ubicación, y los riesgos a los que estás expuesto. Realizar un análisis detallado te ayudará a identificar qué tipo de cobertura es la más adecuada para tus requerimientos.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Otro aspecto clave es investigar diferentes compañías de seguros que ofrezcan servicios en San Marcos TX. Busca un seguro de negocios confiable que no solo ofrezca protección adecuada, sino que también tenga buenas referencias y una sólida reputación en el mercado. Puede ser útil leer opiniones de otros emprendedores y consultar con expertos para encontrar el mejor seguro comercial en San Marcos TX.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Finalmente, no olvides comparar precios y coberturas. Un seguro asequible no siempre es la mejor opción si no proporciona una protección adecuada. Analiza las pólizas en términos de lo que cubren y las exclusiones que puedan tener. Asegúrate de que el seguro que elijas se ajuste a tu presupuesto sin comprometer la seguridad de tu negocio.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;</div></summary> <author><name>Quiverwalrus06</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Brinchmills3130</id> <title>User:Brinchmills3130</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Brinchmills3130"/> <updated>2025-07-02T20:48:29Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Brinchmills3130&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Brinchmills3130 (page does not exist)"><bdi>Brinchmills3130</bdi></a> was created</p></summary> <author><name>Brinchmills3130</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Hebertle7125</id> <title>User:Hebertle7125</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Hebertle7125"/> <updated>2025-07-02T20:48:29Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Hebertle7125&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Hebertle7125 (page does not exist)"><bdi>Hebertle7125</bdi></a> was created</p></summary> <author><name>Hebertle7125</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Kejserchoi6103&diff=3615790&oldid=0</id> <title>Kejserchoi6103</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Kejserchoi6103&diff=3615790&oldid=0"/> <updated>2025-07-02T20:48:22Z</updated> <summary type="html"><p>Created page with &quot;Immunological tests may represent valuable tools for the diagnosis of human tegumentary leishmaniasis (TL) due to their simple execution, less invasive nature and potential us...&quot;</p><p><b>New page</b></p><div>Immunological tests may represent valuable tools for the diagnosis of human tegumentary leishmaniasis (TL) due to their simple execution, less invasive nature and potential use as a point-of-care test. Indeed, several antigenic targets have been used with the aim of improving the restricted scenario for TL-diagnosis. [https://www.selleckchem.com/products/PP242.html Torkinib chemical structure] We performed a worldwide systematic review to identify antigenic targets that have been evaluated for the main clinical forms of TL, such as cutaneous (CL) and mucosal (ML) leishmaniasis. Included were original studies evaluating the sensitivity and specificity of immunological tests for human-TL, CL and/or ML diagnosis using purified or recombinant proteins, synthetic peptides or polyclonal or monoclonal antibodies to detect Leishmania-specific antibodies or antigens. The review methodology followed PRISMA guidelines and all selected studies were evaluated in accordance with QUADAS-2. Thirty-eight original studies from four databases fulfilled the selection criteria. A total of 79 antigens were evaluated for the detection of antibodies as a diagnostic for TL, CL and/or ML by ELISA. Furthermore, three antibodies were evaluated for the detection of antigen by immunochromatographic test (ICT) and immunohistochemistry (IHC) for CL-diagnosis. Several antigenic targets showed 100% of sensitivity and specificity, suggesting potential use for TL-diagnosis in its different clinical manifestations. However, a high number of proof-of-concept studies reinforce the need for further analysis aimed at verifying true diagnostic accuracy in clinical practice.The accurate identification of urban functional areas is of great significance for optimizing urban spatial structure, rationally allocating spatial elements, and promoting the sustainable development of the city. This paper proposes a method to precisely identify urban functional areas by coupling Open Street Map (OSM) and Point of Interest (POI) data. It takes the central urban area of Hangzhou as a case study to analyze the spatial distribution characteristics of the functional areas. The results show that (1) The central urban areas of Hangzhou are divided into 21 functional areas (6 single functional areas, 14 mixed functional areas and 1 comprehensive functional area). (2) The single functional areas and the mixed functional areas show the geographical distribution characteristics of the looping stratification, which means &quot;Core-periphery&quot; differentiation is obvious, and the comprehensive functional area is relatively scattered. (3) The mixed degree of regional function with ecological function and production function is low while comprehensive functional areas are usually associated with higher potential and vitality. (4) The identification results are in great agreement with the actual situation of Hangzhou central urban area, and the method is feasible. Therefore, this paper can provide a reference for urban development planning and management.&lt;br /&gt;&lt;br /&gt; There are few studies describing the clinical course and spontaneous remission of IgA nephropathy (IgAN) in adult patients receiving conservative treatment.