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<?xml version="1.0"?><feed xmlns="http://www.w3.org/2005/Atom" xml:lang="en"> <id>https://humanlove.stream/api.php?hidebots=1&urlversion=1&days=7&limit=50&action=feedrecentchanges&feedformat=atom</id> <title>Human's Love - Recent changes [en]</title> <link rel="self" type="application/atom+xml" href="https://humanlove.stream/api.php?hidebots=1&urlversion=1&days=7&limit=50&action=feedrecentchanges&feedformat=atom"/> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/Special:RecentChanges"/> <updated>2025-07-01T19:54:02Z</updated> <subtitle>Track the most recent changes to the wiki in this feed.</subtitle> <generator>MediaWiki 1.30.0</generator> <entry> <id>https://humanlove.stream/wiki/User:Tankhate32</id> <title>User:Tankhate32</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Tankhate32"/> <updated>2025-07-01T19:53:55Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Tankhate32&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Tankhate32 (page does not exist)"><bdi>Tankhate32</bdi></a> was created</p></summary> <author><name>Tankhate32</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Robertsonsantos3041&diff=3606982&oldid=0</id> <title>Robertsonsantos3041</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Robertsonsantos3041&diff=3606982&oldid=0"/> <updated>2025-07-01T19:53:51Z</updated> <summary type="html"><p>Created page with &quot;agents are safe and effective to ensure sedation prior to painful burn-care procedures.&lt;br /&gt;&lt;br /&gt;Results of this study indicate that dexmedetomidine causes hemodynamic alter...&quot;</p><p><b>New page</b></p><div>agents are safe and effective to ensure sedation prior to painful burn-care procedures.&lt;br /&gt;&lt;br /&gt;Results of this study indicate that dexmedetomidine causes hemodynamic alterations while midazolam causes respiratory depression. However, these effects are not severe, and we conclude that both agents are safe and effective to ensure sedation prior to painful burn-care procedures.&lt;br /&gt;&lt;br /&gt; Nursing is an embodiment of knowledge, clinical work, and interpersonal communication. Effective nursing care has a distinct influence on the overall satisfaction and experience of the patient. Communication is said to be indispensable in the delivery of quality healthcare. Effective communication between nurses and patients has proven to yield better results with pain control and improved psychological status of patients.&lt;br /&gt;&lt;br /&gt; The aim of the study is to explore nurses' perceptions on the role of communication in the management of burns pain.&lt;br /&gt;&lt;br /&gt; A qualitative design with purposive sampling was carried out to recruit 11 registered nurses from a Reconstructive Plastic Surgery and Burns Center in Ghana. To identify the participants' perception on the role of nurse-patient communication in the management of burns pain, a face to face semi-structured interviews were conducted using an interview guide to collect data.&lt;br /&gt;&lt;br /&gt; Thematic analysis was done with various themes emerging. Helping patients manage pain, early detecion.The first half of the year 2020 has been shaped by quarantines and lock-downs all over the world. The novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a pandemic, that slowed down not only social interactions and economy, but also medical and health care. Governments and hospitals were forced to create ad hoc emergency plans maintaining the balance between an adequate participation in collective response of shutting-down to avoid a further spreading of the virus, while preserving the ongoing acute care and simultaneously being able to react to an imminent overextension with a collapse of capacities. The University Hospital Graz is one of the largest hospitals in Austria. As transregional trauma and burn centre it provides care for people from all over Austria and faced special challenges. We present the strategy of the University Hospital Graz in dealing with the COVID-19 pandemic and the way back to (new) normality. The strategy includes infrastructural, patient-centred and staff-centred measures. The continuously low numbers of new infections in Austria allowed a loosening of the lock-down measures already. Particular attention has to be paid to attentive screening of patients and triaging of surgeries during the re-boot. The re-boot needs to be slow and steady to reduce the risk of an infectiological relapse. Once this pandemic is defeated, a careful re-evaluation of the different internationally applied strategies should be performed to be prepared for the future.&lt;br /&gt;&lt;br /&gt; Determination of the depth of burn wounds is still a challenge in clinical practise and fundamental for an optimal treatment. Hyperspectral imaging (HSI) has a high potential to be established as a new contact-free measuring method in medicine. [https://www.selleckchem.com/products/q-vd-oph.html find more] From hyperspectral spectra 3D-perfusion parameters can be estimated and the microcirculatory of burn wounds over the first 72h after thermal injury can be objectively described.&lt;br /&gt;&lt;br /&gt; We used a hyperspectral imaging camera and extended data processing methods to calculate 3D-perfusion parameters of burn wounds from adult patients. The data processing results in the estimation of perfusion parameters like volume fraction and oxygenation of haemoglobin for 6 different layers of the injured skin. The parameters are presented as depth profiles. We analyzed and compared measurements of wounds of different degrees of damage and present the methodology and preliminary results.&lt;br /&gt;&lt;br /&gt; The depth profiles of the perfusion parameters show characteristic features and differences depending on the degree of damage. With Hyperspectral Imaging and the advanced data processing the perfusion characteristics of burn wounds can be visualized in more detail. Based on the analysis of this perfusion characteristics, a new and better reliable classification of burn degrees can be developed supporting the surgeon in the early selection of the optimal treatment.&lt;br /&gt;&lt;br /&gt;The depth profiles of the perfusion parameters show characteristic features and differences depending on the degree of damage. With Hyperspectral Imaging and the advanced data processing the perfusion characteristics of burn wounds can be visualized in more detail. Based on the analysis of this perfusion characteristics, a new and better reliable classification of burn degrees can be developed supporting the surgeon in the early selection of the optimal treatment.&lt;br /&gt;&lt;br /&gt; To investigate the possibility of an association between parental consanguinity and the occurrence of congenital ocular abnormalities.&lt;br /&gt;&lt;br /&gt; A retrospective cross-sectional study was carried out over 3 years, from January 2016 to December 2018, in the pediatric ophthalmology unit of the University Hospital Campus of Lomé (Togo). It included children with congenital ocular abnormalities. Age, gender, geographic origin (city or urban area, village or rural area), degree of consanguinity of parents and types of congenital ocular abnomalities were the variables of study. Odds Ratio (OR) and logistic regression were used to investigate the correlation between parental consanguinity and the occurrence of congenital ocular abnormalities. A P-value of&amp;lt;0.05 was considered statistically significant.&lt;br /&gt;&lt;br /&gt; Among the 103 patients with congenital ocular abnormalities, there were 60 (58.2%) males and 43 (41.8%) females. The mean age of the patients was 16 months, range 1 month-5 years. Patients born to consanguineous parents were 26.2% (27) of the total population. Of these 27 patients, 25 (92.6%) were born to second-cousin marriages and 24 (88.89%) came from a rural area. Parental consanguinity was correlated with developmental abnormalities of the globe (OR=37.50; 95% CI&lt;br /&gt;&lt;br /&gt; [4.46-314.80]; r=3.62; P=0.00), sclerocornea (OR=13.04; 95% CI [1.39-122.54]; r=2.57; P=0.02) and corneal dystrophy (OR=9.37; 95% CI [0.93-94.36]; r=2.24; P=0.02).&lt;br /&gt;&lt;br /&gt; Our study suggests the existence of a correlation between parental consanguinity and the occurrence of congenital ocular abnormalities.&lt;br /&gt;&lt;br /&gt;Our study suggests the existence of a correlation between parental consanguinity and the occurrence of congenital ocular abnormalities.</div></summary> <author><name>Robertsonsantos3041</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Mortensenhess0152</id> <title>User:Mortensenhess0152</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Mortensenhess0152"/> <updated>2025-07-01T19:53:28Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Mortensenhess0152&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Mortensenhess0152 (page does not exist)"><bdi>Mortensenhess0152</bdi></a> was created</p></summary> <author><name>Mortensenhess0152</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Branchnance1968</id> <title>User:Branchnance1968</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Branchnance1968"/> <updated>2025-07-01T19:53:07Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Branchnance1968&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Branchnance1968 (page does not exist)"><bdi>Branchnance1968</bdi></a> was created</p></summary> <author><name>Branchnance1968</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Heavenjumper36&diff=3606981&oldid=0</id> <title>Heavenjumper36</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Heavenjumper36&diff=3606981&oldid=0"/> <updated>2025-07-01T19:52:56Z</updated> <summary type="html"><p>Created page with &quot;In the world of casino games, slots have always already been a favorite amongst players. [https://159.203.17.11/ 7meter] are simple to play, entertaining to look at, and can e...&quot;</p><p><b>New page</b></p><div>In the world of casino games, slots have always already been a favorite amongst players. [https://159.203.17.11/ 7meter] are simple to play, entertaining to look at, and can easily offer big advantages. One of the latest trends that is catching focus in the game playing world is the 7 meter slot machine game. This exciting new concept has turned participants curious and excited to experience a bigger and better way to enjoy slots.&lt;br /&gt;&lt;br /&gt;What Is a 7 Meter Slot?&lt;br /&gt;&lt;br /&gt;A 7 meter slot is the large, specially designed slot machine game machine that is usually around seven feets tall. It is certainly much larger than a new regular slot model and is made to be able to give players a good unique gaming expertise. These machines often come with giant spinning reels, bright colorful lamps, and large exhibit screens. The level of the device makes it the centerpiece in any casino, drawing the attention of the two players and onlookers.&lt;br /&gt;&lt;br /&gt;These slot tools can be obtained from some of the most renowned casinos in typically the world. The huge size makes these people ideal for special events, tournaments, or like a major attraction for the casino floor. The idea behind the seven meter slot is to offer something great, eye-catching, and distinct from your regular games folks are used in order to playing.&lt;br /&gt;&lt;br /&gt;How exactly does It Work?&lt;br /&gt;&lt;br /&gt;As being a regular slot machine, some sort of 7 meter slot operates using re-writing reels that exhibit different symbols. Gamers place their bets, press a switch, or pull a new handle to start the particular game. The giant reels begin in order to spin, and once they will stop, the icons shown around the reels determine whether the gamer wins or loses.&lt;br /&gt;&lt;br /&gt;One of the particular most exciting highlights of these large slot machines is their impressive goldmine prizes. For their dimension and popularity, typically the jackpots offered usually are often much larger than the ones from traditional slot machines. Many of these 7 meter slot machine games are even attached to progressive lottery jackpot systems, where the prize money keeps growing just about every time someone has and doesn’t earn the big reward.&lt;br /&gt;&lt;br /&gt;Why Players Enjoy the 7 Inmiscuirse Slot&lt;br /&gt;&lt;br /&gt;There are numerous factors why players appreciate trying their luck on a seven meter slot. Typically the size alone makes the experience sense grand and stimulating. It’s not only about playing a new game; it’s regarding being portion of a special event. The bright lights, high in volume sounds, and towering presence of the machine create an unforgettable gaming atmosphere.&lt;br /&gt;&lt;br /&gt;Many people in addition believe that larger machines come with bigger payouts. While this isn’t always true, it’s entertaining to dream concerning hitting a huge jackpot on such a massive device. The chance to win life-changing amounts of money makes these machines very attractive to both normal players and novices.&lt;br /&gt;&lt;br /&gt;A Popular Interest at Casinos&lt;br /&gt;&lt;br /&gt;Casinos are usually looking with regard to new ways to draw visitors and keep them entertained. Incorporating a 7 m slot to the gaming floor is a smart shift because it instantly appeals to attention. People walking by can’t support but stop and even look at the towering machine using its multi-colored reels and flashing lights.&lt;br /&gt;&lt;br /&gt;Some casinos even hold unique competitions or situations using these big machines. Players remain competitive against each some other to get the best prizes, generating it a fun and even social gaming exercise. It’s a great way with regard to casinos for growing even more customers and give some thing that most men and women have not seen just before.&lt;br /&gt;&lt;br /&gt; Summary&lt;br /&gt;&lt;br /&gt;The seven meter slot is more than just a big machine — it’s a symbol of how casino gaming is evolving. It offers excitement, entertainment, and the particular chance for players to win big inside an unique method. Whether you’re some sort of regular player or even someone new in order to the casino field, trying your fortune on a several meter slot is definitely an experience you won’t forget.&lt;br /&gt;&lt;br /&gt;As more casinos around the particular world add these kinds of giant machines with their floors, the popularity of the 7 m slot is sure to continue rising. It’s an entertaining, thrilling, and world known way to enjoy one particular of the the majority of beloved casino video games.</div></summary> <author><name>Heavenjumper36</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Farmerbrogaard8123</id> <title>User:Farmerbrogaard8123</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Farmerbrogaard8123"/> <updated>2025-07-01T19:52:51Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Farmerbrogaard8123&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Farmerbrogaard8123 (page does not exist)"><bdi>Farmerbrogaard8123</bdi></a> was created</p></summary> <author><name>Farmerbrogaard8123</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Celikbarrera1358&diff=3606980&oldid=0</id> <title>Celikbarrera1358</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Celikbarrera1358&diff=3606980&oldid=0"/> <updated>2025-07-01T19:52:45Z</updated> <summary type="html"><p>Created page with &quot;Purpose To evaluate normalized short-wavelength fundus autofluorescence (SW-FAF) imaging changes over time as a predictive parameter for the retinal pigment epithelium (RPE) f...&quot;</p><p><b>New page</b></p><div>Purpose To evaluate normalized short-wavelength fundus autofluorescence (SW-FAF) imaging changes over time as a predictive parameter for the retinal pigment epithelium (RPE) function in eyes compromised by acute central serous chorioretinopathy (CSCR) after indocyanine green angiography-guided verteporfin (Visudyne®, Novartis Pharma, Basel, Switzerland) photodynamic therapy (PDT) with a half-fluence rate (25 J/cm2). Methods Quantitative data of SW-FAF grey values (SW-FAF GV) from a 350 μm (SW-350) and 1200 μm (SW-350) and 1200 t-test was calculated to explore the differences of SW-350 and SW-1200 between one month and the long-term follow-up. Results Mean differences (95% CI) in SW-FAF GV between 1 month and 7 years after half-fluence PDT were 0.07 ± 0.11 for SW-350 ([95% CI -0.002; 0.14], p=0.06) and 0.11 ± 0.15 for SW-1200 ([95% CI 0.01; 0.21], p=0.06) and 0.11 ± 0.15 for SW-1200 ([95% CI 0.01; 0.21], p=0.06) and 0.11 ± 0.15 for SW-1200 ([95% CI 0.01; 0.21], p=0.06) and 0.11 ± 0.15 for SW-1200 ([95% CI 0.01; 0.21]. Conclusion After 7 years, normalized SW-FAF GV were significantly lower in eyes with resolved acute CSCR treated with reduced-fluence PDT compared to the follow-up after 1 month without correlation to explicit pattern changes or structural damages. Half-fluence PDT remains a safe and considerable treatment option in acute CSCR. Copyright © 2020 Martin Stattin et al.Purpose To screen out pathogenic genes in a Chinese family with congenital cataract and iris coloboma. Material and Methods. A three-generation family with congenital cataract and iris coloboma from a Han ethnicity was recruited. DNA was extracted from peripheral blood samples collected from all individuals in the family. Whole exon sequencing was employed for screening the disease-causing gene mutations in the proband, and Sanger sequencing was used for other members of the family and a control group of 500 healthy individuals. Bioinformatics analysis and three-dimensional structure predictions were used to predict the impact of amino acid changes on protein structure and function. Results The candidate genes of cataract and iris coloboma were successfully screened out. A heterozygote mutation, CRYGD c.70C&amp;gt;A (p.P24T), was identified as cosegregating with congenital cataracts, while another heterozygous mutation, WFS1 c.1514G&amp;gt;C (p.C505S), which had not been reported previously, cosegregated with congenital ire relevant in further studies aiming to investigate the molecular pathogenesis of iris coloboma and congenital cataract.WFS1 c.1514G&amp;gt;C (p.C505S), which had not been reported previously, cosegregated with congenital iris coloboma. Bioinformatic analyses and three-dimensional structure prediction proved that the three-dimensional structures of CRYGD c.70C&amp;gt;A (p.P24T), was identified as cosegregating with congenital cataracts, while another heterozygous mutation, WFS1 c.1514G&amp;gt;C (p.C505S), which had not been reported previously, cosegregated with congenital iris coloboma. Bioinformatic analyses and three-dimensional structure prediction proved that the three-dimensional structures of CRYGD c.70C&amp;gt;A (p.P24T), was identified as cosegregating with congenital cataracts, while another heterozygous mutation. Copyright © 2020 Bin Li et al.Purpose To observe and analyze the long-term outcomes of patients with neovascular age-related macular degeneration (nAMD) treated with aflibercept monotherapy under the National Health Insurance (NHI) program in Taiwan. Methods This retrospective observational study was conducted at Taipei Veterans General Hospital. Patients with naive nAMD who were treated with aflibercept and followed for more than 3 years were reviewed. The better eye was enrolled if both eyes were affected. Visual acuity (VA) and central macular thickness (CMT) were recorded for 3 years. The lost-to-follow-up rate, number of injections, and predictive factors for visual outcomes were analyzed. Results Ninety-nine eyes in 99 patients were followed up for 3 years. The mean age at onset of nAMD was 82.8 ± 9.26 years, and 65% of the patients were male. Compared with initial visual acuity, 5 (5.1%) of our patients improved their vision for 3 or more lines after 3 years of follow-up, 11 (11.1%) of our patients improved for 1 to 3 lines, 62 (62.6%) patients remained their vision with 1 line or less changes, 15 (15.2%) patients lost their vision for 1 to 3 lines, and 6 (6%) patients lost their vision for 3 or more lines. The CMT was 359 ± 180 µm before treatment and 259 ± 98 after 3 years (p less then 0.001). [https://www.selleckchem.com/products/nf-kb-activator-1.html read more] The mean number of injections was 4.63 ± 1.91 in the first year, 2.13 ± 2.2 in the second year, and 1.42 ± 1.79 in the third year. Multivariate analysis showed that final VA was significantly associated with VA at year 1, the presence of retinal pigment epithelial detachment at year 1, and receiving more than four injections in the first year. Final CMT was only significantly associated with CMT at year 1. Conclusion After 3 years of treatment under the NHI program in Taiwan, 21.2% of the patients with nAMD still had a visual decline despite good anatomical outcomes. More aggressive treatment or other strategies should be used for patients who may have a poor prognosis. Copyright © 2020 Kang-Jung Lo et al.Purpose To report on surgical approaches using amniotic membrane applications and patch grafts in corneal melting and perforations. Anatomical and functional results, including advantages and disadvantages of the interventions, will also be explored. Methods A five-year retrospective analysis of 189 surgical treatments involving corneal melting with perforation was performed. In one evaluated treatment type, a graft of amniotic membrane, often folded one to three times, was sutured with the epithelial side facing the previously mechanically debrided corneal tissue. A larger monolayer amniotic patch was then sutured, with the epithelial side facing the top of the first membrane, to the perilimbal conjunctiva. For corneal patch grafts, the size-fitting technique of graft trephination was applied, and the donor-recipient junctions were sewn with interrupted sutures. All the procedures were evaluated, noting outcomes and complications of surgery, preoperative and postoperative visual acuities, postoperative intraocular pressures, graft rejection, and other late comorbidities and complications.</div></summary> <author><name>Celikbarrera1358</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Rooneytyler8222&diff=3606979&oldid=0</id> <title>Rooneytyler8222</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Rooneytyler8222&diff=3606979&oldid=0"/> <updated>2025-07-01T19:52:44Z</updated> <summary type="html"><p>Created page with &quot;Swimming is a popular exercise for different types of people at different ages. Public swimming pools are places where fungal infections can be easily transferred. The purpose...&quot;</p><p><b>New page</b></p><div>Swimming is a popular exercise for different types of people at different ages. Public swimming pools are places where fungal infections can be easily transferred. The purpose of this study is to evaluate the quality of mycological, parasitological, and physicochemical parameters of swimming pools of Arak city.&lt;br /&gt;&lt;br /&gt; This cross-sectional study was done for 12 months from April 2013 to March 2014 in six indoor active swimming pools of Arak city (A, B, C, D, E, and F). Samples were collected in four seasons, two times/season; each time, two samples were obtained from six specified locations (shallow level pool, deep level pool, dressing rooms, showers, margin of pool walls, and foot-washing sink) from each pool with a total of 576 samples. Physicochemical parameters including water temperature, pH, turbidity, and the residual chlorine were measured on-site. In order to isolate and detect the fungal agents, special filters and culture Sabouraud's dextrose agar, chloramphenicol, and mycosel agar media were applied.ction, the choice of materials, and the long opening hours. Isolation of dermatophytes and Acanthamoeba parasite from the pools' area and foot-washing sink reveals the important role of the public swimming pools in disease transmission.&lt;br /&gt;&lt;br /&gt;Existence of saprophytic fungi and yeast in pools' water is plausible to be considered as an indicator of water resistance to the detergent agents. This high degree of contamination is due to the huge number of visitors, the complexity of construction, the choice of materials, and the long opening hours. Isolation of dermatophytes and Acanthamoeba parasite from the pools' area and foot-washing sink reveals the important role of the public swimming pools in disease transmission.&lt;br /&gt;&lt;br /&gt; The present study intended to further elucidate the role of G protein-coupled estrogen receptor 1 (GPER-1) in ovarian cancer by comparing the effects of a GPER-1 knockdown and treatment with its agonist G-1 on cell growth, apoptosis, and the transcriptome of two ovarian cancer cell lines. Furthermore, the role of GPER-1 in ovarian cancer survival was examined.&lt;br /&gt;&lt;br /&gt; GPER-1 expression in OVCAR-3 and OAW-42 ovarian cancer cells was knocked down by RNAi. The effects on cell growth were measured by means of the fluorimetric cell titer blue assay and on the transcriptome by Affymetrix GeneChip analysis. [https://www.selleckchem.com/products/ac-fltd-cmk.html Selleckchem Ac-FLTD-CMK] The effect of GPER-1 on patient's survival was examined using open source mRNA and clinical data of 1657 ovarian cancer patients.&lt;br /&gt;&lt;br /&gt; GPER-1 knockdown resulted in a significant growth stimulation of both cell lines, whereas treatment with agonist G-1 decreased growth of both cell lines in a dose-dependent manner. Transcriptome analyses revealed a set of 18 genes being conversely regulated after GPER-1 knockdown and G-1 treatment. Generally, treatment with G-1 led to a transcriptome response associated with growth inhibition. In contrast, knockdown of GPER-1 exerted opposite effects, stimulating pathways activating mitosis, but inhibiting pathways associated with apoptosis or interferon signaling. Further analyses using open-access mRNA and clinical data by bioinformatical online tools revealed a longer OS (HR = 0.86, p = 0.057) and PFS (HR = 0.81, p = 0.0035) of ovarian cancer patients with high GPER-1 mRNA expression.&lt;br /&gt;&lt;br /&gt; The results of this study clearly support the hypothesis that GPER-1 acts as a tumor suppressor in ovarian cancer.&lt;br /&gt;&lt;br /&gt;The results of this study clearly support the hypothesis that GPER-1 acts as a tumor suppressor in ovarian cancer.The title of the article is incorrectly published in the original article. The correct article title is &quot;Afatinib is active in osteosarcoma cell lines&quot;.