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<?xml version="1.0" encoding="utf-8"?><feed xmlns="http://www.w3.org/2005/Atom"> <id>https://ijpcr.net/ijpcr/issue/feed</id> <title>International Journal of Pharmacology and Clinical Research (IJPCR)</title> <updated>2025-07-05T11:01:37+00:00</updated> <author> <name>Dr.N.Sriram</name> <email>ijpcreditor@gmail.com</email> </author> <link rel="alternate" href="https://ijpcr.net/ijpcr" /> <link rel="self" type="application/atom+xml" href="https://ijpcr.net/ijpcr/feed/atom" /> <generator uri="http://pkp.sfu.ca/ojs/" version="3.1.2.4">Open Journal Systems</generator> <subtitle type="html"><p><strong><em>International Journal of Pharmacology and Clinical Research (IJPCR) </em></strong>is a peer-reviewed, quarterly official international journal allowing access to abstracts<strong>&nbsp;</strong>and<strong>&nbsp;</strong>full-text. The journal is devoted to the promotion of pharmaceutical sciences and related disciplines (Pharmacology, Biopharmaceutics, Pharmacokinetics, Pharmaceutical Medicinal Chemistry, Computational Chemistry &amp; Molecular Drug Design, Pharmacognosy &amp; Phytochemistry, Pharmaceutical Analysis, Pharmacy Practice, Clinical &amp; Hospital Pharmacy, Cell Biology, Genomics &amp; Proteomics, Pharmacogenomics, Bioinformatics including biotechnology, cell &amp; molecular biology, Pharmaceutical biotechnology/microbiology, medical and other life sciences).</p> <p><strong>ISSN</strong>&nbsp;-&nbsp;<strong><em>International Journal of Pharmacology and Clinical Research (IJPCR)</em></strong></p> <p><strong>Online</strong>:<strong>&nbsp;</strong>2521-2206</p> <p><strong><em>International Journal of Pharmacology and Clinical Research </em></strong>seeks to foster multidisciplinary research and collaboration among scientists, pharmaceutical industries and healthcare sector as well as provide an international forum for the communication and evaluation of data, methods and opinions in pharmaceutical sciences and related disciplines. Although primarily devoted to original research papers, the journal particularly welcomes reviews on current topics of special interest and relevance. All manuscripts will be subjected to rapid peer review. Those of high quality (not previously published and not already under consideration for publication) will be published.</p></subtitle> <entry> <id>https://ijpcr.net/ijpcr/article/view/600</id> <title>Chemical characterization and in vitro anti oxidant evaluation of Tribulus terrestris (Zygophyllaceae)</title> <updated>2025-07-05T05:28:28+00:00</updated> <author> <name>Ponmadasamy M</name> <email>thamilarasi.mmc@gmail.com</email> </author> <author> <name>Ezhilarasi K</name> <email>thamilarasi.mmc@gmail.com</email> </author> <author> <name>Nagaraj R</name> <email>thamilarasi.mmc@gmail.com</email> </author> <author> <name>Hemalatha G</name> <email>thamilarasi.mmc@gmail.com</email> </author> <author> <name>Tamilarasi G</name> <email>thamilarasi.mmc@gmail.com</email> </author> <link rel="alternate" href="https://ijpcr.net/ijpcr/article/view/600" /> <summary type="html" xml:base="https://ijpcr.net/ijpcr/article/view/600"><p>The present study comprises screening of some phytochemical compounds and antioxidant activity in ethanolic and aqueous extracts of&nbsp;<em>Tribulus terrestris</em>. The phytochemical analysis revealed the presence of carbohydrates, proteins and amino acids, alkaloids, tannins, glycosides, flavonoids, terpenoids, steroids, saponins and phenols. The antioxidant activity using hydrogen peroxide radical scavenging assay showed that IC<sub>50</sub> of ethanolic and aqueous extracts were 21.73μg/ml and 36.36μg/ml, respectively.</p> <p>&nbsp;</p></summary> <published>2024-11-26T00:00:00+00:00</published> <rights>Copyright (c) </rights> </entry> <entry> <id>https://ijpcr.net/ijpcr/article/view/601</id> <title>Preparation And In Vitro Evaluation Of Glimepiride Sustained Release Matrix Tablets</title> <updated>2025-07-05T05:28:28+00:00</updated> <author> <name>Rafqua Zeb</name> <email>rafquazeb786@gmail.com</email> </author> <author> <name>Ramakrishna Mungi </name> <email>rafquazeb786@gmail.com</email> </author> <author> <name>K. Balaji</name> <email>rafquazeb786@gmail.com</email> </author> <link rel="alternate" href="https://ijpcr.net/ijpcr/article/view/601" /> <summary type="html" xml:base="https://ijpcr.net/ijpcr/article/view/601"><p>The aim of the present study was to develop sustained release formulation of Glimepiride to maintain constant therapeutic levels of the drug for over 12 hrs. HPMC-K 100 M, Sodium Carboxy Methyl Cellulose, Grewia gum, Almond gum were employed as polymers. All the formulations were passed various physicochemical evaluation parameters and they were found to be within limits. Whereas from the dissolution studies it was evident that the formulation (F9) showed better and desired drug release pattern i.e., 99.9% in 12 hours. It contains the HPMC-K 100 M 1:1 as sustained release material. It followed Zero order release kinetics mechanism.</p></summary> <published>2024-10-18T00:00:00+00:00</published> <rights>Copyright (c) </rights> </entry> <entry> <id>https://ijpcr.net/ijpcr/article/view/602</id> <title>Evaluation Of Anti-Ulcer Activity Of Canthium Dicoccum Extract In Experimental Animal Model</title> <updated>2025-07-05T05:28:28+00:00</updated> <author> <name>Geeta Vani</name> <email>pittalaswathi@gmail.com</email> </author> <author> <name>Pittala Swathi</name> <email>pittalaswathi@gmail.com</email> </author> <author> <name>D. Venkata Ramana</name> <email>pittalaswathi@gmail.com</email> </author> <link rel="alternate" href="https://ijpcr.net/ijpcr/article/view/602" /> <summary type="html" xml:base="https://ijpcr.net/ijpcr/article/view/602"><p>The cause of ulceration in patients is mainly due to hypersecretion of gastric juice and also due to hypersecretion of pepsin. In traditional system of medicine a number of herbal preparations have been used for the treatment of peptic ulcers. There are various medicinal plants has been used for the treatment of gastrointestinal disorders. In view of this, in present study we have to evaluate the anti-ulcer activity of <em>Canthium Dicoccum</em>. Study was carried out, by using three methods i.e.,alcohol, paracetamol and stress induced ulcers in rats pretreated with the doses of 250 mg/kg AQCR and ALCR, 10mg/kg Omeoprazole and 50 mg/kg Ranitidine. To evaluate the antiulcer activity of aqueous and alcoholic extracts of <em>Canthium Dicoccum </em>leaves (AQCR and ALCR) at 250 doses using different experimentally induced gastric ulcer models in rats. Gastric ulcers were induced in rats by 80% alcohol, paracetamol and forced immersion stress induced methods. In alcohol induced ulcer model, paracetamol induced ulcer model and stress induced model the ulcer index was determined. Where as in stress induced ulcers stress plays an important role in ulcerogenesis. &nbsp;In alcohol-induced ulcers, AQCR and ALCR were effective in reducing lesion index and increasing the gastric mucus content. It was also effective in decreasing ulcer index in paracetamol-induced ulcers. All the results obtained with <em>Canthium Dicoccum </em>were dose dependent. <strong>&nbsp;</strong>The results suggest that AQCR and ALCR possesses significant and dose dependent antiulcer activity. The antiulcer activity of AQCR and ALCR can be attributed to its cytoprotective and antisecretory action.