&lt;br /&gt;&lt;br /&gt; Data from 62 adult patients with biopsy-diagnosed IgAN, who received conservative treatment at least 5 years prior, were retrospectively investigated. No patients received corticosteroids, other immunosuppressants, or tonsillectomy. Remission of proteinuria and hematuria were defined as proteinuria &amp;lt;0.3 g/gCr and urine red blood cells (RBC) &amp;lt;5 / high power field (HPF) on three consecutive urinalyses obtained during an observation period of ≥6 months.&lt;br /&gt;&lt;br /&gt; Thirty-eight (61.3%) patients had remission of hematuria, 24 (38.7%) had remission of proteinuria, and 19 (30.6%) had remission of both. Remission rates increased in patients with proteinuria &amp;lt;0.5 g/g Cr at diagnosis. The median time to remission of hematuria was 2.8 years and that of proteinuria was 2.6 years. Patients who showed renal function decline (defined as 30% decline of estimated glomaggressive treatments.&lt;br /&gt;&lt;br /&gt; In order to manage the COVID-19 systemic inflammatory response, it is important to identify clinicopathological characteristics across multiple cohorts.&lt;br /&gt;&lt;br /&gt; The aim of the present study was to compare the 4C mortality score, other measures of the systemic inflammatory response and clinicopathological characteristics in two consecutive cohorts of patients on admission with COVID-19. Electronic patient records for 2 consecutive cohorts of patients admitted to two urban teaching hospitals with COVID-19 during two 7-week periods of the COVID-19 pandemic in Glasgow, U.K. (cohort 1 17/3/2020-1/5/2020) and (cohort 2 18/5/2020-6/7/2020) were examined for routine clinical, laboratory and clinical outcome data.&lt;br /&gt;&lt;br /&gt; Compared with cohort 1, cohort 2 were older (p&amp;lt;0.001), more likely to be female (p&amp;lt;0.05) and have less independent living circumstances (p&amp;lt;0.001). More patients in cohort 2 were PCR positive, CXR negative (both p&amp;lt;0.001) and had low serum albumin concentrations (p&amp;lt;0.001). 30-day mortality was sim strongly independently associated with 30-day mortality in two consecutive cohorts of patients admitted to hospital with COVID-19.&lt;br /&gt;&lt;br /&gt; clinicaltrials.gov NCT04484545.&lt;br /&gt;&lt;br /&gt;clinicaltrials.gov NCT04484545.Generally, in real decision-making, all the pieces of information are used to find the optimal alternatives. However, in many cases, the decision-makers (DMs) only want &quot;how good/bad a thing can become.&quot; One possibility is to classify the alternatives based on minimum (tail) information instead of using all the data to select the optimal options. By considering the opportunity, we first introduce the value at risk (VaR), which is used in the financial field, and the probabilistic interval-valued hesitant fuzzy set (PIVHFS), which is the generalization of the probabilistic hesitant fuzzy set (PHFS). Second, deemed value at risk (DVaR) and reckoned value at risk (RVaR) are proposed to measure the tail information under the probabilistic interval-valued hesitant fuzzy (PIVHF) environment. We proved that RVaR is more suitable than DVaR to differentiate the PIVHFEs with example. After that, a novel complete group decision-making model with PIVHFS is put forward. This study aims to determine the most appropriate alternative using only tail information under the PIVHF environment.</div></summary> <author><name>Kejserchoi6103</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=User:JacquelynAspinal&diff=3615789&oldid=0</id> <title>User:JacquelynAspinal</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=User:JacquelynAspinal&diff=3615789&oldid=0"/> <updated>2025-07-02T20:48:21Z</updated> <summary type="html"><p>Created page with &quot;I&#039;m Jacquelyn and I live in a seaside city in northern France, Yerres. I&#039;m 40 and I&#039;m will soon finish my study at Environmental Management.&lt;br&gt;&lt;br&gt;Feel free to surf to my web...&quot;</p><p><b>New page</b></p><div>I'm Jacquelyn and I live in a seaside city in northern France, Yerres. I'm 40 and I'm will soon finish my study at Environmental Management.&lt;br&gt;&lt;br&gt;Feel free to surf to my web-site: casino, [http://www.grainfather.co.nz/employer/hollywoodbets-spina-zonke related webpage],</div></summary> <author><name>JacquelynAspinal</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Svendsenguthrie8927&diff=3615788&oldid=0</id> <title>Svendsenguthrie8927</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Svendsenguthrie8927&diff=3615788&oldid=0"/> <updated>2025-07-02T20:48:08Z</updated> <summary type="html"><p>Created page with &quot;TransIdentity - Identity Development Among Adolescent Trans*people Identity development is one of the most important developmental tasks of adolescence. Adolescents whose gend...&quot;</p><p><b>New page</b></p><div>TransIdentity - Identity Development Among Adolescent Trans*people Identity development is one of the most important developmental tasks of adolescence. Adolescents whose gender identity does not correspond to the gender assigned at birth (trangender people) are also faced with this challenge, as are cis-gender adolescents of the same age. This study is the first to examine the personality function of identity in transgender adolescents. Based on the self report of a population of 69 adolescents from the outpatient unit for gender dysphoria the extent of identity diffusion measured by AIDA (Assessment of Identity Development in Adolescence) was compared with the values of the normative sample consisting of German-speaking pupils. Both the overall construct of identity diffusion and the areas of continuity and coherence showed average values in the examined young people, which speaks against pathological identity development. Nevertheless, identity diffusion was found in over a third (36 %). Most notably the aspect of stabilising relationships and roles was above average, which suggests that positive role identification from the areas of culture, family and body-self is present to a lesser extent