&lt;br /&gt;&lt;br /&gt; The main aim of the study was to explore the expectations and knowledge of advanced-stage cancer patients about immunotherapy.&lt;br /&gt;&lt;br /&gt; This mixed methods study included 53 cancer patients on immune checkpoint inhibitors (ICIs), 55 cancer patients undergoing chemotherapy (CT), and 53 non-cancer patients. Participants' expectations about ICIs and CT were compared. Additional qualitative data were derived from semi-structured interviews.&lt;br /&gt;&lt;br /&gt; Among patients who did not receive ICIs, 63 (58%) had never heard of ICIs and 94 (87%) had large gaps in their knowledge of ICIs. Among ICI patients, 33 (62%) simply described ICIs without errors. ICI perception was positive, regardless of whether respondents received or had heard of ICIs, which became particularly evident when compared to CT. ICIs were rated as more promising, and all adverse effects were expected to be significantly lower than those of CT. Knowledge about ICIs was also limited in the interviewed ICI patients. Some patients reported adverse effects of ICIs that were mostly mild and well-tolerated or easily treated.&lt;br /&gt;&lt;br /&gt; The lack of understanding of ICIs should be improved by activities to increase the knowledge of ICI patients and the general population. In contrast to CT, ICIs invoked fewer negative associations with efficacy and toxicity. Therefore, attention should be paid to risk awareness when educating patients. (Clinical trial registration number DRKS00011868) Trial Registration German clinical trials register, www.germanctr.de , number DRKS00011868.&lt;br /&gt;&lt;br /&gt;The lack of understanding of ICIs should be improved by activities to increase the knowledge of ICI patients and the general population. In contrast to CT, ICIs invoked fewer negative associations with efficacy and toxicity. Therefore, attention should be paid to risk awareness when educating patients. (Clinical trial registration number DRKS00011868) Trial Registration German clinical trials register, www.germanctr.de , number DRKS00011868.&lt;br /&gt;&lt;br /&gt; The swell of new and diverse radiotracers to predict or monitor tumor response to cancer immunotherapies invites the opportunity for comparative studies to identify optimal platforms. To probe the significance of antibody format on image quality for PD-L1 imaging, we developed and studied the biodistribution of a library of antibodies based on the anti-PD-L1 IgG1 clone C4.&lt;br /&gt;&lt;br /&gt; A C4 minibody and scFv were cloned, expressed, and characterized. The antibodies were functionalized with desferrioxamine and radiolabeled with Zr-89 to enable a rigorous comparison with prior data collected using &lt;br /&gt;&lt;br /&gt; Zr-labeled C4 IgG1. The biodistribution of the radiotracers was evaluated in C57Bl6/J or nu/nu mice bearing B16F10 or H1975 tumors, respectively, which are models that represent high and low tumor autonomous PD-L1 expression.&lt;br /&gt;&lt;br /&gt; The tumor uptake of the &lt;br /&gt;&lt;br /&gt; Zr-C4 minibody was higher than &lt;br /&gt;&lt;br /&gt; Zr-C4 scFv and equivalent to previous data collected using &lt;br /&gt;&lt;br /&gt; Zr-C4 IgG1. However, the peak tumors to normal tissue ratios were generally higher for &lt;br /&gt;&lt;br /&gt; Zr-C4 scFv compared with &lt;br /&gt;&lt;br /&gt; Zr-C4 minibody and &lt;br /&gt;&lt;br /&gt; Zr-IgG1.</div></summary> <author><name>Rooneytyler8222</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Goodmackenzie6890</id> <title>User:Goodmackenzie6890</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Goodmackenzie6890"/> <updated>2025-07-01T19:52:41Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Goodmackenzie6890&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Goodmackenzie6890 (page does not exist)"><bdi>Goodmackenzie6890</bdi></a> was created</p></summary> <author><name>Goodmackenzie6890</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Richhenriksen9362</id> <title>User:Richhenriksen9362</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Richhenriksen9362"/> <updated>2025-07-01T19:52:33Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Richhenriksen9362&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Richhenriksen9362 (page does not exist)"><bdi>Richhenriksen9362</bdi></a> was created</p></summary> <author><name>Richhenriksen9362</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Penngylling2946</id> <title>User:Penngylling2946</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Penngylling2946"/> <updated>2025-07-01T19:52:31Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Penngylling2946&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Penngylling2946 (page does not exist)"><bdi>Penngylling2946</bdi></a> was created</p></summary> <author><name>Penngylling2946</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Riisedwyer0429&diff=3606978&oldid=0</id> <title>Riisedwyer0429</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Riisedwyer0429&diff=3606978&oldid=0"/> <updated>2025-07-01T19:52:30Z</updated> <summary type="html"><p>Created page with &quot;Facial paralysis is a devastating disease, the treatment of which is challenging. The use of the masseteric nerve in facial reanimation has become increasingly popular and has...&quot;</p><p><b>New page</b></p><div>Facial paralysis is a devastating disease, the treatment of which is challenging. The use of the masseteric nerve in facial reanimation has become increasingly popular and has been applied to an expanded range of clinical scenarios. However, appropriate selection of the motor nerve and reanimation method is vital for successful facial reanimation. In this literature review on facial reanimation and the masseter nerve, we summarize and compare various reanimation methods using the masseter nerve. The masseter nerve can be used for direct coaptation with the paralyzed facial nerve for temporary motor input during cross-facial nerve graft regeneration and for double innervation with the contralateral facial nerve. The masseter nerve is favorable because of its proximity to the facial nerve, limited donor site morbidity, and rapid functional recovery. Masseter nerve transfer usually leads to improved symmetry and oral commissure excursion due to robust motor input. However, the lack of a spontaneous, effortless smile is a significant concern with the use of the masseter nerve. A thorough understanding of the advantages and disadvantages of the use of the masseter nerve, along with careful patient selection, can expand its use in clinical scenarios and improve the outcomes of facial reanimation surgery.&lt;br /&gt;&lt;br /&gt; Irritable bowel syndrome (IBS) is the most commonly gastrointestinal diseases. The Rome Foundation's global study on 33 countries shows the total prevalence of IBS under the Rome IV Diagnostic Criteria was 3.8%. It is well established that people with IBS have higher levels of anxiety and depression. The impact of the acupuncture associated with anxiety and depression has been widely studied in Western countries. Acupuncture may be a promising choice for the treatment of anxiety and depression in IBS.&lt;br /&gt;&lt;br /&gt; RCTs of acupuncture for depression and anxiety in IBS will be searched in the relevant database, including PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang Database, Chinese Biomedical Literature Database (CBM), and Chinese Scientific Journal Database (VIP database). The studies of electronic searches will be exported to EndNote V.9.1 software. We will run meta-analyses using the Review Manager (RevMan) V.5.3 software. Any disagreement will be solved in consultation with a third reviewer.&lt;br /&gt;&lt;br /&gt; Our study aims to explore the efficacy of acupuncture for depression and anxiety in IBS and to provide up-to-date evidence for clinical of IBS.&lt;br /&gt;&lt;br /&gt; This study will perform a comprehensive systematic review and meta-analysis on the efficacy of acupuncture for depression and anxiety in IBS, making up for the lack of relevant evidence of the clinical use of acupuncture.&lt;br /&gt;&lt;br /&gt; INPLASY 202120014.&lt;br /&gt;&lt;br /&gt;INPLASY 202120014.&lt;br /&gt;&lt;br /&gt; To investigate the feasibility of arterial spin labeling (ASL) blood flow (BF) and its histogram analysis to distinguish early-stage nasopharyngeal carcinoma (NPC) from nasopharyngeal lymphoid hyperplasia (NPLH).Sixty-three stage T1 NPC patients and benign NPLH patients underwent ASL on a 3.0-T magnetic resonance imaging system. BF histogram parameters were derived automatically, including the mean, median, maximum, minimum, kurtosis, skewness, and variance. Absolute values were obtained for skewness and kurtosis (absolute value of skewness [AVS] and absolute value of kurtosis [AVK], respectively). The Mann-Whitney U test, receiver operating characteristic curve, and multiple logistic regression models were used for statistical analysis.The mean, maximum, and variance of ASL BF values were significantly higher in early-stage NPC than in NPLH (all P &amp;lt; 0.0001), while the median and AVK values of early-stage NPC were also significantly higher than those of NPLH (all P &amp;lt; 0.001). No significant difference dictor of outcome (P less then 0.05).ASL BF and its histogram analysis could distinguish early-stage NPC from NPLH, and the variance value was a unique independent predictor.&lt;br /&gt;&lt;br /&gt; Post-stroke depression (PSD) is one of the most common neuropsychiatric complications after stroke and is associated with increased risk of death and poor functional outcomes. Strong evidence shows that exercise has benefits for depression. However, it is not clear whether exercise has benefits specifically for PSD. This study aims to explore the effects of exercise on PSD and to establish safe and effective exercise prescriptions.&lt;br /&gt;&lt;br /&gt; The PubMed, Cochrane Library and EMBASE, databases will be searched using prespecified search strategies. Randomized controlled trials and non-randomized prospective controlled cohort studies regarding exercise for PSD will be included. The primary outcomes are depression scale and stroke outcome. The secondary outcomes are the occurrence of adverse events, cognitive function, quality of life indices, and the expression of nerve cell factors. The methodological quality of each study will be evaluated by the physiotherapy evidence database scale. The heterogeneity will be evaluated using the I2 test. If I2 &amp;gt; 50%, random effects models will be used in the analysis; otherwise, fixed effects models will be used to pool the data.&lt;br /&gt;&lt;br /&gt; This study will assess the efficacy and safety of exercise for PSD.&lt;br /&gt;&lt;br /&gt; Our findings will be helpful for clinicians to re-examine the clinical decision-making in the treatment of PSD, by assessing the efficacy of a promising treatment modality for patients with PSD.&lt;br /&gt;&lt;br /&gt; Ethical approval is not required because this study is a secondary analysis. The results of this study will be disseminated through journals and academic exchanges.&lt;br /&gt;&lt;br /&gt; INPLASY202110100.&lt;br /&gt;&lt;br /&gt;INPLASY202110100.&lt;br /&gt;&lt;br /&gt; Manual therapy is a common technique for the treatment of (CCS) cervicogenic cephalic syndrome, but the efficiency is various. The aim of the study is to evaluate the evidence pertaining to the efficiency and safety of using manual therapy to treat patients with CCS.&lt;br /&gt;&lt;br /&gt; We searched the electronic databases including PubMed, ScienceDirect, and the Cochrane Library. Only randomized controlled trials (RCTs) were enrolled in this systematic review and cumulative meta-analysis.&lt;br /&gt;&lt;br /&gt; A total of 8 RCTs with 395 patients were included for meta-analysis. [https://www.selleckchem.com/products/pf-3644022.html PF-3644022 MAPKAPK2 inhibitor] Patients who underwent manual therapy showed lower scores of visual analog scale (VAS) (weighted mean difference) WMD = 1.7, 95% confidence interval CI = 0.74-2.65, P = .0005); dizziness handicap inventory (DHI) (WMD = 0.66, 95%CI = 0.31-1, P = .0002); and neck disability index (NDI) (WMD = 0.59, 95%CI = 0.23-0.96, P = .002) and better rotation range of motion (ROM) of the cervical spine (WMD = -6.54, 95%CI = -7.60 to -5.48, P &amp;lt; .0001). However, these patients did not show much benefit from manual therapy with respect to the frequency of CCS episodes and head repositioning accuracy (HRA).</div></summary> <author><name>Riisedwyer0429</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Churchholmberg2660</id> <title>User:Churchholmberg2660</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Churchholmberg2660"/> <updated>2025-07-01T19:52:30Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Churchholmberg2660&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Churchholmberg2660 (page does not exist)"><bdi>Churchholmberg2660</bdi></a> was created</p></summary> <author><name>Churchholmberg2660</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Snedkerlausten4315&diff=3606977&oldid=0</id> <title>Snedkerlausten4315</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Snedkerlausten4315&diff=3606977&oldid=0"/> <updated>2025-07-01T19:52:20Z</updated> <summary type="html"><p>Created page with &quot;Hai rekan online, kalaupun membicarakan sebuah permainan nih bener-bener tak ada batasnya ya. Ditambah lagi permainan yang bisa bawa kita ke zone keuntungan. Yang mana nyata a...&quot;</p><p><b>New page</b></p><div>Hai rekan online, kalaupun membicarakan sebuah permainan nih bener-bener tak ada batasnya ya. Ditambah lagi permainan yang bisa bawa kita ke zone keuntungan. Yang mana nyata anda sudah menyangka dan menerka permainan yang bisa menciptakan atau memberi keuntungan apa itu. Ya betul permainan itu merupakan judi yang mana sanggup memberi sebuah keuntungan untuk siapa sajakah yang memainkan akan tetapi apabila untung. Dari jaman ke era perjudian betul-betul sering sekali jadi pembicaraan hangat. Yang mana ketika ini juga bisa dimainkan secara mudah yang tertolong oleh kemodernan tehnologi. Butuh anda pahami kalau judi online kini sedang ramai meriahnya.&lt;br /&gt;&lt;br /&gt;Karena sangat meriahnya hal tersehut membikin orang yang lain selanjutnya ingin tahu serta minat untuk mainkan serta ingin membentuk keseruanya sendiri. Akan tetapi kadang-kadang ada banyak penduduk yang sangsi akan permainan itu. Oleh maka itu, jadi artikel kesempatan ini dapat kulik lebih dalam kembali terkait kelebihannya. Yang mana hal itu melakukan cuma buat anda yang belum percaya atau kuatir pada permainan itu. Dan kemungkinan tidak usah panjang kali lebar kembali karenanya artikel kesempatan ini bakal menghidangkan atau memperjelas apa saja sich keutamaannya hingga buat anda yang muai jemu di dalam rumah saja daoat membikin kehebohan tertentu dengan bermainan judi.&lt;br /&gt;&lt;br /&gt;Berikut sejumlah keunggulan judi online yang sebaiknya anda kulik&lt;br /&gt;&lt;br /&gt;Punyai banyak website yang sah&lt;br /&gt;&lt;br /&gt;Waktu ini anda tidak semabarangan apabila bermain suatu judi online di gadget. Mengapa begitu? Hal itu karena apabila anda pintar pilih karena itu, anda dapat mendapat situs perjudian yang baik sekali serta udah sah. Yang mana penting anda pahami jika sebuah situs untuk permainan yang memberi keuntungan banyak ini sesuatu site yang sah. [https://guiltystack.com/ thor311] Serta waktu ini anda tak perlu risau bila sebuah situs buat perjudian itu cuma memberi rugi bagus buat anda.&lt;br /&gt;&lt;br /&gt;Yang mana banyak pelaku yang memakai kemodernan tehnologi dengan menipu sebagian orang yang masih mungkin pemula di dalam permainan itu. Mengakibatkan hal semacam itu membuat semuanya orang lebih tidak meyakini kepada site yang sediakan perjudian itu. Namun sekarang ini banyak sekali blog yang udah sah dengan bekerja bersama bersama instansi bank yang bisa dipercaya. Maka hal semacam itu bisa membuat seorang yang baru masuk jadi kian yakin jika situs itu bukan kaleng-kaleng.&lt;br /&gt;&lt;br /&gt;Bisa terbuktikan punyai tipe perjudian yang hebat dan menentang&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;Judi online yang penting anda pahami jika miliki keunggalan dalam soal atau bagian apa saja lho. Dan penting anda kenali jika perjudian itu mempunyai tipe yang lumayan banyak. Hingga tidaklah heran apabila banyak orang atau lehih pasnya yang tidak jemu dengan perjudian. Bahkan juga penting anda pahami banyak juga pemain baik yang udah lama atau masih pemula tertarik mau permainkan serta mengalahkan semuanya macam bermainnya. Yang mana sudah anda kenali serta menerka kalau seluruh tipe perjudian itu semua berikan keuntungan besar buat tiap-tiap pemainnya.&lt;br /&gt;&lt;br /&gt;Nach tersebut sejumlah kelebihan yang mana butuh anda kenali dan kulil lebih dalam dari judi online. Ini baru dua saja yang dapat artikel kami sebutkan. Yang mana penting anda kenali jika ada banyak kembali keunggulan yang lain yang juga dapat membikin anda sangat percaya buat masuk dengan sebuah situs serta menundukkan seluruhnya type perjudian yang ada.&lt;br /&gt;&lt;br /&gt;</div></summary> <author><name>Snedkerlausten4315</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Kokperry8738&diff=3606976&oldid=0</id> <title>Kokperry8738</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Kokperry8738&diff=3606976&oldid=0"/> <updated>2025-07-01T19:52:10Z</updated> <summary type="html"><p>Created page with &quot;© 2019 The Authors. Evolutionary Applications published by John Wiley &amp; Sons Ltd.Temperature plays a multidimensional role in host-pathogen interactions. As an important...&quot;</p><p><b>New page</b></p><div>© 2019 The Authors. Evolutionary Applications published by John Wiley &amp;amp; Sons Ltd.Temperature plays a multidimensional role in host-pathogen interactions. As an important element of climate change, elevated world temperature resulting from global warming presents new challenges to sustainable disease management. Knowledge of pathogen adaptation to global warming is needed to predict future disease epidemiology and formulate mitigating strategies. In this study, 21 Phytophthora infestans isolates originating from seven thermal environments were acclimated for 200&amp;nbsp;days under stepwise increase or decrease of experimental temperatures and evolutionary responses of the isolates to the thermal changes were evaluated. We found temperature acclimation significantly increased the fitness and genetic adaptation of P.&amp;nbsp;infestans isolates at both low and high temperatures. Low-temperature acclimation enforced the countergradient adaptation of the pathogen to its past selection and enhanced the positive association between the pathogen's intrinsic growth rate and aggressiveness. At high temperatures, we found that pathogen growth collapsed near the maximum temperature for growth, suggesting a thermal niche boundary may exist in the evolutionary adaptation of P.&amp;nbsp;infestans. These results indicate that pathogens can quickly adapt to temperature shifts in global warming. If this is associated with environmental conditions favoring pathogen spread, it will threaten future food security and human health and require the establishment of mitigating actions. © 2019 The Authors. Evolutionary Applications published by John Wiley &amp;amp; Sons Ltd.The adaptive potential of invasive species is related to the genetic diversity of the invader, which is influenced by genetic drift and natural selection. Typically, the genetic diversity of invaders is studied with neutral genetic markers; however, the expectation of reduced diversity has not been consistently supported by empirical studies. Here, we describe and interpret genetic diversity at both neutral microsatellite loci and the immune-related MHC-DRB locus of native and invasive populations of raccoon to better understand of how drift and selection impact patterns of genetic diversity during the invasion process. [https://www.selleckchem.com/products/cabotegravir-gsk744-gsk1265744.html learn more] We found that despite the loss of many MHC (major histocompatibility complex) alleles in comparison with native populations, functional MHC supertypes are preserved in the invasive region. In the native raccoon population, the number of supertypes within individuals was higher than expected under a neutral model. The high level of individual functional divergence may facilitate the adaptation to local conditions in the invasive range. In the invasive populations, we also detected increased population structure at microsatellites compared to the MHC locus, further suggesting that balancing selection is acting on adaptively important regions of the raccoon genome. Finally, we found that alleles known to exhibit resistance to rabies in the native range, Prlo-DRB*4, Prlo-DRB*16 and Prlo-DRB*102, were the most common alleles in the European populations, suggesting directional selection is acting on this locus. Our research shows empirical support for the importance of functional immune diversity for adaptation and survival in novel environments. © 2019 The Authors. Evolutionary Applications published by John Wiley &amp;amp; Sons Ltd.Persistent insecticides sprayed onto house walls, and incorporated into insecticide-treated bednets, provide long-acting, cost-effective control of vector-borne diseases such as malaria and leishmaniasis. The high concentrations that occur immediately postdeployment may kill both resistant and susceptible insects. However, insecticide concentration, and therefore killing ability, declines in the months after deployment. As concentrations decline, resistant insects start to survive, while susceptible insects are still killed. The period of time after deployment, within which the mortality of resistant individuals is lower than that of susceptible ones, has been termed the &quot;window of selection&quot; in other contexts. It is recognized as driving resistance in bacteria and malaria parasites, both of which are predominantly haploid. We argue that paying more attention to these mortality differences can help understand the evolution of insecticide resistance. Because insects are diploid, resistance encoded by single genes generates heterozygotes. This gives the potential for a narrower &quot;window of dominance,&quot; within the window of selection, where heterozygote mortality is lower than that of susceptible homozygotes. We explore the general properties of windows of selection and dominance in driving resistance. We quantify their likely effect using data from new laboratory experiments and published data from the laboratory and field. These windows can persist months or years after insecticide deployments. Differential mortalities of resistant, susceptible and heterozygous genotypes, after public health deployments, constitute a major challenge to controlling resistance. Greater attention to mortality differences by genotype would inform strategies to reduce the evolution of resistance to existing and new insecticides. © 2019 The Authors. Evolutionary Applications published by John Wiley &amp;amp; Sons Ltd.Our knowledge of the diversity of potato cyst nematodes in their native areas still remains patchy and should be improved. A previous study based on 42 Peruvian Globodera pallida populations revealed a clear south to north phylogeographic pattern, with five well-supported clades and maximum diversity observed in the south of Peru. In order to investigate this phylogeographic pattern more closely, we genotyped a larger collection of Peruvian populations using both cathepsin L gene sequence data and a new set of 13 microsatellite loci. Using different genetic analyses (STRUCTURE, DAPC), we consistently obtained the same results that led to similar conclusions the presence of a larger genetic diversity than previously known suggesting the presence of cryptic species in the south of Peru. These investigations also allowed us to clarify the geographic borders of the previously described G.&amp;nbsp;pallida genetic clades and to update our knowledge of the genetic structure of this species in its native area, with the presence of additional clades.</div></summary> <author><name>Kokperry8738</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Longmarsh4356</id> <title>User:Longmarsh4356</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Longmarsh4356"/> <updated>2025-07-01T19:51:53Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Longmarsh4356&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Longmarsh4356 (page does not exist)"><bdi>Longmarsh4356</bdi></a> was created</p></summary> <author><name>Longmarsh4356</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Koenigjonasson3753&diff=3606975&oldid=0</id> <title>Koenigjonasson3753</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Koenigjonasson3753&diff=3606975&oldid=0"/> <updated>2025-07-01T19:51:49Z</updated> <summary type="html"><p>Created page with &quot;To reveal the factors governing the chirality transfer from a chiral unimolecule to a supramolecular assembly, we constructed a series of [2]pseudorotaxanes through the interm...