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;</p></summary> <published>2024-10-18T00:00:00+00:00</published> <rights>Copyright (c) </rights> </entry> <entry> <id>https://ijpcr.net/ijpcr/article/view/603</id> <title>Rp-Hplc Method Development And Validation For The Determination of Vismodegib In Pharmaceutical Dosage Form </title> <updated>2025-07-05T05:28:28+00:00</updated> <author> <name>Chikkela Sai Meghana</name> <email>saimeghana415@gmail.com</email> </author> <author> <name>Gorantla Nagamallika</name> <email>saimeghana415@gmail.com</email> </author> <link rel="alternate" href="https://ijpcr.net/ijpcr/article/view/603" /> <summary type="html" xml:base="https://ijpcr.net/ijpcr/article/view/603"><p>A Simple, sensitive, specific and precise RP-HPLC method for the pharmaceutical dose estimation of Vismodegib. Chromatogram was run through AscentisC18 150 x 4.6 mm, 5m. Mobile phase containing 0.1%NA<sub>2</sub>HPO<sub>4</sub>: Acetonitrile taken in the ratio 60:40was pumped through column at a flow rate of 1.0ml/min. Buffer used in this method was Sodium Hydrogen Phosphate (4.0ph) buffer. Temperature was maintained at 30°C. Optimized wavelength selected was 260.0nm. Retention time of Vismodegib was found to be 2.585 min. %RSD of the Vismodegib were and found to be 0.9. %RSD of Method precision of Vismodegib was found to be 0.5.%Recovery was obtained as 99.76% for Vismodegib. LOD, LOQ values obtained from regression equation of Vismodegib were 0.57, 1.72. Regression equation of Vismodegib isy = 37710x + 19681. Retention times were decreased, and that run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.&nbsp; &nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</p></summary> <published>2024-10-16T00:00:00+00:00</published> <rights>Copyright (c) </rights> </entry> <entry> <id>https://ijpcr.net/ijpcr/article/view/604</id> <title>Formulation And Evaluation Of Mouth Dissloving Flims Of Glycopyrrolate</title> <updated>2025-07-05T05:28:28+00:00</updated> <author> <name>S. Priyanka</name> <email>sanugalipriyanka72306@gmail.com</email> </author> <author> <name>Shiva Srikrishna</name> <email>sanugalipriyanka72306@gmail.com</email> </author> <author> <name>K. Nagasree</name> <email>sanugalipriyanka72306@gmail.com</email> </author> <author> <name>K. Shravankumar</name> <email>sanugalipriyanka72306@gmail.com</email> </author> <link rel="alternate" href="https://ijpcr.net/ijpcr/article/view/604" /> <summary type="html" xml:base="https://ijpcr.net/ijpcr/article/view/604"><p>Glycopyrrolate is an opioid pain medication used to treat moderate to moderately severe pain. When taken by mouth in an immediate-release formulation, the onset of pain relief usually begins within an hour. Present work aimed at preparing quick onset of action which is beneficial in hypertension, aiding in the enhancement of bioavailabity and is very convenient for administration without the problem of swallowing and using water. The film was prepared by using polymers such as Sodium alginate, Pectin and HPMC by a solvent casting method.&nbsp; They were evaluated for physical characteristics such as Thickness, Weight Variation, Disintegration time, Drug content, Tensile strength, % Elongation, Folding Endurance and <em>In vitro</em> Dissolution Studies give satisfactory results. The <em>in vitro</em> dissolution time of the optimized batch G7 was found to be 99.54%.&nbsp; The optimized batch <em>in vitro</em> disintegration time was found to 15 sec. &nbsp;</p></summary> <published>2024-10-16T00:00:00+00:00</published> <rights>Copyright (c) </rights> </entry> <entry> <id>https://ijpcr.net/ijpcr/article/view/605</id> <title>A Study On Assessment Of Diabetic Foot Ulcers In A Tertiary Rohini Hospital</title> <updated>2025-07-05T05:28:28+00:00</updated> <author> <name>K. Veera Brahmananda Reddy</name> <email>kunreddy125@gmail.com</email> </author> <author> <name>M. Vidhya</name> <email>kunreddy125@gmail.com</email> </author> <author> <name>D. Swathi</name> <email>kunreddy125@gmail.com</email> </author> <author> <name>K. Shravankumar</name> <email>kunreddy125@gmail.com</email> </author> <link rel="alternate" href="https://ijpcr.net/ijpcr/article/view/605" /> <summary type="html" xml:base="https://ijpcr.net/ijpcr/article/view/605"><p><strong>Background:</strong> Diabetic foot ulcer is one of the most significant and devastating complications of diabetes, and is defined as a foot affected by ulceration that is associated with neuropathy and/or peripheral arterial disease of the lower limb in a patient with diabetes. The global diabetic foot ulcer Prevalence was 6.3% which was higher in males than in females and higher in t2dm than in t1dm.</p> <p>Aims And Objectives: To determine the prevalence, drug prescribing patterns, severity of diabetic foot ulcer and to assess the anxiety and depression using HADS scale in type 2 diabetes patients.</p> <p><strong>Materials And Methodology:</strong> A Prospective observational study with a sample size of 130 patients in a period of 6 months was conducted as per inclusion and exclusion criteria. Clinical data is collected from patients who are diagnosed with diabetic foot ulcer and received anti-diabetic medications.</p> <p><strong>Results:</strong> According to our study males 76.0% ( 99)were more prevalant than females 24.0% (31). Majority of patient were on 127(97.7%)Insulin treatment and 19 were on oral hypoglycaemic treatment and 115 (88.5%)Beta lactamase inhibitors, 113 (86.9%)cephalosporins and 73(56.2%)macrolides were highly prescribed . Majority of patients were in grade - 3 41.5% (54)&nbsp; severity of DFU . Anxiety 28 (21.5%)was majorly observed when compared to the Depression 14 (10.8%) according to HADS scale .</p> <p><strong>Conclusion:</strong> Foot ulcers in patients with diabetes is common, and frequently leads to lower limb amputation unless a prompt, rational, multidisciplinary approach to therapy is taken. The health care providers are recommended to enhance preventive measures in the reduction of foot ulcer through promoting foot self-care practice, giving special emphasis during follow-up of patients who came from rural areas, educating the patient to reduce overweight gain, and managing the neuropathy thoroughly in order to decrease the occurrence of diabetic foot ulcer.