than in the norm sample. The identity-stabilizing feeling of social anchoring appears to be impaired in the young transidents studied.Reactive and proactive cognitive control are fundamental for guiding complex human behaviour. In two experiments, we evaluated the role of both types of cognitive control in navigational search. Participants searched for a single hidden target in a floor array where the salience at the search locations varied (flashing or static lights). An a-priori rule of the probable location of the target (either under a static or a flashing light) was provided at the start of each experiment. Both experiments demonstrated a bias towards rule-adherent locations. Search errors, measured as revisits, were more likely to occur under the flashing rule for searching flashing locations, regardless of the salience of target location in Experiment 1 and at rule-congruent (flashing) locations in Experiment 2. [https://www.selleckchem.com/products/-epicatechin.html L-Epicatechin] Consistent with dual mechanisms of control, rule-adherent search was explained by engaging proactive control to guide goal-maintained search behaviour and by engaging reactive control to avoid revisits to salient (flashing) locations. Experiment 2 provided direct evidence for dual mechanisms of control using a Dot Pattern Expectancy task to distinguish the dominant control mode for a participant. Participants with a reactive control mode generated more revisits to salient (flashing) locations. These data point to complementary roles for proactive and reactive control in guiding navigational search and propose a novel framework for interpreting navigational search.Recent studies have demonstrated that in visual working memory (VWM), only items in an active state can guide attention. Further evidence has revealed that items with higher perceptual salience or items prioritised by a valid retro-cue in VWM tend to be in an active state. However, it is unclear which factor (perceptual salience or retro-cues) is more important for influencing the item state in VWM or whether the factors can act concurrently. Experiment 1 examined the role of perceptual salience by asking participants to hold two features with relatively different perceptual salience (colour vs. shape) in VWM while completing a visual search task. Guidance effects were found when either colour or both colour and shape in VWM matched one of the search distractors but not when shape matched. This demonstrated that the more salient feature in VWM can actively guide attention, while the less salient feature cannot. However, when shape in VWM was cued to be more relevant (prioritised) in Experiment 2, we found guidance effects in both colour-match and shape-match conditions. That is, both more salient but non-cued colour and less salient but cued shape could be active in VWM, such that attentional selection was affected by the matching colour or shape in the visual search task. This suggests that bottom-up perceptual salience and top-down retro-cues can jointly determine the active state in VWM.Wagner's replaced elements model (REM) theory implies that generalisation and summation tests depend on a common similarity parameter, but few studies have assessed generalisation and summation within the same experimental paradigm. Three experiments adapted a methodology used in non-human animal studies to investigate this question in the case of human causal reasoning. The studies combined different amounts of training on simple discriminations (A+ vs. C-), compound discriminations (AB+ vs. CD-), and irrelevant novel cue discriminations (An+ vs. Cn-) with testing on single cues, compound cues, and compounds of cues with novel cues. The results were compared with predictions of Pearce's configural model and Wagner's REM elemental model. They also were examined to determine whether generalisation and summation could be accounted for using a single value for the similarity between stimulus compounds and the separable constituent cues of which the compounds were composed. The findings indicated that each theory needed to include common cues to account for the data.The regenerative effects of stem cells derived from dental tissues have been previously investigated. This study assessed the potential of human tooth stem cells from apical papilla (SCAP) on nerve regeneration. The SCAP collected from nine individuals were characterized and polarized by exposure to interferon-γ (IFN-γ). IFN-γ increased kynurenine and interleukin-6 (IL-6) production by SCAP, without affecting the cell viability. IFN-γ-primed SCAP exhibited a decrease of brain-derived neurotrophic factor (BDNF) mRNA levels, followed by an upregulation of glial cell-derived neurotrophic factor mRNA. Ex vivo, the co-culture of SCAP with neurons isolated from the rat dorsal root ganglion induced neurite outgrowth, accompanied by increased BDNF secretion, irrespective of IFN-γ priming. In vivo, the local application of SCAP reduced the mechanical and thermal hypersensitivity in Wistar rats that had been submitted to sciatic chronic constriction injury. The SCAP also reduced the pain scores, according to the evaluation of the Grimace scale, partially restoring the myelin damage and BDNF immunopositivity secondary to nerve lesion.</div></summary> <author><name>Svendsenguthrie8927</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Ashbyvoigt1187&diff=3615787&oldid=0</id> <title>Ashbyvoigt1187</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Ashbyvoigt1187&diff=3615787&oldid=0"/> <updated>2025-07-02T20:48:07Z</updated> <summary type="html"><p>Created page with &quot;20, 95%CI 0.10-0.38).&lt;br /&gt;&lt;br /&gt; Transwomen self-reported a high prevalence of IPV, which was related to a lower probability of HIV testing. The prevalence of HIV and other S...&quot;</p><p><b>New page</b></p><div>20, 95%CI 0.10-0.38).