&quot;</p><p><b>New page</b></p><div>To reveal the factors governing the chirality transfer from a chiral unimolecule to a supramolecular assembly, we constructed a series of [2]pseudorotaxanes through the intermolecular noncovalent interaction of a pair of chiral binaphthalene crown ethers with achiral secondary ammonium salts with different chromophores, and found that the binaphthalene groups can induce new circular dichroism (CD) signals only in the [2]pseudorotaxane structures between the host crown ethers and the guest molecule with the anthryl group. Density functional theory (DFT) and time-dependent density functional theory (TD-DFT) calculations show that the generation of the new CD signal is mainly due to the intermolecular chiral induction between the anthryl group in the guest and the naphthalene groups in the host.A facile and efficient method for the synthesis of novel 2-substituted 4-tosyl-4,5-dihydrooxazolo[5,4-c]isoquinolines from 4-diazoisoquinolin-3-ones and nitriles is reported. The reaction proceeded through a TfOH-promoted formal [3 + 2] cycloaddition and the products could be conveniently converted to 2-aryloxazolo[5,4-c]isoquinolines and the subsequent 2-(oxazolo[5,4-c]isoquinolin-2-yl)phenol which emitted bright green light in dilute dichloromethane solution and in solid form as well. Simple operation, metal-free and mild reaction conditions, short reaction time and broad substrate scope are the prominent features of this methodology.In the field of gas sensor studies, most researchers are focusing on improving the response of the sensors to detect a low concentration of gas. However, factors that make a large response, such as abundant or strong adsorption sites, also work as a source of noise, resulting in a trade-off between response and noise. Thus, the response alone cannot fully evaluate the performance of sensors, and the signal-to-noise-ratio (SNR) should additionally be considered to design gas sensors with optimal performance. In this regard, thin-film-type sensing materials are good candidates thanks to their moderate response and noise level. In this paper, we investigate the effects of radio frequency (RF) sputtering power for deposition of sensing materials on the SNR of resistor- and field-effect transistor (FET)-type gas sensors fabricated on the same Si wafer. In the case of resistor-type gas sensors, the deposition conditions that improve the response also worsen the noise either by increasing the scattering at the bulk or damaging the interface of the sensing material. Among resistor-type gas sensors with sensing materials deposited with different RF powers, a sensor with low noise shows the largest SNR despite its small response. However, the noise of FET-type gas sensors is not affected by changes in RF power and thus there is no trade-off between response and noise. The results reveal different noise sources depending on the deposition conditions of the sensing material, and provide design guidelines for resistor- and FET-type gas sensors considering noise for optimal performance.Burgeoning interest in the area of bacteria-powered micro robotic systems prompted us to study the dynamics of cargo transport by single bacteria. In this paper, we have studied the swimming behaviour of oil-droplets attached as cargo to the cell bodies of single bacteria. The oil-droplet loaded bacteria exhibit super-diffusive motion which is characterised by a high degree of directional persistence. Interestingly, bacteria could navigate with cargo size as large as 8 μm resulting in an increased rotational drag of more than 2 orders when compared to the free bacteria. The directional change of cargo loaded bacterial trajectories seems to be enhanced by steric hindrance from other oil-droplets present in the environment.The first synthesis of the proposed natural stereoisomer of halisphingosine A, a metabolite of the marine sponge Haliclona tubifera, was accomplished in 11 steps including an enantioselective Henry reaction, a Weinreb amide - acetylide coupling, and stereoselective reductions of the resulting ynone to afford the R,Z-configured allyl alcohol moiety. The synthetic product differed from the natural isolate in some 13C-NMR data. It showed antiproliferative activity at clinically relevant concentrations against six tumour cell lines including such lacking functional tumor suppressor gene p53.The rheology of non-colloidal suspensions of spheres in a viscoelastic matrix, including the viscometric, G', G' and uniaxial extensional responses, is explored. Volume fractions of 50% and less were used. By recognizing that filament stretching between beads begins at a distance comparable to the sphere diameter the unexpected large stresses seen in the uniaxial extension experiments can be understood, and a model is presented. In the experiments there is little variation of the dimensionless elongational stresses with the volume fraction φ. For a volume fraction of 50% the behaviour was different from the other concentrations. An essential finding is that a single-mode model of the Oldroyd-B type is not able to describe the elongational experiments at all-at least two modes are needed. [https://www.selleckchem.com/products/skl2001.html SKL2001] There is clearly a difference between behaviour in elongation and in shear with regards to the action of interparticle friction. With negligible rotation of the particles in elongation the kind of vigorous interparticle rubbing possible in shear does not happen.Hypochlorous acid (HOCl) plays a crucial role in various physiological and pathological processes. However, it is still a challenge to design a xanthene-based near-infrared (NIR) fluorescent probe with a large Stokes shift for sensing HOCl. In this work, a novel mitochondria-targeted fluorescent probe, MXS, with a large Stokes shift based on a xanthene-hemicyanine dyad structure, has been successfully designed and synthesized for the specific detection of HOCl. Gratifyingly, the peak-to-peak Stokes shift of MXS was found to be 130 nm, which was obviously larger than those of conventional rhodamine dyes and most reported xanthene-based hypochlorous acid probes. As expected, MXS exhibited high selectivity, high sensitivity, and fast response time (30 s) for the detection of HOCl via a specific HOCl-promoted intramolecular charge transfer process. 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<del class="diffchange diffchange-inline"> </del>&lt;<del class="diffchange diffchange-inline">/div</del>&gt; &lt;<del class="diffchange diffchange-inline">br </del>/&gt;&lt;<del class="diffchange diffchange-inline">br /</del>&gt; <del class="diffchange diffchange-inline">&#160; </del>&lt;br /&gt;&lt;br /&gt; <del class="diffchange diffchange-inline">&#160; </del>&lt;br /&gt;&lt;br /&gt; <del class="diffchange diffchange-inline">&#160; </del>&lt;br /&gt;&lt;br /&gt; &lt;/div&gt;&lt;br /&gt;&lt;br /&gt; <del class="diffchange diffchange-inline"> </del>&lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt; &lt;br /&gt;&lt;br /&gt;&lt;/div&gt;&lt;br /&gt;&lt;br /&gt;<del class="diffchange diffchange-inline">Een vochtige kruipruimte kan ontstaan door onder andere slechte ventilatie. 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Ze zijn specifiek ontworpen voor vochtige kruipruimtes </del>en <del class="diffchange diffchange-inline">worden in een gelijke laag op </del>de <del class="diffchange diffchange-inline">bodem van de kruipruimte gespoten</del>. <del class="diffchange diffchange-inline">Ze stoppen het vocht vanuit </del>de <del class="diffchange diffchange-inline">bodem en zorgen </del>voor <del class="diffchange diffchange-inline">een droge </del>en <del class="diffchange diffchange-inline">warmere vloer</del>. <del class="diffchange diffchange-inline">Bodemparels worden ook veel gebruikt onder houten vloeren </del>om <del class="diffchange diffchange-inline">houtrot </del>te <del class="diffchange diffchange-inline">voorkomen</del>.<del class="diffchange diffchange-inline">&lt;br /</del>&gt;&lt;br /&gt;<del class="diffchange diffchange-inline">Vocht in kelder kunt u merken door </del>een <del class="diffchange diffchange-inline">muffe lucht in huis</del>, een <del class="diffchange diffchange-inline">koude vloer of schimmel in de muur</del>. <del class="diffchange diffchange-inline">De </del>kruipruimte kan <del class="diffchange diffchange-inline">vochtig worden en kan er water in de kelder blijven staan door verschillende oorzaken</del>. <del class="diffchange diffchange-inline">Dat </del>de <del class="diffchange diffchange-inline">kruipruimte vochtig is</del>, kan <del class="diffchange diffchange-inline">voor veel problemen zorgen</del>. <del class="diffchange diffchange-inline">Naast schimmelvorming in huis</del>, <del class="diffchange diffchange-inline">kunt u ook last krijgen van ongedierte zoals rioolvliegjes of ratten.&lt;br </del>/&gt;&lt;br /&gt;<del class="diffchange diffchange-inline">Via onderstaand formulier ontvang </del>je <del class="diffchange diffchange-inline">vrijblijvend prijsvoorstellen en advies </del>van <del class="diffchange diffchange-inline">maximaal 3 vakmannen actief </del>in <del class="diffchange diffchange-inline">jouw buurt</del>. <del class="diffchange diffchange-inline">Vraag dan zeker verschillende prijsvoorstellen aan bij isolatiespecialisten actief </del>in <del class="diffchange diffchange-inline">je buurt. Zo kan je niet alleen gericht kosten, maar ook adviezen, werkwijzen en uitvoeringstermijnen vergelijken</del>.&lt;br /&gt;&lt;br /&gt;<del class="diffchange diffchange-inline">Wanneer dit </del>vocht <del class="diffchange diffchange-inline">niet weg kan, trekt het omhoog naar </del>de vloer <del class="diffchange diffchange-inline">en muren van je woning</del>, <del class="diffchange diffchange-inline">met alle gevolgen van dien. Een vochtige kruipruimte is vaak </del>de <del class="diffchange diffchange-inline">oorzaak </del>van <del class="diffchange diffchange-inline">schimmels, vochtplekken of een muffe geur in </del>huis. <del class="diffchange diffchange-inline">Dit probleem komt vaak voor in Nederlandse woningen</del>, <del class="diffchange diffchange-inline">zeker bij oudere huizen met een houten vloerconstructie</del>. <del class="diffchange diffchange-inline">Naast schade aan </del>de woning <del class="diffchange diffchange-inline">kan het ook gevolgen hebben voor je gezondheid</del>.&lt;br /&gt;&lt;br /&gt;<del class="diffchange diffchange-inline">Er zijn verschillende oorzaken die er voor kunnen zorgen dat vocht in </del>een kruipruimte <del class="diffchange diffchange-inline">ontstaat</del>. <del class="diffchange diffchange-inline">Bij AVV Vloeren zijn we gespecialiseerd in </del>het <del class="diffchange diffchange-inline">vakkundig aanbrengen van schuimbeton in kruipruimtes</del>. <del class="diffchange diffchange-inline">Met onze expertise zorgen we ervoor dat vochtproblemen tot </del>het <del class="diffchange diffchange-inline">verleden behoren en uw woning een solide en droge basis krijgt.&lt;br /&gt;&lt;br /&gt; [https://buzzinguniverse.com/members/finnegan93hermansen/activity/616646/ Schimmel in huis] de kruipruimte vochtig is, tast dit het hout in </del>de vloer <del class="diffchange diffchange-inline">aan. Water in kelder kan niet makkelijk weg waardoor de rot in de vloer gaat zitten. Een veel voorkomend probleem door een vochtige </del>kruipruimte <del class="diffchange diffchange-inline">is schimmel </del>in <del class="diffchange diffchange-inline">de muren</del>. <del class="diffchange diffchange-inline">Dit is niet alleen schadelijk voor uw woning, maar ook voor uw gezondheid!</del></div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">Lees over de juiste aanpak, wetgeving</ins>, <ins class="diffchange diffchange-inline">vergunningen en duurzame oplossingen. Schimmels zijn zeker voor mensen die toch al last hebben van astma of bronchitis erg vervelend zijn. Maar ook </ins>als uw <ins class="diffchange diffchange-inline">longen gezonde zijn is het niet gezond om schimmelsporen in te ademen</ins>. <ins class="diffchange diffchange-inline">Hierdoor kunt </ins>u <ins class="diffchange diffchange-inline">klachten krijgen als keelpijn, verstopte neus, benauwdheid en veelvuldig niezen en hoesten. [https://squareblogs</ins>.<ins class="diffchange diffchange-inline">net</ins>/<ins class="diffchange diffchange-inline">berntsen37berntsen</ins>/<ins class="diffchange diffchange-inline">last-van-een-vochtige-kruipruimte</ins>-<ins class="diffchange diffchange-inline">kruipkelder-onder-water-schimmels Optrekkend vocht] zien we vaak de volgende drie hoofdproblemen terug. Isolatiechips kunnen in zakken of los worden aangebracht.</ins>&lt;br /&gt;&lt;br /&gt;<ins class="diffchange diffchange-inline">Deze platen kunnen eenvoudig tussen de vloerbalken aangebracht. De platen zijn er in verschillende maten en diktes verkrijgbaar. Bovendien zijn ze snel gemonteerd en dat scheelt in hogere arbeidskosten. Wanneer uw kruipruimte te vochtig is, kan het zijn dat het vocht vocht door de kieren van de vloer of via de meter kast omhoog komt. Wanneer uw kruipruimte zo vochtig is, is het extra belangrijk om de ruimte af te dekken waardoor het vocht niet de woning binnen kan dringen.</ins>&lt;br /&gt;&lt;<ins class="diffchange diffchange-inline">br /</ins>&gt;<ins class="diffchange diffchange-inline">Het wordt over het algemeen afgeraden om iets in een vochtige kruipruimte op te slaan, omdat dit kan leiden tot schimmelgroei en schade aan je spullen. Hoewel het mogelijk is om zelf je kruipruimte te isoleren, is het vaak een complexe taak die specifieke kennis en vaardigheden vereist. Fouten kunnen leiden tot een inefficiënte isolatie en vochtproblemen. Daarom wordt aanbevolen om een professional in te schakelen. Het is normaal dat een kruipruimte enigszins vochtig is, vooral na regen of in bepaalde seizoenen. 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&lt;<ins class="diffchange diffchange-inline">span itemprop=&quot;postalCode&quot;</ins>&gt;<ins class="diffchange diffchange-inline">3818 LE&lt;/span&gt;&lt;br /&gt;&lt;br /&gt;&#160; &#160; &#160; </ins>&lt;br /&gt;&lt;br /&gt; <ins class="diffchange diffchange-inline">&#160; &#160; </ins>&lt;br /&gt;&lt;br /&gt; <ins class="diffchange diffchange-inline">&#160; &#160; </ins>&lt;br /&gt;&lt;br /&gt; <ins class="diffchange diffchange-inline">&#160; </ins>&lt;/div&gt; &lt;br /&gt;&lt;br /&gt; <ins class="diffchange diffchange-inline">&#160; &#160; </ins>&lt;br /&gt;&lt;br /&gt; <ins class="diffchange diffchange-inline">&#160; &#160; </ins>&lt;br /&gt;&lt;br /&gt; <ins class="diffchange diffchange-inline">&#160; &#160; </ins>&lt;br /&gt;&lt;br /&gt; <ins class="diffchange diffchange-inline">&#160; </ins>&lt;/div&gt; &lt;br /&gt;&lt;br /&gt; <ins class="diffchange diffchange-inline">&#160; &lt;br /&gt;&lt;br /&gt;&#160; &#160; &lt;br /&gt;&lt;br /&gt;&#160; &#160; &lt;br /&gt;&lt;br /&gt;&#160; &lt;/div&gt; &lt;br /&gt;&lt;br /&gt;&#160; &lt;br /&gt;&lt;br /&gt;&#160; &lt;br /&gt;</ins>&lt;br /&gt; <ins class="diffchange diffchange-inline">&#160; </ins>&lt;br /&gt;<ins class="diffchange diffchange-inline">&lt;br /&gt; &lt;/div&gt;&lt;br /&gt;&lt;br /&gt;&#160; &lt;br /&gt;&lt;br /&gt; &lt;br </ins>/<ins class="diffchange diffchange-inline">&gt;&lt;br </ins>/<ins class="diffchange diffchange-inline">&gt; </ins>&lt;br /&gt;&lt;br /&gt;<ins class="diffchange diffchange-inline">&lt;/div&gt;&lt;br /&gt;&lt;br /&gt;Daarna is </ins>de <ins class="diffchange diffchange-inline">ruimte binnen enkele dagen geschikt om afgewerkt te worden met bijvoorbeeld laminaat of tegels</ins>. <ins class="diffchange diffchange-inline">Onze specialist komt bij je langs om de huidige vloer te inspecteren </ins>en de <ins class="diffchange diffchange-inline">situatie te analyseren</ins>. <ins class="diffchange diffchange-inline">We kijken samen naar </ins>de <ins class="diffchange diffchange-inline">beste oplossing </ins>voor <ins class="diffchange diffchange-inline">jouw wensen </ins>en <ins class="diffchange diffchange-inline">budget, zonder verborgen kosten</ins>. <ins class="diffchange diffchange-inline">Er zijn drie manieren van drainage </ins>om <ins class="diffchange diffchange-inline">vocht in de kruipruimte tegen </ins>te <ins class="diffchange diffchange-inline">gaan. We lichten de verschillende soorten drainage hieronder toe</ins>. <ins class="diffchange diffchange-inline">De parels zijn geschikt voor lage kruipruimtes, tot ongeveer 30 á 40 centimeter hoog.&lt;br /</ins>&gt;&lt;br /&gt;<ins class="diffchange diffchange-inline">In bijna alle oudere woningen met </ins>een <ins class="diffchange diffchange-inline">kruipruimte kunnen wij CompoFloor toepassen. Zeker bij vochtige kruipruimtes</ins>, <ins class="diffchange diffchange-inline">oude houten vloeren of bij </ins>een <ins class="diffchange diffchange-inline">hoge grondwaterstand is dit een ideale oplossing</ins>. <ins class="diffchange diffchange-inline">Een vochtige </ins>kruipruimte kan <ins class="diffchange diffchange-inline">ernstige problemen veroorzaken voor de staat van je woning</ins>. <ins class="diffchange diffchange-inline">Niet alleen heeft het invloed op </ins>de <ins class="diffchange diffchange-inline">structurele integriteit van je huis</ins>, <ins class="diffchange diffchange-inline">maar het </ins>kan <ins class="diffchange diffchange-inline">ook leiden tot gezondheidsproblemen en hogere energiekosten</ins>. <ins class="diffchange diffchange-inline">In deze blog bespreken we de oorzaken van een vochtige kruipruimte, de gevolgen</ins>, <ins class="diffchange diffchange-inline">en hoe isolatie kan helpen om deze problemen effectief op te lossen. Het is daarom heel erg belangrijk dat u een vochtige kruipruimte tegengaat door het laten aanbrengen van de juiste kruipruimte ventilatie en vloerisolatie.&lt;br </ins>/&gt;&lt;br /&gt;<ins class="diffchange diffchange-inline">Om dat te voorkomen kun </ins>je <ins class="diffchange diffchange-inline">voor betere drainage rondom de woning zorgen. Een </ins>van <ins class="diffchange diffchange-inline">de meest voorkomende oorzaken voor water </ins>in <ins class="diffchange diffchange-inline">de kruipruimte is onvoldoende ventilatie</ins>. <ins class="diffchange diffchange-inline">Als er condens ontstaat is het belangrijk dat er genoeg luchtstromen </ins>in <ins class="diffchange diffchange-inline">de kruipruimte aanwezig zijn om de condens af te voeren</ins>.&lt;br /&gt;&lt;br /&gt; <ins class="diffchange diffchange-inline">[https://etextpad.com/p9vsvuy89l mijn bedrijf] </ins>vocht <ins class="diffchange diffchange-inline">verdampt door spleten in </ins>de vloer, <ins class="diffchange diffchange-inline">waardoor er al gauw 1 tot 10 liter vocht per dag in </ins>de <ins class="diffchange diffchange-inline">binnenlucht </ins>van <ins class="diffchange diffchange-inline">het </ins>huis <ins class="diffchange diffchange-inline">terecht komt</ins>. <ins class="diffchange diffchange-inline">Als het vocht niet goed weggevoerd wordt</ins>, <ins class="diffchange diffchange-inline">beslaan bijvoorbeeld uw ramen</ins>. <ins class="diffchange diffchange-inline">Ook in de rest van </ins>de woning <ins class="diffchange diffchange-inline">kunnen dan schimmels en vochtplekken ontstaan</ins>.&lt;br /&gt;&lt;br /&gt;<ins class="diffchange diffchange-inline">Grondvocht is de voornaamste oorzaak van </ins>een <ins class="diffchange diffchange-inline">vochtige </ins>kruipruimte <ins class="diffchange diffchange-inline">en staat ook wel bekend als doorslaand vocht</ins>. <ins class="diffchange diffchange-inline">Dit ontstaat vaak als </ins>het <ins class="diffchange diffchange-inline">grondwaterpeil te hoog is en/of bij zware regenval</ins>. <ins class="diffchange diffchange-inline">Hierbij komt </ins>het <ins class="diffchange diffchange-inline">grondwater via </ins>de vloer <ins class="diffchange diffchange-inline">je </ins>kruipruimte in.</div></td></tr></table></summary> <author><name>Boyesahin5850</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=User:WendyTimperley&diff=3606972&oldid=0</id> <title>User:WendyTimperley</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=User:WendyTimperley&diff=3606972&oldid=0"/> <updated>2025-07-01T19:51:14Z</updated> <summary type="html"><p>Created page with &quot;I like Fantasy Football!&lt;br&gt;&lt;br&gt;Here is my web blog ... 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[http://g.oog.l.eemail.2.1@laraquejec197.0jo8.23@www.mondaymorninginspiration@Sus.ta.i.n.j.ex.k@fullgluestickyriddl.edynami.c.t.r.a@johndf.gfjhfgjf.ghfdjfhjhjhjfdgh@sybbr%3Er.eces.si.v.e.x.g.z@leanna.langton@c.o.nne.c.t.tn.tu@Go.o.gle.email.2.%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5Cn1@sarahjohnsonw.estbrookbertrew.e.r@hu.fe.ng.k.Ua.ngniu.bi..uk41@Www.Zanele@silvia.woodw.o.r.T.h@meng.luc.h.e.n.4@hu.fe.ng.k.Ua.ngniu.bi..uk41@Www.Zanele@silvia.woodw.o.r.t.h@H.att.ie.M.c.d.o.w.e.ll2.56.6.3@burton.rene@s.jd.u.eh.yds.g.524.87.59.68.4@i.nsult.i.ngp.a.T.l@okongwu.chisom@vi.rt.u.ali.rd.j@H.Att.Ie.M.C.D.O.W.E.Ll2.56.6.3@Burton.Rene@fullgluestickyriddl.edynami.c.t.r.a@johndf.gfjhfgjf.ghfdjfhjhjhjfdgh@sybbr%3Er.eces.si.v.e.x.g.z@leanna.langton@c.o.nne.c.t.tn.tu@Go.o.gle.email.2.%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5Cn1@sarahjohnsonw.estbrookbertrew.e.r@hu.fe.ng.k.Ua.ngniu.bi..uk41@Www.Zanele@silvia.woodw.o.r.t.h@asex.y.52.1@leanna.langton@c.or.r.idortpkm@johndf.gfjhfgjf.ghfdjfhjhjhjfdgh@sybbr%3Er.eces.si.v.e.x.g.z@leanna.langton@c.o.nne.c.t.tn.tu@Go.o.gle.email.2.%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5C%5Cn1@sarahjohnsonw.estbrookbertrew.e.r@hu.fe.ng.k.Ua.ngniu.bi..uk41@Www.Zanele@silvia.woodw.o.r.t.h@switc.h.ex.cb@mengl.uch.en1@britni.vieth_151045@Zel.m.a.Hol.m.e.s84.9.83@n.oc.no.x.p.A.rk.e@ex.p.lo.si.v.edhq.g@Hu.feng.ku.angn.i.ub.i...u.k37@coolh.ottartmassflawles.s.p.a.n.e.r.e.e@hu.fe.ng.k.ua.ngniu.bi..uk41@www.Zanele@silvia.woodw.o.r.t.h@simplisti.cholemellowlunchroom.e@zvanovec.net/phpinfo.php?a%5B%5D=%3Ca+href%3Dhttp%3A%2F%2Fbetofin.com%2Ftools%2Ftheme.php%3Ftheme%3DOQ%3D%3D%26current%3DaHR0cHM6Ly9Xd3cucG9rZXJ0dWJlLmNvbS8%3EWatch+Free+Poker+Tv+Shows%3C%2Fa%3E%3Cmeta+http-equiv%3Drefresh+content%3D0%3Burl%3Dhttps%3A%2F%2FKarung.in%2F%3Fr%3DaHR0cHM6Ly9Xd3cuUG9rZXJ0dWJlLmNvbS8+%2F%3E play poker online]</div></summary> <author><name>WendyTimperley</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Bladtterkelsen4362&diff=3606971&oldid=0</id> <title>Bladtterkelsen4362</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Bladtterkelsen4362&diff=3606971&oldid=0"/> <updated>2025-07-01T19:50:55Z</updated> <summary type="html"><p>Created page with &quot;Background Continuous passive motion (CPM) is frequently used during rehabilitation following total knee arthroplasty (TKA). Low-load resistance training (LLRT) using continuo...&quot;</p><p><b>New page</b></p><div>Background Continuous passive motion (CPM) is frequently used during rehabilitation following total knee arthroplasty (TKA). Low-load resistance training (LLRT) using continuous active motion (CAM) devices is a promising alternative. We investigated the effectiveness of CPM compared to LLRT using the affected leg (CAMuni) and both legs (CAMbi) in the early post-operative rehabilitation.&lt;br /&gt;&lt;br /&gt; (I) LLRT (CAMuni and CAMbi) is superior to CPM, (II) additional training of the unaffected leg (CAMbi) is more effective than unilateral training (CAMuni). [https://www.selleckchem.com/products/prt543.html https://www.selleckchem.com/products/prt543.html] &lt;br /&gt;&lt;br /&gt; Eighty-five TKA patients were randomly assigned to three groups, respectively (i) unilateral CPM of the operated leg; (ii) unilateral CAM of the operated leg (CAMuni); (iii) bilateral alternating CAM (CAMbi). Patients were assessed 1 day before TKA (pre-test), 1 day before discharge (post-test), and 3 months post-operatively (follow-up).&lt;br /&gt;&lt;br /&gt; active knee flexion range of motion (ROM&lt;br /&gt;&lt;br /&gt; ).&lt;br /&gt;&lt;br /&gt; active knee extension ROM (ROM&lt;br /&gt;&lt;br /&gt; ), swelling, pain, C-reactive protein, quality of lifpared to CAMuni. &lt;br /&gt;&lt;br /&gt; Additional LLRT of the unaffected leg (CAMbi) seems to be more effective for recovery of function than training of the affected leg only (CAMuni), which may be mediated by positive transfer effects from the unaffected to the affected limb (cross education) and/or preserved neuromuscular function of the trained, unaffected leg. &lt;br /&gt;&lt;br /&gt; ClinicalTrials.gov Identifier NCT02062138.&lt;br /&gt;&lt;br /&gt;At post-test, improved ROMExt, reduced swelling, and better timed-up-and-go performance were observed in CAMbi compared to CAMuni. Conclusions Additional LLRT of the unaffected leg (CAMbi) seems to be more effective for recovery of function than training of the affected leg only (CAMuni), which may be mediated by positive transfer effects from the unaffected to the affected limb (cross education) and/or preserved neuromuscular function of the trained, unaffected leg. Trial Registration ClinicalTrials.gov Identifier NCT02062138.Elevated BMI in Hidradenitis Suppurativa is associated with decreased response to Adalimumab therapy. BMI is proposed to segregate distinct disease subtypes. It remains unresolved whether a threshold BMI exists above which increased dosages may provide clinical benefit. Individual patient data from 578 PIONEER Phase 3 participants were analyzed. Descriptive, multivariable regression analysis and receiver operating characteristic (ROC) curves were calculated to assess the relationship between BMI and clinical outcome measures using R v3.5.3. Participants in the overweight and obese BMI category had reduced odds (58 and 67%, respectively) of achieving HiSCR [OR = 0.42 (95%CI -0.19, 0.91) p = 0.03], [OR = 0.33 (95%CI 0.16, 0.67) p = 0.002] compared to participants with BMI less then 25. Reduction in AN count and IHS4 score was not significantly associated. ROC analysis did not reveal any cut off value predictive of treatment outcome. No correlation between BMI and baseline disease activity or covariate interactions were identified. These findings suggest BMI is a significant covariate in the setting of lower baseline disease activity, supporting the concept of disease heterogeneity and differential therapeutic response to Adalimumab.Background Since the outbreak of Coronavirus disease 2019 (COVID-19), the government of China adopted many measures which changed people's lifestyle including oral health-related lifestyle to control the transmission. The aim of this study was to investigate oral health status, oral healthcare behaviors, and parental attitudes toward oral healthcare among school-age children in Wuhan during the COVID-19 outbreak and what the status would be when the outbreak is under control. Methods This study was an online cross-sectional survey facing elementary school students in Wuhan. The questionnaire was completed by children's parents or other family members. The information on demographic data, oral health status, oral healthcare behaviors, and parental attitudes toward oral healthcare was collected at the end of school closure. The chi-square test was used to test the association of different questionnaire items. Results A total of 18,383 subjects aged 6-13 years with complete data were included in this investigation, and 44.2% of them suffered pain or discomfort related to teeth and gums during the epidemic. While there might be an increasing need and concern of oral healthcare during the outbreak and even when the outbreak was controlled, the worry of infection made it difficult for people to meet their demands of dental attendance. Conclusion The risk of cross-infection during the treatment had a negative influence on parental attitudes toward dental attendance. Effective measures should be taken to meet people's demands of dental attendance.