</p></summary> <published>2024-10-16T00:00:00+00:00</published> <rights>Copyright (c) </rights> </entry> <entry> <id>https://ijpcr.net/ijpcr/article/view/630</id> <title>Phytochemical Investigation And Pharmacological Activities On Flowers Of Artabotrys Hexapetalus (L.f) Bhandari</title> <updated>2025-07-05T05:28:28+00:00</updated> <author> <name>Annalakshmi. S</name> <email>annalakshmijjm@gmail.com</email> </author> <author> <name>Meena Prabha. P</name> <email>annalakshmijjm@gmail.com</email> </author> <author> <name>B. Sangameswaran</name> <email>annalakshmijjm@gmail.com</email> </author> <link rel="alternate" href="https://ijpcr.net/ijpcr/article/view/630" /> <summary type="html" xml:base="https://ijpcr.net/ijpcr/article/view/630"><p><em>Artabotrys hexapetalus</em>, a climbing shrub native to India and Southeast Asia, has gained attention in traditional medicine for its diverse therapeutic applications. This research examines the ethnobotanical uses, and pharmacological properties of <em>A. hexapetalus</em>, emphasizing its potential as a valuable medicinal plant. This paper aims to consolidate current knowledge, fostering future research into the pharmacological potential of <em>A. hexapetalus</em>. Research on plant part flowers has identified the presence of alkaloids, flavonoids, tannins, phenolics, and terpenoids. It reveals a diverse array of bioactive compounds, supporting its traditional medicinal uses.&nbsp; It reflects a greater reduction in the DPPH radical. % inhibition of <em>Artabotrys hexapetalus </em>48.9 ± 1.5. A lower absorbance reading indicates a higher free radical scavenging activity of the extract. Inhibitors of alpha-glucosidase can slow down the absorption of glucose from the intestines, thereby helping in the management of postprandial hyperglycemia, a common feature of type 2 diabetes mellitus. In this study, the alpha-glucosidase inhibitory activity of <em>Artabotrys hexapetalus</em> flowers was tested at different concentrations and the results were compared to the standard drug acarbose. The growing cells were made in to scratch wounds after the treating with ethanolic extract was noted with MRI image analysis software. The time intervals show the result as 0 hour at 2386659, 24 hours at 1174269, 48 hours at 679741, 72 hours at 324498 wound area (px). The ethanolic extract was given notable results. Despite its wide usage, there is limited published data synthesizing its medicinal properties. This research aims to provide a detailed examination of <em>A. hexapetalus</em>, drawing attention to its potential for pharmacological applications.</p></summary> <published>2024-11-19T00:00:00+00:00</published> <rights>Copyright (c) </rights> </entry> <entry> <id>https://ijpcr.net/ijpcr/article/view/631</id> <title>A Review On Artabotrys hexapetalus (L.F.) Bhandari Botanical description, Traditional uses, Phytochemical and Pharmacological Properties</title> <updated>2025-07-05T05:28:29+00:00</updated> <author> <name>Annalakshmi.S</name> <email>annalakshmijjm@gmail.com</email> </author> <author> <name>Meena Prabha.P</name> <email>annalakshmijjm@gmail.com</email> </author> <link rel="alternate" href="https://ijpcr.net/ijpcr/article/view/631" /> <summary type="html" xml:base="https://ijpcr.net/ijpcr/article/view/631"><p>This review is intended to investigate the published report regarding botanical description, traditional uses and pharmacological properties and put forth the therapeutic potential of&nbsp;<em>Artabotrys hexapetalus&nbsp;</em>(L. f.) Bhandari. It belongs to the family&nbsp;<em>Annonaceae</em>, one of the therapeutically important plants, broadly distributed throughout the world. An extensive review of the literature available in various recognized databases including logical writing and scientific literature, search engines such as, PubMed, Scopus, Google Scholar as well as relevant books, websites, scientific publications, and dissertations were utilized as a source of information that provided an up-to-date review. The objective of the present work is to review the description,traditional uses and pharmacological properties .In the various Artabotrys species, the major compounds are monoterpene and sesquiterpene hydrocarbons and oxygenated sesquiterpenes. The frequently and most commonly identified constituents are β-caryophyllene, caryophyllene oxide, 3-Carene, cyperene, cyperenone and 1,5-epoxy-salvial4(14)-ene. Other constituents seems to be more specific to the respective Artabotrys species</p></summary> <published>2024-11-12T00:00:00+00:00</published> <rights>Copyright (c) </rights> </entry> <entry> <id>https://ijpcr.net/ijpcr/article/view/632</id> <title>A review on pharmacological activities of Abelmoschus esculentus</title> <updated>2025-07-05T05:28:29+00:00</updated> <author> <name>M. Suganya</name> <email>suganyapharmacist@gmail.com</email> </author> <author> <name>P. Meena prabha</name> <email>suganyapharmacist@gmail.com</email> </author> <author> <name>B.Sangameswaran</name> <email>suganyapharmacist@gmail.com</email> </author> <link rel="alternate" href="https://ijpcr.net/ijpcr/article/view/632" /> <summary type="html" xml:base="https://ijpcr.net/ijpcr/article/view/632"><p><em>Abelmoschus esculentus</em>&nbsp;L. Moench (okra) which belongs to the family Malvaceae is a commonly consumed vegetable that consists of the seed component which is rich in polyphenolic compounds. The aim of this study is to highlight the chemical and biological diversity of&nbsp;<em>A. esculentus</em>. This plant contains many vitamins, minerals, proteins and carbohydrates in addition to flavonoids, terpenes, phenolic compounds and sterols. These variations in the chemical composition resulted in different therapeutic activities including antidiabetic, hypolipidemic, antioxidant, antimicrobial, anticancer, wound healing, hepatoprotective, immunomodulator, neuroprotective, and gastroprotective activities in addition to cardioprotective activity.