&lt;br /&gt;&lt;br /&gt; Transwomen self-reported a high prevalence of IPV, which was related to a lower probability of HIV testing. The prevalence of HIV and other STIs was lower than reported in previous studies of Chinese transwomen, while the HIV/STI testing rates were higher. Findings suggest transwomen in China are at risk for IPV and need enhanced HIV prevention services to promote HIV testing in an IPV setting.&lt;br /&gt;&lt;br /&gt;Transwomen self-reported a high prevalence of IPV, which was related to a lower probability of HIV testing. The prevalence of HIV and other STIs was lower than reported in previous studies of Chinese transwomen, while the HIV/STI testing rates were higher. Findings suggest transwomen in China are at risk for IPV and need enhanced HIV prevention services to promote HIV testing in an IPV setting.&lt;br /&gt;&lt;br /&gt; To discuss current and future regulatory and financial issues affecting the field of vascularized composite allotransplantation (VCA).&lt;br /&gt;&lt;br /&gt; Vascularized composite allografts are regulated by the US Department of Health and Human Services Organ Procurement and Transplantation Network Final Rule (42 CFR part 121) in the United States and Directive 2010/53/EU of the European Parliament and the Council of 7 July 2010 in the European Union (EU). However, in the United States and most of the EU, VCA is not yet paid for by insurance or third-party payers and many centers depend upon grant funding, philanthropic gifts, and/or supplemental hospital/institutional funding strategies to pay for the transplants and postoperative care.&lt;br /&gt;&lt;br /&gt; In the absence of randomized clinical trial data, which is infeasible for studying VCA outcomes, consensus data sets are needed to document these procedures' value proposition and have them accepted as part of the standard of care. Procedure and immunosuppression protocol variability applied to a small patient cohort necessitates collaborative efforts by field experts to devise creative approaches, such as determining return-on-investment for anatomical subunits, to better understand these transplants' value and impact on patient quality-of-life.&lt;br /&gt;&lt;br /&gt;In the absence of randomized clinical trial data, which is infeasible for studying VCA outcomes, consensus data sets are needed to document these procedures' value proposition and have them accepted as part of the standard of care. [https://www.selleckchem.com/products/chloroquine-phosphate.html find more] Procedure and immunosuppression protocol variability applied to a small patient cohort necessitates collaborative efforts by field experts to devise creative approaches, such as determining return-on-investment for anatomical subunits, to better understand these transplants' value and impact on patient quality-of-life.&lt;br /&gt;&lt;br /&gt; We report the risks and benefits of utilizing HIV-positive organ donors.&lt;br /&gt;&lt;br /&gt; The utilization of HIV-positive organs came with significant concerns including poor organ quality, increased risk of rejection, HIV disease progression, transmission of varying HIV strains and opportunistic infections, virologic failure due to antiretroviral resistance, increased risk for posttransplant malignancy, and recurrent HIV-associated nephropathy. Recently published data have shown, however, that despite the above mentioned risks, patient survival, and graft survival in persons living with HIV (PLWH) who received a kidney transplant from a HIV-positive donor (D+/R+) is similar to a kidney transplant from a HIV-negative donor (D-/R+).&lt;br /&gt;&lt;br /&gt; To date, 268 PLWH have received an organ from a HIV-positive donor, including 198 kidney transplants and 70 liver/liver-kidney transplants. The utilization of HIV-positive donor organs has proven to be a safe and feasible approach to expanding the donor pool and improving access to lifesaving therapy for PLWH with end-stage organ disease.&lt;br /&gt;&lt;br /&gt;To date, 268 PLWH have received an organ from a HIV-positive donor, including 198 kidney transplants and 70 liver/liver-kidney transplants. The utilization of HIV-positive donor organs has proven to be a safe and feasible approach to expanding the donor pool and improving access to lifesaving therapy for PLWH with end-stage organ disease.&lt;br /&gt;&lt;br /&gt; Hemorrhagic shock (HS) and trauma induce endothelial barrier compromise, inflammation, and aberrant clotting. We have shown that fresh human platelets (Plts) and Plt extracellular vesicles mitigate vascular leak in murine models of injury. Here, we investigate the potential of freeze-dried platelets (FDPlts) to attenuate pulmonary vascular permeability, decrease inflammation, and promote clotting in a murine model of HS.&lt;br /&gt;&lt;br /&gt; Human FDPlts were characterized using in vitro assays of Plt marker expression, aggregation, coagulation, and endothelial cell permeability. An intravital model of vascular injury in the mouse cremaster muscle was used to assess the ability of FDPlts to incorporate into clots. Mouse groups subjected to controlled hemorrhage for 90 minutes were (1) lactated Ringer solution (LR), (2) FDPlts, (3) fresh human Plts, (4) murine whole blood (WB), and (5) shams (only instrumented). Hemorrhagic shock mouse endpoints included coagulation, pulmonary vascular permeability, and lung injury.&lt;br /&gt;&lt;br /&gt; Freeze-dble alternative to fresh Plts in modulating hemostasis and the endotheliopathy associated with injury.&lt;br /&gt;&lt;br /&gt;FDPlts contribute to clot formation similar to fresh human Plts. FDPlts also attenuated vascular permeability in vitro and in vivo. Mouse WB resuscitation but not fresh human Plts attenuated vascular permeability after HS. These data suggest that the effect of FDPlts may be a suitable alternative to fresh Plts in modulating hemostasis and the endotheliopathy associated with injury.