[This corrects the article DOI 10.3389/fcell.2021.675503.].[This corrects the article DOI 10.3389/fcell.2020.598492.].The adenosine monophosphate (AMP)-activated protein kinase (AMPK) was initially identified as an enzyme acting as an &quot;energy sensor&quot; in maintaining energy homeostasis via serine/threonine phosphorylation when low cellular adenosine triphosphate (ATP) level was sensed. AMPK participates in catabolic and anabolic processes at the molecular and cellular levels and is involved in appetite-regulating circuit in the hypothalamus. AMPK signaling also modulates energy metabolism in organs such as adipose tissue, brain, muscle, and heart, which are highly dependent on energy consumption via adjusting the AMP/ADPATP ratio. In clinics, biguanides and thiazolidinediones are prescribed to patients with metabolic disorders through activating AMPK signaling and inhibiting complex I in the mitochondria, leading to a reduction in mitochondrial respiration and elevated ATP production. The role of AMPK in mediating skeletal development and related diseases remains obscure. In this review, in addition to discuss the emerging advances of AMPK studies in energy control, we will also illustrate current discoveries of AMPK in chondrocyte homeostasis, osteoarthritis (OA) development, and the signaling interaction of AMPK with other pathways, such as mTOR (mechanistic target of rapamycin), Wnt, and NF-κB (nuclear factor κB) under OA condition.</div></summary> <author><name>Bladtterkelsen4362</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Gadegaardlittle2070&diff=3606970&oldid=0</id> <title>Gadegaardlittle2070</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Gadegaardlittle2070&diff=3606970&oldid=0"/> <updated>2025-07-01T19:50:48Z</updated> <summary type="html"><p>Created page with &quot;lerate progress. Despite little progress in some areas, maternal and child undernutrition remains a major global health concern, particularly as improvements since 2000 might...&quot;</p><p><b>New page</b></p><div>lerate progress. Despite little progress in some areas, maternal and child undernutrition remains a major global health concern, particularly as improvements since 2000 might be offset by the COVID-19 pandemic.Phenotype prediction is a key goal for medical genetics. Unfortunately, most genome-wide association studies are done in European populations, which reduces the accuracy of predictions via polygenic scores in non-European populations. Here, we use population genetic models to show that human demographic history and negative selection on complex traits can result in population-specific genetic architectures. For traits where alleles with the largest effect on the trait are under the strongest negative selection, approximately half of the heritability can be accounted for by variants in Europe that are absent from Africa, leading to poor performance in phenotype prediction across these populations. Further, under such a model, individuals in the tails of the genetic risk distribution may not be identified via polygenic scores generated in another population. We empirically test these predictions by building a model to stratify heritability between European-specific and shared variants and applied it to 37 traits and diseases in the UK Biobank. Across these phenotypes, ∼30% of the heritability comes from European-specific variants. We conclude that genetic association studies need to include more diverse populations to enable the utility of phenotype prediction in all populations.Sodium glucose co-transporter (SGLT) 2 inhibitors reduce the risk of kidney failure in patients with and without type 2 diabetes (T2D). Although the precise underlying mechanisms for these nephroprotective effects are incompletely understood, various hypotheses have been proposed including reductions in intraglomerular pressure through restoration of tubuloglomerular feedback, blood pressure reduction and favorable effects on vascular function, reduction in tubular workload and hypoxia, and metabolic effects resulting in increased autophagy. Here, we review these mechanisms, which may also explain the beneficial effects of SGLT2 inhibitors on kidney function in patients without T2D.Understanding the mechanisms underlying how T cells become dysfunctional in a tumor microenvironment (TME) will greatly benefit cancer immunotherapy. We found that increased CD36 expression in tumor-infiltrating CD8+ T cells, which was induced by TME cholesterol, was associated with tumor progression and poor survival in human and murine cancers. Genetic ablation of Cd36 in effector CD8+ T cells exhibited increased cytotoxic cytokine production and enhanced tumor eradication. CD36 mediated uptake of fatty acids by tumor-infiltrating CD8+ T cells in TME, induced lipid peroxidation and ferroptosis, and led to reduced cytotoxic cytokine production and impaired antitumor ability. Blocking CD36 or inhibiting ferroptosis in CD8+ T cells effectively restored their antitumor activity and, more importantly, possessed greater antitumor efficacy in combination with anti-PD-1 antibodies. This study reveals a new mechanism of CD36 regulating the function of CD8+ effector T cells and therapeutic potential of targeting CD36 or inhibiting ferroptosis to restore T cell function.It is unclear why some SARS-CoV-2 patients readily resolve infection while others develop severe disease. By interrogating metabolic programs of immune cells in severe and recovered coronavirus disease 2019 (COVID-19) patients compared with other viral infections, we identify a unique population of T cells. These T cells express increased Voltage-Dependent Anion Channel 1 (VDAC1), accompanied by gene programs and functional characteristics linked to mitochondrial dysfunction and apoptosis. The percentage of these cells increases in elderly patients and correlates with lymphopenia. Importantly, T cell apoptosis is inhibited in vitro by targeting the oligomerization of VDAC1 or blocking caspase activity. We also observe an expansion of myeloid-derived suppressor cells with unique metabolic phenotypes specific to COVID-19, and their presence distinguishes severe from mild disease. Overall, the identification of these metabolic phenotypes provides insight into the dysfunctional immune response in acutely ill COVID-19 patients and provides a means to predict and track disease severity and/or design metabolic therapeutic regimens.&lt;br /&gt;&lt;br /&gt; Access to COVID-19 testing remained a salient issue during the early months of the pandemic, therefore this study aimed to identify 1) regional and 2) socioeconomic predictors of perceived ability to access Coronavirus testing.&lt;br /&gt;&lt;br /&gt; An online survey using social media-based advertising was conducted among U.S. adults in April 2020. Participants were asked whether they thought they could acquire a COVID-19 test, along with basic demographic, socioeconomic and geographic information.&lt;br /&gt;&lt;br /&gt; A total of 6,378 participants provided data on perceived access to COVID-19 testing. In adjusted analyses, we found higher income and possession of health insurance to be associated with perceived ability to access Coronavirus testing. Geographically, perceived access was highest (68%) in East South Central division and lowest (39%) in West North Central. Disparities in health insurance coverage did not directly correspond to disparities in perceived access to COVID-19 testing.&lt;br /&gt;&lt;br /&gt; Sex, geographic location, income, and insurance status were associated with perceived access to COVID-19 testing; interventions aimed at improving either access or awareness of measures taken to improve access are warranted. These findings from the pandemic's early months shed light on the importance of disaggregating perceived and true access to screening during such crises.&lt;br /&gt;&lt;br /&gt;Sex, geographic location, income, and insurance status were associated with perceived access to COVID-19 testing; interventions aimed at improving either access or awareness of measures taken to improve access are warranted. [https://www.selleckchem.com/products/lazertinib-yh25448-gns-1480.html check details] These findings from the pandemic's early months shed light on the importance of disaggregating perceived and true access to screening during such crises.</div></summary> <author><name>Gadegaardlittle2070</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Doddbyers1844&diff=3606969&oldid=0</id> <title>Doddbyers1844</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Doddbyers1844&diff=3606969&oldid=0"/> <updated>2025-07-01T19:50:45Z</updated> <summary type="html"><p>Created page with &quot;Photorespiration (PR) is a metabolic repair pathway that acts in oxygenic photosynthetic organisms to degrade a toxic product of oxygen fixation generated by the enzyme ribulo...&quot;</p><p><b>New page</b></p><div>Photorespiration (PR) is a metabolic repair pathway that acts in oxygenic photosynthetic organisms to degrade a toxic product of oxygen fixation generated by the enzyme ribulose 1,5-bisphosphate carboxylase/oxygenase. Within the metabolic pathway, energy is consumed and carbon dioxide released. Consequently, PR is seen as a wasteful process making it a promising target for engineering to enhance plant productivity. Transport and channel proteins connect the organelles accomplishing the PR pathway-chloroplast, peroxisome, and mitochondrion-and thus enable efficient flux of PR metabolites. Although the pathway and the enzymes catalyzing the biochemical reactions have been the focus of research for the last several decades, the knowledge about transport proteins involved in PR is still limited. [https://www.selleckchem.com/products/ly-3475070.html this website] presents a timely state of knowledge with regard to metabolite channeling in PR and the participating proteins. The significance of transporters for implementation of synthetic bypasses to PR is highlighted. As an excursion, the physiological contribution of transport proteins that are involved in C4 metabolism is discussed.PD-1 Immune checkpoint inhibitors, such as Pembrolizumab, can have a durable beneficial therapeutic effect in patients with advanced melanoma. However, not all patients will benefit equally from these therapies, and (potentially life-threatening) immune-related adverse events may occur. In this study, we investigate the value of early response assessment by FDG-PET/CT as a biomarker for predicting survival. We identified all patients with advanced melanoma who were treated with Pembrolizumab in our medical center and underwent a baseline and at least one follow-up FDG-PET/CT. The total metabolic tumor volume (TMTV) was calculated, and the evolution was compared to survival parameters. A total of 77 patients underwent a baseline and at least one follow-up FDG-PET/CT, 36 patients had follow-up imaging within 2-4 months, and 21 patients an FDG-PET/CT 5-6 months after baseline. When the TMTV evolution was categorized into two subgroups (stable/decrease versus increase), an association was found between stability or decrease in TMTV and better PFS and OS. A similar trend, however non-significant, was observed at 5-6 months. The evolution in TMTV as assessed by FDG-PET/CT 2-4 months after treatment initiation is associated with long-term outcomes in patients with advanced melanoma treated with Pembrolizumab.Populations of vector-borne pathogens are shaped by the distribution and movement of vector and reservoir hosts. To study what impact host and vector association have on tick-borne pathogens, we investigated the population structure of Borrelia lusitaniae using multilocus sequence typing (MLST). Novel sequences were acquired from questing ticks collected in multiple North African and European locations and were supplemented by publicly available sequences at the Borrelia Pubmlst database (accessed on 11 February 2020). Population structure of B. lusitaniae was inferred using clustering and network analyses. Maximum likelihood phylogenies for two molecular tick markers (the mitochondrial 16S rRNA locus and a nuclear locus, Tick-receptor of outer surface protein A, trospA) were used to confirm the morphological species identification of collected ticks. Our results confirmed that B. lusitaniae does indeed form two distinguishable populations one containing mostly European samples and the other mostly Portuguese and North African samples. #link# Of interest, Portuguese samples clustered largely based on being from north (European) or south (North African) of the river Targus. As two different Ixodes species (i.e., I. ricinus and I. inopinatus) may vector Borrelia in these regions, reference samples were included for I. inopinatus but did not form monophyletic clades in either tree, suggesting some misidentification. Even so, the trospA phylogeny showed a monophyletic clade containing tick samples from Northern Africa and Portugal south of the river Tagus suggesting a population division in Ixodes on this locus. The pattern mirrored the clustering of B. lusitaniae samples, suggesting a potential co-evolution between tick and Borrelia populations that deserve further investigation.Decussation of axonal tracts is an important hallmark of vertebrate neuroanatomy resulting in one brain hemisphere controlling the contralateral side of the body and also computing the sensory information originating from that respective side. Here, we show that BMP interferes with optic chiasm formation and RGC pathfinding in zebrafish. Experimental induction of BMP4 at 15 hpf results in a complete ipsilateral projection of RGC axons and failure of commissural connections of the forebrain, in part as the result of an interaction with shh signaling, transcriptional regulation of midline guidance cues and an affected optic stalk morphogenesis. Experimental induction of BMP4 at 24 hpf, resulting in only a mild repression of forebrain shh ligand expression but in a broad expression of pax2a in the diencephalon, does not per se prevent RGC axons from crossing the midline. It nevertheless shows severe pathologies of RGC projections e.g., the fasciculation of RGC axons with the ipsilateral optic tract resulting in the innervation of one tectum by two eyes or the projection of RGC axons in the direction of the contralateral eye.CTLA-4 (cytotoxic T-lymphocyte-associated protein 4) was originally defined as a T-lymphocyte antigen and was used as a target in cancer immunotherapy. Unfortunately, the existence of CTLA-4 in cells other than T-lymphocytes is often overlooked. The goal of the present study was to analyze the distribution pattern of CTLA-4 in the human tonsils using a panel of anti-CTLA-4 antibodies of different clones. We found that CTLA-4 was expressed in T-lymphocyte cells of various geneses, including hematopoietic cells and their derivatives (monocytes, macrophages, dendritic, plasma cells, mast cells, and neutrophils), as well as stromal cells of mesodermal (mesenchymal) origin and reticular epithelial cells of ectodermal origin. The expression of CTLA-4 in cells of different origins supports the proposition that CTLA-4 is not restricted to the lymphoid cell lineage and can provide broader effects of CTLA-4 on immune regulation.</div></summary> <author><name>Doddbyers1844</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=H1_id_h1&diff=3606968&oldid=3597995</id> <title>H1 id h1</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=H1_id_h1&diff=3606968&oldid=3597995"/> <updated>2025-07-01T19:50:26Z</updated> <summary type="html"><p></p><table class="diff diff-contentalign-left" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr style="vertical-align: top;" lang="en"> <td colspan="2" style="background-color: white; color:black; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: white; color:black; text-align: center;">Revision as of 19:50, 1 July 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1" >Line 1:</td><td colspan="2" class="diff-lineno">Line 1:</td></tr><tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del class="diffchange diffchange-inline">&lt;</del></div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins class="diffchange diffchange-inline">&lt;</ins></div></td></tr></table></summary> <author><name>Auntpimple6</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Lucaskeith3023&diff=3606967&oldid=0</id> <title>Lucaskeith3023</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Lucaskeith3023&diff=3606967&oldid=0"/> <updated>2025-07-01T19:50:08Z</updated> <summary type="html"><p>Created page with &quot;In fact, 7-day hAFSCs-EB represents itself an initial cellular transformation towards a specialized structure both in recording and in providing different stimuli from the sur...&quot;</p><p><b>New page</b></p><div>In fact, 7-day hAFSCs-EB represents itself an initial cellular transformation towards a specialized structure both in recording and in providing different stimuli from the surrounding environment, organizing structures and cells towards a differentiation fate.The aim of this study is to evaluate the relationship between maternal single nucleotide polymorphisms (SNPs) of methylenetetrahydrofolate reductase (MTHFR) gene with plasma homocysteine (HCY) level and offspring congenital heart diseases (CHDs). 338 mothers with offspring CHDs as case group and 306 mothers of normal children as control group were recruited. Their pregnant histories were interviewed by questionnaire and the MTHFR rsl801133 and rsl801131 were genotyped. The case-control analysis was used to find out the relationship between maternal SNPs of MTHFR gene and offspring CHDs. And the plasma HCY concentration of the mothers of CHDs children was detected. This case-case study was intended to find out the relevance between maternal HCY level and SNPs of MTHFR gene. There were significant differences in the gender of children, occupation of mothers, family history with CHDs, history of abortion, history of adverse pregnancy, early pregnancy health, fetus during pregnancy, pesticide exposure and drug exposure in CHDs group and control group (P less then 0.05). MTHFR rs1801133 was significantly associated with their offspring CHDs in mothers. The polymorphism of maternal MTHFR rs1801133 increased plasma HCY level, especially the homozygous mutation. Besides the environmental factors, our results suggested that the maternal MTHFR rs1801133 polymorphism might be a risk factor of their offspring CHDs, which may be due to the hyperhomocysteinemia by abnormal metabolism of HCY.&lt;br /&gt;&lt;br /&gt; During the COVID-19 outbreak, the presence of extensive white matter microhemorrhages was detected by brain MRIs. The goal of this study was to investigate the origin of this atypical hemorrhagic complication.&lt;br /&gt;&lt;br /&gt; Between March 17 and May 18, 2020, 80 patients with severe COVID-19 infections were admitted for acute respiratory distress syndrome to intensive care units at the University Hospitals of Strasbourg for whom a brain MRI for neurologic manifestations was performed. 19 patients (24%) with diffuse microhemorrhages were compared to 18 control patients with COVID-19 and normal brain MRI.&lt;br /&gt;&lt;br /&gt; The first hypothesis was hypoxemia. The latter seemed very likely since respiratory failure was longer and more pronounced in patients with microhemorrhages (prolonged endotracheal intubation (p = 0.0002), higher FiO&lt;br /&gt;&lt;br /&gt; (p = 0.03), increased use of extracorporeal membrane oxygenation (p = 0.04)). A relevant hypothesis, the role of microangiopathy, was also considered, since patients with microhemorrhages presented a higher increase of the D-Dimers (p = 0.01) and a tendency to more frequent thrombotic events (p = 0.12). Another hypothesis tested was the role of kidney failure, which was more severe in the group with diffuse microhemorrhages (higher creatinine level [median of 293µmol/L versus 112µmol/L, p = 0.04] and more dialysis were introduced in this group during ICU stay [12 versus 5 patients, p = 0.04]).&lt;br /&gt;&lt;br /&gt; Blood-brain barrier dysfunction secondary to hypoxemia and high concentration of uremic toxins seems to be the main mechanism leading to critical illness-associated cerebral microbleeds, and this complication remains to be frequently described in severe COVID-19 patients.&lt;br /&gt;&lt;br /&gt;Blood-brain barrier dysfunction secondary to hypoxemia and high concentration of uremic toxins seems to be the main mechanism leading to critical illness-associated cerebral microbleeds, and this complication remains to be frequently described in severe COVID-19 patients.&lt;br /&gt;&lt;br /&gt; A linear valve-like structure at the pulmonary artery terminus is identified on CT in some patients with patent ductus arteriosus (PDA) and can potentially be mistaken for endarteritis. The purpose of this study was to evaluate the differences in CT features between adult patients with PDA and a linear structure and those without.&lt;br /&gt;&lt;br /&gt; We retrospectively evaluated ECG-gated cardiac CT of 38 patients with PDA dividing them into two groups [patients with linear symmetrical valve-like structure (group1, n = 16), and those without (group 2, n = 22)]. [https://www.selleckchem.com/products/leukadherin-1.html read more] We analyzed CT findings of the PDA including length, minimal and maximal diameter, presence of calcification, and PDA type, comparing the two subgroups. The authors also investigated the prevalence of endarteritis.&lt;br /&gt;&lt;br /&gt; There was no difference in CT findings between the two groups in the prevalence of calcification and length, and minimal and maximal diameter of PDA. Notably the linear valve-like structure was only identified in type 1 PDA (cone-shaped PDA) (p = 0.04), while there were variable types of PDA in group 2. There was only one case of endarteritis as a complication of PDA in group 1. In contrast to a linear valve-like structure, asymmetrical nodular thickening was noted in the patient with endarteritis on CT overlying the pre-existing linear valve-like structure at the pulmonary end of PDA.&lt;br /&gt;&lt;br /&gt; A linear valve-like structure is frequently identified at the pulmonary end in type 1 PDA. This CT finding should not be mistaken for endarteritis in the absence of other clinical evidence.&lt;br /&gt;&lt;br /&gt;A linear valve-like structure is frequently identified at the pulmonary end in type 1 PDA. This CT finding should not be mistaken for endarteritis in the absence of other clinical evidence.&lt;br /&gt;&lt;br /&gt; Laparoscopic repair is a well-accepted treatment modality for perforated peptic ulcer (PPU). However, intraoperative conversion to laparotomy is still not uncommon. We aimed to identify preoperative factors strongly associated with conversion.&lt;br /&gt;&lt;br /&gt; A retrospective review of records of all PPU patients treated between January 2011 and July 2019 was performed. Patients were divided into three groups laparoscopic repair (LR), conversion to laparotomy (CL), and primary laparotomy (PL). Patient demographics, operative findings, and outcomes were compared between the groups. Logistic regression analyses were performed, taking conversion as the outcome.&lt;br /&gt;&lt;br /&gt; Of 822 patients, there were 236, 45, and 541 in the LR, CL, and PL groups, respectively. The conversion rate was 16%. Compared with those in the LR group, patients in the CL group were older (p &amp;lt; 0.001), had higher PULP scores (p &amp;lt; 0.001), had higher ASA scores (p &amp;lt; 0.001) and had hypertension (p = 0.003). PULP score was the only independent risk factor for conversion.</div></summary> <author><name>Lucaskeith3023</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Connollylara9849&diff=3606966&oldid=0</id> <title>Connollylara9849</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Connollylara9849&diff=3606966&oldid=0"/> <updated>2025-07-01T19:50:08Z</updated> <summary type="html"><p>Created page with &quot;iple samples simultaneously. They exploit every sample&#039;s reads to compensate for the low read-depth of individual samples. This improves polymorphism detection and genotype in...&quot;</p><p><b>New page</b></p><div>iple samples simultaneously. They exploit every sample's reads to compensate for the low read-depth of individual samples. This improves polymorphism detection and genotype inference. It may be that small improvements in single-sample settings translate to larger gains in a multi-sample experiment. A study to investigate this is ongoing.&lt;br /&gt;&lt;br /&gt;Recalibrating MAPQ scores delivers modest improvements in single-sample variant calling results. Some variant callers operate on multiple samples simultaneously. They exploit every sample's reads to compensate for the low read-depth of individual samples. This improves polymorphism detection and genotype inference. It may be that small improvements in single-sample settings translate to larger gains in a multi-sample experiment. A study to investigate this is ongoing.&lt;br /&gt;&lt;br /&gt; A burn is an inflammatory injury to the skin or other tissue due to contact with thermal, radioactive, electric, or chemical agents. Burn injury is an important cause of disability and death worldwide. Obesity is a significant public health problem, often causing underlying systemic inflammation. Studying the combined impact of burn injuries on obese patients has become critical to the successful treatment of these patients. The aim of this paper is to highlight the effect of inflammation associated with burn injuries on several body weight group in a rat study.&lt;br /&gt;&lt;br /&gt; Different degrees of obesity and burns were established in rats and divided into a normal weight group, overweight group, obese group, second-degree burn group, third-degree burn group, over-weight second-degree burn group, over-weight third-degree burn group, obese second-degree burn group, and obese third-degree burn group (20 rats per group). Changes in inflammatory factors and growth factor were measured on the 1st, 3rd, 7th and 14th days after burns were inflicted.