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;</p></summary> <published>2024-12-01T00:00:00+00:00</published> <rights>Copyright (c) </rights> </entry> <entry> <id>https://ijpcr.net/ijpcr/article/view/633</id> <title>Pharmacognostical, phytochemical and pharmacological activities on leaves of Abelmoschus esculentus. linn</title> <updated>2025-07-05T05:28:29+00:00</updated> <author> <name>M. Suganya</name> <email>suganyapharmacist@gmail.com</email> </author> <author> <name>P. Meena prabha</name> <email>suganyapharmacist@gmail.com</email> </author> <author> <name>B. Sangameswaran</name> <email>suganyapharmacist@gmail.com</email> </author> <link rel="alternate" href="https://ijpcr.net/ijpcr/article/view/633" /> <summary type="html" xml:base="https://ijpcr.net/ijpcr/article/view/633"><p><em>Abelmoschus esculentus</em>(okra), is a widely cultivated plant, particularly in tropical and subtropical regions. Pharmacognostical involves the study of macroscopic characteristics ofthe leaves of <em>Abelmoschus esculentus</em> are large,lobed,and havea characteristic dark green color.The leaf surface is rough with veins.The leaf’s internal structure consist of an like upper epidermis, lower epidermis,vascularbundle,spongyparenchyma,pallisade parenchyma,. Preliminary physicochemical studies confirmed the purity of the drug.The phytochemical investigation showedthe presence of Alkaloids, Flavonoids, Terpenoids, Anthraquinone glycoside, Phenolic compounds, Saponins.The results indicate that as the concentration of the ethanolic extract increased, the percentage of α-amylase inhibition also increased, demonstrating its potential as an anti-diabetic agent. At the highest concentration (400 μg/mL), the ethanolic extract achieved 63.14% inhibition, compared to 79.19% inhibition observed with acarbose.The results indicate that the concentration of the ethanolic extract achieved 75.64% inhibition, compared to 94.67% inhibition observed with acarbose. The IC₅₀ values indicate that the ethanolic extract has a higher concentration required for 50% inhibition compared to Captopril.</p></summary> <published>2024-11-29T00:00:00+00:00</published> <rights>Copyright (c) </rights> </entry> <entry> <id>https://ijpcr.net/ijpcr/article/view/634</id> <title>Impact Of Patient Information Leaflet And Management Of Levothyroxine Among Pregnant Women With Hypothyroidism</title> <updated>2025-07-05T06:29:24+00:00</updated> <author> <name>B. Mahender</name> <email>bashettimahender@gmail.com</email> </author> <author> <name>A. Rajendraprasad</name> <email>bashettimahender@gmail.com</email> </author> <author> <name>D. Swathi</name> <email>bashettimahender@gmail.com</email> </author> <author> <name>K. Shravankumar</name> <email>bashettimahender@gmail.com</email> </author> <link rel="alternate" href="https://ijpcr.net/ijpcr/article/view/634" /> <summary type="html" xml:base="https://ijpcr.net/ijpcr/article/view/634"><p>Hypothyroidism an endocrine disorder is an underactive thyroid gland, which does not make enough thyroid hormone. Hypothyroidism during pregnancy can have irreversible effects on the fetus. Treatment of hypothyroidism during pregnancy is given with levothyroxine based on the assessment of thyroid functioning. The present study was aimed to counsel patients using patient information leaflet and management of levothyroxine in a tertiary care hospital. The main objectives are to develop a PIL, identify the application and its usefulness, and to understand the drug utilization evaluation in hypothyroid pregnant patients. A prospective observational study was carried out including 98 pregnant women with hypothyroidism during august 2019 to January 2020. A total of 98 patients were enrolled in the study, the percentage distribution of subjects age showed that the age group of 18-25 were predominant. Among them, 48 were in the first trimester. All the patients were counseled using PIL and appropriate feedback was collected. Management of levothyroxine was carried out from the level of TSH and dose of levothyroxine collected during follow up. Hence it can be concluded that patient information leaflets can show a great impact on patients by improving their condition and thus, a reduction in dose can be achieved.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;</p></summary> <published>2024-10-16T00:00:00+00:00</published> <rights>Copyright (c) </rights> </entry> <entry> <id>https://ijpcr.net/ijpcr/article/view/635</id> <title>Evaluation Of Anti-Depressant Effect Of Euphorbia Cyanthophora Leaves In Reserpine Induced Cns Depression In Rats</title> <updated>2025-07-05T06:32:28+00:00</updated> <author> <name>K. Akashraj</name> <email>akash890vkl@gmail.com</email> </author> <author> <name>G. Muthukumaran</name> <email>akash890vkl@gmail.com</email> </author> <link rel="alternate" href="https://ijpcr.net/ijpcr/article/view/635" /> <summary type="html" xml:base="https://ijpcr.net/ijpcr/article/view/635"><p>The Aim is to perform the anti-depressant effect of Ethanolic extract of <em>euphorbia cyanthopora </em>leaves. Initially the plant leaves are collected and subjected for drying. Extraction is done with ethanol for a period of time and was used to perform preliminary phytochemical tests are to be done with the extraction and then the extract was used for the testing the in-vitro anti-oxidant studies and followed by the behavourial studies are done for the estimation of the drug. Then the in-vivo pharmacological studies are done for the estimation then the invitro studies done by sacrifising the animal then the bio chemical studies are to be done and finally the statistical analysis done for the identification of the activity done by the drug.</p></summary> <published>2024-10-18T00:00:00+00:00</published> <rights>Copyright (c) </rights> </entry> <entry> <id>https://ijpcr.net/ijpcr/article/view/636</id> <title>Drug Discovery In Pharmaceutical Industry By Using Artificial Inteligence </title> <updated>2025-07-05T09:48:25+00:00</updated> <author> <name>M.L. Surekha</name> <email>Abbireddyarun77@gmail.com</email> </author> <author> <name>Arunkumar Abbireddy</name> <email>Abbireddyarun77@gmail.com</email> </author> <author> <name>Surya Merugumala</name> <email>Abbireddyarun77@gmail.com</email> </author> <author> <name>Chandu Bandaru</name> <email>Abbireddyarun77@gmail.com</email> </author> <author> <name>RavaliChunduru</name> <email>Abbireddyarun77@gmail.com</email> </author> <author> <name>Haritha Konda</name> <email>Abbireddyarun77@gmail.com</email> </author> <link rel="alternate" href="https://ijpcr.net/ijpcr/article/view/636" /> <summary type="html" xml:base="https://ijpcr.net/ijpcr/article/view/636"><p>The pharmaceutical industry is undergoing a significant transformation with the integration of Artificial Intelligence (AI) in drug discovery. AI algorithms can analyze vast datasets, predict outcomes, and automate tasks, accelerating the identification of potential drug candidates and improving patient care. This article explores the role of AI in pharmaceutical analysis, including drug discovery, clinical trials, quality control, manufacturing, and personalized medicine. By leveraging AI, researchers can optimize lead compounds, predict drug interactions, and identify potential side effects, reducing the time and cost associated with traditional drug discovery methods. Despite challenges, AI has the potential to revolutionize the pharmaceutical industry, enabling faster, more efficient, and patient-centric drug development</p></summary> <published>2024-10-25T00:00:00+00:00</published> <rights>Copyright (c) </rights> </entry> <entry> <id>https://ijpcr.net/ijpcr/article/view/637</id> <title>Pharmacological Evaluation Of Anti Depressant Activity Of Hibiscus Leaves In Animal