&lt;br /&gt;&lt;br /&gt; Falls are the leading cause of traumatic brain injury (TBI) and TBI-related deaths for older persons (age, ≥65 years). Antiplatelet and/or anticoagulant therapy (antithrombotics [ATs]) is generally felt to increase this risk, but the literature is inconsistent. The purpose of this study was to determine the impact of AT use on the rate, severity, and outcomes of TBI in older patients following ground level falls.&lt;br /&gt;&lt;br /&gt; Ground level fall patients from 90 hospitals' trauma registries were selected. Patients were excluded if younger than 65 years or had an Abbreviated Injury Scale score of &amp;gt;2 in a region other than head. Electronic medical record data for preinjury AT therapy were obtained. Patients were grouped by regimen for no AT, single, or multiple agents. Groups were compared on rates of diagnosed TBI, TBI surgery, and mortality.&lt;br /&gt;&lt;br /&gt; There were 33,710 patients (35% male; mean age, 80.5 years; mean Glasgow Coma Scale, 14.6), with 47.6% on single or combination AT therapy. The proportion of patients with TBI diagnoses did not differ between those on no AT (21.</div></summary> <author><name>Ashbyvoigt1187</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Mccoygauthier2653</id> <title>User:Mccoygauthier2653</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Mccoygauthier2653"/> <updated>2025-07-02T20:48:05Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Mccoygauthier2653&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Mccoygauthier2653 (page does not exist)"><bdi>Mccoygauthier2653</bdi></a> was created</p></summary> <author><name>Mccoygauthier2653</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Kellehercurrin9743&diff=3615786&oldid=0</id> <title>Kellehercurrin9743</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Kellehercurrin9743&diff=3615786&oldid=0"/> <updated>2025-07-02T20:47:36Z</updated> <summary type="html"><p>Created page with &quot;Under the 1.2 V and 1.8 V supply voltages, the dynamic range of the HPSDM is extended to approximately 12 dB due to the technique of programmable feedforward coefficients.In t...&quot;</p><p><b>New page</b></p><div>Under the 1.2 V and 1.8 V supply voltages, the dynamic range of the HPSDM is extended to approximately 12 dB due to the technique of programmable feedforward coefficients.In this work, a localized plasmon-based sensor is developed for para-cresol (p-cresol) - a water pollutant detection. A nonadiabatic [Formula see text] of tapered optical fiber (TOF) has been experimentally fabricated and computationally analyzed using beam propagation method. For optimization of sensor's performance, two probes are proposed, where probe 1 is immobilized with gold nanoparticles (AuNPs) and probe 2 is immobilized with the AuNPs along with zinc oxide nanoparticles (ZnO-NPs). The synthesized metal nanomaterials were characterized by ultraviolet-visible spectrophotometer (UV-vis spectrophotometer) and transmission electron microscope (HR-TEM). The nanomaterials coating on the surface of the sensing probe were characterized by a scanning electron microscope (SEM). Thereafter, to increase the specificity of the sensor, the probes are functionalized with tyrosinase enzyme. Different solutions of p-cresol in the concentration range of [Formula see text] - [Formula see text] are prepared in an artificial urine solution for sensing purposes. Different analytes such as uric acid, β -cyclodextrin, L-alanine, and glycine are prepared for selectivity measurement. The linearity range, sensitivity, and limit of detection (LOD) of probe 1 are [Formula see text] - [Formula see text], 7.2 nm/mM (accuracy 0.977), and [Formula see text], respectively; and for probe 2 are [Formula see text] - [Formula see text], 5.6 nm/mM (accuracy 0.981), and [Formula see text], respectively. Thus, the overall performance of probe 2 is quite better due to the inclusion of ZnO-NPs that increase the biocompatibility of sensor probe. The proposed sensor structure has potential applications in the food industry and clinical medicine.We provide an open access dataset of High densitY Surface Electromyogram (HD-sEMG) Recordings (named &quot;Hyser&quot;), a toolbox for neural interface research, and benchmark results for pattern recognition and EMG-force applications. Data from 20 subjects were acquired twice per subject on different days following the same experimental paradigm. We acquired 256-channel HD-sEMG from forearm muscles during dexterous finger manipulations. This Hyser dataset contains five sub-datasets as (1) pattern recognition (PR) dataset acquired during 34 commonly used hand gestures, (2) maximal voluntary muscle contraction (MVC) dataset while subjects contracted each individual finger, (3) one-degree of freedom (DoF) dataset acquired during force-varying contraction of each individual finger, (4) N-DoF dataset acquired during prescribed contractions of combinations of multiple fingers, and (5) random task dataset acquired during random contraction of combinations of fingers without any prescribed force trajectory. Dataset 1 can be used for gesture recognition studies. Datasets 2-5 also recorded individual finger forces, thus can be used for studies on proportional control of neuroprostheses. Our toolbox can be used to (1) analyze each of the five datasets using standard benchmark methods and (2) decompose HD-sEMG signals into motor unit action potentials via independent component analysis. We expect our dataset, toolbox and benchmark analyses can provide a unique platform to promote a wide range of neural interface research and collaboration among neural rehabilitation engineers.We systematically investigate in-vivo the effect of increasing prosthetic knee flexion damping on key features of the swing phase of individuals with transfemoral amputation during walking. Five