&lt;br /&gt;&lt;br /&gt; The ELISA test showed that in the unburned control group, MCP-1, IL-1β and TNF-α protein expressions in the obese and over-weight groups were higher than the normal-weight group (&lt;br /&gt;&lt;br /&gt; &amp;lt;0.05). RT-PCR test showed that the expressions of MCP-1, IL-1β and TNF-α genes in the obese group were higher compared to the overweight and normal weight groups (&lt;br /&gt;&lt;br /&gt; &amp;lt;0.05). Three and 7 days after burns were inflicted, the level of VEGF in the normal weight group was higher than the obese group (&lt;br /&gt;&lt;br /&gt; &amp;lt;0.05), however increased VEGF was not observed on days 1 and 14.&lt;br /&gt;&lt;br /&gt; Burn injury and obesity have a mutually synergistic effect on the body's inflammatory response.&lt;br /&gt;&lt;br /&gt;Burn injury and obesity have a mutually synergistic effect on the body's inflammatory response.Seagrasses are critical habitats for the recruitment and growth of juvenile penaeid shrimps within estuaries and coastal lagoons. The location of a seagrass bed within the lagoon can determine the value of a particular bed for shrimp populations. Consequently, differences in the abundance of shrimp can be found in seagrasses depending on their location. As shrimp density increases, density-dependent effects on biological parameters are more likely to occur. However, knowledge about density-dependent processes on shrimp populations in nursery habitats remains limited. The present investigation was undertaken to examine the effects of population density on shrimp condition in two selected seagrass beds, located at different distance from a tidal inlet, one 25 km away (distant) and the other 1 km away (nearby), in a subtropical coastal lagoon. The study was based on monthly samplings during one year in Laguna Madre (Mexico), performing a total of 36 shrimp trawls (100 m2 each one) within each seagrass bed (n = 3 occur, predominantly within seagrass beds near the tidal inlet. However, this hypothesis needs to be tested in future studies.&lt;br /&gt;&lt;br /&gt; Non-suicidal self-injury (NSSI) among adolescents is prevalent and its rate has increased in recent years worldwide. Previous studies had investigated the association between parenting and childhood NSSI, but little is known about the relationship between parental rearing and repetition and severity of NSSI. The aim of this study was to investigate associations of parenting with NSSI and its repetition and severity in a representative adolescent sample from southwestern China.&lt;br /&gt;&lt;br /&gt; In this cross-sectional study, a sample of 2,705 adolescents (F/M 1,245/1,460; mean age 13.4 ± 2.2 years) was recruited from 14 randomly selected schools in Lincang municipality, Yunnan province, China. A self-report questionnaire was used to collect data. The Adolescent Non-Suicidal Self-Injury Function Assessment Scale and the short Chinese Egna Minnen av Barndoms Uppfostran (s-EMBU-C) were used to evaluate NSSI behaviors and parenting style, respectively. Univariate and multivariate logistic regression models were adopted to exam).&lt;br /&gt;&lt;br /&gt; NSSI is common among adolescents in southwestern China. Negative parenting styles are associated with NSSI, repeated NSSI, and severe NSSI. The development of intervention measures for preventing or reducing NSSI among Chinese adolescents in school settings should consider parenting styles.&lt;br /&gt;&lt;br /&gt;NSSI is common among adolescents in southwestern China. Negative parenting styles are associated with NSSI, repeated NSSI, and severe NSSI. The development of intervention measures for preventing or reducing NSSI among Chinese adolescents in school settings should consider parenting styles.Carrot is an important root vegetable crop abundant in bioactive compounds including carotenoids, vitamins, and dietary fibers. Carrot intake and its products are gradually growing owing to its high antioxidant activity. Auxins are a class of plant hormones that control many processes of plant growth and development. Yet, the effects of exogenous application of auxin on lignin biosynthesis and gene expression profiles of lignin-related genes in carrot taproot are still unclear. [https://www.selleckchem.com/products/cct241533-hydrochloride.html CCT241533] In order to investigate the effect of exogenous indole-3-butyric acid (IBA) on lignin-related gene profiles, lignin accumulation, anatomical structures and morphological characteristics in carrot taproots, carrots were treated with different concentrations of IBA (0, 50, 100, and 150 µM). The results showed that IBA application significantly improved the growth parameters of carrot. The 100 or 150 µM IBA treatment increased the number and area of xylem vessels, whereas transcript levels of lignin-related genes were restricted, resulting in a decline in lignin content in carrot taproots.</div></summary> <author><name>Connollylara9849</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Weberbro9379</id> <title>User:Weberbro9379</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Weberbro9379"/> <updated>2025-07-01T19:49:57Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Weberbro9379&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Weberbro9379 (page does not exist)"><bdi>Weberbro9379</bdi></a> was created</p></summary> <author><name>Weberbro9379</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Hedeknudsen3902</id> <title>User:Hedeknudsen3902</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Hedeknudsen3902"/> <updated>2025-07-01T19:49:55Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Hedeknudsen3902&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Hedeknudsen3902 (page does not exist)"><bdi>Hedeknudsen3902</bdi></a> was created</p></summary> <author><name>Hedeknudsen3902</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Holdenakhtar5623&diff=3606965&oldid=0</id> <title>Holdenakhtar5623</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Holdenakhtar5623&diff=3606965&oldid=0"/> <updated>2025-07-01T19:49:51Z</updated> <summary type="html"><p>Created page with &quot;The results indicate that the ecological risk of CTC in the soil is possible and can be controlled by slurry pit farm practices.Ecological theories can be applied to improve a...&quot;</p><p><b>New page</b></p><div>The results indicate that the ecological risk of CTC in the soil is possible and can be controlled by slurry pit farm practices.Ecological theories can be applied to improve agricultural sustainability. In our study, a core hypothesis behind this claim is that &quot;selfish behaviour&quot; of rice cultivars results in &quot;aversion&quot; to a toxic substance in a multi-cropping system. We studied Changliangyou 772, a low-cadmium rice cultivar, cultivated with 11 different rice cultivars in intercropping and mixed systems. Rice cultivars with medium grain yield, ranging from 25 to 45 g plant-1, had distinctly higher yields in mixtures. Rice varieties with lower grain cadmium concentrations in monocultures had greater reductions in grain cadmium in the mixtures. In the intercropping systems, the yields of Changliangyou 772 were positively correlated with those of the neighbouring rice cultivars, while the grain cadmium showed a negative correlation with the grain cadmium of intercrops in the monocultures. The neighbouring cultivars with low grain cadmium concentrations in the intercropping showed higher cadmium concentrations in the monocultures. The intercropping and mixtures reduced the grain cadmium in two ways 1) they increased the soil pH, resulting in lower cadmium bioavailability; and 2) they enhanced the iron plaque (Ip). However, a high Ip or cadmium concentration that was too high in the Ip weakened the Ip to block cadmium uptake by the roots.Understanding the behavior of heavy metals in wastewater is critical for the development of metal removal and detection techniques. In this study, we characterize the dynamic and evolving size and partitioning behavior of lead (Pb), cadmium (Cd), and arsenite (As(III)) throughout the wastewater treatment train (WWTT). [https://www.selleckchem.com/products/3-o-methylquercetin.html 3-O-Methylquercetin supplier] Metal concentrations were determined in three size fractions (&amp;gt;0.45 μm, 0.45 μm - 5 kDa, and less then 5 kDa), and the partitioning/complexation of the metals was quantified for the less then 0.45 μm fraction. Cd was found to be highly mobile, with the fraction of dissolved Cd gradually increasing throughout the WWTT. As(III) was also highly mobile, with its size distribution and partitioning remaining largely steady, except when FeCl3 was used as a flocculation agent, which led to the formation of arsenic/iron complexes. However, Pb was found primarily in complex forms or adsorbed onto inorganic particulates. The WWTT had little impact on the size and partitioning of Pb, except that the formation of the Pb/iron complex occurred after flocculation with FeCl3. An increase of water hardness slightly increased the metals in the dissolved fraction. Overall, this study provides insight into the evolution of metals throughout the WWTT, offering guidance to users and researchers regarding their treatment and detection.Although it has recently been reported that notable amounts of rare earth elements (REEs) are present in the residual coal ash, little is currently known regarding the association of these elements with the coal ash matrix, thereby limiting the potential for extraction of REEs from coal ash. In this study, we analyzed the binding characteristics of REEs within coal ash via sequential extraction and examined REE recovery during a coal ash recycling process. Major components of coal ash were found to be mineral oxides, mainly composed of Si, Fe, Al, and Ca, and residual carbons. Bottom and fly ashes were found to contain 185.8 mg/kg and 179.2 mg/kg of REEs, respectively. Tessier sequential extraction confirmed that 85 % of REEs are included in the residual fraction of both bottom and fly ashes. Furthermore, BCR sequential extraction revealed that 60-70 % of REEs are contained within the residual fraction, thereby indicating that REEs are strongly bound in both bottom and fly ashes and the use of very strong acids is required for the thorough extraction of REEs from coal ash. Additionally, it was found that 46.3 % of REEs can be recovered from the wastewaters produced during the process of coal ash-derived zeolite synthesis.Microwave-assisted pyrolysis (MAP) of waste printed circuit boards (WPCB) was performed to investigate the characteristics of pyrolysis product and Br fixation. Pyrolysis conversion increased with increasing temperature, reaching 93.3 % at 650 °C. However, increasing heating time did not exhibit remarkable influence on pyrolysis conversion. At 350 °C, phenols were main compounds in the oil accounting for 91.15 %. As the temperature increased to 650 °C, polycyclic aromatic hydrocarbons and monocyclic aromatic hydrocarbons (except phenols) increased to 20.55 % and 19.03 %, respectively. Meanwhile, the total content of CO2, CO, CH4 and H2 in the non-condensable gases increased significantly. Addition of ZSM-5 and kaolin promoted the recombination reaction of pyrolysis products, increased the relative percentage of monocyclic aromatic hydrocarbons (except phenols) and C11-C20 compounds in the oil, and reduced non-condensable gases. The oxygen bomb-ion chromatography was used to evaluate the Br content of pyrolysis residues. Higher pyrolysis temperature enhanced transfer of Br to pyrolysis gas. K2CO3, Na2CO3 and NaOH reacted with hydrogen bromide to generate KBr and NaBr, which significantly improved the Br fixation efficiency of pyrolysis residues (i.e. from 29.11%-99.80%, 96.39 % and 86.69 %, respectively) and reduced Br content in pyrolysis gas.In this study, Pretilachlor polyurea microencapsulate suspension (PMS) with effective controlled release function was carefully prepared. Under the optimal conditions, wall material PM-200 dosage 4%, emulsifier T-60 dosage 4% with S-20 as solvent, the prepared PMS was demonstrated to have encapsulation efficiency approaching to 95.27 ± 0.57 % and high suspension rates of 97.33 ± 0.49 %. Afterwards, PMS was proved to possess average release rate reached to 85.56 %, 55.46 % and 15.85 % respectively in acidic, basic and natural medium. Subsequently, the herbicidal activity of PMS on barnyard grass and the growth safety of rice were evaluated. PMS showed enhanced herbicidal activity against barnyard grass and had lower toxicity to rice growth compared with technical pretilachlor at dose 270-540 g (a.i.)/hm2. In addition, the use safety of PMS was validated to be comparable to that of commercially available pretilachlor emulsifiable concentrate containing additive safener at dose 270-540 g (a.i.)/hm2. Moreover, inhibitory effect of PMS on rice growth was demonstrated to completely eliminated by cooperatively treatment with fenclorim.</div></summary> <author><name>Holdenakhtar5623</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Forrestsong5811&diff=3606964&oldid=0</id> <title>Forrestsong5811</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Forrestsong5811&diff=3606964&oldid=0"/> <updated>2025-07-01T19:49:48Z</updated> <summary type="html"><p>Created page with &quot;Biodiversity of native yeasts, especially in winemaking, has hidden potential. In order to use the value of non-Saccharomyces strains in wine production and to minimise the po...&quot;</p><p><b>New page</b></p><div>Biodiversity of native yeasts, especially in winemaking, has hidden potential. In order to use the value of non-Saccharomyces strains in wine production and to minimise the possibility of its deterioration, it is necessary to thoroughly study the yeast cultures present on grape fruits and in grape must, as well as their metabolic properties. The aim of the study was to characterise the yeast microbiota found during spontaneous fermentation of grape musts obtained from grape varieties 'Rondo', 'Regent' and 'Johanniter'. Grapes from two vineyards (Srebrna Góra and Zadora) located in southern Poland were used for the research. Succession of subsequent groups of yeasts was observed during the process. Metschnikowia pulcherrima yeasts were identified both at the beginning and the end of the process. Hanseniaspora uvarum, Wickerhamomyces onychis and Torulaspora delbrueckii strains were also identified during the fermentation. Torulaspora delbrueckii and Wickerhamomyces onychis strains were identified only in grape musts obtained from grapes of the Zadora vineyard. These strains may be characteristic of this vineyard and shape the identity of wines formed in it. Our research has provided specific knowledge on the biodiversity of yeast cultures on grapes and during their spontaneous fermentation. The research results presented indicate the possibility of using native strains for fermentation of grape musts, allowing to obtain a product with favourable chemical composition and sensory profile.SAM68 is an mRNA-binding protein involved in mRNA processing in the nucleus that forms membraneless compartments called SAM68 Nuclear Bodies (SNBs). We found that intersectin 1 (ITSN1), a multidomain scaffold protein harboring five soluble SH3 domains, interacts with SAM68 proline-rich motifs (PRMs) surrounded by self-adhesive low complexity domains. While SAM68 is poorly soluble in vitro, the interaction of ITSN1 SH3 domains and mRNA with SAM68 enhances its solubility. In HeLa cells, the interaction between the first ITSN1 SH3 domain (SH3A) and P0, the N-terminal PRM of SAM68, induces the dissociation of SNBs. In addition, we reveal the ability of another SH3 domain (SH3D) of ITSN1 to bind to mRNAs. ITSN1 and mRNA may thus act in concert to promote SAM68 solubilization, consistent with the absence of mRNA in SNBs in cells. Together, these results support the notion of a specific chaperoning of PRM-rich SAM68 within nuclear ribonucleoprotein complexes by ITSN1 that may regulate the processing of a fraction of nuclear mRNAs, notably SAM68-controlled splicing events related to higher neuronal functions or cancer progression. This observation may also serve as a putative model of the interaction between other PRM-rich RBPs and signaling proteins harboring SH3 domains.Currently, a novel coronavirus (SARS-CoV-2, also called 2019-nCoV) has triggered pandemic Coronavirus Disease 2019 (COVID-19), an acute infectious respiratory disease that first became epidemic in Wuhan (China) and is now spreading worldwide. Although 2019-nCoV and SARS-CoV are very similar viruses genomically and structurally, the huge number of severe cases and deaths now being caused by 2019-nCoV infections has understandably prompted intense research on the receptor used by it to enter human cells. Angiotensin converting enzyme 2 (ACE2), a functional receptor for SARS-CoV, now appears likely to mediate 2019-nCoV entry into human cells. In this review, we describe the roles performed by ACE2 as an enzymatic catalyst and as a receptor for this novel coronavirus. We also summarize the latest research pertaining to the changes noted in ACE2 expression after viral binding, and the relationships relating to virus transmission and population susceptibility to it. Lastly, we speculate on the pathogenesis of COVID-19 and provide a useful reference for drug development against this aggressive virus.&lt;br /&gt;&lt;br /&gt; Postoperative C5 palsy is a debilitating complication following posterior cervical decompression.&lt;br /&gt;&lt;br /&gt; To create a simple clinical risk score predicting the occurrence of C5 palsy.&lt;br /&gt;&lt;br /&gt; We retrospectively reviewed all patients who underwent posterior cervical decompressions between 2007 and 2017. Data was randomly split into training and validation datasets. Multivariable analysis was performed to construct the model from the training dataset. A scoring system was developed based on the model coefficients and a web-based calculator was deployed.&lt;br /&gt;&lt;br /&gt; The cohort consisted of 415 patients, of which 65 (16%) developed C5 palsy. [https://www.selleckchem.com/products/golidocitinib-1-hydroxy-2-naphthoate.html JAK inhibitor] The optimal model consisted of mean C4/5 foraminal diameter (odds ratio [OR] = 9.1 for lowest quartile compared to highest quartile), preoperative C5 radiculopathy (OR=3.5), and dexterity loss (OR=2.9). The receiver operating characteristic yielded an area under the curve of 0.757 and 0.706 in the training and validation datasets, respectively. Every characteristic was worth 1 point except the lurthermore, modifying the surgical plan in high-risk patients may possibly improve outcomes.&lt;br /&gt;&lt;br /&gt; Slowing myopia progression could decrease the risk of sight-threatening complications.&lt;br /&gt;&lt;br /&gt; To determine whether soft multifocal contact lenses slow myopia progression in children, and whether high add power (+2.50 D) slows myopia progression more than medium (+1.50 D) add power lenses.&lt;br /&gt;&lt;br /&gt; A double-masked randomized clinical trial that took place at 2 optometry schools located in Columbus, Ohio, and Houston, Texas. A total of 294 consecutive eligible children aged 7 to 11 years with -0.75 D to -5.00 D of spherical component myopia and less than 1.00 D astigmatism were enrolled between September 22, 2014, and June 20, 2016. Follow-up was completed June 24, 2019.&lt;br /&gt;&lt;br /&gt; Participants were randomly assigned to wear high add power (n = 98), medium add power (n = 98), or single-vision (n = 98) contact lenses.&lt;br /&gt;&lt;br /&gt; The primary outcome was the 3-year change in cycloplegic spherical equivalent autorefraction, as measured by the mean of 10 autorefraction readings. There were 11 secondary end points, 4 of which were analyzed for add power, and -0.07 mm (95% CI, -0.14 to -0.01) for medium add power vs single vision.&lt;br /&gt;&lt;br /&gt; Among children with myopia, treatment with high add power multifocal contact lenses significantly reduced the rate of myopia progression over 3 years compared with medium add power multifocal and single-vision contact lenses. However, further research is needed to understand the clinical importance of the observed differences.&lt;br /&gt;&lt;br /&gt; ClinicalTrials.gov Identifier NCT02255474.&lt;br /&gt;&lt;br /&gt;ClinicalTrials.gov Identifier NCT02255474.</div></summary> <author><name>Forrestsong5811</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Purcellmoon7951</id> <title>User:Purcellmoon7951</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Purcellmoon7951"/> <updated>2025-07-01T19:49:41Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Purcellmoon7951&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Purcellmoon7951 (page does not exist)"><bdi>Purcellmoon7951</bdi></a> was created</p></summary> <author><name>Purcellmoon7951</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Rodriguezdowns3145&diff=3606963&oldid=0</id> <title>Rodriguezdowns3145</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Rodriguezdowns3145&diff=3606963&oldid=0"/> <updated>2025-07-01T19:49:30Z</updated> <summary type="html"><p>Created page with &quot;The classification of ileal and colonic Crohn&#039;s disease as distinct subphenotypes is well supported by the literature. Understanding of these differences could be exploited to...&quot;</p><p><b>New page</b></p><div>The classification of ileal and colonic Crohn's disease as distinct subphenotypes is well supported by the literature. Understanding of these differences could be exploited to develop more individualised patient care.&lt;br /&gt;&lt;br /&gt; The growing consumers' preferences and concerns regarding healthy ageing, youthful skin appearance, environmental protection and sustainability have triggered an ever-increasing trend towards natural, eco-friendly and ethically sourced anti-ageing products. Accordingly, this paper describes design and evaluation of novel, safe, effective and high-quality emulsion serums, completely based on ingredients of natural origin, intended for improving facial fine lines and wrinkles.&lt;br /&gt;&lt;br /&gt; Model formulations, stabilized by an innovative glycolipid mixed emulsifier (lauryl glucoside/myristyl glucoside/polyglyceryl-6 laurate) and containing Acmella oleracea extract as a model anti-ageing active, were prepared by cold process and fully assessed regarding their rheological behaviour (continuous rotational and oscillatory tests) and physical stability (dynamic-mechanical thermoanalysis - DMTA test). To study and optimize the simultaneous influence of varied formulation factors (emollients and emulsifier concentrations) on crvivo evaluations. Screening of skin irritation effects revealed the absence of potential irritancy of investigated serum, suggesting overall satisfying skin tolerability/preliminary safety. Silicone skin replica image analysis demonstrated noticeable reduction/improvement in all measured skin wrinkle parameters after only 2weeks of test serum application in periorbital and perioral areas, indicating its rapid and beneficial effects on the facial expression lines and wrinkles.&lt;br /&gt;&lt;br /&gt; Altogether, the results corroborate the promising potential of the developed Acmella oleracea extract-loaded emulsion serum as safe, effective and non-invasive natural anti-wrinkle product.&lt;br /&gt;&lt;br /&gt;Altogether, the results corroborate the promising potential of the developed Acmella oleracea extract-loaded emulsion serum as safe, effective and non-invasive natural anti-wrinkle product.Concomitant presence of acute type A dissection, coarctation of aorta and levoatriocardinal vein has not been described. We here present a case of aortic anuerysm complicated by type A dissection with coarctation of aorta and levoatriocardinal vein.Three decades ago, the observation that first trimester fetuses with excess fluid accumulation at the back of the neck were more likely to be aneuploid, gave rise to a new era of prenatal screening. The nuchal translucency (NT) measurement in combination with serum biomarkers and maternal age, resulted in the first trimester combined screening (FTCS) program. The introduction of noninvasive prenatal testing (NIPT) over the past decade has introduced the option for parents to receive highly sensitive and specific screening information for common trisomy from as early as 10 weeks gestation, altering the traditional pathway FTCS pathway. The retention of the 11-13-week NT ultrasound remains important in the detection of structural anomalies; however, the optimal management of pregnancies with a low-risk NIPT result and an isolated increased NT measurement in an era of advanced genomic testing options is a new dilemma for clinicians. For parents, the prolonged period between the initial diagnosis in first trimester, and prognostic information at each successive stage of investigations up to 22-24 weeks, can be emotionally challenging. This article addresses the common questions from parents and clinicians as they navigate the uncertainty of having a fetus diagnosed with an increased NT after a low-risk NIPT result and presents suggested approaches to management.&lt;br /&gt;&lt;br /&gt; Anti-3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMGCR) myopathy is a rare but serious complication of statin use. The aim of this study was to describe the imaging features of statin-associated anti-HMGCR myopathy on thigh muscle magnetic resonance imaging (MRI).&lt;br /&gt;&lt;br /&gt; Thigh muscle MRI images of six patients with statin-associated anti-HMGCR myopathy were reviewed for muscle edema, fatty replacement, and fascial edema in four compartments of each thigh gluteal, anterior, medial, and posterior. Signal intensity ratio (SIR) was calculated in 17 muscles in both thighs on T2-weighted fat-suppressed images. Intracompartmental comparison of T2 SIRs of different muscles were performed.&lt;br /&gt;&lt;br /&gt; All patients demonstrated bilateral symmetrical pan-compartmental muscle edema. Three patients had fatty infiltration, involving gluteal and/or posterior compartments. In the anterior compartment, rectus femoris and vastus lateralis most frequently demonstrated the highest T2 SIR. In the posterior compartment, semimembranosus most frequently demonstrated the highest T2 SIR. [https://www.selleckchem.com/products/agk2.html Selleckchem AGK2] The long head of the biceps femoris always had a higher T2 SIR than the short head.