Models</title> <updated>2025-07-05T09:56:46+00:00</updated> <author> <name>V. Anusha</name> <email>pcopaac2007@gmail.com</email> </author> <author> <name>Ch. Sunitha</name> <email>pcopaac2007@gmail.com</email> </author> <author> <name>L. Harikiran</name> <email>pcopaac2007@gmail.com</email> </author> <link rel="alternate" href="https://ijpcr.net/ijpcr/article/view/637" /> <summary type="html" xml:base="https://ijpcr.net/ijpcr/article/view/637"><p>The objective was to investigate the antidepressant activity of the methanolic extract of leaves of Hibiscus in mice. The study aimed to assess the effect of Hibiscus on antidepressant activity in the brain. The results confirm the antidepressant activity of Hibiscus, as it reduced immobility in both the Forced Swim Test (FST) and Tail Suspension Test (TST). In the present study, Hibiscus significantly increased the frequency of 5-HTP-induced head twitches, Clonidine-induced aggression, and L-DOPA-induced hyperactivity and aggressive behavior, indicating enhanced activity on serotonergic, noradrenergic, and dopaminergic pathways, respectively. Our results also confirm the involvement of these pathways in depression. Pretreatment with Hibiscus significantly increased the levels of superoxide dismutase (SOD) and catalase while simultaneously decreasing lipid peroxidation (LPO) levels in the mice brain, suggesting strong antioxidant activity. Since oxidative stress is reported to play an important role in depression, the antioxidant activity of Hibiscus might be part of the mechanism for its antidepressant effects. Results from behavioral experiments indicate that the antidepressant activity of Hibiscus might be due to its facilitatory effect on serotonergic, noradrenergic, and dopaminergic systems, in addition to its direct antidepressant activity</p></summary> <published>2024-11-07T00:00:00+00:00</published> <rights>Copyright (c) </rights> </entry> <entry> <id>https://ijpcr.net/ijpcr/article/view/638</id> <title>In-Vitro Evaluation Of Anti-Oxidant Activity Of Ageratum Conyzoides Linn Leaves In Animal Models</title> <updated>2025-07-05T09:59:15+00:00</updated> <author> <name>S. Vijayalakshmi</name> <email>pcopaac2007@gmail.com</email> </author> <author> <name>L. Harikiran</name> <email>pcopaac2007@gmail.com</email> </author> <link rel="alternate" href="https://ijpcr.net/ijpcr/article/view/638" /> <summary type="html" xml:base="https://ijpcr.net/ijpcr/article/view/638"><p>Antioxidants are compounds that can inhibit or prevent the oxidation of the easily oxidized substrate. One of the plants as a potential source of bioactive compounds and antioxidant activity (<em>Ageratum conyzoides</em>). This plant was commonly found in the West Africa, Australia, Colombia and India has been used by the society. This study aimed to determine the proximate compositions, bioactive compounds and antioxidant activity from large-leafed mangrove fruit which extracted by methanol.The phytochemical screening was carried on the both extracts of leaves of <em>Ageratum conyzoides</em>, revealed the presence of some active ingredients such asAlkaloid, Flavonoids, Tannins, Saponins, Phenols.The aqueous and alcoholic leaves extract were also evaluated for their antioxidant activity using FRAP assay, Metal chelating assay, DPPH radical scavenging assay, superoxide-radical scavenging assay and Hydrogen peroxide scavenging assay. The result of the present study showed that the ethanolic leaves extract of <em>Ageratum conyzoides</em>has shown the greatest anti-oxidant activity than aqueous extracts. The high scavenging property of may be due to hydroxyl groups existing in the phenolic compounds. Further work is needful to isolate the exact compound which is responsible for antioxidant activity and biophysical characterization can be done in the future</p></summary> <published>2024-11-08T00:00:00+00:00</published> <rights>Copyright (c) </rights> </entry> <entry> <id>https://ijpcr.net/ijpcr/article/view/639</id> <title>Formulation And In Vitro Evaluation Of Rofecoxib Solid Dispersion Tablets With Enhanced Dissolution Rate</title> <updated>2025-07-05T10:02:26+00:00</updated> <author> <name>S. Umamaheshwari</name> <email>pcopaac2007@gmail.com</email> </author> <author> <name>L. Harikiran</name> <email>pcopaac2007@gmail.com</email> </author> <link rel="alternate" href="https://ijpcr.net/ijpcr/article/view/639" /> <summary type="html" xml:base="https://ijpcr.net/ijpcr/article/view/639"><p>The poor solubility of drug substances in water and their low dissolution rate in aqueous G.I.T fluid often leads to insufficient bioavailability. Rofecoxibis a Nonsteroidal anti-inflammatory drug (NSAID) drug which is purely insoluble in water. Since only dissolved drug can pass the gastro intestinal membrane, proper solubility of the drug is ultimately desired. Solubility of the poorly soluble drug, Rofecoxib, is enhanced by formulating solid dispersion using Direct Compression method. Drug and carriers like Mannitol and PVP- K30in different ratios like 1: 1, 1: 2, 1: 3, 1:4, 1:5 and 1:6were used for formulating solid dispersions. The FTIR spectra of the Rofecoxib and polymers alone and in combination show the compatibility of the drug and excipients. The solid dispersions wereevaluated for practical yield and <em>in vitro</em> dissolution. It was concluded that 1:2 ratio of Drug: PVP- K30 shows better <em>in vitro</em> dissolution rate. Further the solid dispersion with highest release rate was formulated in tablet dosage form. The angle of repose, bulk density, tapped density, carr’s index and hausner ratio were calculated for the micromeritic characterization of the powder blend. The tablets were further studied for different pharmacopoeial and non pharmacopoeial evaluation test. Rofecoxib was found to be within the standards.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;</p></summary> <published>2024-11-08T00:00:00+00:00</published> <rights>Copyright (c) </rights> </entry> <entry> <id>https://ijpcr.net/ijpcr/article/view/640</id> <title>Formulation And In Vitro Evaluation of Etodolac Mucoadhesive Sustained Release Tablets</title> <updated>2025-07-05T10:05:28+00:00</updated> <author> <name>P. Alekhya</name> <email>pcopaac2007@gmail.com</email> </author> <author> <name>V. Lavanya</name> <email>pcopaac2007@gmail.com</email> </author> <author> <name>B. Thejovathi</name> <email>pcopaac2007@gmail.com</email> </author> <link rel="alternate" href="https://ijpcr.net/ijpcr/article/view/640" /> <summary type="html" xml:base="https://ijpcr.net/ijpcr/article/view/640"><p>Etodolac is commonlyused moderate pain, fever, and inflammation.The project was designed with an aim to develop and evaluate sustainedrelease Etodolac tabletwhich will reduce the dosing frequency and have better patient complianceand less fluctuations in plasma concentration. The matrix tablets were prepared by the direct compression method.The prepared sustained release tabletswere evaluated for angle of repose, bulk density, tapped density, Carr’s index, Hausner’s ratio at the precompression stage and thickness, weight variation, hardness, friability, drug content, <em>in vitro</em> drug release study at the post compression stage. <em>In vitro</em> dissolution studies (USP dissolution ratetest apparatus II, 50 rpm, 37°C ± 0.5°C) was carried out for the first 2 h in 0.1 N HCl (1.2 pH) and followed6.8 phosphate buffer for 12 h as a dissolution medium. The optimized formulation F-4 was shownmaximum drug release 98.31 in 12 h of dissolution. The release kinetic data of formulation F-4 shown Peppas release kinetics. FT-IR studies revealed that there was no interaction between the drug and polymers.