experienced prosthesis users walked using a prototype device in a motion capture laboratory. A range of interchangeable hydraulic rotary dampers was used to progressively modify swing phase flexion resistance in isolation. Toe clearance (TC; vertical distance toe to floor), effective leg length (ELL; distance hip to toe), and knee flexion angle during swing phase were computed, alongside the sensitivities of vertical toe position to angular displacements at the hip, knee and ankle. Key features of these profiles were compared across 5 damping conditions. With higher damping, knee extension occurred earlier in swing phase, promoting greater symmetry. [https://www.selleckchem.com/products/omaveloxolone-rta-408.html selleck compound] However, with implications for toe catch, minimum TC reduced, and minimum TC and maximum ELL occurred earlier; temporally closer to mid-swing, when the limb must pass the stance limb. Further, TC became less sensitive to changes in hip flexion, suggesting a lesser ability to control toe clearance without employing proximal or contralateral compensations. There is a trade-off between key features related to gait safety when selecting an appropriate resistance for a mechanical prosthetic knee. In addition to highlighting broader implications surrounding swing phase damping selection for the optimization of mechanical knees, this work reveals design considerations that may be of utility in the formulation of control strategies for computerized devices.Multiple cylinders detection from large-scale and complex point clouds is a historical but challenging problem, considering the efficiency and accuracy. We propose a novel framework, named slicing-tracking-detection (STD), that detects multiple cylinders accurately and simultaneously from point clouds of large-scale and complex process plants. In this framework, the 3D cylinder detection problem is reformulated as a cylinder ingredients tracking task based on multi-object tracking (MOT). Firstly, we generate slices from the input point cloud, and render them to slice sequence. Then, the cycle of a cylinder is modeled with a Markov Decision Process (MDP), where the ingredient is tracked with a template and the miss tracking is associated with ingredient proposals through reinforcement learning. Finally, by applying MDP for each cylinder, multiple cylinders can be detected simultaneously and accurately. Extensive experiments show that the proposed STD framework can significantly outperform the state-of-the-art approaches in efficiency, accuracy, and robustness. The source code is available at http//zhiyongsu.github.io.</div></summary> <author><name>Kellehercurrin9743</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Walkerkaspersen9675</id> <title>User:Walkerkaspersen9675</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Walkerkaspersen9675"/> <updated>2025-07-02T20:47:22Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Walkerkaspersen9675&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Walkerkaspersen9675 (page does not exist)"><bdi>Walkerkaspersen9675</bdi></a> was created</p></summary> <author><name>Walkerkaspersen9675</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Hellerchang6469</id> <title>User:Hellerchang6469</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Hellerchang6469"/> <updated>2025-07-02T20:47:16Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Hellerchang6469&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Hellerchang6469 (page does not exist)"><bdi>Hellerchang6469</bdi></a> was created</p></summary> <author><name>Hellerchang6469</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=El_seguro_de_negocios_Ms_all_de_una_pliza&diff=3615785&oldid=3615170</id> <title>El seguro de negocios Ms all de una pliza</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=El_seguro_de_negocios_Ms_all_de_una_pliza&diff=3615785&oldid=3615170"/> <updated>2025-07-02T20:47:12Z</updated> <summary type="html"><p></p><table class="diff diff-contentalign-left" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr style="vertical-align: top;" lang="en"> <td colspan="2" style="background-color: white; color:black; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: white; color:black; text-align: center;">Revision as of 20:47, 2 July 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1" >Line 1:</td><td colspan="2" class="diff-lineno">Line 1:</td></tr><tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>&lt;p&gt;El seguro de negocios es una herramienta fundamental para cualquier empresario que busque proteger su inversión y asegurar la continuidad de sus operaciones. En un entorno económico cada vez más incierto, contar con un respaldo confiable se vuelve indispensable. No se trata solo de una póliza que se activa ante un siniestro, sino de una estrategia integral que permite a las empresas enfrentar desafíos inesperados y minimizar riesgos. En ciudades como San Marcos, TX, la demanda de un seguro comercial adecuado ha aumentado, ya que los empresarios se dan cuenta de que su importancia va más allá de un simple cumplimiento normativo.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;En este artículo, exploraremos el verdadero significado del seguro de negocios y cómo este puede influir en el éxito y la estabilidad de una empresa. Desde el mejor seguro comercial en San Marcos, TX, hasta opciones asequibles que se adaptan a diferentes necesidades, entenderemos cómo seleccionar el seguro de negocios adecuado puede hacer la diferencia entre una recuperación rápida tras un contratiempo y la pérdida permanente de un negocio. Acompáñanos en este recorrido donde profundizaremos en los beneficios y la tranquilidad que proporciona contar con un seguro comercial confiable en San Marcos, TX.