&lt;br /&gt;&lt;br /&gt; Statin-associated anti-HMGCR myopathy commonly demonstrates bilateral symmetrical pan-compartmental edema on thigh muscle MRI, with anterolateral predilection in the anterior compartment, and greater involvement of the semimembranosus with relative sparing of the short head of the biceps femoris in the posterior compartment. These observations can contribute to the diagnosis of statin-associated anti-HMGCR myopathy.&lt;br /&gt;&lt;br /&gt;Statin-associated anti-HMGCR myopathy commonly demonstrates bilateral symmetrical pan-compartmental edema on thigh muscle MRI, with anterolateral predilection in the anterior compartment, and greater involvement of the semimembranosus with relative sparing of the short head of the biceps femoris in the posterior compartment. These observations can contribute to the diagnosis of statin-associated anti-HMGCR myopathy.Kaposi's sarcoma-associated herpesvirus (KSHV) is an oncogenic virus associated with several human malignancies. KSHV lytic replication promotes the spread of infection and progression of KSHV-associated malignancies; however, the mechanism regulating KSHV lytic replication remains unclear. In this study, we investigated the role of nitric oxide (NO) in KSHV lytic replication. In the TREx BCBL1-RTA KSHV lytic replication cell system, induction of KSHV lytic replication increased intracellular and extracellular NO. Chemical inhibition of NO production resulted in a lower level of KSHV lytic replication as shown by a reduced level of infectious virions, and decreased levels of viral lytic transcripts and proteins. In a second KSHV lytic replication system of iSLK-RGB-BAC16 cells, we confirmed that KSHV lytic replication increased NO production. Chemical inhibition of NO production resulted in reduced numbers of cells expressing enhanced green fluorescent protein and blue fluorescent protein, two reporters that closely track the expression of KSHV early and late genes, respectively.</div></summary> <author><name>Rodriguezdowns3145</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Bandar_Judi_Online_Bonus_Besar_Banyak_Disenangi&diff=3606962&oldid=3409037</id> <title>Bandar Judi Online Bonus Besar Banyak Disenangi</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Bandar_Judi_Online_Bonus_Besar_Banyak_Disenangi&diff=3606962&oldid=3409037"/> <updated>2025-07-01T19:49:18Z</updated> <summary type="html"><p></p><table class="diff diff-contentalign-left" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr style="vertical-align: top;" lang="en"> <td colspan="2" style="background-color: white; color:black; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: white; color:black; text-align: center;">Revision as of 19:49, 1 July 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l1" >Line 1:</td><td colspan="2" class="diff-lineno">Line 1:</td></tr><tr><td class='diff-marker'>−</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div>Broker judi online buat mengerjakan penempatan bet waktu ini <del class="diffchange diffchange-inline">benar-benar begitu begitu </del>banyak yang dapat diputuskan. <del class="diffchange diffchange-inline">Dalam perihal tersebut pastinya </del>beberapa bettor akan temukan untung yang besar dari <del class="diffchange diffchange-inline">bermain </del>judi online yang <del class="diffchange diffchange-inline">waktu </del>ini <del class="diffchange diffchange-inline">lebih </del>ringan <del class="diffchange diffchange-inline">buat </del>dikerjakan. <del class="diffchange diffchange-inline">[https://dripwinter.com/ hoki311] Support buat kerjakan </del>bet sekarang tentunya lebih gampang <del class="diffchange diffchange-inline">serta </del>dapat <del class="diffchange diffchange-inline">diperoleh </del>oleh <del class="diffchange diffchange-inline">banyak </del>bettor dengan lega. Ada begitu banyak <del class="diffchange diffchange-inline">alternatif website </del>agen atau Bandar taruhan judi yang <del class="diffchange diffchange-inline">benar-benar ada dan </del>dapat kita putuskan dan tidak semua <del class="diffchange diffchange-inline">memang </del>tawarkan bonus besar. <del class="diffchange diffchange-inline">Untuk </del>dapat <del class="diffchange diffchange-inline">mendapati </del>salah satunya opsi yang tawarkan bonus besar, kita <del class="diffchange diffchange-inline">seharusnya </del>Coba melakukan <del class="diffchange diffchange-inline">penelusuran </del>terlebih dulu hingga <del class="diffchange diffchange-inline">sampai lantas </del>kita dapat mendapatkan <del class="diffchange diffchange-inline">salah satunya alternatif </del>yang terunggul.&lt;br /&gt;&lt;br /&gt;<del class="diffchange diffchange-inline">Kelapangan dalam lakukan </del>bet online <del class="diffchange diffchange-inline">waktu </del>ini <del class="diffchange diffchange-inline">pasti </del>dengan <del class="diffchange diffchange-inline">dukungan </del>dari bandar bet online yang <del class="diffchange diffchange-inline">selalu </del>berikan semua <del class="diffchange diffchange-inline">keringanan </del>buat <del class="diffchange diffchange-inline">lakukan </del>bet. Apabila bet <del class="diffchange diffchange-inline">dikerjakan secara </del>tepat <del class="diffchange diffchange-inline">serta </del>sesuai <del class="diffchange diffchange-inline">rancangan </del>tujuan bet yang seharunya <del class="diffchange diffchange-inline">karenanya </del>dalam perihal <del class="diffchange diffchange-inline">tersebut </del>kemenangan <del class="diffchange diffchange-inline">serta </del>keuntungan yang <del class="diffchange diffchange-inline">banyak </del>bakal <del class="diffchange diffchange-inline">terus-menerus digapai </del>banyak bettor. 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Bonus yang dijajakannya itu bahwasanya banyak <del class="diffchange diffchange-inline">sekali </del>tetapi <del class="diffchange diffchange-inline">pastinya </del>tidak <del class="diffchange diffchange-inline">segalanya </del>dapat <del class="diffchange diffchange-inline">diyakini tapi </del>ada diantaranya yang palsu <del class="diffchange diffchange-inline">serta </del>penipu. <del class="diffchange diffchange-inline">Menjadi </del>evaluasi pastinya anda mesti dapat mengenali beberapa <del class="diffchange diffchange-inline">tipe </del>bonus yang <del class="diffchange diffchange-inline">dikatakan </del>salah satunya <del class="diffchange diffchange-inline">merupakan</del>:&lt;br /&gt;&lt;br /&gt;1. Bonus <del class="diffchange diffchange-inline">peserta </del>anyar - ini yaitu <del class="diffchange diffchange-inline">type </del>bonus pertama<del class="diffchange diffchange-inline">-tama </del>yang waktu ini lebih banyak dijajakan serta menjadi satu diantara bonus umum. <del class="diffchange diffchange-inline">Metode </del>yang dapat <del class="diffchange diffchange-inline">dijalankan buat </del>dapat <del class="diffchange diffchange-inline">mendapat </del>bonus ini pula amatlah <del class="diffchange diffchange-inline">gampang dijalankan</del>. Siapa-siapa saja dapat melaksanakannya <del class="diffchange diffchange-inline">terhitung beberapa </del>pemula sebab Ketentuannya hanya butuh mendaftarkan account.&lt;br /&gt;&lt;br /&gt;2. Bonus komisi referal - <del class="diffchange diffchange-inline">sesudah </del>itu ada juga macam bonus yang lain dijajakan <del class="diffchange diffchange-inline">umumnya dikatakan </del>dengan bonus komisi referal. Bonus itu menjadi salah satunya opsi model bonus yang <del class="diffchange diffchange-inline">memikat buat </del>dicoba diputuskan <del class="diffchange diffchange-inline">dan </del>dipakai. <del class="diffchange diffchange-inline">Trik </del>kerjanya pula perlu <del class="diffchange diffchange-inline">menerima </del>orang <del class="diffchange diffchange-inline">buat </del>masuk lewat link referal anda.&lt;br /&gt;&lt;br /&gt;3. Bonus rollingan - tipe bonus <del class="diffchange diffchange-inline">seterusnya </del>yang pula banyak dijajakan ialah model bonus rollingan. Bonus yang <del class="diffchange diffchange-inline">satu </del>berikut <del class="diffchange diffchange-inline">umumnya ditawari </del>untuk banyak <del class="diffchange diffchange-inline">anggota anyar</del>. <del class="diffchange diffchange-inline">Maknanya </del>memanglah Anda <del class="diffchange diffchange-inline">bisa </del>mencoba <del class="diffchange diffchange-inline">menjadi </del>anggota baru <del class="diffchange diffchange-inline">biar </del>anda <del class="diffchange diffchange-inline">dapat </del>mencoba pahami beberapa ketentuannya <del class="diffchange diffchange-inline">termaksud </del>deposit.&lt;br /&gt;&lt;br /&gt;Beberapa <del class="diffchange diffchange-inline">tipe </del>bonus di atas lah yang selanjutnya <del class="diffchange diffchange-inline">sekian lama ini termashyur juga </del>banyak yang coba penuhi kriteria nya <del class="diffchange diffchange-inline">buat </del>dapat <del class="diffchange diffchange-inline">memperoleh </del>bonus judi online.&lt;br /&gt;&lt;br /&gt;Check copyscape; http://prntscr.com/zb83cb&lt;br /&gt;&lt;br /&gt;</div></td><td class='diff-marker'>+</td><td style="color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div>Broker judi online buat mengerjakan penempatan bet waktu ini <ins class="diffchange diffchange-inline">amat sangat </ins>banyak yang dapat diputuskan. <ins class="diffchange diffchange-inline">Di dalam masalah ini tentunya </ins>beberapa bettor akan temukan untung yang besar dari <ins class="diffchange diffchange-inline">main </ins>judi online yang <ins class="diffchange diffchange-inline">sekarang </ins>ini <ins class="diffchange diffchange-inline">kian </ins>ringan <ins class="diffchange diffchange-inline">untuk </ins>dikerjakan. <ins class="diffchange diffchange-inline">Dukungan untuk lakukan </ins>bet sekarang <ins class="diffchange diffchange-inline">ini </ins>tentunya lebih gampang <ins class="diffchange diffchange-inline">dan </ins>dapat <ins class="diffchange diffchange-inline">diterima </ins>oleh <ins class="diffchange diffchange-inline">beberapa </ins>bettor dengan lega. Ada begitu banyak <ins class="diffchange diffchange-inline">opsi web </ins>agen atau Bandar taruhan judi yang <ins class="diffchange diffchange-inline">siap serta </ins>dapat kita putuskan dan tidak semua <ins class="diffchange diffchange-inline">memanglah </ins>tawarkan bonus besar. <ins class="diffchange diffchange-inline">Buat </ins>dapat <ins class="diffchange diffchange-inline">mendapatkan </ins>salah satunya opsi yang tawarkan bonus besar, kita <ins class="diffchange diffchange-inline">baiknya </ins>Coba melakukan <ins class="diffchange diffchange-inline">pelacakan </ins>terlebih dulu hingga <ins class="diffchange diffchange-inline">setelah itu </ins>kita dapat mendapatkan <ins class="diffchange diffchange-inline">satu diantaranya opsi </ins>yang terunggul.&lt;br /&gt;&lt;br /&gt;<ins class="diffchange diffchange-inline">Keringanan saat kerjakan </ins>bet online <ins class="diffchange diffchange-inline">sekarang </ins>ini <ins class="diffchange diffchange-inline">pastinya </ins>dengan <ins class="diffchange diffchange-inline">support </ins>dari bandar bet online yang <ins class="diffchange diffchange-inline">terus-menerus </ins>berikan semua <ins class="diffchange diffchange-inline">keluasaan </ins>buat <ins class="diffchange diffchange-inline">kerjakan </ins>bet. Apabila bet <ins class="diffchange diffchange-inline">dijalankan dengan cara </ins>tepat <ins class="diffchange diffchange-inline">dan </ins>sesuai <ins class="diffchange diffchange-inline">prinsip </ins>tujuan bet yang seharunya <ins class="diffchange diffchange-inline">karena itu di </ins>dalam perihal <ins class="diffchange diffchange-inline">ini </ins>kemenangan <ins class="diffchange diffchange-inline">dan </ins>keuntungan yang <ins class="diffchange diffchange-inline">besar </ins>bakal <ins class="diffchange diffchange-inline">selalu diperoleh </ins>banyak bettor. Kemenangan besar amatlah <ins class="diffchange diffchange-inline">kemungkinan </ins>serta benar-benar habisnya <ins class="diffchange diffchange-inline">untuk </ins>kita <ins class="diffchange diffchange-inline">temukan bila </ins>kita <ins class="diffchange diffchange-inline">memang dapat </ins>masuk <ins class="diffchange diffchange-inline">dan </ins>main di <ins class="diffchange diffchange-inline">satu diantaranya </ins>opsi bandar yang <ins class="diffchange diffchange-inline">cocok </ins>yang benar-benar <ins class="diffchange diffchange-inline">tawarkan </ins>Beberapa kelebihan.&lt;br /&gt;&lt;br /&gt;<ins class="diffchange diffchange-inline">Variasi Bonus yang Dijajakan Bandar Judi Online</ins>&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;&lt;br /&gt;<ins class="diffchange diffchange-inline">Pastinya </ins>Anda mesti dapat mencoba cari info serta Dalami perihal beberapa <ins class="diffchange diffchange-inline">macam </ins>bonus yang <ins class="diffchange diffchange-inline">sepanjang </ins>ini lebih banyak <ins class="diffchange diffchange-inline">disodori sama </ins>situs <ins class="diffchange diffchange-inline">Broker </ins>judi online terpercaya dan terbaik. Bonus yang dijajakannya itu bahwasanya banyak <ins class="diffchange diffchange-inline">akan </ins>tetapi <ins class="diffchange diffchange-inline">tentu saja </ins>tidak <ins class="diffchange diffchange-inline">seluruhnya </ins>dapat <ins class="diffchange diffchange-inline">diakui akan tetapi </ins>ada <ins class="diffchange diffchange-inline">satu </ins>diantaranya yang palsu <ins class="diffchange diffchange-inline">dan </ins>penipu. <ins class="diffchange diffchange-inline">Sebagai </ins>evaluasi pastinya anda mesti dapat mengenali beberapa <ins class="diffchange diffchange-inline">model </ins>bonus yang <ins class="diffchange diffchange-inline">diterangkan </ins>salah satunya <ins class="diffchange diffchange-inline">yaitu</ins>:&lt;br /&gt;&lt;br /&gt;1. <ins class="diffchange diffchange-inline">[https://www.lacktr.com/ ratu311] </ins>Bonus <ins class="diffchange diffchange-inline">anggota </ins>anyar - ini yaitu <ins class="diffchange diffchange-inline">macam </ins>bonus pertama <ins class="diffchange diffchange-inline">kali </ins>yang waktu ini lebih banyak dijajakan serta menjadi satu diantara bonus umum. <ins class="diffchange diffchange-inline">Langkah </ins>yang dapat <ins class="diffchange diffchange-inline">dilaksanakan untuk </ins>dapat <ins class="diffchange diffchange-inline">memperoleh </ins>bonus ini pula amatlah <ins class="diffchange diffchange-inline">simpel dikerjakan</ins>. Siapa-siapa saja dapat melaksanakannya <ins class="diffchange diffchange-inline">tergolong banyak </ins>pemula sebab Ketentuannya hanya butuh mendaftarkan account.&lt;br /&gt;&lt;br /&gt;2. Bonus komisi referal - <ins class="diffchange diffchange-inline">setelah </ins>itu ada juga macam bonus yang lain dijajakan <ins class="diffchange diffchange-inline">kebanyakan disebutkan </ins>dengan bonus komisi referal. Bonus itu menjadi salah satunya opsi model bonus yang <ins class="diffchange diffchange-inline">bagus untuk </ins>dicoba diputuskan <ins class="diffchange diffchange-inline">serta </ins>dipakai. <ins class="diffchange diffchange-inline">Metode </ins>kerjanya pula perlu <ins class="diffchange diffchange-inline">menarik </ins>orang <ins class="diffchange diffchange-inline">untuk </ins>masuk lewat link referal anda.&lt;br /&gt;&lt;br /&gt;3. Bonus rollingan - tipe bonus <ins class="diffchange diffchange-inline">setelah itu </ins>yang pula banyak dijajakan ialah model bonus rollingan. Bonus yang berikut <ins class="diffchange diffchange-inline">kebanyakan disodori </ins>untuk banyak <ins class="diffchange diffchange-inline">peserta baru</ins>. <ins class="diffchange diffchange-inline">Berarti </ins>memanglah Anda <ins class="diffchange diffchange-inline">dapat </ins>mencoba <ins class="diffchange diffchange-inline">untuk jadi </ins>anggota baru <ins class="diffchange diffchange-inline">supaya </ins>anda <ins class="diffchange diffchange-inline">bisa </ins>mencoba pahami beberapa ketentuannya <ins class="diffchange diffchange-inline">tergolong </ins>deposit.&lt;br /&gt;&lt;br /&gt;Beberapa <ins class="diffchange diffchange-inline">model </ins>bonus di atas lah yang selanjutnya <ins class="diffchange diffchange-inline">sampai kini popular dan </ins>banyak yang coba penuhi kriteria nya <ins class="diffchange diffchange-inline">untuk </ins>dapat <ins class="diffchange diffchange-inline">mendapati </ins>bonus judi online.&lt;br /&gt;&lt;br /&gt;Check copyscape; http://prntscr.com/zb83cb&lt;br /&gt;&lt;br /&gt;</div></td></tr></table></summary> <author><name>Polojune73</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Herrerawolf0623&diff=3606961&oldid=0</id> <title>Herrerawolf0623</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Herrerawolf0623&diff=3606961&oldid=0"/> <updated>2025-07-01T19:49:15Z</updated> <summary type="html"><p>Created page with &quot;Background Nipple pain is a common cause of early cessation of breastfeeding. A nipple shield (shield) is often used to improve breastfeeding comfort. There are concerns that...&quot;</p><p><b>New page</b></p><div>Background Nipple pain is a common cause of early cessation of breastfeeding. A nipple shield (shield) is often used to improve breastfeeding comfort. There are concerns that shield use may limit milk transfer. The aims of this study were to determine whether shield use reduces milk transfer and maternal nipple pain. Methods A within-subject study of two groups of breastfeeding dyads (infants less then 6 months) was conducted; Control Group (CG) no breastfeeding difficulties; Pain Group (PG) shield used for nipple pain. There were two monitored sessions where shield use was randomized. Test weights and pain questionnaires were completed, and percentage of available milk removed (PAMR) was calculated. Results Twenty-five PG (6 ± 4 postnatal weeks) and 34 CG (9 ± 6 postnatal weeks) had similar 24-hour milk production (PG 676 ± 239 mL, CG 775 ± 162 mL, p = 0.083). PG mean milk transfer volume and PAMR did not differ with shield use (no shield 46 mL, 59%; shield 40 mL, 53%, volume p = 0.38, PAMR p = 0.64). CG mean volume and PAMR were reduced with shield use (no shield 65 mL, 64%; shield 31 mL, 33%, volume p less then 0.001, PAMR p less then 0.001). PG pain scores were similar with and without shield use (Visual Analog Scale p = 0.44, McGill p = 0.97). Conclusions Shield use did not impact either milk production or milk transfer in breastfeeding women experiencing nipple pain.&lt;br /&gt;&lt;br /&gt; To reach expert consensus on a definition for recovery following minor and moderate road traffic crash-related injuries and key factors that influence recovery, and to explore expert perspectives on risk identification methods.&lt;br /&gt;&lt;br /&gt; A three-round Delphi study was conducted in which 47 experts (insurance representatives, health care professionals and researchers) were consulted.&lt;br /&gt;&lt;br /&gt; Strong expert agreement (86%) was reached for the definition &quot;&lt;br /&gt;&lt;br /&gt; Agreed key factors that influenced recovery included resilience; coping skills; recovery expectations; pre-existing physical and mental health; workplace support; and, collaboration between the injured individual, treating providers and claim handlers. Expert perspectives on risk identification methods were mixed.&lt;br /&gt;&lt;br /&gt; An accepted definition for recovery following minor and moderate road traffic crash-related injury was established, which could facilitate communication and engagement between different rehabilitation stakeholders. Strong consensus was achieved on nine key fa-related injuries.&lt;br /&gt;&lt;br /&gt; Sexual health, a basic human right, maybe disrupted after a spinal cord injury (SCI) and is often not addressed in rehabilitation. [https://www.selleckchem.com/products/ve-822.html ATR inhibitor] This quality improvement initiative embedded sexual health education and support for patients with SCI into clinical practice.&lt;br /&gt;&lt;br /&gt; In 2017-2018 a team of clinicians, researchers and persons with SCI developed and implemented a new sexual health practice in SCI rehabilitation. A systematic process was undertaken which included implementation science principles; the PLISSIT model and Sexual Rehabilitation Framework were foundational to the new practice.&lt;br /&gt;&lt;br /&gt; Adult inpatients with SCI began receiving the sexual health practice in June 2018. After 6 months, patient and health care provider surveys were conducted. Patients reported increased awareness of sexual health resources and increased satisfaction with sexual health concerns being addressed. Clinicians reported increased comfort in addressing patients' sexual health concerns and increased awareness of sexual health resources.&lt;br /&gt;&lt;br /&gt; Embves of SCI patients and supports a more comprehensive and holistic rehabilitation. It normalizes sexual health concerns and questions in an SCI rehabilitation facility. IMPLICATIONS FOR REHABILITATION Sexual health is noted to be a top priority among persons with spinal cord injury, however, this area of care is often overlooked by healthcare providers across the rehabilitation continuum. A team of clinicians, researchers, and persons with SCI used a systematic process to address this gap by developing and implementing a new sexual health practice in the SCI rehabilitation program. This quality improvement initiative resulted in increased clinician knowledge and confidence in this domain of practice and greater patient satisfaction in having their sexual health needs to be addressed during rehabilitation.In late 2020, the Supreme Court began hearing a case challenging the Affordable Care Act (ACA), which led to coverage gains for many low-income, reproductive-age women. To explore potential implications of a full ACA repeal for this population, we examined gains experienced after Medicaid expansion, assuming that such gains may be reversed. Using restricted 2013 to 2014 data from the Medical Expenditure Panel Survey for 1190 women ages 18 to 44 with household incomes below 138% of the federal poverty level, we compared the change in healthcare spending and utilization for women living in expansion states to the change in non-expansion states using a difference-in-differences design. We found that if Medicaid expansion were overturned, Medicaid coverage is likely to decrease, as well as Medicaid spending and prescription drug utilization.Although studies point to a relationship between debt and crime, there is a limited understanding of their reciprocal relationship and possible mediating risk factors. Moreover, knowledge about the prevalence and scope of debt among offenders is lacking. Therefore, the present study analyzed 250 client files including risk assessment data from the Dutch probation service on the prevalence of debt and possibly related risk factors. The results show that debt is highly prevalent and complex, which underlines the importance of acquiring more knowledge about debt as a potential risk factor for relapse during supervision. It was found that problems with regard to childhood and living situation, education and work/daytime activities, and mental and physical health may be possible underlying risk factors in the relationship between debt and crime. These insights can help professionals adequately support clients with regard to debt in order to prevent recidivism.</div></summary> <author><name>Herrerawolf0623</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Axelsensoelberg3946</id> <title>User:Axelsensoelberg3946</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Axelsensoelberg3946"/> <updated>2025-07-01T19:48:54Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Axelsensoelberg3946&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Axelsensoelberg3946 (page does not exist)"><bdi>Axelsensoelberg3946</bdi></a> was created</p></summary> <author><name>Axelsensoelberg3946</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Pallesenknowles2811&diff=3606960&oldid=0</id> <title>Pallesenknowles2811</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Pallesenknowles2811&diff=3606960&oldid=0"/> <updated>2025-07-01T19:48:50Z</updated> <summary type="html"><p>Created page with &quot;vical cancer.There is increasing research interest in the application of the ecosystem services (ES) concept in the environmental risk assessment of chemicals to support formu...&quot;</p><p><b>New page</b></p><div>vical cancer.There is increasing research interest in the application of the ecosystem services (ES) concept in the environmental risk assessment of chemicals to support formulating and operationalising regulatory environmental protection goals and making environmental risk assessment more policy- and value-relevant. This requires connecting ecosystem structure and processes to ecosystem function and henceforth to provision of ecosystem goods and services and their economic valuation. Ecological production functions (EPFs) may help to quantify these connections in a transparent manner and to predict ES provision based on function-related descriptors for service providing species, communities, ecosystems or habitats. We review scientific literature for EPFs to evaluate availability across provisioning and regulation and maintenance services (CICES v5.1 classification). We found quantitative production functions for nearly all ES, often complemented with economic valuation of physical or monetary flows. We studied the serviation therefore would seem best substantiated by EPFs at the level of functional group.Since maintenance hemodialysis (HD) first became available in the United States in 1962, there has been tremendous growth in the population of patients with kidney failure. [https://www.selleckchem.com/products/a-83-01.html A-83-01 in vitro] HD has become a routine treatment carried out in outpatient clinics, hospitals, nursing facilities, and in patients' homes. Although it is a complex procedure, HD is quite safe. Serious complications are uncommon due to the use of modern HD machines and water treatment systems as well as the development of strict protocols to monitor various aspects of the HD treatment. The practicing nephrologist must be knowledgeable about life-threatening complications that can occur during HD and be able to recognize, manage, and prevent them. This installment in the AJKD Core Curriculum in Nephrology reviews the pathogenesis, management, and prevention of 9 HD emergencies. The HD emergencies covered include dialyzer reactions, dialysis disequilibrium syndrome, uremic/dialysis-associated pericarditis, air embolism, venous needle dislodgement, vascular access hemorrhage, hemolysis, dialysis water contamination, and arrhythmia episodes.