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;</p></summary> <published>2024-11-11T00:00:00+00:00</published> <rights>Copyright (c) </rights> </entry> <entry> <id>https://ijpcr.net/ijpcr/article/view/641</id> <title>Design, Synthesis, Characterization, Invitro And Invivo Evaluation Of Anticancer, Anti-Alzheimer’s, Antibacterial Activity Of Indole And Aza Indole Derivatives</title> <updated>2025-07-05T10:08:39+00:00</updated> <author> <name>P. Raju</name> <email>pcopaac2007@gmail.com</email> </author> <author> <name>K. Hariprasad</name> <email>pcopaac2007@gmail.com</email> </author> <author> <name>K. Sundeep</name> <email>pcopaac2007@gmail.com</email> </author> <link rel="alternate" href="https://ijpcr.net/ijpcr/article/view/641" /> <summary type="html" xml:base="https://ijpcr.net/ijpcr/article/view/641"><p>The indole and azaindole classes of heterocyclic compounds are among the most active and powerful classes of chemicals due to the great variety of biological and pharmacological effects they exhibit. As part of this research, we synthesized oxyindole hydrazine carboxymide, which inhibits ACHE and tyrosine kinase, and cyclized azaindole sulphonamide, which acts on PhosphotidylIonositide 3-kinase and Acetylchlorine Esterase. All of these chemicals were created synthetically and then analyzed using spectroscopic methods. The chemicals that were synthesized were tested for several purposes, including anti-cancer activity using the MTT assay in HeLa and MCF cell lines, anti-bacterial activity using the cup plate agar diffusion method, in vivo behavioral pharmacological activity, and Alzheimer's activity using the Ellmans method and in vitro brain ACHES. Research into docking has revealed promising interactions with a variety of receptors. Excellent anti-cancer, anti-Alzheimer's, and antibacterial action was exhibited by all of the compounds. Oxindole hydrazine carboxymide, acetylchlorine esterase inhibitors, aza indole sulphonamide, cancer, bacteria, cup plate agar diffusion method, Ellman's method</p></summary> <published>2024-11-11T00:00:00+00:00</published> <rights>Copyright (c) </rights> </entry> <entry> <id>https://ijpcr.net/ijpcr/article/view/642</id> <title>Tizanidine-Loaded Nanogel: Fabrication, Characterization, And Potential Biomedical Applications Of A Synthetic Polymer-Based Delivery System</title> <updated>2025-07-05T10:12:46+00:00</updated> <author> <name>R. Suresh</name> <email>suresh.krs20011@gmail.com</email> </author> <author> <name>A. Tamilarasu</name> <email>suresh.krs20011@gmail.com</email> </author> <author> <name>S. Chandra</name> <email>suresh.krs20011@gmail.com</email> </author> <author> <name>N. Senthil Kumar</name> <email>suresh.krs20011@gmail.com</email> </author> <link rel="alternate" href="https://ijpcr.net/ijpcr/article/view/642" /> <summary type="html" xml:base="https://ijpcr.net/ijpcr/article/view/642"><p>Nanogels, defined as highly cross-linked nano-sized hydrogel systems, offer unique advantages for drug delivery due to their hydrophilic networks capable of imbibing water or physiological fluids. This study focuses on the fabrication, characterization, and potential biomedical applications of a tizanidine-loaded nanogel using synthetic polymers. The nanogel was prepared using a homogenization technique, resulting in a stable O/W emulsion that transformed into nanogel. Characterization included Fourier-transform infrared spectroscopy (FTIR) for compatibility studies, particle size analysis using Malvern Zeta sizer, and zeta potential measurement. The drug content and release profile were evaluated using spectrophotometry and Franz diffusion cell, respectively. The optimized formulation (F9) demonstrated superior drug release (83.62% over 24 hours) and stability, with a particle size of 449 nm and zeta potential of 13.3 mV. In vitro release studies confirmed a sustained release pattern, enhancing cellular uptake and bioavailability. The study concludes that the tizanidine-loaded nanogel, formulated using cost-effective methods, can effectively deliver drugs transdermally, reducing administration frequency and side effects, making it a promising candidate for muscle spasm treatment.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;</p></summary> <published>2024-11-12T00:00:00+00:00</published> <rights>Copyright (c) </rights> </entry> <entry> <id>https://ijpcr.net/ijpcr/article/view/643</id> <title>Formulation And Evaluation Of Flutamide-Loaded Nanoparticles By Precipitation Method</title> <updated>2025-07-05T10:16:14+00:00</updated> <author> <name>Mohd Abdul Hadi</name> <email>hadi.lcp@gmail.com</email> </author> <author> <name>Ch. Mounika</name> <email>hadi.lcp@gmail.com</email> </author> <link rel="alternate" href="https://ijpcr.net/ijpcr/article/view/643" /> <summary type="html" xml:base="https://ijpcr.net/ijpcr/article/view/643"><p>Nanoparticles represent a promising drug delivery system of controlled and targeted drug release. They are specially designed to release the drug in the vicinity of target tissue. The aim of this study was to prepare and evaluate PLGA nanoparticles containing Flutamide in different drug to polymer ratio. SEM indicated that nanoparticles have a discrete spherical structure. FT-IR studies indicated that there was no chemical interaction between drug and polymer and stability of drug. The <em>in vitro </em>release behaviour from all the drug loaded batches was found to be Higuchi release and provided sustained release over a period of 12 h. The developed formulation overcome and alleviates the drawbacks and limitations of Flutamide sustained release formulations and could possibility be advantageous in terms of increased bioavailability of lamivudine</p></summary> <published>2024-11-12T00:00:00+00:00</published> <rights>Copyright (c) </rights> </entry> <entry> <id>https://ijpcr.net/ijpcr/article/view/644</id> <title>Formulation Of Transdermal Approach- Patch For The Treatment Of Angina Using Nifedipine As Model Drug</title> <updated>2025-07-05T10:29:28+00:00</updated> <author> <name>Nampelly Karnakar </name> <email>karnakar6988@gmail.com</email> </author> <author> <name>R. Chandini</name> <email>karnakar6988@gmail.com</email> </author> <author> <name>P. Sravanthi</name> <email>karnakar6988@gmail.com</email> </author> <link rel="alternate" href="https://ijpcr.net/ijpcr/article/view/644" /> <summary type="html" xml:base="https://ijpcr.net/ijpcr/article/view/644"><p>The skin can be used as the site for drug administration for continuous transdermal drug infusion into the systemic circulation. For the continuous diffusion penetration of the drugs through the intact skin surface membrane-moderated systems, matrix dispersion type systems, adhesive diffusion controlled systems and micro reservoir systems have been developed. Various penetration enhancers are used for the drug diffusion through skin. In matrix dispersion type systems, the drug is dispersed in the solvent along with the polymers and solvent allowed to evaporate forming a homogeneous drug-polymer matrix. &nbsp;Matrix type systems were developed in the present study. In the present work, an attempt has been made to develop a matrix-type transdermal therapeutic system comprising of Nifedipine with different concentration of various polymers alone using solvent evaporation technique. The physicochemical compatibility of the drug and the polymers was studied by infrared spectroscopy. The results obtained showed no physical-chemical incompatibility between the drug and the polymers. F4 formulation has been selected as the best formulation among all the other formulations. The <em>in vitro</em> drug diffusion studies from the formulation were found to be sustained release. All the evaluation parameters obtained from the best formulation were found to be satisfactory. The data obtained from the <em>in vitro</em> release studies were fitted to various kinetic models like zero order, first order, Higuchi model and peppas model. From the kinetic data it was found that drug release follows peppas model release by diffusion technique from the polymer</p></summary> <published>2024-11-12T00:00:00+00:00</published> <rights>Copyright (c) </rights> </entry> <entry> <id>https://ijpcr.net/ijpcr/article/view/645</id> <title>Formulation And Evaluation Of Gastro Retentive Floating Microspheres Of Orlistat</title> <updated>2025-07-05T10:34:46+00:00</updated> <author> <name>P. Sravanthi</name> <email>sravs.peram@gmail.com</email> </author> <author> <name>P. Harshitha</name> <email>sravs.peram@gmail.com</email> </author> <author> <name>Nampelly Karnakar</name> <email>sravs.peram@gmail.com</email> </author> <author> <name>B. Swapna</name> <email>sravs.peram@gmail.com</email> </author> <link rel="alternate" href="https://ijpcr.net/ijpcr/article/view/645" /> <summary type="html" xml:base="https://ijpcr.net/ijpcr/article/view/645"><p>Gastroretentive dosage forms&nbsp; have&nbsp; potential&nbsp; for&nbsp; use&nbsp; as&nbsp; controlled-&nbsp; release drug&nbsp; delivery systems. The aim of the&nbsp; present&nbsp; study&nbsp; is&nbsp; formulation&nbsp; and&nbsp; characterization&nbsp; of&nbsp; floating&nbsp; microspheres&nbsp; using Orlistat as a model drug for the management of Orlistat is generally prescribed for arthritis-related inflammatory pains or severe toothaches that result in the inflammation of the gums. Floating microspheres were prepared by solvent evaporation technique using Sodium alginate, Guar gum, and Hpmc as release retarding polymers. The floating microspheres were evaluated for percentage yield (%), Mean particle size, drug content, drug entrapment efficiency, <em>In vitro </em>Buoyancy and <em>in vitro </em>drug release studies. Compatibility studies were performed by&nbsp; fourier&nbsp; transform&nbsp; infrared&nbsp; (FTIR)&nbsp; technique. The prepared microspheres showed prolonged drug release of 12 h. The optimized formulation (F4) showed better drug release 97.36 % for 12 hours. It was concluded that developed floating microspheres of Orlistat offers a suitable and practical approach for&nbsp; prolonged&nbsp; release&nbsp; of&nbsp; drug&nbsp; over&nbsp; an&nbsp; extended&nbsp; period&nbsp; of&nbsp; time&nbsp; and&nbsp; thus&nbsp; oral&nbsp; bioavailability, efficacy and patient compliance is improved.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;</p></summary> <published>2024-11-12T00:00:00+00:00</published> <rights>Copyright (c) </rights> </entry> <entry> <id>https://ijpcr.net/ijpcr/article/view/646</id> <title>Evaluation Of Anti Asthmatic Activity Of Capparis Decidua In Animal Models</title> <updated>2025-07-05T10:41:08+00:00</updated> <author> <name>C. Nagamani</name> <email>manisunil212@gmail.com</email> </author> <author> <name>A. Swetha kumari</name> <email>manisunil212@gmail.com</email> </author> <author> <name>A. Srinivasa Rao</name> <email>manisunil212@gmail.com</email> </author> <author> <name>K. Sumalatha</name> <email>manisunil212@gmail.com</email> </author> <author> <name>P.Balaji</name> <email>manisunil212@gmail.com</email> </author> <link rel="alternate" href="https://ijpcr.net/ijpcr/article/view/646" /> <summary type="html" xml:base="https://ijpcr.net/ijpcr/article/view/646"><p>Asthma is a chronic disease that affects approximately 300 million people worldwide. Although wide range of drug is available, the relief provided by them is mainly symptomatic and short lived. Moreover, the side effects of these drugs are also quite disturbing. There are many natural herbs that can be used for asthma, treatment. <em>Capparisdeciduas </em>is traditionally used to treat asthma.</p> <p><strong>Objective: </strong>Although these plants possess diverse pharmacological actions, the scientific data on anti-asthmatic actions of this plant has got little attention. An attempt has been made to evaluate antiasthamatic activity of <em>Capparisdeciduas </em>of aqueous and alcoholic extracts of medicinal plant.</p> <p><strong>Materials and methods: </strong>Different groups of guinea pigs (350-500 g) of either sex were subjected to acetylcholine (n = 5) and histamine-induced (n = 10) airway constriction.</p> <p><strong>Results: </strong>AQECD and ALECD (200 and 300 mg/kg) showed potent bronchodilator activity on histamine-and acetylcholine-induced airway constriction in guinea pigs. These extract has shown the sub-effective dose produced at 100, 200 and 300 mg/kg in all the models. These LD50 values fall within the practically non-toxic range.</p> <p><strong>Discussion and conclusion: </strong>The present study for the first time indicates anti-asthmatic, acute, sub-acute studies of <em>Capparisdeciduas </em>medicinal plants, confirming their traditional claims. The anti-asthmatic action of <em>Capparisdeciduas </em>could be due to the inhibition of the synthesis, release or action of histamine and acetylcholine effect.