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;h3 id=&quot;tipos-de-seguro-de-negocios&quot;&gt;Tipos de Seguro de Negocios&lt;/h3&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Existen diversos tipos de seguros de negocios que se adaptan a las necesidades específicas de cada empresa. <del class="diffchange diffchange-inline">[https://www.folkd.com/submit/www.aseguranzaentexas.com/seguro-de-negocios-san-marcos-tx/ Confiable Seguro De Negocios San Marcos TX] </del>de los más comunes es el seguro de responsabilidad civil, que protege a los negocios contra reclamos por daños a terceros, ya sea por lesiones o daños a la propiedad. Este tipo de seguro es esencial para cualquier empresa, ya que brinda una capa de protección frente a incidentes que puedan resultar en costosas demandas.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Otro tipo importante es el seguro de propiedad comercial, que cubre los daños a los bienes físicos de la empresa, como edificios, maquinarias y inventario. Este seguro es fundamental en San Marcos TX, ya que las empresas pueden estar expuestas a diversos riesgos, incluidos incendios, robos o desastres naturales. Al tener un seguro de propiedad confiable, las empresas pueden recuperarse más fácilmente de pérdidas imprevistas.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Además, el seguro de interrupción de negocios es clave para las empresas que dependen de ingresos constantes. Este seguro proporciona una compensación por pérdidas de ingresos cuando la operación comercial se ve interrumpida debido a un evento cubierto, como un incendio o un desastre natural. Para garantizar la estabilidad económica, contar con el mejor seguro comercial en San Marcos TX puede marcar la diferencia en la continuidad de las operaciones de un negocio.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;h3 id=&quot;beneficios-del-seguro-comercial&quot;&gt;Beneficios del Seguro Comercial&lt;/h3&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;El seguro comercial ofrece múltiples beneficios que son vitales para la protección y el crecimiento de cualquier negocio. En primer lugar, proporciona una cobertura financiera ante eventos inesperados que pueden perjudicar la operación de la empresa, como incendios, robos o desastres naturales. Esto permite a los empresarios concentrarse en sus actividades diarias sin el temor constante de perder su inversión.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Además, contar con un seguro de negocios confiable en San Marcos TX ayuda a incrementar la confianza de los clientes y proveedores. Al tener una póliza de seguro, se demuestra un compromiso con la responsabilidad y la estabilidad, lo que puede ser un factor decisivo para los clientes al elegir entre distintos proveedores. Esto no solo fortalece la reputación de la empresa, sino que también puede abrir nuevas oportunidades de colaboración y venta.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Finalmente, el acceso a un seguro asequible en San Marcos TX permite a las pequeñas y medianas empresas gestionar mejor sus costos operativos. Al elegir las coberturas adecuadas según sus necesidades específicas, los empresarios pueden equilibrar su presupuesto y garantizar que estén protegidos sin afectar negativamente su rentabilidad. <del class="diffchange diffchange-inline">Esta estrategia </del>es clave para asegurar la continuidad del negocio a largo plazo.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;h3 id=&quot;cómo-elegir-el-mejor-seguro-en-san-marcos-tx&quot;&gt;Cómo Elegir el Mejor Seguro en San Marcos TX&lt;/h3&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Elegir el mejor seguro de negocios en San Marcos TX es esencial para proteger tu inversión y garantizar la continuidad de tus operaciones. Primero, es importante evaluar las necesidades específicas de tu empresa. Considera factores como el tipo de industria, el tamaño de tu negocio y los riesgos potenciales que enfrentas. Realiza una lista de lo que deseas proteger y busca una póliza que se ajuste a esas necesidades, asegurando así que tengas una cobertura adecuada y confiable.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Otro aspecto a tener en cuenta es comparar diferentes opciones de seguros. Investiga diversas compañías y sus ofertas, prestando atención a los beneficios, exclusiones y costos. No te quedes solo con el precio; lo más barato no siempre significa que recibirás el mejor servicio o cobertura. Opta por un seguro de negocios en San Marcos TX que sea asequible, pero que también ofrezca una atención al cliente de calidad y respuestas rápidas en caso de reclamaciones.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Finalmente, considera consultar con un agente de seguros especializado en el área. Un profesional experimentado puede ofrecerte asesoría personalizada y ayudarte a entender mejor las particularidades de las pólizas disponibles. Con su ayuda, podrás tomar una decisión informada y elegir el mejor seguro comercial en San Marcos TX que se adapte a tus necesidades y te ofrezca la tranquilidad necesaria para seguir creciendo.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;</div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>&lt;p&gt;El seguro de negocios es una herramienta fundamental para cualquier empresario que busque proteger su inversión y asegurar la continuidad de sus operaciones. En un entorno económico cada vez más incierto, contar con un respaldo confiable se vuelve indispensable. No se trata solo de una póliza que se activa ante un siniestro, sino de una estrategia integral que permite a las empresas enfrentar desafíos inesperados y minimizar riesgos. En ciudades como San Marcos, TX, la demanda de un seguro comercial adecuado ha aumentado, ya que los empresarios se dan cuenta de que su importancia va más allá de un simple cumplimiento normativo.