&lt;br /&gt;&lt;br /&gt; COVID-19 vaccine hesitancy is a major obstacle for pandemic mitigation. As vaccine hesitancy occurs along multiple dimensions, we used a social-ecological framework to guide the examination of COVID-19 vaccine intentions.&lt;br /&gt;&lt;br /&gt; Using an online survey in the US conducted in July 2020, we examined intentions to obtain a COVID-19 vaccine, once available. 592 respondents provided data, including measures of demographics, vaccine history, social norms, perceived risk, and trust in sources of COVID-19 information. Bivariate and multivariate multinomial models were used to compare respondents who intended to be vaccinated against COVID-19 to respondents who did not intend or were ambivalent about COVID-19 vaccination.&lt;br /&gt;&lt;br /&gt; Only 59.1% of the sample reported that they intended to obtain a COVID-19 vaccine. In the multivariate multinomial model, those respondents who did not intend to be vaccinated, as compared to those who did, had significantly lower levels of trust in the CDC as a source of COVID-19 information (aOR=0.29paigns, including social network diffusion strategies and cross-partisan messaging, to promote vaccine trust. The racial and gender differences in vaccine intentions also suggest the need to tailor campaigns based on gender and race.&lt;br /&gt;&lt;br /&gt; Multiple candidates of COVID-19 vaccines have entered Phase III clinical trials in the United States (US). There is growing optimism that social distancing restrictions and face mask requirements could be eased with widespread vaccine adoption soon.&lt;br /&gt;&lt;br /&gt; We developed a dynamic compartmental model of COVID-19 transmission for the four most severely affected states (New York, Texas, Florida, and California). We evaluated the vaccine effectiveness and coverage required to suppress the COVID-19 epidemic in scenarios when social contact was to return to pre-pandemic levels and face mask use was reduced. Daily and cumulative COVID-19 infection and death cases from 26th January to 15th September 2020 were obtained from the Johns Hopkins University Coronavirus resource center and used for model calibration.&lt;br /&gt;&lt;br /&gt; Without a vaccine (scenario 1), the spread of COVID-19 could be suppressed in these states by maintaining strict social distancing measures and face mask use levels. But relaxing social distancing restrictions toonths would not substantially alter the epidemic trend if the current non-pharmaceutical interventions are maintained.&lt;br /&gt;&lt;br /&gt; The degree to which the US population can relax social distancing restrictions and face mask use will depend greatly on the effectiveness and coverage of a potential COVID-19 vaccine if future epidemics are to be prevented. Only a highly effective vaccine will enable the US population to return to life as it was before the pandemic.&lt;br /&gt;&lt;br /&gt;The degree to which the US population can relax social distancing restrictions and face mask use will depend greatly on the effectiveness and coverage of a potential COVID-19 vaccine if future epidemics are to be prevented. Only a highly effective vaccine will enable the US population to return to life as it was before the pandemic.Chlamydia trachomatis is the causative agent of a highly prevalent sexually transmitted bacterial disease and is associated with a number of severe disease complications. Current therapy options are successful at treating disease, but patients are left without protective immunity and do not benefit the majority asymptomatic patients who do not seek treatment. As such, there is a clear need for a broad acting, protective vaccine that can prevent transmission and protect against symptomatic disease presentation. There are three key elements that underlie successful vaccine development 1) Chlamydia biology and immune-evasion adaptations, 2) the correlates of protection that prevent disease in natural and experimental infection, 3) reflection upon the evidence provided by previous vaccine attempts. In this review, we give an overview of the unique intra-cellular biology of C. trachomatis and give insight into the dynamic combination of adaptations that allow Chlamydia to subvert host immunity and survive within the cell.</div></summary> <author><name>Pallesenknowles2811</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Munozsears0713&diff=3606959&oldid=0</id> <title>Munozsears0713</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Munozsears0713&diff=3606959&oldid=0"/> <updated>2025-07-01T19:48:47Z</updated> <summary type="html"><p>Created page with &quot;In litter-bearing mammals, conditions experienced early in life can have long-lasting consequences on adult behavioral and physiological phenotypes, including reproductive fit...&quot;</p><p><b>New page</b></p><div>In litter-bearing mammals, conditions experienced early in life can have long-lasting consequences on adult behavioral and physiological phenotypes, including reproductive fitness and survival. Using data from a large database, we focused our analysis on the consequences of litter composition on the reproductive performance of 131 mouse lemur males during their first breeding season. For male offspring, body mass at birth and at weaning only depended on the litter size (from one to 3), with the lowest values in triplets. Early growth had no relationship with the future reproductive success when males entered their first breeding season. When mouse lemurs were kept in groups with 2 or 3 competitors, males entered sexual competition for priority access to females in estrus, leading to a hierarchy with the dominant male ensuring the successful mating of the females. Genetic paternity tests showed that males born in same-sex litters (M, MM, MMM) were more competitive and fathered more offspring than males born in mixed-sex litters (MF, MMF, MFF), indicating the negative impact of a sister on male reproductive success. [https://www.selleckchem.com/products/masm7.html this website] However, testosterone levels were unrelated to early growth or litter sex composition but were dependent on social interactions during sexual competition, with higher values in successful males. The effects of litter composition on the mating success of male mouse lemurs might mainly occur through social interactions between male offspring born in same-sex litters. Play fighting between juvenile males could play a major role in their acquisition of the skills required to succeed in sexual competition.The susceptibility to depression has been attributed to the chronic stress and genetic factors but still fails to identify definite biomarkers. The present study aimed to investigate the role of disrupted Notch signaling in the medial prefrontal cortex of the chronic social defeat stress (CSDS) mice and Wistar Kyoto (WKY) rats. RNA-sequencing and quantitative real-time PCR analyses evidenced the involvement of Notch signaling pathway in depression. Western blotting reported an increased level of Notch2 and NF-κB and a decreased level of Hes1 and Bcl2/Bax ratio both in the susceptible mice when compared with the control or resilient ones and in the depression WKY rats when compared with the Wistar or non-depression WKY groups. Further analysis showed that the above-mentioned changes were significantly correlated with the depression-like behaviors and that the elicited Notch2 strongly correlated with the upregulated NF-κB, not with the downregulated Hes1 or Bcl2/Bax ratio. In conclusion, the increased Notch2/NF-κB signaling in the medial prefrontal cortex may mediate depression susceptibility, providing a potential diagnostic biomarker or therapeutic target for treating major depressive disorder.This study investigates the forces that contributed to severe shortages in personal protective equipment in the US during the COVID-19 crisis. Problems from a dysfunctional costing model in hospital operating systems were magnified by a very large demand shock triggered by acute need in healthcare and panicked marketplace behavior that depleted domestic PPE inventories. The lack of effective action on the part of the federal government to maintain and distribute domestic inventories, as well as severe disruptions to the PPE global supply chain, amplified the problem. Analysis of trade data shows that the US is the world's largest importer of face masks, eye protection, and medical gloves, making it highly vulnerable to disruptions in exports of medical supplies. We conclude that market prices are not appropriate mechanisms for rationing inputs to health because health is a public good. Removing the profit motive for purchasing PPE in hospital costing models, strengthening government capacity to maintain and distribute stockpiles, developing and enforcing regulations, and pursuing strategic industrial policy to reduce US dependence on imported PPE will help to better protect healthcare workers with adequate supplies of PPE.Although socioeconomic, behavioural, psychological, and biological factors have been individually linked to multimorbidity, data on the importance of these factors are limited. Our study aimed to determine the leading predictors for multimorbidity of chronic conditions in middle-aged Australian adults using machine learning methods. We included 53,867 participants aged 45-64 years from the 45 and Up Study who were free of eleven predefined chronic conditions at baseline (2006-2009) in the analysis. Incident multimorbidity was defined by the co-existence of ≥2, ≥3, or ≥ 4 conditions during follow-up until December 31, 2016. The five leading predictors for multimorbidity in men were age (7.2-20.5% of total variance), body mass index (6.5-15.4%), smoking (4.0-8.3%), chicken intake (3.6-7.5%), and red meat intake (4.6-6.3%) across the three definitions. Leading predictors varied across the three definitions in women, but the four common ones were body mass index (6.3-20.1%), age (6.2-16.4%), chicken intake (4.1-8.3%), and red meat intake (4.2-4.7%). The ten leading modifiable health factors accounted for 39.4-46.1% of total variance across the three definitions. Men with 6-10 health factors had 46-54% lower risks for multimorbidity compared with those reporting ≤2. The corresponding percentage for women was 45-52%. Non-behavioural factors including psychological distress, low education and income and high relative economic disadvantage were among the leading risk factors for multimorbidity. In conclusion, modifications on behavioural factors including diets, physical activity, smoking, alcohol consumption may reduce the risk of multimorbidity in middle-aged adults, whereas individuals with low socioeconomic status or psychological distress are at the highest priority for intervention.The current COVID-19 pandemic is the most severe pandemic of the 21st century, on track to having a rising death toll. Beyond causing respiratory distress, COVID-19 may also cause mortality by way of suicide. The pathways by which emerging viral disease outbreaks (EVDOs) and suicide are related are complex and not entirely understood. We aimed to systematically review the evidence on the association between EVDOs and suicidal behaviors and/or ideation. An electronic search was conducted using five databases Medline, Embase, Web of Science, PsycINFO and Scopus in April 2020. A rapid systematic review was carried out, which involved separately and independently extracting quantitative data of selected articles. The electronic search yielded 2480 articles, of which 9 met the inclusion criteria. Most of the data were collected in Hong Kong (n = 3) and the USA (n = 3). Four studies reported a slight but significant increase in deaths by suicide during EVDOs. The increase in deaths by suicide was mainly reported during the peak epidemic and in older adults.</div></summary> <author><name>Munozsears0713</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Holassiter8511&diff=3606958&oldid=0</id> <title>Holassiter8511</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Holassiter8511&diff=3606958&oldid=0"/> <updated>2025-07-01T19:48:42Z</updated> <summary type="html"><p>Created page with &quot;Patients in the precommitment group performed the prescribed self-directed gamified cognitive training twice as often as control group patients who were not offered precommitm...&quot;</p><p><b>New page</b></p><div>Patients in the precommitment group performed the prescribed self-directed gamified cognitive training twice as often as control group patients who were not offered precommitment (on 50% vs. 21% of days, pcorr = .004, d = .87, CI95% = [.31, 1.42]), and, as a consequence, reached a three times higher total training dose (90.21 vs. 33.60 minutes, pcorr = .004, d = .83, CI95% = [.27, 1.38]). And, add-on self-directed cognitive training was associated with stronger improvements in visuospatial and verbal working-memory performance (pcorr =.002, d = .72, and pcorr = .036, d = .62). Our decision-neuroscientific add-on intervention strongly increased the performed amount of an effective cognitive training in severely impaired stroke patients. These results warrant a full clinical trial to directly link decision neuroscientific interventions to clinical outcome.Adult zebrafish are increasingly used to interrogate mechanisms of disease development and tissue regeneration. Yet, the prospect of large-scale genetics in adult zebrafish has traditionally faced a host of biological and technical challenges, including inaccessibility of adult tissues to high-throughput phenotyping and the spatial and technical demands of adult husbandry. Here, we describe an experimental pipeline that combines high-efficiency CRISPR/Cas9 mutagenesis with functional phenotypic screening to identify genes required for spinal cord repair in adult zebrafish. Using CRISPR/Cas9 dual-guide ribonucleic proteins, we show selective and combinatorial mutagenesis of 17 genes at 28 target sites with efficiencies exceeding 85% in adult F0 'crispants'. We find that capillary electrophoresis is a reliable method to measure indel frequencies. Using a quantifiable behavioral assay, we identify seven single- or duplicate-gene crispants with reduced functional recovery after spinal cord injury. To rule out off-target effects, we generate germline mutations that recapitulate the crispant regeneration phenotypes. This study provides a platform that combines high-efficiency somatic mutagenesis with a functional phenotypic readout to perform medium- to large-scale genetic studies in adult zebrafish.&lt;br /&gt;&lt;br /&gt; The anti-melanoma differentiation-associated gene 5 (MDA5) antibody is the main predictor of interstitial lung disease (ILD) in dermatomyositis (DM) and clinically amyopathic dermatomyositis (CADM). Nevertheless, a subset of MDA5+ patients have a favorable prognosis. We aimed to determine the possibility of using anti-MDA5 antibody isotypes and IgG subclasses for evaluating ILD risk.&lt;br /&gt;&lt;br /&gt; The isotypes (IgG, IgA and IgM) of anti-MDA5 were detected in serum samples of 36 anti-MDA5+ patients with DM/CADM using enzyme-linked immunosorbent assay (ELISA). IgG subclasses of anti-MDA5 antibodies were further investigated. Laboratory findings and cumulative survival were analyzed based on the isotypes of anti-MDA5 and subclasses of anti-MDA5 IgG.&lt;br /&gt;&lt;br /&gt; Among the MDA5+ patients with DM/CADM, the positive rates of anti-MDA5 IgG, IgA, IgM were 100%, 97%, and 6%, respectively. The positive rates of anti-MDA5 IgG1, IgG2, IgG3, and IgG4 were 72%, 25%, 0%, and 28%, respectively. The incidence of acute interstitial pneumonia, mortality rate, and serum ferritin were significantly higher in anti-MDA5 IgG1+ patients than those in anti-MDA5 IgG1- patients with DM/CADM (P = 0.0027, 0.015, 0.0011, respectively). The sensitivity and specificity of anti-MDA5 IgG1 for predicting mortality were 100% and 41.7%, respectively. A combination of anti-MDA5 IgG1 and IgG4 for predicting mortality, yielded better specificity (87.5%).&lt;br /&gt;&lt;br /&gt; IgA and IgG are the primary anti-MDA5 antibody isotypes. Anti-MDA5 IgG1 is the primary component of MDA5 IgG subclasses and anti-MDA5 IgG1 and IgG4 might serve as useful biomarkers for predicting mortality in DM-ILD.&lt;br /&gt;&lt;br /&gt;IgA and IgG are the primary anti-MDA5 antibody isotypes. Anti-MDA5 IgG1 is the primary component of MDA5 IgG subclasses and anti-MDA5 IgG1 and IgG4 might serve as useful biomarkers for predicting mortality in DM-ILD.&lt;br /&gt;&lt;br /&gt; 'PoseFilter' is a PyMOL plugin that assists in analyses and filtering of docked poses. PoseFilter enables automatic detection of symmetric poses from docking outputs and can be accessed using both graphical user interface and command-line options within the PyMOL program. Two methods of analyses, root mean square deviations (RMSD) and interaction fingerprints, are available from this plugin. [https://www.selleckchem.com/products/ab928.html Etrumadenant] The capabilities of the plugin are demonstrated using docking outputs from different oligomeric protein-ligand complexes.&lt;br /&gt;&lt;br /&gt; The plugin can be downloaded from the GitHub page, https//github.com/skalyaanamoorthy/PoseFilter.&lt;br /&gt;&lt;br /&gt; Supplementary data are available at Bioinformatics online.&lt;br /&gt;&lt;br /&gt;Supplementary data are available at Bioinformatics online.&lt;br /&gt;&lt;br /&gt; The purpose of this study was to investigate sex-specific lower limb biomechanical adaptations during a standardized load carriage task in response to a targeted physical training program.&lt;br /&gt;&lt;br /&gt; Twenty-five healthy civilians (males [n = 13] and females [n = 12]) completed a load carriage task (5 km at 5.5 km·h-1, wearing a 23 kg vest) before and after a 10-week lower-body-focused training program. Kinematics and ground reaction force data were collected during the task and were used to estimate lower limb joint kinematics and kinetics (i.e., moments and powers). Direct statistical comparisons were not conducted due to different data collection protocols between sexes. A two-way repeated measures ANOVA tested for significant interactions between, and main effects of training and distance marched for male and female data, respectively.&lt;br /&gt;&lt;br /&gt; Primary kinematic and kinetic changes were observed at the knee and ankle joints for males and at the hip and knee joints for females. Knee joint moments increased for both sexeslly demanding military roles.&lt;br /&gt;&lt;br /&gt; The re-emergence of armored warfare in modern conflicts has resulted in a higher number of extremity injuries, burns, and brain injuries. Despite this dramatic increase, little is reported on the type of injuries caused and their management. This review summarizes the publicly available literature and reports on the rate and type of injuries related to armored warfare, their medical outcomes, and management limitations.&lt;br /&gt;&lt;br /&gt; This rapid evidence review involves a systematic literature search, followed by a non-systematic literature review. The reason for choosing this approach was the inherent lack of quantitative outcome data in the literature to satisfy the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. The study also used content analysis to study all peer-reviewed articles, focusing on similarities and differences in the findings necessary to formulate tentative results. The electronic search included PubMed, Scopus, and Web of Science, using the following search string &quot;Armored; Injuries; Mechanized; Morbidity; Mortality; War; Warfare&quot;, alone or in combination.</div></summary> <author><name>Holassiter8511</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Dugganlundgaard5904</id> <title>User:Dugganlundgaard5904</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Dugganlundgaard5904"/> <updated>2025-07-01T19:48:40Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Dugganlundgaard5904&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Dugganlundgaard5904 (page does not exist)"><bdi>Dugganlundgaard5904</bdi></a> was created</p></summary> <author><name>Dugganlundgaard5904</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Wowslot777&diff=3606957&oldid=3544423</id> <title>Wowslot777</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Wowslot777&diff=3606957&oldid=3544423"/> <updated>2025-07-01T19:48:37Z</updated> <summary type="html"><p></p><a href="https://humanlove.stream/index.php?title=Wowslot777&amp;diff=3606957&amp;oldid=3544423">Show changes</a></summary> <author><name>Fruiteye7</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Valentinsawyer6711&diff=3606956&oldid=0</id> <title>Valentinsawyer6711</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Valentinsawyer6711&diff=3606956&oldid=0"/> <updated>2025-07-01T19:48:37Z</updated> <summary type="html"><p>Created page with &quot;The idea that households produce and consume their own energy, that is, energy self-sufficiency at a very local level, captures the popular imagination and commands political...&quot;</p><p><b>New page</b></p><div>The idea that households produce and consume their own energy, that is, energy self-sufficiency at a very local level, captures the popular imagination and commands political support across parts of Europe. This paper investigates the technical and economic feasibility of household energy self-sufficiency in Switzerland, which can be seen as representative for other regions with a temperate climate, by 2050. We compare sixteen cases that vary across four dimensions household type, building type, electricity demand reduction, and passenger vehicle use patterns. We assume that photovoltaic (PV) electricity supplies all energy, which implies a complete shift away from fossil fuel based heating and internal combustion engine vehicles. Two energy storage technologies are considered short-term storage in lithium-ion batteries and long-term storage with hydrogen, requiring an electrolyzer, storage tank, and a fuel cell for electricity conversion. We examine technological feasibility and total system costs for self-sufficient households compared to base cases that rely on fossil fuels and the existing power grid. PV efficiency and available rooftop/facade area are most critical with respect to the overall energy balance. Single-family dwellings with profound electricity demand reduction and urban mobility patterns achieve self-sufficiency most easily. Multi-family buildings with conventional electricity demand and rural mobility patterns can only be self-sufficient if PV efficiency increases, and all of the roof plus most of the facade can be covered with PV. All self-sufficient cases are technically feasible but more expensive than fully electrified grid-connected cases. Self-sufficiency may even become cost-competitive in some cases depending on storage and fossil fuel prices. Thus, if political measures improve their financial attractiveness or individuals decide to shoulder the necessary investments, self-sufficient buildings may start to become increasingly prevalent.Ambiguity aversion-the tendency to avoid options whose outcome probabilities are unknown-is a ubiquitous phenomenon. While in some cases ambiguity aversion is an adaptive strategy, in many situations it leads to suboptimal decisions, as illustrated by the famous Ellsberg Paradox. Behavioral interventions for reducing ambiguity aversion should therefore be of substantial practical value. [https://www.selleckchem.com/products/vx-661.html Tezacaftor in vivo] Here we test a simple intervention, aimed at reducing ambiguity aversion in an experimental design, where aversion to ambiguity leads to reduced earnings. Participants made a series of choices between a reference lottery with a 50% chance of winning $5, and another lottery, which offered more money, but whose outcome probability was either lower than 50% (risky lottery) or not fully known (ambiguous lottery). Similar to previous studies, participants exhibited both risk and ambiguity aversion in their choices. They then went through one of three interventions. Two groups of participants learned about the Ellsberg Paradox and their own suboptimal choices, either by actively calculating the objective winning probability of the ambiguous lotteries, or by observing these calculations. A control group learned about base-rate neglect, which was irrelevant to the task. Following the intervention, participants again made a series of choices under risk and ambiguity. Participants who learned about the Ellsberg Paradox were more tolerant of ambiguity, yet ambiguity aversion was not completely abolished. At the same time, these participants also exhibited reduced aversion to risk, suggesting inappropriate generalization of learning to an irrelevant decision domain. Our results highlight the challenge for behavioral interventions generating a strong, yet specific, behavioral change.BACKGROUND Trachoma elimination efforts are hampered by limited understanding of Chlamydia trachomatis (Ct) transmission routes. Here we aimed to detect Ct DNA at non-ocular sites and on eye-seeking flies. METHODS A population-based household survey was conducted in Oromia Region, Ethiopia. Ocular and non-ocular (faces, hands, clothing, water containers and sleeping surfaces) swabs were collected from all individuals. Flies were caught from faces of children. Flies, ocular swabs and non-ocular swabs were tested for Ct by quantitative PCR. RESULTS In total, 1220 individuals in 247 households were assessed. Active trachoma (trachomatous inflammation-follicular) and ocular Ct were detected in 10% and 2% of all-ages, and 21% and 3% of 1-9-year-olds, respectively. Ct was detected in 12% (95% CI8-15%) of tested non-ocular swabs from ocular-positive households, but in none of the non-ocular swabs from ocular-negative households. Ct was detected on 24% (95% CI18-32%) of flies from ocular-positive households and 3% (95% CI1-6%) of flies from ocular-negative households. CONCLUSION Ct DNA was detected on hands, faces and clothing of individuals living in ocular-positive households suggesting that this might be a route of transmission within Ct infected households. In addition, we detected Ct on flies from ocular-positive households and occasionally in ocular-negative households suggesting that flies might be a vector for transmission within and between Ct infected and uninfected households. These potential transmission routes may need to be simultaneously addressed to suppress transmission.Severe dengue was perceived as one clinical disease entity until the WHO 2009 classification stratified it into severe vascular leakage, severe bleeding, and severe organ dysfunction. The objectives of this study were to investigate the potential use of severe dengue categories as endpoints for intervention research. 