</p></summary> <published>2024-11-12T00:00:00+00:00</published> <rights>Copyright (c) </rights> </entry> <entry> <id>https://ijpcr.net/ijpcr/article/view/647</id> <title>Anti Diabetic Activity And Anti Hyperlipidemic Activity Of Catharanthus Roseus</title> <updated>2025-07-05T10:50:19+00:00</updated> <author> <name>Ramana hechhu</name> <email>hechhu.ramana@gmail.com</email> </author> <author> <name>Ch. Sirisha</name> <email>hechhu.ramana@gmail.com</email> </author> <author> <name>Avanapu Srinivasa Rao</name> <email>hechhu.ramana@gmail.com</email> </author> <author> <name>R. Ramya Krsishna</name> <email>hechhu.ramana@gmail.com</email> </author> <author> <name>A. Prasad</name> <email>hechhu.ramana@gmail.com</email> </author> <link rel="alternate" href="https://ijpcr.net/ijpcr/article/view/647" /> <summary type="html" xml:base="https://ijpcr.net/ijpcr/article/view/647"><p><strong>Objective</strong>: To investigate the anti-diabetic and anti Hyperlipidemic activity of methanol extract of <em>Catharanthus roseus </em>in male Wistar rats.</p> <p><strong>Material</strong> <strong>&amp;</strong> <strong>m</strong><strong>ethod:</strong> In this model of Hyperlipidemia, 30 adult male wistar rats (150-200gms) were evenly divided into 5 groups in both groups. Group-1 and Group-2 served as untreated and model controls respectively, while Group-3, 4 and 5 were the treatments groups which were simultaneously treated with standard, 200 and 400 mg/kg extract respectively along with High Fat Diet and Triton x 100. On last day, blood samples for biochemical parameters, were obtained under inhaled diether anaesthesia. In the model of anti diabetic animals were evenly divided into 5 groups.</p> <p><strong>R</strong><strong>esults: </strong>HFD and Triton x 100 treatment caused Hyperlipidemia as evidenced by marked elevation in Cholesterol, Triglycerides, LDL, VLDL and decrease in HDL levels. Co-administration of extract with HFD and Triton x 100 decreased rise Cholesterol, Triglycerides, LDL, VLDL and increase in HDL levels.</p> <p>Glucose loading caused hyperglycemia by elevation of glucose which was significantly reduced by treatment with standard and extract.</p> <p><strong>C</strong><strong>onclusion:</strong> It was observed that the methanol extract of <em>Catharanthus roseus </em>conferred anti diabetic and Anti- Hyperlipidemia activity by biochemical observation against HFD and Triton-x-100 induced Hyperlipidemia in rats. In the near future could constitute a lead to discovery of a novel drug for treatment of drug induced Hyperlipidemia and diabetes.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; &nbsp;</p></summary> <published>2024-11-12T00:00:00+00:00</published> <rights>Copyright (c) </rights> </entry> <entry> <id>https://ijpcr.net/ijpcr/article/view/648</id> <title>Impact of patient information leaflet and management of levothyroxine among pregnant women with hypothyroidism</title> <updated>2025-07-05T10:54:13+00:00</updated> <author> <name>Kotari Srikanth</name> <email>srikanthkotari7747@gmail.com</email> </author> <author> <name>D. Swathi</name> <email>srikanthkotari7747@gmail.com</email> </author> <author> <name>Rajendraprasad</name> <email>srikanthkotari7747@gmail.com</email> </author> <link rel="alternate" href="https://ijpcr.net/ijpcr/article/view/648" /> <summary type="html" xml:base="https://ijpcr.net/ijpcr/article/view/648"><p>Hypothyroidism an endocrine disorder is an underactive thyroid gland, which does not make enough thyroid hormone. Hypothyroidism during pregnancy can have irreversible effects on the fetus. Treatment of hypothyroidism during pregnancy is given with levothyroxine based on the assessment of thyroid functioning. The present study was aimed to counsel patients using patient information leaflet and management of levothyroxine in a tertiary care hospital. The main objectives are to develop a PIL, identify the application and its usefulness, and to understand the drug utilization evaluation in hypothyroid pregnant patients. A prospective observational study was carried out including 98 pregnant women with hypothyroidism during august 2019 to January 2020. A total of 98 patients were enrolled in the study, the percentage distribution of subjects age showed that the age group of 18-25 were predominant. Among them, 48 were in the first trimester. All the patients were counseled using PIL and appropriate feedback was collected. Management of levothyroxine was carried out from the level of TSH and dose of levothyroxine collected during follow up. Hence it can be concluded that patient information leaflets can show a great impact on patients by improving their condition and thus, a reduction in dose can be achieved</p></summary> <published>2024-11-23T00:00:00+00:00</published> <rights>Copyright (c) </rights> </entry> <entry> <id>https://ijpcr.net/ijpcr/article/view/649</id> <title>Evaluation of Antioxidant and Antibacterial Activity of Hydroethanolic Root Extract of Milllingtonia Hortensis L</title> <updated>2025-07-05T11:01:37+00:00</updated> <author> <name>Prabha Hullatti</name> <email>prabha4vin@gmail.com</email> </author> <author> <name>Maniteja Tunga</name> <email>prabha4vin@gmail.com</email> </author> <author> <name>Akshay C.N</name> <email>prabha4vin@gmail.com</email> </author> <author> <name>Revanth K Patankar</name> <email>prabha4vin@gmail.com</email> </author> <author> <name>Sahana Suresh Raikar</name> <email>prabha4vin@gmail.com</email> </author> <author> <name>Sandeep Karbasappa Kubsad</name> <email>prabha4vin@gmail.com</email> </author> <link rel="alternate" href="https://ijpcr.net/ijpcr/article/view/649" /> <summary type="html" xml:base="https://ijpcr.net/ijpcr/article/view/649"><p>The present study investigates the Antioxidant and Antibacterial activity of hydroethanolic extract of <em>Millingtonia hortensis</em> L root. Initially extract is prepared by maceration process. And phytochemical screening reveals the presence of phytochemicals like carbohydrate, flavonoid, tannins, glycosides and alkaloids. Antioxidant potential of hydroethanolic extract of <em>Millingtonia hortensis</em> L root is assessed by DPPH scavenging assay, revealing a strong dose dependent scavenging effect, with IC<sub>50</sub> values indicating significant Antioxidant activity. Additionally, the antibacterial activity was tested against gram negative bacteria’s such as <em>E coli</em> and <em>klebsiella</em> and gram-positive bacteria like <em>S aureus</em>. By using cup plate method. The extract processes considerable Antibacterial activity. These reveals the therapeutical potential of hydroethanolic extract of <em>Millingtonia hortensis</em> L root as Antibacterial agent. Further research is needed to elucidate its applications in health and medicine</p></summary> <published>2024-11-26T00:00:00+00:00</published> <rights>Copyright (c) </rights> </entry> </feed> If you would like to create a banner that links to this page (i.e. this validation result), do the following:
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