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;En este artículo, exploraremos el verdadero significado del seguro de negocios y cómo este puede influir en el éxito y la estabilidad de una empresa. Desde el mejor seguro comercial en San Marcos, TX, hasta opciones asequibles que se adaptan a diferentes necesidades, entenderemos cómo seleccionar el seguro de negocios adecuado puede hacer la diferencia entre una recuperación rápida tras un contratiempo y la pérdida permanente de un negocio. Acompáñanos en este recorrido donde profundizaremos en los beneficios y la tranquilidad que proporciona contar con un seguro comercial confiable en San Marcos, TX.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;h3 id=&quot;tipos-de-seguro-de-negocios&quot;&gt;Tipos de Seguro de Negocios&lt;/h3&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Existen diversos tipos de seguros de negocios que se adaptan a las necesidades específicas de cada empresa. <ins class="diffchange diffchange-inline">Uno </ins>de los más comunes es el seguro de responsabilidad civil, que protege a los negocios contra reclamos por daños a terceros, ya sea por lesiones o daños a la propiedad. Este tipo de seguro es esencial para cualquier empresa, ya que brinda una capa de protección frente a incidentes que puedan resultar en costosas demandas.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Otro tipo importante es el seguro de propiedad comercial, que cubre los daños a los bienes físicos de la empresa, como edificios, maquinarias y inventario. Este seguro es fundamental en San Marcos TX, ya que las empresas pueden estar expuestas a diversos riesgos, incluidos incendios, robos o desastres naturales. Al tener un seguro de propiedad confiable, las empresas pueden recuperarse más fácilmente de pérdidas imprevistas.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Además, el seguro de interrupción de negocios es clave para las empresas que dependen de ingresos constantes. Este seguro proporciona una compensación por pérdidas de ingresos cuando la operación comercial se ve interrumpida debido a un evento cubierto, como un incendio o un desastre natural. Para garantizar la estabilidad económica, contar con el mejor seguro comercial en San Marcos TX puede marcar la diferencia en la continuidad de las operaciones de un negocio.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;h3 id=&quot;beneficios-del-seguro-comercial&quot;&gt;Beneficios del Seguro Comercial&lt;/h3&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;El seguro comercial ofrece múltiples beneficios que son vitales para la protección y el crecimiento de cualquier negocio. En primer lugar, proporciona una cobertura financiera ante eventos inesperados que pueden perjudicar la operación de la empresa, como incendios, robos o desastres naturales. Esto permite a los empresarios concentrarse en sus actividades diarias sin el temor constante de perder su inversión.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Además, contar con un seguro de negocios confiable en San Marcos TX ayuda a incrementar la confianza de los clientes y proveedores. Al tener una póliza de seguro, se demuestra un compromiso con la responsabilidad y la estabilidad, lo que puede ser un factor decisivo para los clientes al elegir entre distintos proveedores. Esto no solo fortalece la reputación de la empresa, sino que también puede abrir nuevas oportunidades de colaboración y venta.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Finalmente, el acceso a un seguro asequible en San Marcos TX permite a las pequeñas y medianas empresas gestionar mejor sus costos operativos. Al elegir las coberturas adecuadas según sus necesidades específicas, los empresarios pueden equilibrar su presupuesto y garantizar que estén protegidos sin afectar negativamente su rentabilidad. <ins class="diffchange diffchange-inline">[https://pinshape.com/users/8461305-soundwalrus67 Seguro De Negocios San Marcos TX] </ins>es clave para asegurar la continuidad del negocio a largo plazo.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;h3 id=&quot;cómo-elegir-el-mejor-seguro-en-san-marcos-tx&quot;&gt;Cómo Elegir el Mejor Seguro en San Marcos TX&lt;/h3&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Elegir el mejor seguro de negocios en San Marcos TX es esencial para proteger tu inversión y garantizar la continuidad de tus operaciones. Primero, es importante evaluar las necesidades específicas de tu empresa. Considera factores como el tipo de industria, el tamaño de tu negocio y los riesgos potenciales que enfrentas. Realiza una lista de lo que deseas proteger y busca una póliza que se ajuste a esas necesidades, asegurando así que tengas una cobertura adecuada y confiable.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Otro aspecto a tener en cuenta es comparar diferentes opciones de seguros. Investiga diversas compañías y sus ofertas, prestando atención a los beneficios, exclusiones y costos. No te quedes solo con el precio; lo más barato no siempre significa que recibirás el mejor servicio o cobertura. Opta por un seguro de negocios en San Marcos TX que sea asequible, pero que también ofrezca una atención al cliente de calidad y respuestas rápidas en caso de reclamaciones.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;&lt;p&gt;Finalmente, considera consultar con un agente de seguros especializado en el área. Un profesional experimentado puede ofrecerte asesoría personalizada y ayudarte a entender mejor las particularidades de las pólizas disponibles. Con su ayuda, podrás tomar una decisión informada y elegir el mejor seguro comercial en San Marcos TX que se adapte a tus necesidades y te ofrezca la tranquilidad necesaria para seguir creciendo.&lt;/p&gt;&lt;br /&gt;&lt;br /&gt;</div></td></tr></table></summary> <author><name>Quiverwalrus06</name></author> </entry> </feed>If you would like to create a banner that links to this page (i.e. this validation result), do the following:
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