271 patients with severe dengue among 1734 confirmed dengue patients were followed prospectively in this hospital-based observational study in Latin America and Asia. We compared the distribution of severe dengue categories according to gender and age (below/above 15y), and determined the relative frequency and the overlap of severe dengue categories in the same patients. In a next step, we extended the analysis to candidate moderate severity categories, based on recently suggested definitions which were adapted for our purposes. Severe vascular leakage occurred in 244 (90%), severe bleeding in 39 (14%), and severe organ dysfunction in 28 (10%) of 271 severe dengue patients. A higher frequency of severe leakage was seen in children or adolescents ( less then 15y) compared to adults.</div></summary> <author><name>Valentinsawyer6711</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=User_talk:Researchh5&diff=3606955&oldid=0</id> <title>User talk:Researchh5</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=User_talk:Researchh5&diff=3606955&oldid=0"/> <updated>2025-07-01T19:48:34Z</updated> <summary type="html"><p>Created page with &quot;[https://www.psilocybecubensis-shop.com/ psilocybin gummies] Welcome to our magical corner of the internet, where we invite you to embark on a captivating exploration of Psil...&quot;</p><p><b>New page</b></p><div>[https://www.psilocybecubensis-shop.com/ psilocybin gummies]<br /><br />Welcome to our magical corner of the internet, where we invite you to embark on a captivating exploration of Psilocybe Cubensis and the extraordinary world of magic mushrooms. With a focus on Psilocybe Cubensis, we aim to provide you with an immersive experience, empowering you with knowledge, insights, and resources to delve into the awe-inspiring realm of these fascinating fungi.</div></summary> <author><name>Researchh5</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Spotstring66</id> <title>User:Spotstring66</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Spotstring66"/> <updated>2025-07-01T19:48:28Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Spotstring66&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Spotstring66 (page does not exist)"><bdi>Spotstring66</bdi></a> was created</p></summary> <author><name>Spotstring66</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Bossenegeberg6828</id> <title>User:Bossenegeberg6828</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Bossenegeberg6828"/> <updated>2025-07-01T19:48:15Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Bossenegeberg6828&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Bossenegeberg6828 (page does not exist)"><bdi>Bossenegeberg6828</bdi></a> was created</p></summary> <author><name>Bossenegeberg6828</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Albrechtsennash8828&diff=3606954&oldid=0</id> <title>Albrechtsennash8828</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Albrechtsennash8828&diff=3606954&oldid=0"/> <updated>2025-07-01T19:47:58Z</updated> <summary type="html"><p>Created page with &quot;Similar results were observed in the alternative latent trajectory models accounting for other variables. CONCLUSION Our models show that subjects with higher SDMT scores at b...&quot;</p><p><b>New page</b></p><div>Similar results were observed in the alternative latent trajectory models accounting for other variables. CONCLUSION Our models show that subjects with higher SDMT scores at baseline showed improvement, while subjects with lower SDMT scores at baseline showed worsening. Baseline age and disease duration were also associated with SDMT performance.Objective The study objectives were (1) to create a new 10-item scale, the 'Lebanese Anxiety Scale' (LAS-10), inspired by the diagnostic criteria of DSM-5, and the HAM-A and STAI scales and (2) to evaluate the performance of this new scale on a sample of Lebanese individuals.Methods This cross-sectional study enrolled 1332 community dwelling participants between November 2017 and March 2018.Results In sample 1, the participants' mean age was 28.08 years (63.9% females). The LAS items converged over a solution of two factors that had an Eigenvalue over 1, explaining a total of 51.97% of the variance (αCronbach=0.857). The optimal cut-off between healthy controls and anxious patients was 13.50 according to the ROC curve. The sensitivity and specificity were good at this cut-off (77.5% and 70.8%, respectively). The area under the curve was high 0.811 [0.778-0.845]; p less then .001. The positive predicted value of the LAS-10 score in sample 1 was 26.9%, whereas the negative predicted value was 95.2%.Conclusion The results of the present study show that the LAS-10 is a tool that can be used in clinical practice and research to screen for anxiety.KEY POINTSThe positive predicted value of the LAS-10 score was 26.9%.Its negative predicted value was 95.2%.People with scores above 13.5 be referred to a health care professional for further assessment.The LAS-10 is a tool can be used in clinical practice and research to screen for anxiety.Future studies are needed to validate the LAS-10 in other countries.A prodrome is considered an early set of signs or symptoms indicating the onset of a disease or illness. In multiple sclerosis (MS), the prodromal period is the months or years before our current, classic understanding of &quot;MS symptom onset.&quot; Prodromal periods are well recognized in other neurodegenerative conditions and more recently have been shown in MS. In this Viewpoint, we reflect on the emerging evidence surrounding the MS prodrome, including features that may be common across chronic inflammatory and neurodegenerative diseases. Finally, we discuss the implications for future disease prevention in MS.Introduction The present study aims to explore the characteristics and differences of the ReHo, ALFF and fALFF of brain in the resting state of depression and first-degree relatives, in order to identify candidate central prodromal biomarkers of depression.Method Three groups of medication-free patients (39-59 years old) was involved in this study, including the patients with major depression disorder (MDD group, n = 15), healthy volunteers with first-degree relatives with MDD (first-degree relatives group, n = 15), healthy volunteers with no personal or family history of MDD (the control group [HC], n = 15). Participants underwent functional MRI while staying in a resting state after a conventional MRI scanning on a clinical 3 T system(Siemens Skyra, Germany).Results The ReHo, ALFF and fALFF values are different in brain of MDD, first-degree relatives, and HC (p less then .05). MDD patients exhibited abnormal spontaneous activity in multiple brain regions which are closely related to emotion regulation and perception. The present findings provide further insight into the pathological mechanisms underlying MDD.Conclusion With the widespread abnormal values of brain in MDD and first-degree relatives measured, we can get a hypothesis that these abnormalities may be associated with cognitive network disorders and emotional distress in MDD.Key pointsThe fMRI could increase the early validity of MDD as a new diagnostic and disease-monitoring tool.Monitoring ReHo, ALFF, fALFF values using fMRI can provide insight into the presence and evolution of MDD disease and permit objective evaluation of brain abnormalities.It appears that ReHo, ALFF, fALFF could be used as markers for monitoring disease progression and treatment effects in MDD patients in the future.The aim of this study was to investigate carnitine action against negative effects of etoposide on stem/progenitor spermatogonia and on sperm production. Carnitine (250 mg/kg body weight/day) and etoposide (5 mg/kg body weight/day) were administered from 25-days postpartum to 32-days postpartum. Testes were collected at 32-days postpartum, 64-days postpartum, and 127-days postpartum, and submitted to the immuno-labeling of UTF1, SOX2, and PLZF proteins to identify undifferentiated spermatogonia populations. At 127-days postpartum, sperm were collected for analysis. Carnitine+etoposide group showed a higher numerical density of spermatogonia labeled for all studied proteins at 64-days postpartum (critical age) compared to the etoposide group. Moreover, there was an improvement of spermatic parameters and sperm DNA integrity in rats of the carnitine+etoposide group in comparison with rats of the etoposide group. The results suggest that carnitine improves the self-renewal of undifferentiated spermatogonia and promotes a partial protection on them, alleviating the etoposide harmful late effects and leading to an enhancement of the sperm parameters in adulthood.BACKGROUND There is evidence of cognitive-motor coupling in multiple sclerosis (MS) such that the slowing of cognitive processing speed correlates with the worsening of walking speed and endurance. OBJECTIVE The current study first established the presence of cognitive-motor coupling and second examined the possibility that volumes of subcortical gray matter (SGM) structures and aerobic capacity might explain the coupling of cognitive and motor functions in persons with MS. METHODS We included data from 62 persons with clinically definite MS who underwent assessments of cognitive processing speed, walking performance, and aerobic capacity, and completed magnetic resonance imaging (MRI) within 7 days of the aforementioned assessments. [https://www.selleckchem.com/products/medica16.html MEDICA16 concentration] RESULTS The strong correlations between cognitive processing speed and walking performance were attenuated in magnitude and not statistically significant when controlling for aerobic capacity alone and aerobic capacity and SGM volumes together. The associations between cognitive processing speed and walking performance remained statistically significant when controlling for SGM volumes alone.</div></summary> <author><name>Albrechtsennash8828</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Loftlyons3269&diff=3606953&oldid=0</id> <title>Loftlyons3269</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Loftlyons3269&diff=3606953&oldid=0"/> <updated>2025-07-01T19:47:58Z</updated> <summary type="html"><p>Created page with &quot;Both among-population and within-population variations in azoxystrobin tolerance increased as experimental temperatures increased. We also found that isolates with higher azox...&quot;</p><p><b>New page</b></p><div>Both among-population and within-population variations in azoxystrobin tolerance increased as experimental temperatures increased. We also found that isolates with higher azoxystrobin tolerance adapted to a broader thermal niche. These results suggest that global warming may enhance the risk of developing pesticide resistance in plant pathogens and highlight the increased challenges of administering pesticides for effective management of plant diseases to support agricultural production and ecological sustainability under future thermal conditions.DNA methylation data facilitate the development of accurate molecular estimators of chronological age or &quot;epigenetic clocks.&quot; We present a robust epigenetic clock for the beluga whale, Delphinapterus leucas, developed for an endangered population in Cook Inlet, Alaska, USA. We used a custom methylation array to measure methylation levels at 37,491 cytosine-guanine sites (CpGs) from skin samples of dead whales (n = 67) whose chronological ages were estimated based on tooth growth layer groups. Using these calibration data, a penalized regression model selected 23 CpGs, providing an R 2 = 0.92 for the training data; and an R 2 = 0.74 and median absolute age error = 2.9 years for the leave one out cross-validation. We applied the epigenetic clock to an independent dataset of 38 skin samples collected with a biopsy dart from living whales between 2016 and 2018. Age estimates ranged from 11 to 27 years. We also report sex correlations in CpG data and describe an approach of identifying the sex of an animal using DNA methylation. The epigenetic estimators of age and sex presented here have broad applications for conservation and management of Cook Inlet beluga whales and potentially other cetaceans.Insecticides can exert strong selection on insect pest species, including those that vector diseases, and have led to rapid evolution of resistance. Despite such rapid evolution, relatively little is known about standing genetic variation for resistance in insecticide-susceptible populations of many species. To help fill this knowledge gap, we generated genotyping-by-sequencing data from insecticide-susceptible Phlebotomus papatasi and Lutzomyia longipalpis sand flies that survived or died from a sub-diagnostic exposure to either permethrin or malathion using a modified version of the Centers for Disease Control and Prevention bottle bioassay. Multi-locus genome-wide association mapping methods were used to quantify standing genetic variation for insecticide resistance in these populations and to identify specific alleles associated with insecticide survival. For each insecticide treatment, we estimated the proportion of the variation in survival explained by the genetic data (i.e., &quot;chip&quot; heritability) and the number and contribution of individual loci with measurable effects. #link# For all treatments, survival to an insecticide exposure was heritable with a polygenic architecture. Both P. papatasi and L. longipalpis had alleles for survival that resided within many genes throughout their genomes. The implications for resistance conferred by many alleles, as well as inferences made about the utility of laboratory insecticide resistance association studies compared to field observations, are discussed.Preserving biodiversity under rapidly changing climate conditions is challenging. One approach for estimating impacts and their magnitude is to model current relationships between genomic and environmental data and then to forecast those relationships under future climate scenarios. In this way, understanding future genomic and environmental relationships can help guide management decisions, such as where to establish new protected areas where populations might be buffered from high temperatures or major changes in rainfall. However, climate warming is only one of many anthropogenic threats one must consider in rapidly developing parts of the world. In Central Africa, deforestation, mining, and infrastructure development are accelerating population declines of rainforest species. Here we investigate multiple anthropogenic threats in a Central African rainforest songbird, the little greenbul (Andropadus virens). We examine current climate and genomic variation in order to explore the association between genome an integrated conceptual model demonstrating how the approach for a single species can be expanded to many taxonomically diverse species.We consider approaches for conserving genetic diversity from plant populations whose destruction is imminent. We do this using SNP genotype data from two endangered species, Pimelea spicata and Eucalyptus sp. Cattai. For both species, we genotyped plants from a 'condemned' population and designed ex situ collections, characterizing how the size and composition of the collection affected the genetic diversity preserved. [https://www.selleckchem.com/products/NVP-AUY922.html click here] with previous observations, populations where genetic diversity was optimized captured more alleles than populations of equal size chosen at random. This benefit of optimization was larger when the propagation population was small. That is, small numbers of individuals (e.g. 20) needed to be selected carefully to capture a comparable proportion of alleles to optimized populations, but larger random populations (e.g. &amp;gt;48) captured almost as many alleles as optimized populations. We then examined strategies for generating translocation populations based on the horticultural constraintsplication of approaches that were useful in different circumstances.Reintroductions are a powerful tool for the recovery of endangered species. However, their long-term success is strongly influenced by the genetic diversity of the reintroduced population. The chances of population persistence can be improved by enhancing the population's adaptive ability through the mixing of individuals from different sources. However, where source populations are too diverse the reintroduced population could also suffer from outbreeding depression or unsuccessful admixture due to behavioural or genetic barriers. For the reintroduction of Asiatic wild ass Equus hemionus ssp. in Israel, a breeding core was created from individuals of two different subspecies (E. h. onager &amp;amp; E. h. kulan). Today the population comprises approximately 300 individuals and displays no signs of outbreeding depression. The aim of this study was a population genomic evaluation of this conservation reintroduction protocol. We used maximum likelihood methods and genetic clustering analyses to investigate subspecies admixture and test for spatial autocorrelation based on subspecies ancestry.</div></summary> <author><name>Loftlyons3269</name></author> </entry> <entry> <id>https://humanlove.stream/wiki/User:Doylegibbons3113</id> <title>User:Doylegibbons3113</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/wiki/User:Doylegibbons3113"/> <updated>2025-07-01T19:47:48Z</updated> <summary type="html"><p>User account <a href="/index.php?title=User:Doylegibbons3113&amp;action=edit&amp;redlink=1" class="new mw-userlink" title="User:Doylegibbons3113 (page does not exist)"><bdi>Doylegibbons3113</bdi></a> was created</p></summary> <author><name>Doylegibbons3113</name></author> </entry> <entry> <id>https://humanlove.stream/index.php?title=Philipsenkristoffersen4631&diff=3606952&oldid=0</id> <title>Philipsenkristoffersen4631</title> <link rel="alternate" type="text/html" href="https://humanlove.stream/index.php?title=Philipsenkristoffersen4631&diff=3606952&oldid=0"/> <updated>2025-07-01T19:47:41Z</updated> <summary type="html"><p>Created page with &quot;Sports participation has the potential to contribute to young people&#039;s health. A prerequisite for young people to benefit from sports is that they stay in sports. Studies that...&quot;</p><p><b>New page</b></p><div>Sports participation has the potential to contribute to young people's health. A prerequisite for young people to benefit from sports is that they stay in sports. Studies that consider both personal and contextual factors are needed to unpack the broader health-promoting potential of youth sports. The purpose of the study is to contribute to knowledge about the health-promoting potential of young people's participation in organized sports by exploring youth perspectives on what makes a sports club health-promoting with a focus on health resources that young people consider important for sports club participation. For this cross-sectional study a brief survey was conducted with 15-16 year old students (n = 123) at two schools in Sweden, asking three open-ended questions about their participation in sports. The study used a salutogenic theory-driven analysis in combination with statistical analysis. Five health resources that young people consider important for sports club participation are revealed. On an individual, more 'swimmer'-related level, these are personal well-being and social relations, including relationally meaningful activities, and on an organizational level, relating to the 'river', that sports clubs offer a supportive and well-functioning environment. For sports clubs to be health-promoting settings for young people and thus hopefully to reduce drop-out, we need a more sustainable approach emphasizing drop-in, drop-through, and drop-over as a continuous iterative process. We also need to consider the complexity of sports participation for young people, involving individual, organizational and environmental issues.We show a description of pregnancy cohorts in the European region. Our investigation identified 66 pregnancy cohorts, mostly hosted in Western Central Europe. Among these 66 cohorts, 24 began recruitment before the year 2000, while six cohorts are still enrolling. The most common topics were lifestyle, environment and nutrition with allergies and neurodevelopment being a minority. We observed a pattern of positive correlations between data collected using medical records, structured interviews, and the collection of biological samples. Objectively assessed data were negatively correlated with self-administered questionnaires. Eight cohorts addressed intrauterine exposure, focusing on environmental pollutants such as endocrine-disrupting chemicals. The effects of these compounds on the developing foetus have been studied greatly, but more research on their effects is still needed. Many cohorts investigated genetics through the collection of biological samples from the mothers and children, to improve knowledge on the mother-to-child transmission of genetic information, antibodies, microbiota, etc. Paediatric epidemiology represents an important field of research since preserving healthy lives from conception onwards is the most efficient way to improve population health. According to our report, it seems that this field of research is well developed in Europe, where numerous high profile studies are currently ongoing.To address climate change, health, and food-related challenges at the international and regional level, policy makers and researchers are starting to acknowledge the importance of building and developing sustainable food systems (SFSs). This study aims to discuss the drivers of, barriers to, and policy recommendations for developing sustainable food systems in four European countries (Germany, Italy, Norway, and Romania). [https://www.selleckchem.com/products/lyg-409.html this website] We used critical frame analysis to investigate national policy documents on sustainable food systems and conducted in-depth interviews with various national stakeholders representing policy makers, agrifood businesses, and civil society. The novelty of this research lies in comparing national policy approaches and stakeholders' opinions on SFS development in a multi-country analysis. These European countries have different conditions in terms of geography, socioeconomic situation, environmental performance, and sustainability orientation. Several cross-cultural differences and gaps in the existing national policies for sustainable food systems were identified, and solutions that help overcome these issues have been suggested. The first step in developing SFS should focus on interdisciplinary and trans-sectorial policy integration combined with increasing stakeholder collaboration across all sectors of the economy. We also recommend more active involvement of consumers in the food system, developing information-sharing networks, and increasing collaborations within the food supply chains.This study constructed a moderated mediation model based on problem behavior theory to explore the psychological mechanism of family functioning interaction with pathological internet use. We used the Adolescent Pathological Internet Use Scale, General Functioning Scale, Trait Hope Scale, and Social Withdrawal Scale to measure internet use in 1223 middle school students. The results showed that (1) pathological internet use was negatively correlated with family functioning and hope, and positively correlated with social withdrawal; family functioning was positively correlated with hope, and negatively correlated with social withdrawal; hope was negatively correlated with social withdrawal; (2) family functioning could not only directly predict pathological internet use, but also indirectly predict pathological internet use through hope; and (3) the mediating effect of family functioning on pathological internet use was moderated by social withdrawal, which was stronger for individuals with low social withdrawal but not significant for individuals with high social withdrawal. This study revealed the internal mechanism of the relation between family functioning and adolescents' pathological internet use, which has theoretical significance for improving adolescents' hope and reducing their pathological internet use.Given health threats of climate change, a comprehensive review of the impacts of ambient temperature and ar pollution on suicide is needed. We performed systematic literature review and meta-analysis of suicide risks associated with short-term exposure to ambient temperature and air pollution. Pubmed, Scopus, and Web of Science were searched for English-language publications using relevant keywords. Observational studies assessing risks of daily suicide and suicide attempts associated with temperature, particulate matter with aerodynamic diameter ≤10 μm (PM10) and ≤2.5 mm (PM2.5), ozone (O3), sulfur dioxide (SO2), nitrogen dioxide (NO2), and carbon monoxide (CO) were included. Data extraction was independently performed in duplicate. Random-effect meta-analysis was applied to pool risk ratios (RRs) for increases in daily suicide per interquartile range (IQR) increase in exposure. Meta-regression analysis was applied to examine effect modification by income level based on gross national income (GNI) per capita, national suicide rates, and average level of exposure factors.</div></summary> <author><name>Philipsenkristoffersen4631</name></author> </entry> </feed>If you would like to create a banner that links to this page (i.e. this validation result), do the following:
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